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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2voj NAD Alanine dehydrogenase 1.4.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2voj NADAlanine dehydrogenase 1.4.1.1 1.261
2vhv NAIAlanine dehydrogenase 1.4.1.1 1.025
2vhx NADAlanine dehydrogenase 1.4.1.1 1.018
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.985
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.915
1pjc NADAlanine dehydrogenase / 0.884
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.804
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.798
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.790
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.786
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.781
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.778
1uxj NADMalate dehydrogenase / 0.774
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.770
3wsw NADL-lactate dehydrogenase / 0.769
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.768
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.767
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.767
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.766
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.765
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.756
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.755
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.752
3jv7 NADSecondary alcohol dehydrogenase / 0.752
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.751
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.750
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.749
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.745
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.745
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.744
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.743
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.743
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.742
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.740
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.739
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.739
4c4o NADSADH / 0.738
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.738
1u7h NADPutative ornithine cyclodeaminase / 0.737
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.737
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.736
1uxk NADMalate dehydrogenase / 0.734
4oaq NDPR-specific carbonyl reductase / 0.732
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.731
1x7d NADPutative ornithine cyclodeaminase / 0.729
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.727
3two NDPMannitol dehydrogenase / 0.725
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.724
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.724
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.724
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.724
2o4c NADErythronate-4-phosphate dehydrogenase / 0.723
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.723
4j43 NADUncharacterized protein / 0.723
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.722
2yy7 NADL-threonine dehydrogenase / 0.721
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.720
3ggp NADPrephenate dehydrogenase / 0.719
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.719
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.719
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.718
3adp NAILambda-crystallin 1.1.1.45 0.718
3tri NAPPyrroline-5-carboxylate reductase / 0.718
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.717
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.717
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.715
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.715
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.714
2dph NADFormaldehyde dismutase / 0.714
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.714
3ikt NADRedox-sensing transcriptional repressor Rex / 0.714
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.713
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.713
3oet NADErythronate-4-phosphate dehydrogenase / 0.713
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.712
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.712
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.710
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.710
4j4b NAIUncharacterized protein / 0.710
1c1d NAIPhenylalanine dehydrogenase / 0.709
5bsg NAPPyrroline-5-carboxylate reductase / 0.709
2ph5 NADHomospermidine synthase / 0.708
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.707
4j49 NADUncharacterized protein / 0.707
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.704
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.703
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.703
4jk3 NADUncharacterized protein / 0.703
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.703
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.701
1yqx NAPSinapyl alcohol dehydrogenase / 0.700
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.699
3q2k NAIProbable oxidoreductase / 0.698
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.697
4b7x NAPProbable oxidoreductase / 0.697
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.697
4z0p NDPNAD-dependent dehydrogenase / 0.697
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.696
4j49 NAIUncharacterized protein / 0.696
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.696
5a02 NAPGlucose-fructose oxidoreductase / 0.696
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.695
1vi2 NADQuinate/shikimate dehydrogenase / 0.695
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.694
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.694
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.694
3zw9 NADPeroxisomal bifunctional enzyme 1.1.1.35 0.694
4weq NAPNAD-dependent dehydrogenase / 0.694
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.693
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.693
1pzh NADLactate dehydrogenase / 0.692
2xaa NADSecondary alcohol dehydrogenase / 0.691
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.690
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.689
3f3s NADLambda-crystallin homolog / 0.689
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.689
3ing NDPHomoserine dehydrogenase related protein / 0.688
4xgi NADGlutamate dehydrogenase / 0.687
5lc1 NADL-threonine 3-dehydrogenase / 0.687
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.685
5a04 NDPGlucose-fructose oxidoreductase / 0.685
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.684
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.684
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.684
2aa3 AP0L-lactate dehydrogenase / 0.684
5a03 NDPGlucose-fructose oxidoreductase / 0.684
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.683
3abi NADUncharacterized protein / 0.682
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.682
4xq9 NADHomospermidine synthase 2.5.1.44 0.682
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.681
5a1t NAIL-lactate dehydrogenase / 0.681
3keo NADRedox-sensing transcriptional repressor Rex / 0.680
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.680
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.679
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.679
3uko NADAlcohol dehydrogenase class-3 / 0.679
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.679
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.678
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.677
2jd1 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.677
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.677
4xyb NDPFormate dehydrogenase / 0.677
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.676
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.676
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.675
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.675
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.675
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.674
3kb6 NADD-lactate dehydrogenase / 0.674
1u8x NADMaltose-6'-phosphate glucosidase 3.2.1.122 0.673
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.673
4ros APRMalate dehydrogenase / 0.673
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.672
1ie3 NADMalate dehydrogenase / 0.672
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.672
3ket NADRedox-sensing transcriptional repressor Rex / 0.671
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.670
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.670
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.670
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.670
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.670
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.669
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.669
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.668
4plp NADHomospermidine synthase 2.5.1.44 0.668
1yqd NAPSinapyl alcohol dehydrogenase / 0.667
3ntq NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.667
4xrg NADHomospermidine synthase 2.5.1.44 0.667
5a06 NDPGlucose-fructose oxidoreductase / 0.667
1guy NADMalate dehydrogenase / 0.666
1pzg A3DLactate dehydrogenase / 0.666
2nad NADFormate dehydrogenase / 0.664
2h63 NAPBiliverdin reductase A 1.3.1.24 0.663
2y05 NAPProstaglandin reductase 1 / 0.663
3tqh NDPQuinone oxidoreductase / 0.663
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.663
2qg4 NADUDP-glucose 6-dehydrogenase 1.1.1.22 0.662
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.662
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.662
3x2f NAIAdenosylhomocysteinase / 0.662
4k28 NADShikimate dehydrogenase family protein / 0.662
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.662
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.661
4tvb NADHomospermidine synthase 2.5.1.44 0.661
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.660
1vjt NADAlpha-glucosidase, putative / 0.660
2h29 DNDProbable nicotinate-nucleotide adenylyltransferase / 0.660
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.660
4cpd NADAlcohol dehydrogenase / 0.660
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.660
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.659
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.658
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.657
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.657
2ome NADC-terminal-binding protein 2 / 0.657
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.657
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.657
4pz2 NADAldehyde dehydrogenase 2-6 / 0.657
1lua NAPBifunctional protein MdtA 1.5.1.5 0.656
3gvi ADPMalate dehydrogenase / 0.656
4xqc NADHomospermidine synthase 2.5.1.44 0.656
1ebu NDAHomoserine dehydrogenase 1.1.1.3 0.655
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.655
2vwh NAPGlucose 1-dehydrogenase / 0.655
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.655
3m2t NADProbable dehydrogenase / 0.655
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.655
2fkn NADUrocanate hydratase 4.2.1.49 0.654
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.654
5bsf NADPyrroline-5-carboxylate reductase / 0.654
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.653
3d64 NADAdenosylhomocysteinase / 0.653
4l0q NADAlcohol dehydrogenase class-3 / 0.653
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.652
3ec7 NADInositol 2-dehydrogenase / 0.652
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.652
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.652
3wle NAD(R)-specific carbonyl reductase / 0.652
4euf NADTrans-2-enoyl-CoA reductase [NADH] / 0.652
4y0k NAPAntE / 0.652
3b4w NADAldehyde dehydrogenase family protein / 0.651
3hwr NDP2-dehydropantoate 2-reductase / 0.651
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.651
4pzd NAD3-Hydroxyacyl-CoA dehydrogenase / 0.651
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.651
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.651
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.650
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.650
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.650
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.650
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.650
4oqy NDP(S)-imine reductase / 0.650