sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1s0z | EB1 | Vitamin D3 receptor |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1s0z | EB1 | Vitamin D3 receptor | / | 1.000 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.799 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.798 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.789 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.772 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.752 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.739 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.716 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.712 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.711 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.706 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.700 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.698 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.694 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.694 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.693 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.691 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.686 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.685 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.685 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.683 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.677 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.676 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.673 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.672 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.672 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.672 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.672 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.670 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.667 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.667 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.666 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.666 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.665 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.663 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.663 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.662 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.661 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.660 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.659 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.657 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.656 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.656 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.656 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.655 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.654 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.651 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.650 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.649 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.646 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.646 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.644 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.643 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.643 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.642 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.639 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.639 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.638 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.636 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.633 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.632 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.629 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.623 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.622 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.619 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.614 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.611 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.609 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.605 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.594 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.561 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.499 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.499 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.493 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.486 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.486 | |
| 2qo6 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.483 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.482 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.481 | |
| 4l9q | 9TP | Serum albumin | / | 0.480 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.479 | |
| 1ysx | 4EB | Serum albumin | / | 0.477 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.477 | |
| 3wd7 | COA | Acridone synthase | / | 0.477 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.476 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.475 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.474 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.474 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.474 | |
| 1k74 | 544 | Peroxisome proliferator-activated receptor gamma | / | 0.473 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.473 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 1ie4 | T44 | Transthyretin | / | 0.472 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.472 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 3bej | MUF | Bile acid receptor | / | 0.471 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.471 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.470 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.470 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.470 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.469 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.469 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.469 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.468 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 3d5f | L41 | Peroxisome proliferator-activated receptor delta | / | 0.468 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.468 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.467 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.467 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.466 | |
| 3iup | NDP | Possible NADH oxidoreductase | / | 0.466 | |
| 1n4s | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.465 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.465 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.465 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.464 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.464 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.463 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.463 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.463 | |
| 4l9k | EHF | Serum albumin | / | 0.463 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.462 | |
| 1tw4 | CHD | Fatty acid-binding protein, liver | / | 0.462 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.462 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.462 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.461 | |
| 1ppj | SMA | Cytochrome b | / | 0.461 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 3lu8 | IQX | Serum albumin | / | 0.461 | |
| 3up0 | D7S | aceDAF-12 | / | 0.461 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.460 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.460 | |
| 1sn5 | T3 | Transthyretin | / | 0.459 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.459 | |
| 4kvx | ACO | N-terminal acetyltransferase A complex catalytic subunit ard1 | 2.3.1.88 | 0.459 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.459 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.459 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.458 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.458 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.457 | |
| 4l8u | 9AZ | Serum albumin | / | 0.457 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.457 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.456 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.456 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.456 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.456 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.455 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.454 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.454 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.454 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.454 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.453 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.453 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.453 | |
| 3d3e | D3E | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.453 | |
| 4jk4 | DIU | Serum albumin | / | 0.453 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.453 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.453 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.452 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 2qu6 | 857 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.452 | |
| 3m8p | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.452 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.451 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.451 | |
| 2cmv | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.451 | |
| 3wg6 | NDP | NADPH-dependent conjugated polyketone reductase C1 | / | 0.451 | |
| 4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 | 0.451 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.450 | |
| 3dl9 | V2H | Vitamin D 25-hydroxylase | / | 0.450 | |
| 3k9u | ACO | Spermidine N(1)-acetyltransferase | / | 0.450 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.450 | |
| 4ez5 | 0RS | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.450 | |
| 4h38 | 0YX | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.450 | |
| 4i2p | G73 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.449 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.449 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.448 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.448 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.448 | |
| 2j3k | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.448 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 3hv5 | R24 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.448 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.448 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 1ci7 | CB3 | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.447 | |
| 3u4u | LNH | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.447 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.447 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.446 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.446 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.446 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.446 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.446 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.446 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.446 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.445 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.445 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.445 | |
| 3up3 | XCA | aceDAF-12 | / | 0.445 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4jr5 | 1LS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.445 | |
| 4nxw | ADP | Mitochondrial dynamics protein MID51 | / | 0.445 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.445 | |
| 1ee0 | CAA | 2-pyrone synthase | / | 0.444 | |
| 2go4 | TUX | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.444 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.444 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 3wxy | COA | Uncharacterized protein | / | 0.444 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4nmk | NAP | Aldehyde dehydrogenase | / | 0.444 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.444 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.443 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.443 | |
| 3beg | ANP | SRSF protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.443 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.443 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 4iah | 1DX | Alr2278 protein | / | 0.443 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.443 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.443 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.443 | |
| 4y95 | 746 | Tyrosine-protein kinase | / | 0.443 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.442 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.442 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.442 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.442 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.442 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.442 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 5doz | NDP | JamJ | / | 0.442 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.442 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.441 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.441 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.441 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.441 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.441 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.441 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.440 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.440 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3axw | TID | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.440 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.440 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.440 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.440 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.440 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.440 |