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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hy81STSerine/threonine-protein kinase PAK 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hy81STSerine/threonine-protein kinase PAK 12.7.11.11.000
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.542
4gmy0X5Tyrosine-protein kinase JAK2/0.534
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.533
3zep1NXTyrosine-protein kinase JAK32.7.10.20.531
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.521
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.520
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.519
3zh8C58Protein kinase C iota type2.7.11.130.518
4jia1K3Tyrosine-protein kinase JAK2/0.518
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.518
3at4CCKCasein kinase II subunit alpha2.7.11.10.517
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.516
2in6839Wee1-like protein kinase2.7.10.20.512
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.510
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.508
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.508
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.507
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.502
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.499
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.497
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.496
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.495
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.495
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.495
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.494
2qo9ANPEphrin type-A receptor 32.7.10.10.493
4hvi19STyrosine-protein kinase JAK32.7.10.20.493
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.493
1bygSTUTyrosine-protein kinase CSK/0.491
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.491
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.491
4jqeANPCasein kinase II subunit alpha2.7.11.10.491
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.490
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.490
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.490
4nka2K7Fibroblast growth factor receptor 1/0.489
2vd5BI8Myotonin-protein kinase2.7.11.10.487
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.487
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.486
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.486
4qmlANPSerine/threonine-protein kinase 242.7.11.10.486
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.485
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.485
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.485
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.484
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.484
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.483
2hog710Serine/threonine-protein kinase Chk12.7.11.10.483
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.483
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.482
2yn8STUEphrin type-B receptor 42.7.10.10.482
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.482
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.482
4bcmT7ZCyclin-dependent kinase 22.7.11.220.482
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.481
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.481
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.480
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.480
4ez50RSCyclin-dependent kinase 62.7.11.220.480
4qnaX11Serine/threonine-protein kinase 242.7.11.10.480
3cr0809Wee1-like protein kinase2.7.10.20.479
3gxlQIGTGF-beta receptor type-12.7.11.300.479
4grb0XGCasein kinase II subunit alpha2.7.11.10.479
4qmpDKISerine/threonine-protein kinase 242.7.11.10.479
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.478
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.478
4hvh19RTyrosine-protein kinase JAK32.7.10.20.478
2pvnP63Casein kinase II subunit alpha2.7.11.10.477
2x6dX6DAurora kinase A2.7.11.10.477
3l8p0CEAngiopoietin-1 receptor2.7.10.10.477
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.477
4hgs15GCasein kinase I isoform gamma-32.7.11.10.477
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.476
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.476
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.476
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.476
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.476
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.475
1wvxBD4Death-associated protein kinase 12.7.11.10.475
2izrBRKCasein kinase I isoform gamma-32.7.11.10.475
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.475
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
1pkdUCNCyclin-dependent kinase 22.7.11.220.474
4j97ACPFibroblast growth factor receptor 2/0.474
3ggfGVDSerine/threonine-protein kinase 26/0.473
3u4uLNHCasein kinase II subunit alpha2.7.11.10.472
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.472
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.471
1yvj4STTyrosine-protein kinase JAK32.7.10.20.471
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.471
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.471
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.471
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.471
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.471
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
1om1IQACasein kinase II subunit alpha2.7.11.10.470
2j0m4STFocal adhesion kinase 12.7.10.20.470
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.470
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.470
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.470
4aqc88ATyrosine-protein kinase JAK2/0.470
4dgnLU2Casein kinase II subunit alpha2.7.11.10.470
4j95ACPFibroblast growth factor receptor 2/0.470
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.468
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.468
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.468
2z2w770Wee1-like protein kinase2.7.10.20.468
3a7hATPSerine/threonine-protein kinase 242.7.11.10.468
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.468
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.467
2izuP01Casein kinase I isoform gamma-32.7.11.10.467
3be9P04Casein kinase II subunit alpha2.7.11.10.467
3lpbNVBTyrosine-protein kinase JAK2/0.467
3t8oATPRhodopsin kinase/0.467
3zewSTUEphrin type-B receptor 42.7.10.10.467
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.467
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.466
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.466
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.466
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.466
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.466
5e8wSTUTGF-beta receptor type-12.7.11.300.466
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
2w05FRTCyclin-dependent kinase 22.7.11.220.465
3q9xEMOCasein kinase II subunit alpha2.7.11.10.465
3rak03ZCyclin-dependent kinase 22.7.11.220.465
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.465
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.465
1oiyN41Cyclin-dependent kinase 22.7.11.220.464
1x8b824Wee1-like protein kinase2.7.10.20.464
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.463
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.463
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.463
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.462
2izt23DCasein kinase I isoform gamma-32.7.11.10.462
4f081RSTyrosine-protein kinase JAK2/0.462
4o0wADNAurora kinase A2.7.11.10.462
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
1zrzBI1Protein kinase C iota type2.7.11.130.461
2cchATPCyclin-dependent kinase 22.7.11.220.461
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.461
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.461
4bgg844Activin receptor type-12.7.11.300.461
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.461
4qmzB49Serine/threonine-protein kinase 242.7.11.10.461
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.460
1vjy460TGF-beta receptor type-12.7.11.300.460
2izsBRQCasein kinase I isoform gamma-32.7.11.10.460
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.460
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.459
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.459
2csnCKICasein kinase I homolog 12.7.11.10.459
4c61LMMTyrosine-protein kinase JAK2/0.459
4c62XWWTyrosine-protein kinase JAK2/0.459
4erwSTUCyclin-dependent kinase 22.7.11.220.459
4ji91M3Tyrosine-protein kinase JAK2/0.459
4wboANWRhodopsin kinase/0.459
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.458
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.458
4bcnT9NCyclin-dependent kinase 22.7.11.220.458
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.458
4qmySTUSerine/threonine-protein kinase 242.7.11.10.458
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.457
1xjdSTUProtein kinase C theta type2.7.11.130.457
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.457
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.457
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.457
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.457
4bbe3O4Tyrosine-protein kinase JAK2/0.457
4dgo0JWCasein kinase II subunit alpha2.7.11.10.457
1aq1STUCyclin-dependent kinase 22.7.11.220.456
1e9hINRCyclin-dependent kinase 22.7.11.220.456
2iw84SPCyclin-dependent kinase 22.7.11.220.456
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.456
3iok1P6Tyrosine-protein kinase JAK2/0.456
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.456
4fkv61KCyclin-dependent kinase 22.7.11.220.456
3eb0DRKUncharacterized protein/0.455
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.455
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.455
4g1wG1WMitogen-activated protein kinase 82.7.11.240.455
4qo9627Serine/threonine-protein kinase 242.7.11.10.455
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.454
4gk4L90Ephrin type-A receptor 32.7.10.10.454
4jr7GNPCasein kinase II subunit alpha2.7.11.10.454
1g5sI17Cyclin-dependent kinase 22.7.11.220.453
2x1nX1NCyclin-dependent kinase 22.7.11.220.453
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.453
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.453
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.453
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.453
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.453
4nks2M2Fibroblast growth factor receptor 1/0.453
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
1fvv107Cyclin-dependent kinase 22.7.11.220.452
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.452
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.452
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.452
4aguD15Cyclin-dependent kinase-like 1/0.452
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4c4h7RODual specificity protein kinase TTK2.7.12.10.452
4ix6ADPUncharacterized protein/0.452
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.451
3a62STURibosomal protein S6 kinase beta-12.7.11.10.451
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.451
4fv9E71Mitogen-activated protein kinase 12.7.11.240.451
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.451
1oi9N20Cyclin-dependent kinase 22.7.11.220.450
2pvlP55Casein kinase II subunit alpha2.7.11.10.450
2pwlACPFibroblast growth factor receptor 2/0.450
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.450
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.450
3js2VM1Fibroblast growth factor receptor 1/0.450
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.450
5dr9SKEAurora kinase A2.7.11.10.450
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.449
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.449
3at3ATKCasein kinase II subunit alpha2.7.11.10.449
3gubGUBDeath-associated protein kinase 12.7.11.10.449
3uli1N3Cyclin-dependent kinase 22.7.11.220.449
4bbfO19Tyrosine-protein kinase JAK2/0.449
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.449
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4hge15VTyrosine-protein kinase JAK2/0.449
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.449
5auwQUEDeath-associated protein kinase 12.7.11.10.449
1u54ACPActivated CDC42 kinase 1/0.448
2bujSTUSerine/threonine-protein kinase 16/0.448
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.448
2i40BLZCyclin-dependent kinase 22.7.11.220.448
2w17I19Cyclin-dependent kinase 22.7.11.220.448
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.448
4gub0Y4Casein kinase II subunit alpha2.7.11.10.448
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.448
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.447
2of4979Tyrosine-protein kinase Lck2.7.10.20.447
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.447
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.447
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.446
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.446
2w1fL0FAurora kinase A2.7.11.10.446
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.446
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.446
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.445
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.445
4qms1N1Serine/threonine-protein kinase 242.7.11.10.445
1eh4IC1Casein kinase I homolog 12.7.11.10.444
1oecAA2Fibroblast growth factor receptor 2/0.444
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
2j0j4STFocal adhesion kinase 12.7.10.20.444
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.444
2vv9IM9Cyclin-dependent kinase 22.7.11.220.444
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.444
3biz61EWee1-like protein kinase2.7.10.20.444
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.444
3s1h56ZCyclin-dependent kinase 22.7.11.220.444
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.444
4fob0USALK tyrosine kinase receptor2.7.10.10.444
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.444
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
3c4xATPRhodopsin kinase/0.443
3nga3NGCasein kinase II subunit alpha2.7.11.10.443
3wowANPCasein kinase II subunit alpha2.7.11.10.443
4gk3L87Ephrin type-A receptor 32.7.10.10.443
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.443
5cshATPCasein kinase II subunit alpha2.7.11.10.443
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.442
3e5aVX6Aurora kinase A2.7.11.10.442
3umw596Serine/threonine-protein kinase pim-12.7.11.10.442
4e4m0NHTyrosine-protein kinase JAK2/0.442
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.442
4wkqIREEpidermal growth factor receptor2.7.10.10.442
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.441
2pvhP19Casein kinase II subunit alpha2.7.11.10.441
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.441
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.441
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
4fx360KCyclin-dependent kinase 22.7.11.220.441
5e8xSTUTGF-beta receptor type-12.7.11.300.441
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.440
2ittAEEEpidermal growth factor receptor2.7.10.10.440
2qoqANPEphrin type-A receptor 32.7.10.10.440
2xikJ60Serine/threonine-protein kinase 252.7.11.10.440
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.440
3rvg17PTyrosine-protein kinase JAK2/0.440
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.440
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.440
4j99ACPFibroblast growth factor receptor 2/0.440