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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.11.000
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.704
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.656
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.634
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.623
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.623
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.612
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.603
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.603
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.597
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.596
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.596
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.590
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.589
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.588
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.588
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.588
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.586
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.585
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.584
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.584
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.583
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.583
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.583
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.575
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.575
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.574
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.572
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.572
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.571
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.568
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.566
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.562
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.562
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.560
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.558
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.557
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.552
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.551
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.549
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.544
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.544
3umw596Serine/threonine-protein kinase pim-12.7.11.10.543
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.540
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.540
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.534
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.528
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.523
4i22IREEpidermal growth factor receptor2.7.10.10.518
3mtfA3FActivin receptor type-12.7.11.300.516
4jq8KJ8Epidermal growth factor receptor2.7.10.10.508
4fob0USALK tyrosine kinase receptor2.7.10.10.506
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.497
4bgg844Activin receptor type-12.7.11.300.493
4yuqKS1Calmodulin-like domain protein kinase/0.493
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.491
2wihP48Cyclin-dependent kinase 22.7.11.220.490
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.488
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.487
3uyt0CKCasein kinase I isoform delta2.7.11.10.486
4gmy0X5Tyrosine-protein kinase JAK2/0.485
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.484
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.484
4grb0XGCasein kinase II subunit alpha2.7.11.10.482
3bqr4RBDeath-associated protein kinase 3/0.481
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.481
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.481
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.480
3gc9B45Mitogen-activated protein kinase 112.7.11.240.479
4riyADPEpidermal growth factor receptor2.7.10.10.478
1xjdSTUProtein kinase C theta type2.7.11.130.477
3a4pDFQHepatocyte growth factor receptor2.7.10.10.476
3gubGUBDeath-associated protein kinase 12.7.11.10.476
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.476
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.474
3kf7L9GMitogen-activated protein kinase 14/0.474
3oom507Activin receptor type-12.7.11.300.474
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.473
3bu5ATPInsulin receptor2.7.10.10.473
3mvl38PMitogen-activated protein kinase 14/0.473
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.473
2itpAEEEpidermal growth factor receptor2.7.10.10.472
3w33W19Epidermal growth factor receptor2.7.10.10.472
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.472
2ittAEEEpidermal growth factor receptor2.7.10.10.470
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.470
4wboANWRhodopsin kinase/0.470
1aq1STUCyclin-dependent kinase 22.7.11.220.469
2iw84SPCyclin-dependent kinase 22.7.11.220.469
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.469
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.469
4b99R4LMitogen-activated protein kinase 72.7.11.240.468
4kbk1QGCasein kinase I isoform delta2.7.11.10.468
4othDRNSerine/threonine-protein kinase N1/0.468
2h96893Mitogen-activated protein kinase 82.7.11.240.467
2wxvWXVCyclin-dependent kinase 22.7.11.220.467
3du8553Glycogen synthase kinase-3 beta2.7.11.260.467
4dgnLU2Casein kinase II subunit alpha2.7.11.10.467
4fnyI3KALK tyrosine kinase receptor2.7.10.10.467
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.467
4hgt15GCasein kinase I isoform delta2.7.11.10.467
4hni16WCasein kinase I isoform epsilon2.7.11.10.467
1h1s4SPCyclin-dependent kinase 22.7.11.220.466
1pkdUCNCyclin-dependent kinase 22.7.11.220.465
1wvxBD4Death-associated protein kinase 12.7.11.10.465
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.465
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.465
1eh4IC1Casein kinase I homolog 12.7.11.10.464
3ormAGSSerine/threonine protein kinase/0.464
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.464
4bchT7ZCyclin-dependent kinase 92.7.11.220.464
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.464
1y0s331Peroxisome proliferator-activated receptor delta/0.463
3t8oATPRhodopsin kinase/0.463
4iaq2GM5-hydroxytryptamine receptor 1B/0.462
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.462
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.461
3q9xEMOCasein kinase II subunit alpha2.7.11.10.461
3u4uLNHCasein kinase II subunit alpha2.7.11.10.461
4dymIYZActivin receptor type-12.7.11.300.461
4gw83RASerine/threonine-protein kinase pim-12.7.11.10.461
4hvi19STyrosine-protein kinase JAK32.7.10.20.461
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.460
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.460
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.460
4aa5NQBMitogen-activated protein kinase 14/0.460
4nk92K5Fibroblast growth factor receptor 1/0.460
2chlDKICasein kinase I isoform gamma-32.7.11.10.459
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.459
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.459
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
2hog710Serine/threonine-protein kinase Chk12.7.11.10.458
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.458
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.458
1m17AQ4Epidermal growth factor receptor2.7.10.10.457
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.457
3iw4LW4Protein kinase C alpha type2.7.11.130.457
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.457
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.457
4kba1QMCasein kinase I isoform delta2.7.11.10.457
1o5rFR9Adenosine deaminase3.5.4.40.456
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.456
2iw94SPCyclin-dependent kinase 22.7.11.220.456
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.456
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.456
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.456
4loqSB4Mitogen-activated protein kinase 14/0.456
2ckeIQUDeath-associated protein kinase 2/0.455
2izsBRQCasein kinase I isoform gamma-32.7.11.10.455
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.455
3a60STURibosomal protein S6 kinase beta-12.7.11.10.455
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.455
2pvnP63Casein kinase II subunit alpha2.7.11.10.454
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.454
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.454
3l8p0CEAngiopoietin-1 receptor2.7.10.10.454
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.454
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.454
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.454
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.454
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.453
4ib4ERM5-hydroxytryptamine receptor 2B/0.453
5cvhADPCasein kinase II subunit alpha2.7.11.10.453
1qxlFR8Adenosine deaminase3.5.4.40.452
1umlFR4Adenosine deaminase3.5.4.40.452
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.452
2izuP01Casein kinase I isoform gamma-32.7.11.10.452
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.452
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.452
4erwSTUCyclin-dependent kinase 22.7.11.220.452
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.452
5auvAGIDeath-associated protein kinase 12.7.11.10.452
1oiyN41Cyclin-dependent kinase 22.7.11.220.451
2acxANPG protein-coupled receptor kinase 62.7.11.160.451
2jedLG8Protein kinase C theta type2.7.11.130.451
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.451
4kb81QNCasein kinase I isoform delta2.7.11.10.451
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.451
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.450
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.450
2izrBRKCasein kinase I isoform gamma-32.7.11.10.450
3mpaSB2Mitogen-activated protein kinase 14/0.450
5f0a1FBcGMP-dependent protein kinase, putative/0.450
1zys199Serine/threonine-protein kinase Chk12.7.11.10.449
2x1nX1NCyclin-dependent kinase 22.7.11.220.449
3w2sW2REpidermal growth factor receptor2.7.10.10.449
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.449
2i40BLZCyclin-dependent kinase 22.7.11.220.448
4eok4SPCyclin-dependent kinase 22.7.11.220.448
1ywrLI9Mitogen-activated protein kinase 14/0.447
2fgiPD1Fibroblast growth factor receptor 1/0.447
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.447
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.447
3vryB43Tyrosine-protein kinase HCK2.7.10.20.447
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.447
4fod0UVALK tyrosine kinase receptor2.7.10.10.447
4fx360KCyclin-dependent kinase 22.7.11.220.447
4gu610NFocal adhesion kinase 12.7.10.20.447
4hvh19RTyrosine-protein kinase JAK32.7.10.20.447
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.446
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.446
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.446
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.446
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4c4h7RODual specificity protein kinase TTK2.7.12.10.446
4hnf16WCasein kinase I isoform delta2.7.11.10.446
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.446
5av2KMPDeath-associated protein kinase 12.7.11.10.446
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.445
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.445
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.445
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.445
2xa4AZ5Tyrosine-protein kinase JAK2/0.445
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.445
4g1wG1WMitogen-activated protein kinase 82.7.11.240.445
4jrvKJVEpidermal growth factor receptor2.7.10.10.445
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.444
1u4dDBQActivated CDC42 kinase 1/0.444
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
5cu6ATPCasein kinase II subunit alpha2.7.11.10.444
1v7aFRCAdenosine deaminase3.5.4.40.443
2j0m4STFocal adhesion kinase 12.7.10.20.443
2pvlP55Casein kinase II subunit alpha2.7.11.10.443
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.443
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.443
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.443
4jqeANPCasein kinase II subunit alpha2.7.11.10.443
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.443
5auwQUEDeath-associated protein kinase 12.7.11.10.443
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.442
2izt23DCasein kinase I isoform gamma-32.7.11.10.442
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.442
2wpa889Cyclin-dependent kinase 22.7.11.220.442
3nga3NGCasein kinase II subunit alpha2.7.11.10.442
4c02TAKActivin receptor type-12.7.11.300.442
4hjoAQ4Epidermal growth factor receptor2.7.10.10.442
4jr3KJREpidermal growth factor receptor2.7.10.10.442
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.441
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.441
2excJNKMitogen-activated protein kinase 102.7.11.240.441
3r9dX6BCyclin-dependent kinase 22.7.11.220.441
4anqVGHALK tyrosine kinase receptor2.7.10.10.441
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.440
2j0k4STFocal adhesion kinase 12.7.10.20.440
2xb7GUIALK tyrosine kinase receptor2.7.10.10.440
3at3ATKCasein kinase II subunit alpha2.7.11.10.440
3at4CCKCasein kinase II subunit alpha2.7.11.10.440
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.440
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.440
3s2pPMUCyclin-dependent kinase 22.7.11.220.440
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.440
3uvqFS8Mitogen-activated protein kinase 14/0.440
3zxtACPDeath-associated protein kinase 12.7.11.10.440
4ansVGHALK tyrosine kinase receptor2.7.10.10.440
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.440
4ih8B43Calmodulin-domain protein kinase 1/0.440
4qmzB49Serine/threonine-protein kinase 242.7.11.10.440