sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 1.143 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.958 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.927 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.926 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.917 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.912 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.911 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.906 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.889 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.887 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.886 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.873 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.862 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.854 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.852 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.851 | |
| 4kwh | NAP | Reductase homolog | / | 0.850 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.848 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.847 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.846 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.846 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.844 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.841 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.831 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.831 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.831 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.829 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.828 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.828 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.825 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.821 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.821 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.820 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.820 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.819 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.819 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.819 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.818 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.817 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.814 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.810 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.808 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.807 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.807 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.806 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.805 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.805 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.804 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.804 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.801 | |
| 4qec | NAP | ElxO | / | 0.801 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.796 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.795 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.794 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.793 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.793 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.790 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.789 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.789 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.788 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.788 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.787 | |
| 3sju | NDP | Keto reductase | / | 0.787 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.784 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.784 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.784 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.779 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.779 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.776 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.773 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.772 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.771 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.770 | |
| 1iy8 | NAD | Levodione reductase | / | 0.767 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.767 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.766 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.766 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.764 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.764 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.764 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.763 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.763 | |
| 4qed | NAP | ElxO | / | 0.763 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.763 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.762 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.761 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.760 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.759 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.759 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.757 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.757 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.756 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.756 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.755 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.754 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.754 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.752 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.752 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.752 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.752 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.750 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.750 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.748 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.747 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.747 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.746 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.746 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.746 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.745 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.745 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.744 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.743 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.741 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.740 | |
| 4yac | NAI | C alpha-dehydrogenase | / | 0.740 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.739 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.739 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.738 | |
| 1nai | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.738 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.737 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.736 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.735 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.735 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.735 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.735 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.732 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.730 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.729 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.729 | |
| 1sny | NAP | LD36273p | / | 0.727 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.727 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.726 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.725 | |
| 3mje | NDP | AmphB | / | 0.724 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.724 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.723 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.723 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.721 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.721 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.721 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.720 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.720 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.719 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.719 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.718 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.717 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.716 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.716 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.716 | |
| 4hxy | NDP | Plm1 | / | 0.715 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.715 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.713 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.713 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.713 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.712 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.709 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.708 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.708 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.708 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.707 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.707 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.706 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.705 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.704 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.704 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.704 | |
| 2x86 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.703 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.703 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.702 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.702 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.702 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.701 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.701 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.699 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.699 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.698 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.697 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.696 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.696 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.696 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.696 | |
| 4u7w | NDP | MxaA | / | 0.696 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.695 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.694 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.694 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.693 | |
| 3hwr | NDP | 2-dehydropantoate 2-reductase | / | 0.692 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.690 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.690 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.688 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.687 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.687 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.687 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.687 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.687 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.686 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.685 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.685 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.684 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.684 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.684 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.683 | |
| 2eq7 | NAD | Dihydrolipoyl dehydrogenase | / | 0.683 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.683 | |
| 4iv8 | SAM | Phosphoethanolamine N-methyltransferase,putative | / | 0.683 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.683 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.681 | |
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 | 0.680 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.680 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.680 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.680 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.680 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.678 | |
| 1ahh | NAD | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.677 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.676 | |
| 3uce | NDP | Dehydrogenase | / | 0.675 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.675 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.674 | |
| 2c7q | SAH | Modification methylase HhaI | 2.1.1.37 | 0.674 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.674 | |
| 3ad9 | FAD | Subunit beta of sarcosine oxidase | / | 0.674 | |
| 5je3 | SAH | Methyl transferase | / | 0.674 | |
| 3pef | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.673 | |
| 3cn8 | FAD | Polyamine oxidase FMS1 | / | 0.672 | |
| 3hja | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.672 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.671 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.671 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.671 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.670 | |
| 1grg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.670 | |
| 3mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.670 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.669 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.668 | |
| 3ssm | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.668 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.667 | |
| 1i9g | SAM | tRNA (adenine(58)-N(1))-methyltransferase TrmI | / | 0.667 | |
| 1rpn | NDP | GDP-mannose 4,6-dehydratase | / | 0.667 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.666 | |
| 1w8d | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.663 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 3zhb | NAP | Putative dehydrogenase | / | 0.662 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.661 | |
| 3bgv | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.661 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.661 | |
| 3pdu | NAP | Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase | / | 0.661 | |
| 3bmo | NAP | Pteridine reductase | / | 0.660 | |
| 3nt2 | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.660 | |
| 3pvz | NAD | UDP-N-acetylglucosamine 4,6-dehydratase | / | 0.660 | |
| 4b69 | FAD | L-ornithine N(5)-monooxygenase | / | 0.660 | |
| 4guu | FA9 | Lysine-specific histone demethylase 1B | 1 | 0.659 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.658 | |
| 3l4s | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.657 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.657 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.656 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.656 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.655 | |
| 1y56 | ATP | Uncharacterized protein | / | 0.655 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.655 | |
| 2np7 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.655 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.655 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.655 | |
| 4ek9 | EP4 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.655 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.655 | |
| 4txi | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.654 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.653 | |
| 2bh2 | SAH | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | / | 0.653 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.653 | |
| 4j2w | FAD | Kynurenine 3-monooxygenase | / | 0.653 | |
| 4kvz | SAH | PtnL protein | / | 0.653 | |
| 1nhs | FAD | NADH peroxidase | 1.11.1.1 | 0.652 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.652 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.652 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.652 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.651 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.651 | |
| 4l4x | NDP | AmphI | / | 0.651 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.650 | |
| 3v1y | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.650 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.650 |