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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3f5u ANP Death-associated protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 1.045
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.921
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.904
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.903
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.884
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.874
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.867
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.864
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.844
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.830
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.816
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.802
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.795
2olc ADPMethylthioribose kinase 2.7.1.100 0.784
2yaa ATPDeath-associated protein kinase 2 / 0.777
4ysj ADPCalmodulin-like domain protein kinase / 0.776
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.772
3c4z ADPRhodopsin kinase / 0.772
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.769
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.769
3c50 ADPRhodopsin kinase / 0.765
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.765
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.764
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.763
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.763
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.763
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.761
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.760
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.759
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.758
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.756
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.756
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.755
5dr2 ATPAurora kinase A 2.7.11.1 0.754
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.753
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
2pui ADPMethylthioribose kinase 2.7.1.100 0.751
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.751
4xlv ACPInsulin receptor 2.7.10.1 0.751
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.750
3oro AGSSerine/threonine protein kinase / 0.749
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.747
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.746
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.745
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.745
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
1ol6 ATPAurora kinase A 2.7.11.1 0.743
2pul ACPMethylthioribose kinase 2.7.1.100 0.743
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.740
3qc9 ADPRhodopsin kinase / 0.735
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.735
5dos ATPAurora kinase A 2.7.11.1 0.735
5iqb GNPBifunctional AAC/APH 2.3.1 0.735
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.734
2vqd AP2Biotin carboxylase 6.3.4.14 0.734
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
4utd ACPAurora kinase A 2.7.11.1 0.734
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.732
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.730
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.729
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
5dt4 ATPAurora kinase A 2.7.11.1 0.728
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.727
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.722
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.722
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.722
4c3r ACPAurora kinase A 2.7.11.1 0.721
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.721
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.720
3ori AGSSerine/threonine protein kinase / 0.720
4qny ANPMitogen activated protein kinase, putative / 0.720
5dn3 ATPAurora kinase A 2.7.11.1 0.720
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.719
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
5dt3 ATPAurora kinase A 2.7.11.1 0.718
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.717
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.717
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.717
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.717
4o4f ATPKinase / 0.716
4dee ADPAurora kinase A 2.7.11.1 0.714
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.714
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.713
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.713
3t8o ATPRhodopsin kinase / 0.713
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.712
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
5iqa GNPBifunctional AAC/APH 2.3.1 0.712
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.711
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.711
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
4o4e ATPKinase / 0.710
1u54 ACPActivated CDC42 kinase 1 / 0.709
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.709
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.708
2dwb ANPAurora kinase A 2.7.11.1 0.708
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.708
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.708
5iqd GNPBifunctional AAC/APH 2.3.1 0.708
5iqe GNPBifunctional AAC/APH 2.3.1 0.708
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.707
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.707
1cm8 ANPMitogen-activated protein kinase 12 / 0.706
3q5i ANPProtein kinase, putative / 0.706
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.705
2pun ACPMethylthioribose kinase 2.7.1.100 0.704
2pup ADPMethylthioribose kinase 2.7.1.100 0.704
3llt ANPProtein serine/threonine kinase-1 / 0.704
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.704
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.703
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.703
2py3 ACPFibroblast growth factor receptor 2 / 0.702
4q5h ANPProtein kinase OspG 2.7 0.702
2pzp ACPFibroblast growth factor receptor 2 / 0.701
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.700
3cly ACPFibroblast growth factor receptor 2 / 0.700
4ffl ADPUncharacterized protein / 0.700
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.700
5iqf GDPBifunctional AAC/APH 2.3.1 0.700
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
3rv4 ADPBiotin carboxylase 6.3.4.14 0.698
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.698
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.698
5iqh GNPBifunctional AAC/APH 2.3.1 0.698
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.697
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.697
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.697
3c4w ATPRhodopsin kinase / 0.696
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.696
1m0w ANPGlutathione synthetase 6.3.2.3 0.695
3ort AGSSerine/threonine protein kinase / 0.695
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.695
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.694
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.694
3orp AGSSerine/threonine protein kinase / 0.693
4ceg ADPAurora kinase A 2.7.11.1 0.693
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.693
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.692
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.692
5drd ATPAurora kinase A 2.7.11.1 0.692
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.691
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.691
1ol5 ADPAurora kinase A 2.7.11.1 0.690
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.690
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.690
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.689
1mq4 ADPAurora kinase A 2.7.11.1 0.688
3bu5 ATPInsulin receptor 2.7.10.1 0.688
4bn1 ADPAurora kinase A 2.7.11.1 0.688
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.687
3nie ANPMitogen-activated protein kinase / 0.687
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.686
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.686
5dnr ATPAurora kinase A 2.7.11.1 0.686
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.685
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.684
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.684
5byl GCPBifunctional AAC/APH 2.3.1 0.684
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.682
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
3orm AGSSerine/threonine protein kinase / 0.682
5l8k ADPAurora kinase A 2.7.11.1 0.682
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.681
2wqe ADPAurora kinase A 2.7.11.1 0.681
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.681
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.681
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.681
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.681
5eg3 ACPFibroblast growth factor receptor 2 / 0.681
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.680
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.679
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.679
4o1p ANPRibonuclease L / 0.679
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.679
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.678
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.678
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.678
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.677
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.677
3tdw GDPGentamicin resistance protein / 0.677
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.677
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.676
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.676
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.675
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.675
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.674
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.674
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.673
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.673
2zdg ADPD-alanine--D-alanine ligase / 0.672
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.671
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.671
2p0a ANPSynapsin-3 / 0.670
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.670
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.670
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.670
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.669
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.669
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.668
1e8x ATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.667
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.667
3wo1 ADPAlanine--anticapsin ligase / 0.667
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.667
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.666
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.666
1px2 ATPSynapsin-1 / 0.665
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.665
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.664
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.663
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.663
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.662
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.661
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.661
5l8l ADPAurora kinase A 2.7.11.1 0.661
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.659
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.659
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.659
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.659
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.658
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.657
5iqg GDPBifunctional AAC/APH 2.3.1 0.657
4mv3 ACPBiotin carboxylase 6.3.4.14 0.656
1ol7 ADPAurora kinase A 2.7.11.1 0.655
2pyw ADPMethylthioribose kinase 2.7.1.100 0.655
3wnz ADPAlanine--anticapsin ligase / 0.655
5iqi GNPBifunctional AAC/APH 2.3.1 0.655
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.654
4mv8 ACPBiotin carboxylase 6.3.4.14 0.654
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.653
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.653
3r5f ATPD-alanine--D-alanine ligase / 0.653
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.653
4ffm ADPUncharacterized protein / 0.653
4o4d ATPKinase / 0.653
2j9g ADPBiotin carboxylase 6.3.4.14 0.652
2pz5 ACPFibroblast growth factor receptor 2 / 0.652
3c4x ATPRhodopsin kinase / 0.652
4jrn ANPRhoptry kinase family protein / 0.652
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.650
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.650
3wo0 ADPAlanine--anticapsin ligase / 0.650
4bgb ADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases / 0.650
4c3p ACPAurora kinase A 2.7.11.1 0.650