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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fwkADPHomoserine kinase2.7.1.39

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1fwkADPHomoserine kinase2.7.1.391.000
1h73ANPHomoserine kinase2.7.1.390.521
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.516
3b20NADGlyceraldehyde-3-phosphate dehydrogenase/0.494
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.491
3oqfS51Renin3.4.23.150.489
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.488
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.486
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.483
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.482
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.481
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.478
5a3cNADSIR2 family protein/0.477
3hwrNDP2-dehydropantoate 2-reductase/0.474
1mjbACOHistone acetyltransferase ESA1/0.473
3oqkS52Renin3.4.23.150.473
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.472
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.471
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.471
3wmxNADNAD dependent epimerase/dehydratase/0.471
5a3bAPRSIR2 family protein/0.471
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.469
1xddAAYIntegrin alpha-L/0.469
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.469
3b70NAPEnoyl reductase LovC10.469
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.469
1dhjMTXDihydrofolate reductase1.5.1.30.468
1qrpHH0Pepsin A-43.4.23.10.468
1h51FMNPentaerythritol tetranitrate reductase/0.467
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.467
2ou2ACOHistone acetyltransferase KAT5/0.467
4e5yNDPGDP-L-fucose synthase1.1.1.2710.467
2ikuLIYRenin3.4.23.150.466
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.464
2zb3NDPProstaglandin reductase 21.3.1.480.464
3jynNDPQuinone oxidoreductase/0.464
1u3dFADCryptochrome-1/0.463
2y05NAPProstaglandin reductase 1/0.463
3d3wNAPL-xylulose reductase1.1.1.100.462
1wntNAPL-xylulose reductase1.1.1.100.461
3to6LYS_CMCHistone acetyltransferase ESA1/0.461
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.460
3il1B5DGlutamate receptor 2/0.460
1tehNADAlcohol dehydrogenase class-31.1.1.10.459
4gh5NADShort-chain dehydrogenase/reductase SDR/0.459
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1cf3FADGlucose oxidase1.1.3.40.458
1qorNDPQuinone oxidoreductase 1/0.458
2aa3AP0L-lactate dehydrogenase/0.458
3bgcLJHGag-Pol polyprotein3.4.23.160.458
3o3pGDDGlycosyl transferase, family 2/0.458
4kl9NDPDihydrofolate reductase1.5.1.30.458
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.458
1k6cMK1Gag-Pol polyprotein3.4.23.160.457
2vcmM11Isopenicillin N synthase1.21.3.10.457
1k6vXN2Gag-Pol polyprotein3.4.23.160.456
2c0cNAPProstaglandin reductase 310.456
2q4bNAPUncharacterized protein At5g02240/0.456
3d7kD7KBenzaldehyde lyase/0.456
1e3eNAIAlcohol dehydrogenase 41.1.1.10.455
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.455
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.455
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
2wdzNADGalactitol dehydrogenase/0.455
3atzFMNProstaglandin F2a synthase/0.455
4djaFAD(6-4) photolyase/0.455
4j7xNAPSepiapterin reductase1.1.1.1530.455
4uunNAIL-lactate dehydrogenase/0.455
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.455
5lc1NADL-threonine 3-dehydrogenase/0.455
1zemNADXylitol dehydrogenase/0.454
3ieuGDPGTPase Era/0.454
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.454
1rneC60Renin3.4.23.150.453
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.453
3gy0NAPNAD(P)-dependent oxidoreductase/0.453
3ksdNADGlyceraldehyde-3-phosphate dehydrogenase 1/0.453
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.453
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.453
3qwbNDPProbable quinone oxidoreductase1.6.5.50.453
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.453
1h50FMNPentaerythritol tetranitrate reductase/0.452
1h63FMNPentaerythritol tetranitrate reductase/0.452
1rwbNADGlucose 1-dehydrogenase1.1.1.470.452
2dteNAIGlucose 1-dehydrogenase related protein/0.452
2vtbFADCryptochrome DASH, chloroplastic/mitochondrial/0.452
4b8wNAPGDP-L-fucose synthase1.1.1.2710.452
4jx1CAHCamphor 5-monooxygenase1.14.15.10.452
4p63NADProbable deoxyhypusine synthase2.5.1.460.452
4z24FADPutative GMC-type oxidoreductase R13510.452
1mg5NAIAlcohol dehydrogenase1.1.1.10.451
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.451
3a1nNADNDP-sugar epimerase/0.451
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.451
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.451
4dfrMTXDihydrofolate reductase1.5.1.30.451
4enhFVXCholesterol 24-hydroxylase/0.451
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.451
4jjiNADAlcohol dehydrogenase class-3/0.451
4q71FADBifunctional protein PutA/0.451
4q72FADBifunctional protein PutA/0.451
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.450
1k6tXN1Gag-Pol polyprotein3.4.23.160.450
1n5dNDPCarbonyl reductase [NADPH] 1/0.450
1nboNADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic1.2.1.130.450
2dfvNADL-threonine 3-dehydrogenase/0.450
2ftoCB3Thymidylate synthase/0.450
2givACOHistone acetyltransferase KAT8/0.450
2nq8ZIDEnoyl-ACP reductase/0.450
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.450
4ki8ADP60 kDa chaperonin/0.450
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.450
1pr9NAPL-xylulose reductase1.1.1.100.449
2g5cNADPrephenate dehydrogenase/0.449
2jn3JN3Fatty acid-binding protein, liver/0.449
2qn7HBZGlycogen phosphorylase, muscle form2.4.1.10.449
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.449
3toxNAPPutative oxidoreductase/0.449
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
4yryFADGlutamate synthase, beta subunit/0.449
2gjlFMNNitronate monooxygenase1.13.12.160.448
2p5uNADUDP-glucose 4-epimerase/0.448
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.448
3ijoB4DGlutamate receptor 2/0.448
3lqfNADGalactitol dehydrogenase/0.448
4ia7BIVVitamin D3 receptor A/0.448
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.448
1ma0NADAlcohol dehydrogenase class-31.1.1.10.447
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.447
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.447
2bpw1INGag-Pol polyprotein3.4.23.160.447
2d4vNADIsocitrate dehydrogenase [NADP]/0.447
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.447
2ft9CHDFatty acid-binding protein 2, liver/0.447
2fzwNADAlcohol dehydrogenase class-31.1.1.10.447
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.447
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.447
2qo9ANPEphrin type-A receptor 32.7.10.10.447
3dmeFADPutative conserved exported protein/0.447
3docNADGlyceraldehyde-3-phosphate dehydrogenase/0.447
3drcMTXDihydrofolate reductase1.5.1.30.447
3r5yF42Uncharacterized protein/0.447
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.447
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.446
2eklNADD-3-phosphoglycerate dehydrogenase/0.446
2i4qUA4Renin3.4.23.150.446
3eksCY9Actin-5C/0.446
3ru9NADUDP-N-acetylglucosamine 4-epimerase/0.446
4ambDUDPutative glycosyl transferase/0.446
4gxs0YSGlutamate receptor 2/0.446
4q73FADBifunctional protein PutA/0.446
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.446
1geeNADGlucose 1-dehydrogenase1.1.1.470.445
3bg7FADPyranose 2-oxidase/0.445
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.445
4g2fC07Ephrin type-A receptor 32.7.10.10.445
4u03GTPCyclic GMP-AMP synthase/0.445
4yagNAIC alpha-dehydrogenase/0.445
1j21ATPArgininosuccinate synthase/0.444
1knrFADL-aspartate oxidase1.4.3.160.444
1p31EPUUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.444
1psa0ZLPepsin A3.4.23.10.444
1t2cNAIL-lactate dehydrogenase1.1.1.270.444
1xs7MMIBeta-secretase 13.4.23.460.444
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.444
2il2LIXRenin3.4.23.150.444
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.444
2ywwATPAspartate carbamoyltransferase regulatory chain/0.444
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.444
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.444
3uylTYDProbable NDP-rhamnosyltransferase/0.444
3vyeVYERenin3.4.23.150.444
4bb3KKAIsopenicillin N synthase1.21.3.10.444
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.443
1np7FADCryptochrome DASH/0.443
1yb5NAPQuinone oxidoreductase1.6.5.50.443
2a92NAIL-lactate dehydrogenase/0.443
2iko7IGRenin3.4.23.150.443
3c212BADNA integrity scanning protein DisA/0.443
3fpaDTBATP-dependent dethiobiotin synthetase BioD/0.443
3lpkZ76Beta-secretase 13.4.23.460.443
3ukoNADAlcohol dehydrogenase class-3/0.443
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.443
4g1cCNANAD-dependent protein deacylase sirtuin-5, mitochondrial/0.443
4ia1BIVVitamin D3 receptor A/0.443
1c2tGARPhosphoribosylglycinamide formyltransferase/0.442
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.442
1gcoNADGlucose 1-dehydrogenase1.1.1.470.442
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.442
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.442
2v13C40Renin3.4.23.150.442
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.442
3cz7ACOHistone acetyltransferase RTT1092.3.1.480.442
3d8bADPFidgetin-like protein 13.6.40.442
3d91REMRenin3.4.23.150.442
3gw9VNILanosterol 14-alpha-demethylase/0.442
3jzdNADMaleylacetate reductase/0.442
3zkyWT4Isopenicillin N synthase1.21.3.10.442
4ejmNAPPutative zinc-binding dehydrogenase/0.442
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.442
4h6rFDAProline dehydrogenase/0.442
4yaoFMNNADPH--cytochrome P450 reductase/0.442
1f4fTP3Thymidylate synthase/0.441
1hwzNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.441
1jioDEB6-deoxyerythronolide B hydroxylase/0.441
1k6pXN3Gag-Pol polyprotein3.4.23.160.441
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.441
2ejvNADL-threonine 3-dehydrogenase/0.441
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
3och2MXDihydrofolate reductase1.5.1.30.441
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.441
4u7wNDPMxaA/0.441
4yxm2BADNA integrity scanning protein DisA/0.441
5jlaNADPutative short-chain dehydrogenase/reductase/0.441
1f8fNADBenzyl alcohol dehydrogenase/0.440
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.440
1lf3EH5Plasmepsin-23.4.23.390.440
1y0s331Peroxisome proliferator-activated receptor delta/0.440
1z7eUGABifunctional polymyxin resistance protein ArnA/0.440
1z7yAA5Cysteine synthase 12.5.1.470.440
2a7r5GPGMP reductase 2/0.440
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.440
2iyaZIOOleandomycin glycosyltransferase/0.440
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.440
2w6oOA3Biotin carboxylase6.3.4.140.440
3cid318Beta-secretase 13.4.23.460.440
3d8vUD1Bifunctional protein GlmU/0.440
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.440
3iaeD7KBenzaldehyde lyase/0.440
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.440
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
3vspEK8Peroxisome proliferator-activated receptor gamma/0.440
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.440
4emtC2EStimulator of interferon genes protein/0.440
4jicFMNGTN Reductase/0.440
4o1mNADEnoyl-acyl carrier reductase/0.440
4rvgTYDD-mycarose 3-C-methyltransferase/0.440
5ijzNAPNADP-specific glutamate dehydrogenase1.4.1.40.440