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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vhx NAD Alanine dehydrogenase 1.4.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vhx NADAlanine dehydrogenase 1.4.1.1 1.226
2vhz NAIAlanine dehydrogenase 1.4.1.1 1.107
2vhw NAIAlanine dehydrogenase 1.4.1.1 1.073
2vhv NAIAlanine dehydrogenase 1.4.1.1 1.027
2voj NADAlanine dehydrogenase 1.4.1.1 1.018
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.822
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.814
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.813
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.786
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.783
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.783
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.781
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.777
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.776
1pjc NADAlanine dehydrogenase / 0.774
3uko NADAlcohol dehydrogenase class-3 / 0.774
4j4b NAIUncharacterized protein / 0.766
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.766
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.763
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.762
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.761
1f8f NADBenzyl alcohol dehydrogenase / 0.757
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.756
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.753
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.753
3ikt NADRedox-sensing transcriptional repressor Rex / 0.751
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.747
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.747
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.745
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.745
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.742
3wv7 ADPHmd co-occurring protein HcgE / 0.741
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.740
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.739
4c4o NADSADH / 0.739
4k28 NADShikimate dehydrogenase family protein / 0.739
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.738
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.737
3wle NAD(R)-specific carbonyl reductase / 0.736
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.734
3jv7 NADSecondary alcohol dehydrogenase / 0.733
3wv8 ATPHmd co-occurring protein HcgE / 0.732
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.731
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.730
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.730
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.729
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.729
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.729
4z0p NDPNAD-dependent dehydrogenase / 0.729
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.727
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.727
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.727
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.726
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.726
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.725
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.725
4jji NADAlcohol dehydrogenase class-3 / 0.725
1dap NDPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.723
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.723
3x2f NAIAdenosylhomocysteinase / 0.723
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.723
4j43 NADUncharacterized protein / 0.723
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.723
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.721
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.721
1uxj NADMalate dehydrogenase / 0.721
1o6z NADMalate dehydrogenase / 0.720
4j49 NADUncharacterized protein / 0.720
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.720
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.719
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.719
4j49 NAIUncharacterized protein / 0.719
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.719
4l0q NADAlcohol dehydrogenase class-3 / 0.717
4weq NAPNAD-dependent dehydrogenase / 0.717
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.716
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.715
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.715
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.714
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.711
1guy NADMalate dehydrogenase / 0.710
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.709
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.709
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.708
2cda NAPGlucose 1-dehydrogenase / 0.708
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.708
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.708
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.707
3d64 NADAdenosylhomocysteinase / 0.707
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.707
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.705
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.705
3ket NADRedox-sensing transcriptional repressor Rex / 0.704
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.703
1u7h NADPutative ornithine cyclodeaminase / 0.703
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.702
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.702
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.702
4xqc NADHomospermidine synthase 2.5.1.44 0.702
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.701
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.701
2dph NADFormaldehyde dismutase / 0.699
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.699
3kb6 NADD-lactate dehydrogenase / 0.698
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.698
1sow NADL-lactate dehydrogenase 1.1.1.27 0.697
1x7d NADPutative ornithine cyclodeaminase / 0.697
3oet NADErythronate-4-phosphate dehydrogenase / 0.697
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.696
3adp NAILambda-crystallin 1.1.1.45 0.696
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.696
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.695
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.695
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.695
2v7g NADUrocanate hydratase 4.2.1.49 0.694
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.694
4dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.693
3wsw NADL-lactate dehydrogenase / 0.692
1ur5 NADMalate dehydrogenase / 0.691
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.691
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.690
3keo NADRedox-sensing transcriptional repressor Rex / 0.689
4oaq NDPR-specific carbonyl reductase / 0.689
3zdf NADGlyceraldehyde-3-phosphate dehydrogenase / 0.688
1pzh NADLactate dehydrogenase / 0.687
3m2t NADProbable dehydrogenase / 0.687
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.686
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.686
3ggo NAIPrephenate dehydrogenase / 0.685
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.685
4ebf NADPhosphonate dehydrogenase 1.20.1.1 0.685
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.684
1u8x NADMaltose-6'-phosphate glucosidase 3.2.1.122 0.684
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.684
1emd NADMalate dehydrogenase / 0.683
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.683
4gl4 NAIAlcohol dehydrogenase class-3 / 0.683
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.683
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.682
2fkn NADUrocanate hydratase 4.2.1.49 0.681
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.681
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.681
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.680
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.680
1ptj SNDNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.678
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.678
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.678
3q2k NAIProbable oxidoreductase / 0.678
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.678
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.677
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.677
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.677
4lcj NADC-terminal-binding protein 2 / 0.677
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.677
1b8v NADMalate dehydrogenase / 0.676
1bmd NADMalate dehydrogenase / 0.675
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.675
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.675
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.675
3tri NAPPyrroline-5-carboxylate reductase / 0.675
1wzi NDPMalate dehydrogenase / 0.673
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.673
2nad NADFormate dehydrogenase / 0.673
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.673
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.672
3two NDPMannitol dehydrogenase / 0.672
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.672
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.671
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.671
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.671
4i1i NADMalate dehydrogenase / 0.671
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.671
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.670
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.670
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.670
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.670
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.670
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.669
4b7x NAPProbable oxidoreductase / 0.669
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.668
2dfv NADL-threonine 3-dehydrogenase / 0.668
2ph5 NADHomospermidine synthase / 0.668
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.668
1c1d NAIPhenylalanine dehydrogenase / 0.667
2wsb NADGalactitol dehydrogenase / 0.666
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.666
4xyb NDPFormate dehydrogenase / 0.666
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.665
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.664
1kc1 NDPdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.664
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.664
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.663
4jk3 NADUncharacterized protein / 0.663
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.662
1vjt NADAlpha-glucosidase, putative / 0.662
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.662
5a02 NAPGlucose-fructose oxidoreductase / 0.662
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.661
1wze NADMalate dehydrogenase / 0.661
2gsd NADFormate dehydrogenase / 0.661
3ec7 NADInositol 2-dehydrogenase / 0.661
4d79 ATPtRNA threonylcarbamoyladenosine dehydratase 6.1 0.661
1dc6 NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.660
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.660
2qg4 NADUDP-glucose 6-dehydrogenase 1.1.1.22 0.660
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.660
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.660
4plp NADHomospermidine synthase 2.5.1.44 0.660
1a7k NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.659
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.659
3ntq NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.659
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.659
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.659
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
1hku NADC-terminal-binding protein 1 1.1.1 0.657
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.657
2oor NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.657
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.657
1nyt NAPShikimate dehydrogenase (NADP(+)) / 0.656
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.656
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.656
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.656
3v1y NADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic 1.2.1.12 0.656
4cpd NADAlcohol dehydrogenase / 0.656
1ywg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
2d8a NADL-threonine 3-dehydrogenase / 0.655
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.654
1qor NDPQuinone oxidoreductase 1 / 0.654
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.654
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.653
1gv0 NADMalate dehydrogenase / 0.653
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.653
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.653
3ing NDPHomoserine dehydrogenase related protein / 0.653
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.653
2x0r NADMalate dehydrogenase / 0.652
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.652
3x2e NAIAdenosylhomocysteinase / 0.652
1vi2 NADQuinate/shikimate dehydrogenase / 0.651
2jd1 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.651
3tsc NADUncharacterized protein / 0.650
5bsf NADPyrroline-5-carboxylate reductase / 0.650