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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ccb SAH tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 1.166
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 1.135
1i9g SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.956
2pwy SAHtRNA (adenine(58)-N(1))-methyltransferase TrmI 2.1.1.220 0.895
2yvl SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.888
3lga SAHtRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI 2.1.1.219 0.879
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.869
3orh SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.827
1yf3 SAHDNA adenine methylase / 0.815
2plw SAMRibosomal RNA methyltransferase, putative / 0.791
2bzg SAHThiopurine S-methyltransferase 2.1.1.67 0.778
5fa5 MTAProtein arginine N-methyltransferase 5 / 0.778
3duw SAHO-methyltransferase, putative / 0.770
3lcc SAHThiocyanate methyltransferase 1 / 0.770
3emd SFGMethyltransferase / 0.769
4azw SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.762
4oa5 SAHO-methyltransferase family protein / 0.762
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.761
3c3y SAHO-methyltransferase / 0.760
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.755
2px2 SAHGenome polyprotein 2.7.7.48 0.754
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.754
4xvy SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.754
2hnk SAHSAM-dependent O-methyltransferase / 0.751
3grr SAHProbable ribosomal RNA small subunit methyltransferase A / 0.749
3v8v SAMRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.748
3ssm SAHMycinamicin VI 2''-O-methyltransferase / 0.747
3tr6 SAHO-methyltransferase / 0.746
5il2 SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.746
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.745
3v97 SAHRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.743
1khh SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.742
1p1c SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.742
3evb SAHGenome polyprotein 2.1.1.56 0.742
4kwc SAHMethyltransferase domain family / 0.742
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.741
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.741
3ou2 SAHSAM-dependent methyltransferase / 0.741
5je2 SAHMethyl transferase / 0.740
1l3i SAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) / 0.739
4gbe SAHDNA adenine methylase 2.1.1.72 0.739
4nec SAHPutative SAM-dependent methyltransferase / 0.738
5jr3 SAHCarminomycin 4-O-methyltransferase DnrK 2.1.1.292 0.735
3cbg SAHO-methyltransferase / 0.734
4e2x SAHMethyltransferase / 0.733
2g1p SAHDNA adenine methylase 2.1.1.72 0.732
3fri SAH16S rRNA methylase / 0.731
4mwz SAMPhosphoethanolamine N-methyltransferase, putative / 0.731
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.728
1nbi SAMGlycine N-methyltransferase 2.1.1.20 0.727
2i9k SAHModification methylase HhaI 2.1.1.37 0.727
3gry SAMProbable ribosomal RNA small subunit methyltransferase A / 0.726
4iv0 SAMPhosphoethanolamine N-methyltransferase, putative / 0.726
4yac NAIC alpha-dehydrogenase / 0.726
2ji7 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.725
4hc4 SAHProtein arginine N-methyltransferase 6 / 0.725
4uy6 SAHHistidine N-alpha-methyltransferase / 0.725
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.723
4dmg SAMUncharacterized protein / 0.723
4qdk SAHMagnesium-protoporphyrin O-methyltransferase 2.1.1.11 0.721
3mte SAM16S rRNA (adenine(1408)-N(1))-methyltransferase 2.1.1.180 0.720
3kpj SAHPhenylethanolamine N-methyltransferase 2.1.1.28 0.719
1nbh SAMGlycine N-methyltransferase 2.1.1.20 0.718
1boo SAHModification methylase PvuII 2.1.1.113 0.717
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.717
3vyw SAMUncharacterized protein / 0.717
1p1b SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.716
2bm9 SAMCephalosporin hydroxylase CmcI / 0.715
3lcv SAM16S rRNA (guanine(1405)-N(7))-methyltransferase 2.1.1.179 0.715
4o29 SAHProtein-L-isoaspartate O-methyltransferase / 0.715
4rtk SAHDNA adenine methylase 2.1.1.72 0.715
1qan SAHrRNA adenine N-6-methyltransferase 2.1.1.184 0.714
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.714
4tm3 FADKtzI / 0.714
3lkz SFGGenome polyprotein / 0.713
3q87 SAMN6 ADENINE SPECIFIC DNA METHYLASE (METHYLTRANSFERASE SUPERFAMILY) / 0.712
4x7y SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.712
3e23 SAMUncharacterized protein / 0.711
3pt9 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.711
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.709
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.708
2zzm SAMtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.708
4fp9 SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.708
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.708
4k6m SAHGenome polyprotein / 0.707
5k7u SAMN6-adenosine-methyltransferase 70 kDa subunit / 0.707
2px5 SAHGenome polyprotein 2.7.7.48 0.706
4lwp SAHArginine N-methyltransferase, putative / 0.706
1f3l SAHProtein arginine N-methyltransferase 3 / 0.705
7mht SAHModification methylase HhaI 2.1.1.37 0.705
2eju SAHtRNA (guanine(26)-N(2))-dimethyltransferase / 0.704
2o06 MTASpermidine synthase 2.5.1.16 0.704
3axs SFGtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase / 0.703
3p97 SAMGenome polyprotein 2.1.1.56 0.703
3rw9 DSHSpermidine synthase 2.5.1.16 0.703
4ctj SAMGenome polyprotein / 0.703
1r00 SAHAclacinomycin 10-hydroxylase RdmB 4.1.1 0.702
2uyh SAHModification methylase HhaI 2.1.1.37 0.702
3iei SAHLeucine carboxyl methyltransferase 1 2.1.1.233 0.701
3go4 SAHUncharacterized protein / 0.700
4krh SAMPhosphoethanolamine N-methyltransferase 2 / 0.700
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.699
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.699
3reo SAH(Iso)eugenol O-methyltransferase 2.1.1.146 0.699
4kdr SAHUbiquinone biosynthesis O-methyltransferase / 0.699
5f2k SAHUncharacterized protein / 0.699
5jjr SAHGenome polyprotein / 0.698
1skm SAHModification methylase HhaI 2.1.1.37 0.697
2nxe SAMRibosomal protein L11 methyltransferase 2.1.1 0.697
3eey SAMrRNA methylase / 0.697
3wst SAHProtein arginine N-methyltransferase 7 2.1.1 0.697
4fgz SAHPhosphoethanolamine N-methyltransferase / 0.697
4hh4 SAHCcbJ / 0.697
1ori SAHProtein arginine N-methyltransferase 1 / 0.696
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.696
3swr SFGDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.696
2v74 SAHHistone-arginine methyltransferase CARM1 / 0.695
3dh0 SAMUncharacterized protein / 0.695
3egv SAHRibosomal protein L11 methyltransferase 2.1.1 0.695
4j33 FADKynurenine 3-monooxygenase / 0.695
4kvz SAHPtnL protein / 0.695
5bp9 SAHPutative methyltransferase protein / 0.695
1bc5 SAHChemotaxis protein methyltransferase 2.1.1.80 0.694
1wy7 SAHUncharacterized protein / 0.694
2hms NAIKtr system potassium uptake protein A / 0.694
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.693
2gs9 SAHUncharacterized protein / 0.693
2oy0 SAHGenome polyprotein / 0.693
1eg2 MTAModification methylase RsrI 2.1.1.72 0.692
4blw SAHRibosomal RNA large subunit methyltransferase J / 0.692
4ctk SAMGenome polyprotein / 0.692
2hmv ADPKtr system potassium uptake protein A / 0.691
3cjt SAHRibosomal protein L11 methyltransferase 2.1.1 0.691
4poo SAMPutative RNA methylase / 0.691
2qa2 FADPolyketide oxygenase CabE / 0.690
3ou6 SAMSAM-dependent methyltransferase / 0.690
3tos SAHCalS11 / 0.690
4gqb 0XUProtein arginine N-methyltransferase 5 / 0.690
5dwq SFGHistone-arginine methyltransferase CARM1 / 0.690
2c7q SAHModification methylase HhaI 2.1.1.37 0.689
2vdv SAMtRNA (guanine-N(7)-)-methyltransferase / 0.689
4rtj SFGDNA adenine methylase 2.1.1.72 0.689
4tlz FADKtzI / 0.689
4wxx SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.689
2nyu SAMrRNA methyltransferase 2, mitochondrial / 0.688
4gek GEKCarboxy-S-adenosyl-L-methionine synthase / 0.688
4rvd SAMD-mycarose 3-C-methyltransferase / 0.687
4x3q SAHSibL / 0.687
3lcu SAH16S rRNA (guanine(1405)-N(7))-methyltransferase 2.1.1.179 0.686
3nwb 659Catechol O-methyltransferase 2.1.1.6 0.686
3sr4 TT8Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.686
5icf SAH(S)-norcoclaurine 6-O-methyltransferase / 0.686
1g60 SAMModification methylase MboII 2.1.1.72 0.685
5d4v SAHUncharacterized protein MJ0489 / 0.685
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.684
3lby SAHUncharacterized protein / 0.684
4c04 SFGProtein arginine N-methyltransferase 6 / 0.684
4g56 SAHProtein arginine N-methyltransferase 5 / 0.684
1rje SAHLeucine carboxyl methyltransferase 1 2.1.1.233 0.683
2ih2 NEAModification methylase TaqI 2.1.1.72 0.683
2yqz SAMUncharacterized protein / 0.683
3ely SAHMethyltransferase / 0.683
5je3 SAHMethyl transferase / 0.683
2pxa SAHGenome polyprotein 2.7.7.48 0.682
2qe6 SAMUncharacterized protein / 0.682
4gf5 SAHCalS11 / 0.682
4qpp SAHProtein arginine N-methyltransferase 6 / 0.682
3dmg SAHProbable ribosomal RNA small subunit methyltransferase / 0.681
3mht SAHModification methylase HhaI 2.1.1.37 0.681
1u2d NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.680
5d4u SAMUncharacterized protein MJ0489 / 0.680
5je4 SAHMethyl transferase / 0.680
2ytz SAHtRNA (guanine(26)-N(2))-dimethyltransferase / 0.679
4ax8 SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.679
2p35 SAHTrans-aconitate 2-methyltransferase / 0.678
3a4t SFGtRNA (cytosine(48)-C(5))-methyltransferase 2.1.1 0.678
3uj7 SAMPhosphoethanolamine N-methyltransferase / 0.678
5bp7 SAHSAM-dependent methyltransferase / 0.678
2ibt NEAModification methylase TaqI 2.1.1.72 0.677
4guv FADTetX family tetracycline inactivation enzyme / 0.677
5eku SAHArginine N-methyltransferase, putative / 0.677
5fa8 SAMRibosomal protein L11 methyltransferase, putative / 0.677
1g1a NADdTDP-glucose 4,6-dehydratase / 0.676
4fzv SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.676
4u7t SAHDNA (cytosine-5)-methyltransferase 3A 2.1.1.37 0.676
1jr4 CL4Catechol O-methyltransferase 2.1.1.6 0.675
1rjd SAMLeucine carboxyl methyltransferase 1 2.1.1.233 0.675
3o7w SAMLeucine carboxyl methyltransferase 1 2.1.1.233 0.675
4c03 SFGProtein arginine N-methyltransferase 6 / 0.675
4dcm SAMRibosomal RNA large subunit methyltransferase G 2.1.1.174 0.675
4xcx SAHSmall RNA 2'-O-methyltransferase / 0.675
2a14 SAHIndolethylamine N-methyltransferase 2.1.1.49 0.674
2zwv SAHProbable ribosomal RNA small subunit methyltransferase / 0.674
4m37 SAHProtein arginine N-methyltransferase 7 2.1.1 0.674
5ahk FADAcetolactate synthase II, large subunit / 0.674
3ldf SAHUncharacterized protein / 0.673
4ckc SAHmRNA-capping enzyme catalytic subunit 2.1.1.56 0.673
4y9d NAIC alpha-dehydrogenase / 0.673
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.672
1sqf SAMRibosomal RNA small subunit methyltransferase B 2.1.1.176 0.672
2cww SAHUncharacterized protein / 0.672
3p8z SAHGenome polyprotein 2.1.1.56 0.672
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
3elu SAMMethyltransferase / 0.671
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.671
2i62 SAHNicotinamide N-methyltransferase 2.1.1.1 0.670
3dlc SAMSAM (And some other nucleotide) binding motif:Generic methyltransferase / 0.670
3sso SAHMycinamicin VI 2''-O-methyltransferase / 0.670
4gc9 SAMDimethyladenosine transferase 1, mitochondrial 2.1.1 0.670
5cku FADL-ornithine N(5)-monooxygenase / 0.670
2p3q SAHGenome polyprotein / 0.669
3eld SFGMethyltransferase / 0.669
4obw SAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial / 0.669
4yuz S4MSpermidine synthase, putative / 0.669
1r6a SAHGenome polyprotein 2.7.7.48 0.668
2p5u NADUDP-glucose 4-epimerase / 0.668
3a25 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.668
3iv6 SAMUncharacterized protein / 0.668
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.668
1zq9 SAMProbable dimethyladenosine transferase / 0.667
3dmh SAMProbable ribosomal RNA small subunit methyltransferase / 0.667
3lhd SAHtRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI 2.1.1.219 0.667
4c05 SAHProtein arginine N-methyltransferase 6 / 0.667
5dto SAHGenome polyprotein / 0.667
9mht SAHModification methylase HhaI 2.1.1.37 0.667
10mh SAHModification methylase HhaI 2.1.1.37 0.666
2oor NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.666
3gwz SAHMitomycin biosynthesis 6-O-methyltransferase / 0.666
3kkj FADRenalase / 0.666
3sgl SAMtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.666
3t7s SAMUncharacterized protein / 0.666
4ce0 SAHProbable O-methyltransferase / 0.665
4eki 0QKHistone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.665
3evc SAHGenome polyprotein 2.1.1.56 0.664
4mok FADPyranose 2-oxidase / 0.664
2ih5 NEAModification methylase TaqI 2.1.1.72 0.663
3fpf MTAUncharacterized protein / 0.663
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.663
3wv7 ADPHmd co-occurring protein HcgE / 0.663
4b69 FADL-ornithine N(5)-monooxygenase / 0.663
1fjx SAHModification methylase HhaI 2.1.1.37 0.662
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.662
2c20 NADUDP-glucose 4-epimerase / 0.661
2oo5 TXDNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.660
5i39 FADL-amino acid deaminase / 0.660
1mht SAHModification methylase HhaI 2.1.1.37 0.659
1x15 NADNAD(P) transhydrogenase subunit alpha 1.6.1.2 0.659
2dpm SAMModification methylase DpnIIA 2.1.1.72 0.659
4r6x SAHPhosphoethanolamine N-methyltransferase / 0.659
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.658
3fws ANPTranscriptional repressor CcpN / 0.658
4o4l GTPTubulin alpha-1B chain / 0.658
4rtl SFGDNA adenine methylase 2.1.1.72 0.658
1qzz SAMAclacinomycin 10-hydroxylase RdmB 4.1.1 0.657
2zfu SAHRibosomal RNA-processing protein 8 / 0.657
1nw5 SAMModification methylase RsrI 2.1.1.72 0.656
2pkk 2FAAdenosine kinase 2.7.1.20 0.656
3p2e SAH16S rRNA (adenine(1408)-N(1))-methyltransferase 2.1.1.180 0.656
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.656
3pt6 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.656
4uck SAMLarge structural protein / 0.656
2zul SAMProbable ribosomal RNA small subunit methyltransferase / 0.655
3p9k SAHCaffeic acid O-methyltransferase / 0.655
2eg5 SAH7-methylxanthosine synthase 1 / 0.654
2zcj SAHModification methylase HhaI 2.1.1.37 0.654
3eva SAHGenome polyprotein 2.1.1.56 0.654
3tm4 SAMUncharacterized protein / 0.654
1af7 SAHChemotaxis protein methyltransferase 2.1.1.80 0.653
2a9z 26AAdenosine kinase 2.7.1.20 0.653
2okc SAMProbable type I restriction enzyme BthVORF4518P M protein 2.1.1.72 0.653
2pan FADGlyoxylate carboligase 4.1.1.47 0.653
2zbp SAMRibosomal protein L11 methyltransferase 2.1.1 0.653
2zwa SAHtRNA wybutosine-synthesizing protein 4 2.1.1.290 0.653
3h5n ATPMccB protein / 0.653
4dkj SAHCytosine-specific methyltransferase / 0.653
4eaj ATP5'-AMP-activated protein kinase subunit gamma-1 / 0.653
1u28 NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.652
2bh2 SAH23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD / 0.652
2d32 ANPGlutamate--cysteine ligase 6.3.2.2 0.652
5f8e SAHPossible transcriptional regulatory protein / 0.652
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.651
1f8g NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.651
1z3c SA8mRNA cap guanine-N7 methyltransferase 2.1.1.56 0.651
1zem NADXylitol dehydrogenase / 0.651
4yv0 S4MSpermidine synthase, putative / 0.651
5e72 SAMN2, N2-dimethylguanosine tRNA methyltransferase / 0.651
3nwe 662Catechol O-methyltransferase 2.1.1.6 0.650
3ua3 SAHProtein arginine N-methyltransferase 5 / 0.650