sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.624 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.622 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.619 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.618 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.602 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.595 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.586 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.586 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.583 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.583 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.582 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.576 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.576 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.576 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.573 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.572 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.572 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.570 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.568 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.568 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.568 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.567 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.565 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.562 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.562 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.562 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.560 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.558 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.557 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.556 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.555 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.553 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.552 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.552 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.551 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.550 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.550 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.549 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.549 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.548 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.548 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.547 | |
| 3qly | 55V | Uncharacterized protein | / | 0.547 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.546 | |
| 3eek | 53S | Uncharacterized protein | / | 0.545 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.544 | |
| 3cse | N22 | Uncharacterized protein | / | 0.544 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.543 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.539 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.538 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.536 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.534 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 3eej | 53R | Uncharacterized protein | / | 0.533 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.533 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.532 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.532 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.530 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.529 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.529 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.529 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.527 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.526 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.525 | |
| 3eel | 53T | Uncharacterized protein | / | 0.525 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3ix9 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3tq8 | TOP | Dihydrofolate reductase | / | 0.520 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.520 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.519 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.514 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 3eem | 53V | Uncharacterized protein | / | 0.514 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.514 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.514 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.513 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.511 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 1dre | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.502 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.500 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.500 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.499 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.499 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 3sqy | Q11 | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.496 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.494 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.490 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.489 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.488 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.487 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.487 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.485 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4j7x | SAS | Sepiapterin reductase | 1.1.1.153 | 0.484 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.484 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.482 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.478 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.477 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.477 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.473 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.473 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.472 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 4qi9 | MTX | Dihydrofolate reductase | / | 0.471 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1rh3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.466 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.466 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.466 | |
| 3iqz | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.465 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.465 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.464 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3a0i | AJI | Glucokinase | 2.7.1.2 | 0.463 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.462 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.462 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2bxm | IMN | Serum albumin | / | 0.461 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.461 | |
| 4iv2 | 1GR | Estrogen receptor | / | 0.461 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.461 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.460 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.460 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.460 | |
| 3m09 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4bbh | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.458 | |
| 2ync | YNC | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.458 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 3vbq | 0F5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4b11 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.456 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.456 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.456 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.456 | |
| 1lud | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3h18 | PMS | Esterase/lipase | / | 0.455 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 4c2z | MYA | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.455 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.453 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.452 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 3g8d | ADP | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.452 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.452 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4ucn | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.451 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 3bgp | VX1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 4cby | KEE | Histone deacetylase 4 | 3.5.1.98 | 0.450 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1fkw | PUR | Adenosine deaminase | 3.5.4.4 | 0.449 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2xiz | XIZ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 3lu8 | IQX | Serum albumin | / | 0.449 | |
| 3r0t | FU9 | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4c68 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.449 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.449 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.449 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.449 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.448 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.448 | |
| 4bwa | N0B | Pyrrolysine--tRNA ligase | / | 0.448 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.448 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.448 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.448 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.447 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.447 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.447 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.447 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.447 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.447 | |
| 3zhb | NAP | Putative dehydrogenase | / | 0.447 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.446 | |
| 2xvv | 9DN | Serum albumin | / | 0.446 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.446 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.446 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.446 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.446 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.445 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2bxq | IMN | Serum albumin | / | 0.445 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 3hll | I46 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3i0r | RT3 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4j7u | YTZ | Sepiapterin reductase | 1.1.1.153 | 0.445 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.444 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3b9l | AZZ | Serum albumin | / | 0.444 | |
| 3sr5 | Q12 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.443 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.443 | |
| 1rt4 | UC1 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.443 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.443 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.443 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.443 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.442 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.442 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.441 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.441 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2ayr | L4G | Estrogen receptor | / | 0.441 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.441 | |
| 2wpw | ACO | Orf14 | / | 0.441 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.441 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.441 | |
| 3ghh | 2NF | CD38 molecule | / | 0.441 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.441 | |
| 4bqr | IBH | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 2bil | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.440 | |
| 3bgr | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.440 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4zas | TYD | CalS13 | / | 0.440 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.440 |