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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eos1ROCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4eos1ROCyclin-dependent kinase 22.7.11.221.000
1h1r6CPCyclin-dependent kinase 22.7.11.220.590
4eop1ROCyclin-dependent kinase 22.7.11.220.587
1h1pCMGCyclin-dependent kinase 22.7.11.220.584
4eoi1ROCyclin-dependent kinase 22.7.11.220.565
4eol1ROCyclin-dependent kinase 22.7.11.220.557
3qu0X40Cyclin-dependent kinase 22.7.11.220.555
4eon1ROCyclin-dependent kinase 22.7.11.220.547
3rpv26ZCyclin-dependent kinase 22.7.11.220.541
3sqq99ZCyclin-dependent kinase 22.7.11.220.540
3qtzX42Cyclin-dependent kinase 22.7.11.220.537
4eor4SPCyclin-dependent kinase 22.7.11.220.536
1h1s4SPCyclin-dependent kinase 22.7.11.220.534
1oguST8Cyclin-dependent kinase 22.7.11.220.534
3r9hZ67Cyclin-dependent kinase 22.7.11.220.534
3qqkX02Cyclin-dependent kinase 22.7.11.220.532
3r9dX6BCyclin-dependent kinase 22.7.11.220.527
3qruX19Cyclin-dependent kinase 22.7.11.220.525
3fz1B98Cyclin-dependent kinase 22.7.11.220.524
4fkr45KCyclin-dependent kinase 22.7.11.220.524
3s0o50ZCyclin-dependent kinase 22.7.11.220.523
4fx360KCyclin-dependent kinase 22.7.11.220.522
1vyzN5BCyclin-dependent kinase 22.7.11.220.521
3unj0BXCyclin-dependent kinase 22.7.11.220.521
4bcpT3CCyclin-dependent kinase 22.7.11.220.520
3qtuX44Cyclin-dependent kinase 22.7.11.220.518
2iw84SPCyclin-dependent kinase 22.7.11.220.517
3ddqRRCCyclin-dependent kinase 22.7.11.220.517
1vyw292Cyclin-dependent kinase 22.7.11.220.516
2iw94SPCyclin-dependent kinase 22.7.11.220.516
3ral04ZCyclin-dependent kinase 22.7.11.220.516
4acm7YGCyclin-dependent kinase 22.7.11.220.516
1e9hINRCyclin-dependent kinase 22.7.11.220.514
1w0xOLOCyclin-dependent kinase 22.7.11.220.514
3qqfX07Cyclin-dependent kinase 22.7.11.220.512
3qzgX67Cyclin-dependent kinase 22.7.11.220.511
1pkdUCNCyclin-dependent kinase 22.7.11.220.509
3iggEFQCyclin-dependent kinase 22.7.11.220.509
3qtxX43Cyclin-dependent kinase 22.7.11.220.509
2b55D31Cyclin-dependent kinase 22.7.11.220.508
3ddpRC8Cyclin-dependent kinase 22.7.11.220.508
3rak03ZCyclin-dependent kinase 22.7.11.220.508
3rk909ZCyclin-dependent kinase 22.7.11.220.508
2c5nCK8Cyclin-dependent kinase 22.7.11.220.507
1h1q2A6Cyclin-dependent kinase 22.7.11.220.506
3qzhX69Cyclin-dependent kinase 22.7.11.220.506
3sw418KCyclin-dependent kinase 22.7.11.220.506
1urwI1PCyclin-dependent kinase 22.7.11.220.504
2btsU32Cyclin-dependent kinase 22.7.11.220.504
3my5RFZCyclin-dependent kinase 22.7.11.220.504
3rk507ZCyclin-dependent kinase 22.7.11.220.503
4bcnT9NCyclin-dependent kinase 22.7.11.220.503
1di8DTQCyclin-dependent kinase 22.7.11.220.502
1ke9LS5Cyclin-dependent kinase 22.7.11.220.502
1oi9N20Cyclin-dependent kinase 22.7.11.220.501
3r1yX76Cyclin-dependent kinase 22.7.11.220.501
3s2pPMUCyclin-dependent kinase 22.7.11.220.501
1ke5LS1Cyclin-dependent kinase 22.7.11.220.500
3dogNNNCyclin-dependent kinase 22.7.11.220.500
3rmf20ZCyclin-dependent kinase 22.7.11.220.500
2w1hL0FCyclin-dependent kinase 22.7.11.220.499
2x1nX1NCyclin-dependent kinase 22.7.11.220.499
3qtrX36Cyclin-dependent kinase 22.7.11.220.499
2b52D42Cyclin-dependent kinase 22.7.11.220.498
1ke6LS2Cyclin-dependent kinase 22.7.11.220.497
1oiyN41Cyclin-dependent kinase 22.7.11.220.497
2wxvWXVCyclin-dependent kinase 22.7.11.220.497
3s1h56ZCyclin-dependent kinase 22.7.11.220.497
4fkw62KCyclin-dependent kinase 22.7.11.220.497
1gih1PUCyclin-dependent kinase 22.7.11.220.496
1p2a5BNCyclin-dependent kinase 22.7.11.220.496
2wihP48Cyclin-dependent kinase 22.7.11.220.496
3r7vZ02Cyclin-dependent kinase 22.7.11.220.496
4nj32KDCyclin-dependent kinase 22.7.11.220.496
1pxmCK5Cyclin-dependent kinase 22.7.11.220.495
3py0SU9Cyclin-dependent kinase 22.7.11.220.495
2c6o4SPCyclin-dependent kinase 22.7.11.220.494
4bcmT7ZCyclin-dependent kinase 22.7.11.220.494
4ez30S0Cyclin-dependent kinase 22.7.11.220.494
1v1k3FPCyclin-dependent kinase 22.7.11.220.493
3ql8X01Cyclin-dependent kinase 22.7.11.220.493
3r6xX84Cyclin-dependent kinase 22.7.11.220.493
3rjc06ZCyclin-dependent kinase 22.7.11.220.493
1ke8LS4Cyclin-dependent kinase 22.7.11.220.492
1unlRRCCyclin-dependent-like kinase 52.7.11.10.492
2w05FRTCyclin-dependent kinase 22.7.11.220.492
2w06FRVCyclin-dependent kinase 22.7.11.220.492
3roy22ZCyclin-dependent kinase 22.7.11.220.492
3unk0BYCyclin-dependent kinase 22.7.11.220.490
4bgh3I6Cyclin-dependent kinase 22.7.11.220.490
1ckpPVBCyclin-dependent kinase 22.7.11.220.489
1oitHDTCyclin-dependent kinase 22.7.11.220.489
3qqhX0ACyclin-dependent kinase 22.7.11.220.489
3rk708ZCyclin-dependent kinase 22.7.11.220.489
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.488
3qqlX03Cyclin-dependent kinase 22.7.11.220.488
3rm719ZCyclin-dependent kinase 22.7.11.220.488
1gij2PUCyclin-dependent kinase 22.7.11.220.487
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.487
3r73X87Cyclin-dependent kinase 22.7.11.220.487
3rpo24ZCyclin-dependent kinase 22.7.11.220.487
3qwjX6ACyclin-dependent kinase 22.7.11.220.486
3r1sX73Cyclin-dependent kinase 22.7.11.220.486
1pxoCK7Cyclin-dependent kinase 22.7.11.220.485
2wpa889Cyclin-dependent kinase 22.7.11.220.485
3ig7EFPCyclin-dependent kinase 22.7.11.220.485
3qwkX62Cyclin-dependent kinase 22.7.11.220.485
1b39ATPCyclin-dependent kinase 22.7.11.220.484
4ek816KCyclin-dependent kinase 22.7.11.220.484
1g5sI17Cyclin-dependent kinase 22.7.11.220.483
2uzoC62Cyclin-dependent kinase 22.7.11.220.483
3ezrEZRCyclin-dependent kinase 22.7.11.220.482
4fki09KCyclin-dependent kinase 22.7.11.220.482
4fkpLS5Cyclin-dependent kinase 22.7.11.220.482
4fkq42KCyclin-dependent kinase 22.7.11.220.482
4bcoT6QCyclin-dependent kinase 22.7.11.220.481
1e1xNW1Cyclin-dependent kinase 22.7.11.220.480
3qxoX65Cyclin-dependent kinase 22.7.11.220.480
3r7iX9ICyclin-dependent kinase 22.7.11.220.480
3raiX85Cyclin-dependent kinase 22.7.11.220.480
3rni21ZCyclin-dependent kinase 22.7.11.220.480
1dm2HMDCyclin-dependent kinase 22.7.11.220.479
1ke7LS3Cyclin-dependent kinase 22.7.11.220.479
2btrU73Cyclin-dependent kinase 22.7.11.220.479
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.479
3r7yZ04Cyclin-dependent kinase 22.7.11.220.479
3rm618ZCyclin-dependent kinase 22.7.11.220.479
2w17I19Cyclin-dependent kinase 22.7.11.220.478
3rkb12ZCyclin-dependent kinase 22.7.11.220.477
3rpr25ZCyclin-dependent kinase 22.7.11.220.477
1pxkCK3Cyclin-dependent kinase 22.7.11.220.476
2wotZZGTGF-beta receptor type-12.7.11.300.476
3tnwF18Cyclin-dependent kinase 22.7.11.220.476
2xnbY8LCyclin-dependent kinase 22.7.11.220.475
3qtqX35Cyclin-dependent kinase 22.7.11.220.475
4fkj11KCyclin-dependent kinase 22.7.11.220.475
4fko20KCyclin-dependent kinase 22.7.11.220.475
4qmpDKISerine/threonine-protein kinase 242.7.11.10.475
2a0cCK9Cyclin-dependent kinase 22.7.11.220.474
2r3kSCQCyclin-dependent kinase 22.7.11.220.474
3r1qX75Cyclin-dependent kinase 22.7.11.220.474
2r64740Cyclin-dependent kinase 22.7.11.220.473
3r71X86Cyclin-dependent kinase 22.7.11.220.473
4eok4SPCyclin-dependent kinase 22.7.11.220.473
1oiqHDUCyclin-dependent kinase 22.7.11.220.472
2cchATPCyclin-dependent kinase 22.7.11.220.472
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.472
2vttLZDCyclin-dependent kinase 22.7.11.220.472
3lfnA27Cyclin-dependent kinase 22.7.11.220.472
4cfnJYMCyclin-dependent kinase 22.7.11.220.472
1oiuN76Cyclin-dependent kinase 22.7.11.220.471
2vu3LZECyclin-dependent kinase 22.7.11.220.471
3r7eX88Cyclin-dependent kinase 22.7.11.220.470
3r9oZ71Cyclin-dependent kinase 22.7.11.220.470
1r78FMDCyclin-dependent kinase 22.7.11.220.469
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.469
3ti1B49Cyclin-dependent kinase 22.7.11.220.469
4lyn1YGCyclin-dependent kinase 22.7.11.220.469
1b38ATPCyclin-dependent kinase 22.7.11.220.468
3lfsA07Cyclin-dependent kinase 22.7.11.220.468
1e1vCMGCyclin-dependent kinase 22.7.11.220.467
2r3o2SCCyclin-dependent kinase 22.7.11.220.467
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.467
1h0w207Cyclin-dependent kinase 22.7.11.220.466
3mtfA3FActivin receptor type-12.7.11.300.466
3r8pZ46Cyclin-dependent kinase 22.7.11.220.466
4kd11QKCyclin-dependent kinase 22.7.11.220.466
1y91CT9Cyclin-dependent kinase 22.7.11.220.465
3axwTIDCasein kinase II subunit alpha2.7.11.10.465
3r8lZ30Cyclin-dependent kinase 22.7.11.220.465
3rpy27ZCyclin-dependent kinase 22.7.11.220.465
4fkv61KCyclin-dependent kinase 22.7.11.220.465
3r28XA0Cyclin-dependent kinase 22.7.11.220.464
4bgg844Activin receptor type-12.7.11.300.464
4erwSTUCyclin-dependent kinase 22.7.11.220.464
2j9mPY8Cyclin-dependent kinase 22.7.11.220.463
2xmyCDKCyclin-dependent kinase 22.7.11.220.463
3rahO1ZCyclin-dependent kinase 22.7.11.220.463
2r3r6SCCyclin-dependent kinase 22.7.11.220.462
1fvt106Cyclin-dependent kinase 22.7.11.220.461
1fvv107Cyclin-dependent kinase 22.7.11.220.461
2a4lRRCCyclin-dependent kinase 22.7.11.220.461
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.461
2c6iDT1Cyclin-dependent kinase 22.7.11.220.460
2pmlANPUncharacterized protein/0.460
2r3mSCXCyclin-dependent kinase 22.7.11.220.460
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.460
4fks46KCyclin-dependent kinase 22.7.11.220.460
2vv9IM9Cyclin-dependent kinase 22.7.11.220.459
3pj8404Cyclin-dependent kinase 22.7.11.220.459
3qziX72Cyclin-dependent kinase 22.7.11.220.459
3r7uX96Cyclin-dependent kinase 22.7.11.220.458
2duv371Cyclin-dependent kinase 22.7.11.220.457
2r3lSCWCyclin-dependent kinase 22.7.11.220.457
3bhtMFRCyclin-dependent kinase 22.7.11.220.457
4eomATPCyclin-dependent kinase 22.7.11.220.457
3qzfX66Cyclin-dependent kinase 22.7.11.220.456
1v0oINRCell division control protein 2 homolog2.7.11.220.455
2xru400Aurora kinase A2.7.11.10.455
3qx2X63Cyclin-dependent kinase 22.7.11.220.455
5dr2ATPAurora kinase A2.7.11.10.455
4dgo0JWCasein kinase II subunit alpha2.7.11.10.454
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.453
3at4CCKCasein kinase II subunit alpha2.7.11.10.453
3pxyJWSCyclin-dependent kinase 22.7.11.220.453
1pxpCK8Cyclin-dependent kinase 22.7.11.220.452
3uli1N3Cyclin-dependent kinase 22.7.11.220.452
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.452
1finATPCyclin-dependent kinase 22.7.11.220.451
1h0vUN4Cyclin-dependent kinase 22.7.11.220.451
2c4g514Cyclin-dependent kinase 22.7.11.220.451
4fkt48KCyclin-dependent kinase 22.7.11.220.451
1unhIXMCyclin-dependent-like kinase 52.7.11.10.450
2r3gSC9Cyclin-dependent kinase 22.7.11.220.450
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4eooATPCyclin-dependent kinase 22.7.11.220.449
2c6tDT5Cyclin-dependent kinase 22.7.11.220.448
2uzeC95Cyclin-dependent kinase 22.7.11.220.448
3sw719KCyclin-dependent kinase 22.7.11.220.448
5aniES4Cyclin-dependent kinase 22.7.11.220.448
2i40BLZCyclin-dependent kinase 22.7.11.220.447
2uzlC94Cyclin-dependent kinase 22.7.11.220.447
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.447
2w1fL0FAurora kinase A2.7.11.10.447
4ek610KCyclin-dependent kinase 22.7.11.220.447
3bheBZNGag-Pol polyprotein3.4.23.160.446
4gmy0X5Tyrosine-protein kinase JAK2/0.446
2dwbANPAurora kinase A2.7.11.10.445
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.445
2r3iSCFCyclin-dependent kinase 22.7.11.220.444
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4nc3ERM5-hydroxytryptamine receptor 2B/0.444
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.444
2r3p3SCCyclin-dependent kinase 22.7.11.220.443
3qxpX64Cyclin-dependent kinase 22.7.11.220.443
3r8zZ63Cyclin-dependent kinase 22.7.11.220.442
2uznC96Cyclin-dependent kinase 22.7.11.220.441
3lfqA28Cyclin-dependent kinase 22.7.11.220.441
3q43D66M1 family aminopeptidase3.4.110.441
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.441
4o0wADNAurora kinase A2.7.11.10.441
2bhhRYUCyclin-dependent kinase 22.7.11.220.440
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.440