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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2f2uM77Rho-associated protein kinase 22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2f2uM77Rho-associated protein kinase 22.7.11.11.000
3ncz3NCRho-associated protein kinase 12.7.11.10.584
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.555
4fv6E57Mitogen-activated protein kinase 12.7.11.240.553
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.552
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.545
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
2etrY27Rho-associated protein kinase 12.7.11.10.532
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
3a8wATPProtein kinase C iota type2.7.11.130.531
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.530
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.526
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.517
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
3i60E86Mitogen-activated protein kinase 12.7.11.240.510
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.508
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.507
2j0m4STFocal adhesion kinase 12.7.10.20.506
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
4otiMI1Serine/threonine-protein kinase N1/0.503
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.501
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
4hge15VTyrosine-protein kinase JAK2/0.500
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.499
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.498
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
3gu83GUDeath-associated protein kinase 12.7.11.10.497
4l9i8PRRhodopsin kinase/0.497
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
4ic7ANPMitogen-activated protein kinase 72.7.11.240.494
2ojj82AMitogen-activated protein kinase 12.7.11.240.493
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
4ehzJAKTyrosine-protein kinase JAK1/0.491
3c4xATPRhodopsin kinase/0.490
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.489
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
2w05FRTCyclin-dependent kinase 22.7.11.220.483
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.483
2b7aIZATyrosine-protein kinase JAK2/0.482
4eooATPCyclin-dependent kinase 22.7.11.220.481
4aqc88ATyrosine-protein kinase JAK2/0.480
4bcmT7ZCyclin-dependent kinase 22.7.11.220.480
3t8oATPRhodopsin kinase/0.479
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.478
2uzbC75Cyclin-dependent kinase 22.7.11.220.478
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.478
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.477
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
4e6d0NUTyrosine-protein kinase JAK2/0.477
4ivb1J5Tyrosine-protein kinase JAK1/0.477
1fvv107Cyclin-dependent kinase 22.7.11.220.475
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.475
3h3sH15Collagen type IV alpha-3-binding protein/0.475
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.474
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.472
3eyhIZATyrosine-protein kinase JAK1/0.472
2vv9IM9Cyclin-dependent kinase 22.7.11.220.471
3my5RFZCyclin-dependent kinase 22.7.11.220.471
3zh8C58Protein kinase C iota type2.7.11.130.471
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.469
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.469
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.469
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2yaaATPDeath-associated protein kinase 2/0.468
4mqy2CWUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.468
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.468
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.466
3h3t16HCollagen type IV alpha-3-binding protein/0.466
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.466
4a81DXCMajor pollen allergen Bet v 1-A/0.465
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.465
4jia1K3Tyrosine-protein kinase JAK2/0.465
4nifANPMitogen-activated protein kinase 12.7.11.240.465
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.464
3nynSGVG protein-coupled receptor kinase 62.7.11.160.464
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
4o0wADNAurora kinase A2.7.11.10.464
4i5cC5ITyrosine-protein kinase JAK1/0.463
2cciATPCyclin-dependent kinase 22.7.11.220.462
3hx4ANPCalmodulin-domain protein kinase 1/0.462
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4ji91M3Tyrosine-protein kinase JAK2/0.462
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.461
3tkuM77Serine/threonine-protein kinase MRCK beta2.7.11.10.461
4gk3L87Ephrin type-A receptor 32.7.10.10.461
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
4ix6ADPUncharacterized protein/0.461
3c4wATPRhodopsin kinase/0.460
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.460
2ckeIQUDeath-associated protein kinase 2/0.459
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.459
1jklANPDeath-associated protein kinase 12.7.11.10.458
1m2pHNACasein kinase II subunit alpha2.7.11.10.458
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.458
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.458
3lpbNVBTyrosine-protein kinase JAK2/0.458
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.458
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.458
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.457
3h3qH13Collagen type IV alpha-3-binding protein/0.457
4hgs15GCasein kinase I isoform gamma-32.7.11.10.457
2c6lDT4Cyclin-dependent kinase 22.7.11.220.456
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.456
2vtqLZACyclin-dependent kinase 22.7.11.220.456
4btjADPTau-tubulin kinase 12.7.11.10.456
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.455
4j99ACPFibroblast growth factor receptor 2/0.455
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
2dxvSAHDiphthine synthase/0.454
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.454
1rfvADPPyridoxal kinase2.7.1.350.453
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.453
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.453
3rak03ZCyclin-dependent kinase 22.7.11.220.453
1yvj4STTyrosine-protein kinase JAK32.7.10.20.452
2dxwSAHDiphthine synthase/0.452
3w2sW2REpidermal growth factor receptor2.7.10.10.452
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.452
4qnyANPMitogen activated protein kinase, putative/0.452
2pvmP29Casein kinase II subunit alpha2.7.11.10.451
3juhANPCasein kinase II subunit alpha2.7.11.10.451
5av2KMPDeath-associated protein kinase 12.7.11.10.451
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3c4zADPRhodopsin kinase/0.450
3ibqATPPyridoxal kinase/0.450
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.450
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4hvi19STyrosine-protein kinase JAK32.7.10.20.450
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.450
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.450
3r9uFADThioredoxin reductase/0.449
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.449
4zj8SUVOrexin receptor type 1/0.449
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.448
3ckqUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.448
3pe2E1BCasein kinase II subunit alpha2.7.11.10.448
1fm4DXCMajor pollen allergen Bet v 1-L/0.447
2fvdLIACyclin-dependent kinase 22.7.11.220.447
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.447
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.447
4aguD15Cyclin-dependent kinase-like 1/0.447
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.446
2owvSAHDiphthine synthase/0.446
2wxvWXVCyclin-dependent kinase 22.7.11.220.446
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.446
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.446
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.446
4btjATPTau-tubulin kinase 12.7.11.10.446
4f081RSTyrosine-protein kinase JAK2/0.446
4fmqANPMitogen-activated protein kinase 12.7.11.240.446
5aut2ANDeath-associated protein kinase 12.7.11.10.446
5f8fSFGPossible transcriptional regulatory protein/0.446
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.445
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.445
4e4n0NLTyrosine-protein kinase JAK1/0.445
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.445
3nux3NVCyclin-dependent kinase 62.7.11.220.444
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.444
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.443
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.443
2cchATPCyclin-dependent kinase 22.7.11.220.443
2cjmATPCyclin-dependent kinase 22.7.11.220.443
2eglSAHDiphthine synthase/0.443
3be9P04Casein kinase II subunit alpha2.7.11.10.443
3dds26BGlycogen phosphorylase, liver form2.4.1.10.443
3iok1P6Tyrosine-protein kinase JAK2/0.443
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.443
1w8cN69Cyclin-dependent kinase 22.7.11.220.442
2oxtSAMGenome polyprotein/0.442
3keuATPPyridoxal kinase2.7.1.350.442
5c1mCLRMu-type opioid receptor/0.442
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.441
2c6iDT1Cyclin-dependent kinase 22.7.11.220.441
2vesGVRUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.441
3lltANPProtein serine/threonine kinase-1/0.441
3tnwF18Cyclin-dependent kinase 22.7.11.220.441
1e9hINRCyclin-dependent kinase 22.7.11.220.440
2egbSAHDiphthine synthase/0.440
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2ijmADPFocal adhesion kinase 12.7.10.20.440
2vu3LZECyclin-dependent kinase 22.7.11.220.440
2xszATPRuvB-like 23.6.4.120.440
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3s1h56ZCyclin-dependent kinase 22.7.11.220.440
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.440
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.440
5e8ySTUTGF-beta receptor type-22.7.11.300.440