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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kbk1QGCasein kinase I isoform delta2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kbk1QGCasein kinase I isoform delta2.7.11.11.000
3uyt0CKCasein kinase I isoform delta2.7.11.10.613
1eh4IC1Casein kinase I homolog 12.7.11.10.573
4kb81QNCasein kinase I isoform delta2.7.11.10.572
4hnf16WCasein kinase I isoform delta2.7.11.10.526
4hni16WCasein kinase I isoform epsilon2.7.11.10.519
4dgnLU2Casein kinase II subunit alpha2.7.11.10.516
3hmm855TGF-beta receptor type-12.7.11.300.515
4yuqKS1Calmodulin-like domain protein kinase/0.511
2pvmP29Casein kinase II subunit alpha2.7.11.10.510
4g170VNCasein kinase I isoform gamma-32.7.11.10.510
2izrBRKCasein kinase I isoform gamma-32.7.11.10.508
3sheI85MAP kinase-activated protein kinase 32.7.11.10.508
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.508
2pvhP19Casein kinase II subunit alpha2.7.11.10.506
3be9P04Casein kinase II subunit alpha2.7.11.10.506
3u4uLNHCasein kinase II subunit alpha2.7.11.10.503
4anmWULCasein kinase II subunit alpha2.7.11.10.502
3w33W19Epidermal growth factor receptor2.7.10.10.501
4fv9E71Mitogen-activated protein kinase 12.7.11.240.500
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.499
3i60E86Mitogen-activated protein kinase 12.7.11.240.495
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.495
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.495
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.493
4bgg844Activin receptor type-12.7.11.300.493
4dymIYZActivin receptor type-12.7.11.300.493
3mtfA3FActivin receptor type-12.7.11.300.492
4kbc1QJCasein kinase I isoform delta2.7.11.10.490
1g5sI17Cyclin-dependent kinase 22.7.11.220.488
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.486
4grb0XGCasein kinase II subunit alpha2.7.11.10.486
4hge15VTyrosine-protein kinase JAK2/0.486
4i22IREEpidermal growth factor receptor2.7.10.10.486
2pvlP55Casein kinase II subunit alpha2.7.11.10.484
3q9xEMOCasein kinase II subunit alpha2.7.11.10.483
2pvnP63Casein kinase II subunit alpha2.7.11.10.482
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.482
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.482
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.481
1pmn984Mitogen-activated protein kinase 102.7.11.240.480
3gubGUBDeath-associated protein kinase 12.7.11.10.480
4g160VMCasein kinase I isoform gamma-32.7.11.10.480
2b52D42Cyclin-dependent kinase 22.7.11.220.479
3uzp0CKCasein kinase I isoform delta2.7.11.10.479
5e8wSTUTGF-beta receptor type-12.7.11.300.479
1m2pHNACasein kinase II subunit alpha2.7.11.10.478
3nynSGVG protein-coupled receptor kinase 62.7.11.160.478
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.477
3kf7L9GMitogen-activated protein kinase 14/0.476
1vjy460TGF-beta receptor type-12.7.11.300.475
4c02TAKActivin receptor type-12.7.11.300.475
2yaaATPDeath-associated protein kinase 2/0.474
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.474
3w32W32Epidermal growth factor receptor2.7.10.10.474
1xjdSTUProtein kinase C theta type2.7.11.130.473
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.473
4qmzB49Serine/threonine-protein kinase 242.7.11.10.473
4fv6E57Mitogen-activated protein kinase 12.7.11.240.472
4kba1QMCasein kinase I isoform delta2.7.11.10.472
2ghmLICMitogen-activated protein kinase 14/0.471
1om1IQACasein kinase II subunit alpha2.7.11.10.470
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.470
3hl7I47Mitogen-activated protein kinase 14/0.470
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.470
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.470
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.470
2btsU32Cyclin-dependent kinase 22.7.11.220.469
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.469
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.469
3w2sW2REpidermal growth factor receptor2.7.10.10.468
4c4f7CEDual specificity protein kinase TTK2.7.12.10.468
1ouk084Mitogen-activated protein kinase 14/0.467
2wotZZGTGF-beta receptor type-12.7.11.300.467
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.466
3bqr4RBDeath-associated protein kinase 3/0.466
3lltANPProtein serine/threonine kinase-1/0.466
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.466
4ix6ADPUncharacterized protein/0.466
1h1s4SPCyclin-dependent kinase 22.7.11.220.465
2iw94SPCyclin-dependent kinase 22.7.11.220.465
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.465
2p33J07Mitogen-activated protein kinase 102.7.11.240.465
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.465
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.465
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.464
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.464
2x1nX1NCyclin-dependent kinase 22.7.11.220.463
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.463
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.463
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.463
3mpaSB2Mitogen-activated protein kinase 14/0.463
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.463
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.463
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.462
2izsBRQCasein kinase I isoform gamma-32.7.11.10.461
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.461
4loqSB4Mitogen-activated protein kinase 14/0.461
2ijmADPFocal adhesion kinase 12.7.10.20.460
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.460
3gxlQIGTGF-beta receptor type-12.7.11.300.460
4btjADPTau-tubulin kinase 12.7.11.10.460
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.460
1m2rMNYCasein kinase II subunit alpha2.7.11.10.459
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.459
4fkv61KCyclin-dependent kinase 22.7.11.220.459
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.458
3fln3FNMitogen-activated protein kinase 14/0.458
3mvl38PMitogen-activated protein kinase 14/0.458
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.458
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.457
2w17I19Cyclin-dependent kinase 22.7.11.220.457
3ormAGSSerine/threonine protein kinase/0.457
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.457
4ic7ANPMitogen-activated protein kinase 72.7.11.240.457
1oirHDYCyclin-dependent kinase 22.7.11.220.456
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.456
2j0m4STFocal adhesion kinase 12.7.10.20.456
2vv9IM9Cyclin-dependent kinase 22.7.11.220.456
2xikJ60Serine/threonine-protein kinase 252.7.11.10.456
3kvxFMYMitogen-activated protein kinase 102.7.11.240.456
4aacAAVMitogen-activated protein kinase 14/0.456
4dgmAGICasein kinase II subunit alpha2.7.11.10.456
4lopSB4Mitogen-activated protein kinase 14/0.456
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.455
2uzbC75Cyclin-dependent kinase 22.7.11.220.455
3ddpRC8Cyclin-dependent kinase 22.7.11.220.455
3gc9B45Mitogen-activated protein kinase 112.7.11.240.455
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.455
3axwTIDCasein kinase II subunit alpha2.7.11.10.454
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.454
4dgo0JWCasein kinase II subunit alpha2.7.11.10.454
5e8ySTUTGF-beta receptor type-22.7.11.300.454
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.453
2wouZZFTGF-beta receptor type-12.7.11.300.453
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.453
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.453
3nww3NWMitogen-activated protein kinase 14/0.453
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.453
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.453
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.453
1gii1PUCyclin-dependent kinase 22.7.11.220.452
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.452
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.452
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.451
1aq1STUCyclin-dependent kinase 22.7.11.220.450
1dawANPCasein kinase II subunit alpha2.7.11.10.450
3zh8C58Protein kinase C iota type2.7.11.130.450
4jqeANPCasein kinase II subunit alpha2.7.11.10.450
5br4NADLactaldehyde reductase1.1.1.770.450
1csnATPCasein kinase I homolog 12.7.11.10.449
1ke5LS1Cyclin-dependent kinase 22.7.11.220.449
3dt1P40Mitogen-activated protein kinase 14/0.449
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.449
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.449
4c4jX21Dual specificity protein kinase TTK2.7.12.10.449
4hvi19STyrosine-protein kinase JAK32.7.10.20.449
4jq8KJ8Epidermal growth factor receptor2.7.10.10.449
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.449
4xlvACPInsulin receptor2.7.10.10.449
1u54ACPActivated CDC42 kinase 1/0.448
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.448
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.448
2ckeIQUDeath-associated protein kinase 2/0.448
2izuP01Casein kinase I isoform gamma-32.7.11.10.448
3sw719KCyclin-dependent kinase 22.7.11.220.448
3ttiKBIMitogen-activated protein kinase 102.7.11.240.448
4aa4QC0Mitogen-activated protein kinase 14/0.448
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.448
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.448
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.447
2jedLG8Protein kinase C theta type2.7.11.130.447
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.447
4ewqMWLMitogen-activated protein kinase 14/0.447
2c475IDCasein kinase I isoform gamma-2/0.446
3zewSTUEphrin type-B receptor 42.7.10.10.446
4bcoT6QCyclin-dependent kinase 22.7.11.220.446
5ax35IDMitogen-activated protein kinase 12.7.11.240.446
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.445
1yw2PGJMitogen-activated protein kinase 14/0.445
1ywrLI9Mitogen-activated protein kinase 14/0.445
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.445
3rjc06ZCyclin-dependent kinase 22.7.11.220.445
3s1h56ZCyclin-dependent kinase 22.7.11.220.445
3ttjJBIMitogen-activated protein kinase 102.7.11.240.445
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.445
4jboWPHAurora kinase A2.7.11.10.445
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.445
1dayGNPCasein kinase II subunit alpha2.7.11.10.444
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.444
2znpK55Peroxisome proliferator-activated receptor delta/0.444
3ezvEZVCyclin-dependent kinase 22.7.11.220.444
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.444
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.444
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.444
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.444
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.443
1u4dDBQActivated CDC42 kinase 1/0.443
2csnCKICasein kinase I homolog 12.7.11.10.443
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.443
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
2o0uC0MMitogen-activated protein kinase 102.7.11.240.443
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.443
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.443
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.443
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.443
3rkb12ZCyclin-dependent kinase 22.7.11.220.443
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.443
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.443
1di8DTQCyclin-dependent kinase 22.7.11.220.442
1m17AQ4Epidermal growth factor receptor2.7.10.10.442
1oi9N20Cyclin-dependent kinase 22.7.11.220.442
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
3c50ADPRhodopsin kinase/0.442
3nwq2NCGag-Pol polyprotein3.4.23.160.442
3s2pPMUCyclin-dependent kinase 22.7.11.220.442
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.442
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.442
4lxhC1EAlpha/beta hydrolase fold/0.442
4qmlANPSerine/threonine-protein kinase 242.7.11.10.442
2btrU73Cyclin-dependent kinase 22.7.11.220.441
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.441
2izt23DCasein kinase I isoform gamma-32.7.11.10.441
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.441
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.441
4nk92K5Fibroblast growth factor receptor 1/0.441
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.440
1pxlCK4Cyclin-dependent kinase 22.7.11.220.440
1py5PY1TGF-beta receptor type-12.7.11.300.440
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.440
3cgfJNFMitogen-activated protein kinase 102.7.11.240.440
3igoANPCalmodulin-domain protein kinase 1, putative/0.440
4aqc88ATyrosine-protein kinase JAK2/0.440
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.440
4jbpYPHAurora kinase A2.7.11.10.440
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.440
4ux9ANPMitogen-activated protein kinase 82.7.11.240.440