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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2eglSAHDiphthine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2eglSAHDiphthine synthase/1.000
2dxwSAHDiphthine synthase/0.817
2dxvSAHDiphthine synthase/0.809
2e16SAHDiphthine synthase/0.807
2ek7SAHDiphthine synthase/0.791
2pcmSAHDiphthine synthase/0.791
2en5SAHDiphthine synthase/0.788
2pb4SAHDiphthine synthase/0.782
2e8qSAHDiphthine synthase/0.773
2emrSAHDiphthine synthase/0.772
2owvSAHDiphthine synthase/0.772
2eh5SAHDiphthine synthase/0.769
2ejkSAHDiphthine synthase/0.766
2e8sSAHDiphthine synthase/0.763
2egsSAHDiphthine synthase/0.758
2eniSAHDiphthine synthase/0.754
2emuSAHDiphthine synthase/0.749
2e8hSAHDiphthine synthase/0.746
2dekSAHDiphthine synthase/0.744
2ed5SAHDiphthine synthase/0.743
2el0SAHDiphthine synthase/0.736
2egbSAHDiphthine synthase/0.733
2p6dSAHDiphthine synthase/0.731
2dv7SAHDiphthine synthase/0.724
2e08SAHDiphthine synthase/0.718
2ehlSAHDiphthine synthase/0.716
2p6kSAHDiphthine synthase/0.713
2p2xSAHDiphthine synthase/0.712
2huxSAHDiphthine synthase/0.704
2ekaSAHDiphthine synthase/0.703
2pchSAHDiphthine synthase/0.693
2dsgSAHDiphthine synthase/0.682
2owkSAHDiphthine synthase/0.674
2dv4SAHDiphthine synthase/0.671
2hr8SAHDiphthine synthase/0.669
2p5fSAHDiphthine synthase/0.667
2p6lSAHDiphthine synthase/0.664
1vceSAHDiphthine synthase/0.654
2owuSAHDiphthine synthase/0.651
2p5cSAHDiphthine synthase/0.650
2ejjSAHDiphthine synthase/0.649
1wngSAHDiphthine synthase/0.648
2e7rSAHDiphthine synthase/0.646
2eleSAHDiphthine synthase/0.639
2pcgSAHDiphthine synthase/0.634
2dv3SAHDiphthine synthase/0.633
2eh2SAHDiphthine synthase/0.631
2pciSAHDiphthine synthase/0.631
2pb6SAHDiphthine synthase/0.630
2eeqSAHDiphthine synthase/0.625
2ek2SAHDiphthine synthase/0.620
2dxxSAHDiphthine synthase/0.617
2p6iSAHDiphthine synthase/0.616
2dshSAHDiphthine synthase/0.610
2e07SAHDiphthine synthase/0.610
2e4nSAHDiphthine synthase/0.605
2pcaSAHDiphthine synthase/0.603
2dsiSAHDiphthine synthase/0.598
2ek4SAHDiphthine synthase/0.597
2pb5SAHDiphthine synthase/0.597
2z6rSAHDiphthine synthase/0.593
2huqSAHDiphthine synthase/0.581
2ed3SAHDiphthine synthase/0.580
2eldSAHDiphthine synthase/0.580
2hutSAHDiphthine synthase/0.577
2huvSAHDiphthine synthase/0.577
2pckSAHDiphthine synthase/0.570
2e17SAHDiphthine synthase/0.569
2owfSAHDiphthine synthase/0.568
2el3SAHDiphthine synthase/0.567
2owgSAHDiphthine synthase/0.564
2p9dSAHDiphthine synthase/0.560
2e8rSAHDiphthine synthase/0.557
2eh4SAHDiphthine synthase/0.556
2ek3SAHDiphthine synthase/0.548
2dv5SAHDiphthine synthase/0.546
2ejzSAHDiphthine synthase/0.539
2e15SAHDiphthine synthase/0.523
2xhd7T9Glutamate receptor 2/0.496
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.495
3ig6438Urokinase-type plasminogen activator3.4.21.730.489
1lbcCYZGlutamate receptor 2/0.482
5dp2NAPCurF/0.480
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.476
4g7gVFVLanosterol 14-alpha-demethylase/0.475
2q5g1FAPeroxisome proliferator-activated receptor delta/0.474
4i1iNADMalate dehydrogenase/0.471
1xe55FEPlasmepsin-23.4.23.390.470
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.469
1tqf32PBeta-secretase 13.4.23.460.466
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.466
1x1cSAHC-20 methyltransferase/0.465
1g63FMNEpidermin decarboxylase4.1.10.464
4a8v2ANMajor pollen allergen Bet v 1-J/0.464
1x1aSAMC-20 methyltransferase/0.463
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.463
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.463
3vt7VDXVitamin D3 receptor/0.463
1f8fNADBenzyl alcohol dehydrogenase/0.462
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.462
1ja1FMNNADPH--cytochrome P450 reductase/0.461
1v9aSAHUncharacterized protein/0.461
3clrFADElectron transfer flavoprotein subunit alpha/0.461
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
3gw9VNILanosterol 14-alpha-demethylase/0.460
4ji91M3Tyrosine-protein kinase JAK2/0.460
1me6IVSPlasmepsin-23.4.23.390.459
3ijoB4DGlutamate receptor 2/0.459
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
1y0s331Peroxisome proliferator-activated receptor delta/0.458
2is0I03Beta-secretase 13.4.23.460.458
3lqfNADGalactitol dehydrogenase/0.458
2p5uNADUDP-glucose 4-epimerase/0.457
2qbuSAHPrecorrin-2 methyltransferase/0.457
3dv5BAVBeta-secretase 13.4.23.460.457
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.457
4ejvLCLTranscriptional regulator TcaR/0.457
1zeoC01Peroxisome proliferator-activated receptor gamma/0.456
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.456
2ifaFMNUncharacterized protein/0.456
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.456
3vt8YI3Vitamin D3 receptor/0.456
4oqyNDP(S)-imine reductase/0.456
5hwsNAP2-dehydropantoate 2-reductase/0.456
2viyVG3Beta-secretase 13.4.23.460.455
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3pb3SAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.455
3pndFADFAD:protein FMN transferase/0.455
1nzdUPGDNA beta-glucosyltransferase/0.454
1xddAAYIntegrin alpha-L/0.454
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.454
3zh8C58Protein kinase C iota type2.7.11.130.454
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4tuvCPZCytochrome P450 1191.140.454
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.454
2bn4FMNNADPH--cytochrome P450 reductase/0.453
3tjzGNPADP-ribosylation factor 1/0.453
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.453
2aa3AP0L-lactate dehydrogenase/0.452
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.452
2he5NDPAldo-keto reductase family 1 member C211.1.10.452
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.452
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.452
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.452
1nhhANPDNA mismatch repair protein MutL/0.451
2ahrNAPPyrroline-5-carboxylate reductase/0.451
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.451
2ou2ACOHistone acetyltransferase KAT5/0.451
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.451
4exg916Beta-secretase 13.4.23.460.451
1cdoNADAlcohol dehydrogenase 11.1.1.10.450
1u3cFADCryptochrome-1/0.450
1x1dSAHC-20 methyltransferase/0.450
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.450
2znq401Peroxisome proliferator-activated receptor delta/0.450
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.450
3ai3NDPNADPH-sorbose reductase/0.450
4i8zG08Gag-Pol polyprotein3.4.23.160.450
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.450
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.449
2xx91NFGlutamate receptor 2/0.449
3bc3OPTCathepsin L13.4.22.150.449
3vt9YI4Vitamin D3 receptor/0.449
4fv7E94Mitogen-activated protein kinase 12.7.11.240.449
1bxoPP7Penicillopepsin-13.4.23.200.448
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.448
2fznFADBifunctional protein PutA1.5.5.20.448
2wedPP6Penicillopepsin-13.4.23.200.448
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3oibFDAPutative acyl-CoA dehydrogenase/0.448
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.448
4egbNADdTDP-glucose 4,6-dehydratase/0.448
1ma0NADAlcohol dehydrogenase class-31.1.1.10.447
2npfMOUElongation factor 2/0.447
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.447
2q4bNAPUncharacterized protein At5g02240/0.447
3in6FMNUncharacterized protein/0.447
3to6LYS_CMCHistone acetyltransferase ESA1/0.447
1mp0NADAlcohol dehydrogenase class-31.1.1.10.446
1rfvADPPyridoxal kinase2.7.1.350.446
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.446
2irzI02Beta-secretase 13.4.23.460.446
3pqbVGPPutative oxidoreductase/0.446
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.446
3vqsJT1Genome polyprotein/0.446
4uymVOR14-alpha sterol demethylase Cyp51B/0.446
1g1aNADdTDP-glucose 4,6-dehydratase/0.445
2a94AP0L-lactate dehydrogenase1.1.1.270.445
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.445
3cic316Beta-secretase 13.4.23.460.445
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.445
3ixp834Ecdysone receptor/0.445
3oht1N1Mitogen-activated protein kinase/0.445
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.445
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.444
2hm1LIQBeta-secretase 13.4.23.460.444
3a3gDLZLumazine protein/0.444
3c1y2BADNA integrity scanning protein DisA/0.444
3nutSAHPrecorrin-3 methylase/0.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4dc0NDPPutative ketoacyl reductase1.3.10.444
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.444
4h3f10OBeta-secretase 13.4.23.460.444
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.444
1kp3ATPArgininosuccinate synthase6.3.4.50.443
1y4lSVRBasic phospholipase A2 homolog 2/0.443
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.443
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.443
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.443
3hl0NADMaleylacetate reductase/0.443
4bb3KKAIsopenicillin N synthase1.21.3.10.443
4m83ERYOleandomycin glycosyltransferase2.4.10.443
4wucANPDNA gyrase subunit B/0.443
4wudANPDNA gyrase subunit B/0.443
5d3qGDPDynamin-13.6.5.50.443
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.443
1bim0QBRenin3.4.23.150.442
1fm4DXCMajor pollen allergen Bet v 1-L/0.442
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.442
2a5kAZPReplicase polyprotein 1ab3.4.220.442
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.442
2gv8NDPThiol-specific monooxygenase1.14.130.442
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2pswCOAN-alpha-acetyltransferase 50/0.442
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.442
3il1B5DGlutamate receptor 2/0.442
3lzs017Gag-Pol polyprotein3.4.23.160.442
3qe2FMNNADPH--cytochrome P450 reductase/0.442
4irnFADAnaB/0.442
4m4922YL-lactate dehydrogenase A chain1.1.1.270.442
4nbwNADShort-chain dehydrogenase/reductase SDR/0.442
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.442
5c1mCLRMu-type opioid receptor/0.442
5fm7ADPRuvB-like helicase/0.442
1pjcNADAlanine dehydrogenase/0.441
1x1bSAHC-20 methyltransferase/0.441
2bjfDXCCholoylglycine hydrolase3.5.1.240.441
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.441
2q7vFADThioredoxin reductase/0.441
3ibdCPZCytochrome P450 2B61.14.130.441
3lpkZ76Beta-secretase 13.4.23.460.441
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.441
4djy0KRBeta-secretase 13.4.23.460.441
4yxm2BADNA integrity scanning protein DisA/0.441
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2iyfERYOleandomycin glycosyltransferase2.4.10.440
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.440
2oapANPType II secretion system protein (GspE-2)/0.440
2om9AJAPeroxisome proliferator-activated receptor gamma/0.440
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.440
2xlrFADPutative flavin-containing monooxygenase/0.440
2ylwFADPhenylacetone monooxygenase1.14.13.920.440
3gwfNAPCyclohexanone monooxygenase/0.440
3mdmFJZCholesterol 24-hydroxylase/0.440
3pwm017Gag-Pol polyprotein3.4.23.160.440
3sdi3SDProteasome subunit beta type-53.4.25.10.440
3sdi3SDProteasome subunit beta type-63.4.25.10.440
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440