Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2egl | SAH | Diphthine synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2egl | SAH | Diphthine synthase | / | 1.000 | |
| 2dxw | SAH | Diphthine synthase | / | 0.817 | |
| 2dxv | SAH | Diphthine synthase | / | 0.809 | |
| 2e16 | SAH | Diphthine synthase | / | 0.807 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.791 | |
| 2pcm | SAH | Diphthine synthase | / | 0.791 | |
| 2en5 | SAH | Diphthine synthase | / | 0.788 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.782 | |
| 2e8q | SAH | Diphthine synthase | / | 0.773 | |
| 2emr | SAH | Diphthine synthase | / | 0.772 | |
| 2owv | SAH | Diphthine synthase | / | 0.772 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.769 | |
| 2ejk | SAH | Diphthine synthase | / | 0.766 | |
| 2e8s | SAH | Diphthine synthase | / | 0.763 | |
| 2egs | SAH | Diphthine synthase | / | 0.758 | |
| 2eni | SAH | Diphthine synthase | / | 0.754 | |
| 2emu | SAH | Diphthine synthase | / | 0.749 | |
| 2e8h | SAH | Diphthine synthase | / | 0.746 | |
| 2dek | SAH | Diphthine synthase | / | 0.744 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.743 | |
| 2el0 | SAH | Diphthine synthase | / | 0.736 | |
| 2egb | SAH | Diphthine synthase | / | 0.733 | |
| 2p6d | SAH | Diphthine synthase | / | 0.731 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.724 | |
| 2e08 | SAH | Diphthine synthase | / | 0.718 | |
| 2ehl | SAH | Diphthine synthase | / | 0.716 | |
| 2p6k | SAH | Diphthine synthase | / | 0.713 | |
| 2p2x | SAH | Diphthine synthase | / | 0.712 | |
| 2hux | SAH | Diphthine synthase | / | 0.704 | |
| 2eka | SAH | Diphthine synthase | / | 0.703 | |
| 2pch | SAH | Diphthine synthase | / | 0.693 | |
| 2dsg | SAH | Diphthine synthase | / | 0.682 | |
| 2owk | SAH | Diphthine synthase | / | 0.674 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.671 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.669 | |
| 2p5f | SAH | Diphthine synthase | / | 0.667 | |
| 2p6l | SAH | Diphthine synthase | / | 0.664 | |
| 1vce | SAH | Diphthine synthase | / | 0.654 | |
| 2owu | SAH | Diphthine synthase | / | 0.651 | |
| 2p5c | SAH | Diphthine synthase | / | 0.650 | |
| 2ejj | SAH | Diphthine synthase | / | 0.649 | |
| 1wng | SAH | Diphthine synthase | / | 0.648 | |
| 2e7r | SAH | Diphthine synthase | / | 0.646 | |
| 2ele | SAH | Diphthine synthase | / | 0.639 | |
| 2pcg | SAH | Diphthine synthase | / | 0.634 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.633 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.631 | |
| 2pci | SAH | Diphthine synthase | / | 0.631 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.630 | |
| 2eeq | SAH | Diphthine synthase | / | 0.625 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.620 | |
| 2dxx | SAH | Diphthine synthase | / | 0.617 | |
| 2p6i | SAH | Diphthine synthase | / | 0.616 | |
| 2dsh | SAH | Diphthine synthase | / | 0.610 | |
| 2e07 | SAH | Diphthine synthase | / | 0.610 | |
| 2e4n | SAH | Diphthine synthase | / | 0.605 | |
| 2pca | SAH | Diphthine synthase | / | 0.603 | |
| 2dsi | SAH | Diphthine synthase | / | 0.598 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.597 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.597 | |
| 2z6r | SAH | Diphthine synthase | / | 0.593 | |
| 2huq | SAH | Diphthine synthase | / | 0.581 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.580 | |
| 2eld | SAH | Diphthine synthase | / | 0.580 | |
| 2hut | SAH | Diphthine synthase | / | 0.577 | |
| 2huv | SAH | Diphthine synthase | / | 0.577 | |
| 2pck | SAH | Diphthine synthase | / | 0.570 | |
| 2e17 | SAH | Diphthine synthase | / | 0.569 | |
| 2owf | SAH | Diphthine synthase | / | 0.568 | |
| 2el3 | SAH | Diphthine synthase | / | 0.567 | |
| 2owg | SAH | Diphthine synthase | / | 0.564 | |
| 2p9d | SAH | Diphthine synthase | / | 0.560 | |
| 2e8r | SAH | Diphthine synthase | / | 0.557 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.556 | |
| 2ek3 | SAH | Diphthine synthase | / | 0.548 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.546 | |
| 2ejz | SAH | Diphthine synthase | / | 0.539 | |
| 2e15 | SAH | Diphthine synthase | / | 0.523 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.496 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.495 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.489 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.482 | |
| 5dp2 | NAP | CurF | / | 0.480 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.476 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.475 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.474 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.471 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.470 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.469 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.466 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.465 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.464 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.464 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.463 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.463 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.463 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.462 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.462 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.461 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.461 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.461 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.460 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.460 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.459 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.458 | |
| 2is0 | I03 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.458 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.457 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.457 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.457 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.457 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.456 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.456 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.456 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.456 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.456 | |
| 5hws | NAP | 2-dehydropantoate 2-reductase | / | 0.456 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3pb3 | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.455 | |
| 3pnd | FAD | FAD:protein FMN transferase | / | 0.455 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.454 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.454 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.454 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.454 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.454 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.453 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.453 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.453 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.452 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.452 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.452 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.452 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.452 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.451 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.451 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.451 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.451 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.451 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.450 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.450 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.450 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.450 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.450 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.450 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.450 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.450 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.449 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.449 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.449 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.449 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.448 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.448 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.448 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.448 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.448 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.448 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 2npf | MOU | Elongation factor 2 | / | 0.447 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.447 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.447 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.447 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.446 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.446 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.446 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.446 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.446 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.446 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.445 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3clx | X22 | E3 ubiquitin-protein ligase XIAP | 6.3.2 | 0.445 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.445 | |
| 3oht | 1N1 | Mitogen-activated protein kinase | / | 0.445 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.444 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3a3g | DLZ | Lumazine protein | / | 0.444 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.444 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.444 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.444 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.443 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.443 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.443 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.443 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.443 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.443 | |
| 4wuc | ANP | DNA gyrase subunit B | / | 0.443 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.443 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.443 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.442 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.442 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.442 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.442 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.442 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.442 | |
| 2rl1 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.442 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.442 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 4irn | FAD | AnaB | / | 0.442 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.442 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.442 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.442 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.441 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.441 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.441 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.441 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.441 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.441 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.441 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.440 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.440 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.440 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2ylw | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.440 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.440 | |
| 3pwm | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3sdi | 3SD | Proteasome subunit beta type-5 | 3.4.25.1 | 0.440 | |
| 3sdi | 3SD | Proteasome subunit beta type-6 | 3.4.25.1 | 0.440 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 |