scPDB - Distribution of Binding site Similarity values of 1gul entry / Site 4

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1gul	GLY_GGL_ICY	Glutathione S-transferase A4	2.5.1.18

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1gul	GLY_GGL_ICY	Glutathione S-transferase A4	2.5.1.18	1.000
3ik7	BOB	Glutathione S-transferase A4	2.5.1.18	0.546
2r6k	GTX	Glutathione S-transferase A1	2.5.1.18	0.508
1gsf	EAA	Glutathione S-transferase A1	2.5.1.18	0.502
1dgh	NDP	Catalase	1.11.1.6	0.501
3dd0	EZL	Carbonic anhydrase 2	4.2.1.1	0.492
3ik9	BOB	Glutathione S-transferase A1	2.5.1.18	0.492
3sfh	1DI	Histone deacetylase 8	3.5.1.98	0.481
1b48	HAG	Glutathione S-transferase A4	2.5.1.18	0.480
3dgq	EAA	Glutathione S-transferase P	2.5.1.18	0.478
3ie3	N11	Glutathione S-transferase P	2.5.1.18	0.478
1kyx	CRM	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.475
1dgg	NDP	Catalase	1.11.1.6	0.473
4gtt	7TQ	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.473
4zzi	1NS	NAD-dependent protein deacetylase sirtuin-1	3.5.1	0.473
1aqv	0HG	Glutathione S-transferase P	2.5.1.18	0.472
2xiq	5AD	Methylmalonyl-CoA mutase, mitochondrial	/	0.472
1dgf	NDP	Catalase	1.11.1.6	0.471
2wn6	NDP	ADP-ribosyltransferase enzymatic component	/	0.471
2q94	A04	Methionine aminopeptidase	/	0.469
4mvc	CDC	Choline-phosphate cytidylyltransferase A	/	0.469
1eno	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	1.3.1.9	0.468
2ixk	TDO	dTDP-4-dehydrorhamnose 3,5-epimerase	5.1.3.13	0.468
3frk	TQP	QdtB	/	0.468
4cb6	29R	Polymerase basic protein 2	/	0.468
1pq9	44B	Oxysterols receptor LXR-beta	/	0.467
2a58	RBF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.467
1wl4	COA	Acetyl-CoA acetyltransferase, cytosolic	2.3.1.9	0.466
1qs2	NAD	Vip2Ac	/	0.464
2a2s	GSN	Glutathione S-transferase P	2.5.1.18	0.464
2ouy	CMP	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.463
3gf4	UPG	UDP-galactopyranose mutase	5.4.99.9	0.463
3mjr	AC2	Deoxycytidine kinase	2.7.1.74	0.463
3nwl	NDP	Catalase	1.11.1.6	0.463
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.462
2w6c	BM4	Acetylcholinesterase	3.1.1.7	0.462
3ktl	GTX	Glutathione S-transferase A1	2.5.1.18	0.462
1enp	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	1.3.1.9	0.461
1qti	GNT	Acetylcholinesterase	3.1.1.7	0.461
1u65	CP0	Acetylcholinesterase	3.1.1.7	0.461
3epy	COA	Acyl-CoA-binding domain-containing protein 7	/	0.460
3fkt	SII	Beta-secretase 1	3.4.23.46	0.460
3mj4	URM	UDP-galactopyranose mutase	/	0.460
5c1g	GDU	Histo-blood group ABO system transferase	/	0.460
1pl6	572	Sorbitol dehydrogenase	1.1.1.14	0.459
1tow	CRZ	Fatty acid-binding protein, adipocyte	/	0.459
2vd0	D27	Hematopoietic prostaglandin D synthase	/	0.459
1w4l	GL8	Acetylcholinesterase	3.1.1.7	0.458
3ggs	2FD	Purine nucleoside phosphorylase	2.4.2.1	0.458
3sff	0DI	Histone deacetylase 8	3.5.1.98	0.458
3sn7	540	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.458
13gs	SAS	Glutathione S-transferase P	2.5.1.18	0.457
2jgs	BTN	Avidin	/	0.457
2cbr	A80	Cellular retinoic acid-binding protein 1	/	0.456
2vi5	Y19	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.456
1aka	PLP	Aspartate aminotransferase, mitochondrial	2.6.1.1	0.455
1kbo	340	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.455
1xp8	AGS	Protein RecA	/	0.455
2r6j	NDP	Eugenol synthase 1	1.1.1.318	0.455
4b6s	2HN	3-dehydroquinate dehydratase	4.2.1.10	0.455
1xr2	C2F	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase	2.1.1.14	0.454
1bwl	FMN	NADPH dehydrogenase 1	1.6.99.1	0.453
1fxu	GU7	Purine nucleoside phosphorylase	2.4.2.1	0.453
1uhh	CZP	Aequorin-2	/	0.453
3e34	ED1	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	/	0.453
3e34	ED1	Protein farnesyltransferase subunit beta	2.5.1.58	0.453
3h3t	16H	Collagen type IV alpha-3-binding protein	/	0.453
4eqk	MGT	Polymerase basic protein 2	/	0.453
4uy6	SAH	Histidine N-alpha-methyltransferase	/	0.453
1tll	FMN	Nitric oxide synthase, brain	1.14.13.39	0.452
2our	CMP	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.452
2ouu	35G	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.452
4bft	ZVT	Pantothenate kinase	2.7.1.33	0.452
4ey6	GNT	Acetylcholinesterase	3.1.1.7	0.452
2pnc	CLU	Primary amine oxidase, liver isozyme	/	0.451
2xui	TZ5	Acetylcholinesterase	3.1.1.7	0.451
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.451
5fbh	TCR	Extracellular calcium-sensing receptor	/	0.451
2glr	GTX	Glutathione S-transferase P 1	2.5.1.18	0.450
1yw8	A75	Methionine aminopeptidase 2	/	0.449
3q44	D50	M1 family aminopeptidase	3.4.11	0.449
3zv7	NHG	Acetylcholinesterase	3.1.1.7	0.449
4ifn	12O	Kelch-like ECH-associated protein 1	/	0.449
4nv1	0FX	Formyl transferase	/	0.449
1aqu	EST	Estrogen sulfotransferase, testis isoform	2.8.2.4	0.448
1dgb	NDP	Catalase	1.11.1.6	0.448
1o2g	696	Prothrombin	3.4.21.5	0.448
2a2d	ANP	N-acetylgalactosamine kinase	2.7.1.157	0.448
2ges	COK	Pantothenate kinase	2.7.1.33	0.448
3dzk	NMN	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	3.2.2.6	0.448
3hl4	CDC	Choline-phosphate cytidylyltransferase A	/	0.448
3sni	546	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.448
3v0o	4GW	Histo-blood group ABO system transferase	/	0.448
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.448
4ge9	0L0	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	2.6.1.39	0.448
4h6k	FMN	NADPH dehydrogenase 1	1.6.99.1	0.448
2pk3	A2R	GDP-6-deoxy-D-mannose reductase	/	0.447
4mlp	2CX	Cryptochrome-2	/	0.447
4wlj	IK2	Kynurenine--oxoglutarate transaminase 1	2.6.1.7	0.447
5c80	URI	Uridine phosphorylase	/	0.447
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.446
1yry	MSG	Purine nucleoside phosphorylase	2.4.2.1	0.446
2oac	GTB	Glutathione S-transferase P 1	2.5.1.18	0.446
2x0f	TRH	WsaF	/	0.446
3f8s	PF2	Dipeptidyl peptidase 4	/	0.446
4kp6	1S1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.446
1gss	LEE	Glutathione S-transferase P	2.5.1.18	0.445
1jf0	CZH	Obelin	/	0.445
1v3q	2DI	Purine nucleoside phosphorylase	2.4.2.1	0.445
3dy8	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.445
3hdy	GDU	UDP-galactopyranose mutase	/	0.445
4bfs	ZVS	Pantothenate kinase	2.7.1.33	0.445
4jsr	1NQ	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.445
4xrb	NDP	Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc	/	0.445
1lv8	9PP	Purine nucleoside phosphorylase	2.4.2.1	0.444
1ps9	MDE	2,4-dienoyl-CoA reductase	1.3.1.34	0.444
2wo7	ASV	Isopenicillin N synthase	1.21.3.1	0.444
3ugr	IMN	Aldo-keto reductase family 1 member C3	/	0.444
1muu	GDX	GDP-mannose 6-dehydrogenase	1.1.1.132	0.443
1nhk	CMP	Nucleoside diphosphate kinase	2.7.4.6	0.443
1x1c	SAH	C-20 methyltransferase	/	0.443
2bjf	DXC	Choloylglycine hydrolase	3.5.1.24	0.443
3jsw	JAR	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.443
3jun	AJD	Phenazine biosynthesis protein A/B	/	0.443
4fl0	PLP	Aminotransferase ALD1, chloroplastic	2.6.1	0.443
1lnm	DTX	Bilin-binding protein	/	0.442
1oc1	ASV	Isopenicillin N synthase	1.21.3.1	0.442
1x2h	LPA	Lipoate-protein ligase A	6.3.1.20	0.442
3hxc	BD6	Geranylgeranyl transferase type-2 subunit beta	2.5.1.60	0.442
3nu0	3TU	Dihydrofolate reductase	1.5.1.3	0.442
3uzz	ASD	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.442
4bfy	ZVY	Pantothenate kinase	2.7.1.33	0.442
4to2	DGT	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.442
1pwy	AC2	Purine nucleoside phosphorylase	2.4.2.1	0.441
1tg2	H2B	Phenylalanine-4-hydroxylase	1.14.16.1	0.441
2c6c	24I	Glutamate carboxypeptidase 2	3.4.17.21	0.441
2cek	N8T	Acetylcholinesterase	3.1.1.7	0.441
2xb9	XNW	3-dehydroquinate dehydratase	4.2.1.10	0.441
3fr5	I4A	Fatty acid-binding protein, adipocyte	/	0.441
4bfz	ZVZ	Pantothenate kinase	2.7.1.33	0.441
4dyp	0MS	Nucleoprotein	/	0.441
4fcb	0T7	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.441
4nqg	CZH	Mitrocomin	/	0.441
4rxp	DTP	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.441
1p91	SAM	23S rRNA (guanine(745)-N(1))-methyltransferase	/	0.440
2e8u	IPE	Geranylgeranyl pyrophosphate synthase	/	0.440
3myt	EQU	Steroid Delta-isomerase	5.3.3.1	0.440