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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.21.000
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.696
2b7aIZATyrosine-protein kinase JAK2/0.539
4ivc1J6Tyrosine-protein kinase JAK1/0.523
4k771Q4Tyrosine-protein kinase JAK1/0.523
5dt0SKEAurora kinase A2.7.11.10.522
5drdATPAurora kinase A2.7.11.10.505
4k6z1Q3Tyrosine-protein kinase JAK1/0.500
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.495
4e4l0NHTyrosine-protein kinase JAK1/0.494
4ei40Q2Tyrosine-protein kinase JAK1/0.494
4ivb1J5Tyrosine-protein kinase JAK1/0.491
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.488
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.486
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.485
4fx360KCyclin-dependent kinase 22.7.11.220.485
4o0sADNAurora kinase A2.7.11.10.485
4ivd15TTyrosine-protein kinase JAK1/0.484
4qmpDKISerine/threonine-protein kinase 242.7.11.10.484
3eyhIZATyrosine-protein kinase JAK1/0.482
5dpvSKEAurora kinase A2.7.11.10.478
5dr9SKEAurora kinase A2.7.11.10.478
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.476
2xikJ60Serine/threonine-protein kinase 252.7.11.10.474
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.474
4qmySTUSerine/threonine-protein kinase 242.7.11.10.474
3rk909ZCyclin-dependent kinase 22.7.11.220.473
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.473
4hge15VTyrosine-protein kinase JAK2/0.472
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.471
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.471
2dcnADP2-keto-3-deoxy-gluconate kinase/0.470
4e4m0NHTyrosine-protein kinase JAK2/0.470
1e1xNW1Cyclin-dependent kinase 22.7.11.220.469
2jkoBIJFocal adhesion kinase 12.7.10.20.469
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.469
3qqkX02Cyclin-dependent kinase 22.7.11.220.469
2x6dX6DAurora kinase A2.7.11.10.468
3iok1P6Tyrosine-protein kinase JAK2/0.468
3rvg17PTyrosine-protein kinase JAK2/0.468
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.467
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
3r6xX84Cyclin-dependent kinase 22.7.11.220.467
3zep1NXTyrosine-protein kinase JAK32.7.10.20.467
3zmmF9JTyrosine-protein kinase JAK2/0.467
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.467
2dwbANPAurora kinase A2.7.11.10.466
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.466
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.466
3p7nFMNLight-activated DNA-binding protein EL222/0.465
4e5w0NTTyrosine-protein kinase JAK1/0.465
1pxmCK5Cyclin-dependent kinase 22.7.11.220.464
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.464
3ggfGVDSerine/threonine-protein kinase 26/0.464
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.463
1p2a5BNCyclin-dependent kinase 22.7.11.220.463
2i40BLZCyclin-dependent kinase 22.7.11.220.463
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.463
2bkzSBCCyclin-dependent kinase 22.7.11.220.462
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.462
2w1eL0EAurora kinase A2.7.11.10.462
2wotZZGTGF-beta receptor type-12.7.11.300.462
4eon1ROCyclin-dependent kinase 22.7.11.220.462
4fkg4CKCyclin-dependent kinase 22.7.11.220.462
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
1urwI1PCyclin-dependent kinase 22.7.11.220.461
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.461
4acm7YGCyclin-dependent kinase 22.7.11.220.461
4bgh3I6Cyclin-dependent kinase 22.7.11.220.461
1m2rMNYCasein kinase II subunit alpha2.7.11.10.460
2d8aNADL-threonine 3-dehydrogenase/0.460
2jkqVG8Focal adhesion kinase 12.7.10.20.460
3ral04ZCyclin-dependent kinase 22.7.11.220.460
4dgo0JWCasein kinase II subunit alpha2.7.11.10.460
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.459
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
4o0wADNAurora kinase A2.7.11.10.458
3s0o50ZCyclin-dependent kinase 22.7.11.220.457
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.457
4ez30S0Cyclin-dependent kinase 22.7.11.220.457
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.457
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.456
2btrU73Cyclin-dependent kinase 22.7.11.220.456
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
3qqhX0ACyclin-dependent kinase 22.7.11.220.456
4c3rACPAurora kinase A2.7.11.10.456
4fkpLS5Cyclin-dependent kinase 22.7.11.220.456
4fkv61KCyclin-dependent kinase 22.7.11.220.456
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.455
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.455
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.455
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.455
3vspEK8Peroxisome proliferator-activated receptor gamma/0.455
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.455
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.455
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.455
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3cgoJNOMitogen-activated protein kinase 102.7.11.240.454
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.454
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.454
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.454
2pvnP63Casein kinase II subunit alpha2.7.11.10.453
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
3sw418KCyclin-dependent kinase 22.7.11.220.453
4aqc88ATyrosine-protein kinase JAK2/0.453
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.453
1oirHDYCyclin-dependent kinase 22.7.11.220.452
1qp8NDP2-hydroxyacid dehydrogenase/0.452
2w06FRVCyclin-dependent kinase 22.7.11.220.452
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.452
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.452
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.452
4eomATPCyclin-dependent kinase 22.7.11.220.452
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.452
4tuvCPZCytochrome P450 1191.140.452
2xb7GUIALK tyrosine kinase receptor2.7.10.10.451
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
5j23A2RPutative 2-hydroxyacid dehydrogenase/0.451
2o12FMNChorismate synthase/0.450
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.450
3qu0X40Cyclin-dependent kinase 22.7.11.220.450
3raiX85Cyclin-dependent kinase 22.7.11.220.450
3rpv26ZCyclin-dependent kinase 22.7.11.220.450
2izsBRQCasein kinase I isoform gamma-32.7.11.10.449
3bhtMFRCyclin-dependent kinase 22.7.11.220.449
3pj8404Cyclin-dependent kinase 22.7.11.220.449
3roy22ZCyclin-dependent kinase 22.7.11.220.449
3sheI85MAP kinase-activated protein kinase 32.7.11.10.449
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.449
3w32W32Epidermal growth factor receptor2.7.10.10.449
4jr7GNPCasein kinase II subunit alpha2.7.11.10.449
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.449
1ckpPVBCyclin-dependent kinase 22.7.11.220.448
1h1r6CPCyclin-dependent kinase 22.7.11.220.448
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.448
2iw84SPCyclin-dependent kinase 22.7.11.220.448
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.448
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.448
3qtrX36Cyclin-dependent kinase 22.7.11.220.448
3w33W19Epidermal growth factor receptor2.7.10.10.448
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.448
5dr6SKEAurora kinase A2.7.11.10.448
1dm2HMDCyclin-dependent kinase 22.7.11.220.447
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.447
2r3lSCWCyclin-dependent kinase 22.7.11.220.447
2wouZZFTGF-beta receptor type-12.7.11.300.447
2wxvWXVCyclin-dependent kinase 22.7.11.220.447
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.447
3a62STURibosomal protein S6 kinase beta-12.7.11.10.447
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.447
4lb2DM5Serum albumin/0.447
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.446
2jkkBI9Focal adhesion kinase 12.7.10.20.446
3el9DR7Gag-Pol polyprotein3.4.23.160.446
3pxkPXKFocal adhesion kinase 12.7.10.20.446
3rmf20ZCyclin-dependent kinase 22.7.11.220.446
3t8oATPRhodopsin kinase/0.446
5dn3ATPAurora kinase A2.7.11.10.446
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.445
2np8CC3Aurora kinase A2.7.11.10.445
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.445
3slkNDPPolyketide synthase extender module 2/0.445
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.445
5dosATPAurora kinase A2.7.11.10.445
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.444
2rc3NADCBS domain/0.444
4f081RSTyrosine-protein kinase JAK2/0.444
4fkw62KCyclin-dependent kinase 22.7.11.220.444
5dt3ATPAurora kinase A2.7.11.10.444
1om1IQACasein kinase II subunit alpha2.7.11.10.443
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.443
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
4yswFADXanthine dehydrogenase/oxidase/0.443
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.442
1vjy460TGF-beta receptor type-12.7.11.300.442
2w17I19Cyclin-dependent kinase 22.7.11.220.442
2w1dL0DAurora kinase A2.7.11.10.442
2w6qOA5Biotin carboxylase6.3.4.140.442
3at3ATKCasein kinase II subunit alpha2.7.11.10.442
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.442
3rm719ZCyclin-dependent kinase 22.7.11.220.442
4ctaATPCinA-like protein/0.442
4ek610KCyclin-dependent kinase 22.7.11.220.442
4i22IREEpidermal growth factor receptor2.7.10.10.442
2gjnFMNNitronate monooxygenase1.13.12.160.441
2w1fL0FAurora kinase A2.7.11.10.441
2w1hL0FCyclin-dependent kinase 22.7.11.220.441
4anmWULCasein kinase II subunit alpha2.7.11.10.441
4bwxAGSPAB-dependent poly(A)-specific ribonuclease subunit pan3/0.441
5e92ANPTGF-beta receptor type-22.7.11.300.441
1gih1PUCyclin-dependent kinase 22.7.11.220.440
1oguST8Cyclin-dependent kinase 22.7.11.220.440
1xjdSTUProtein kinase C theta type2.7.11.130.440
2c6tDT5Cyclin-dependent kinase 22.7.11.220.440
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.440
2p4yC03Peroxisome proliferator-activated receptor gamma/0.440
3dogNNNCyclin-dependent kinase 22.7.11.220.440
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440
3qwjX6ACyclin-dependent kinase 22.7.11.220.440
3qzgX67Cyclin-dependent kinase 22.7.11.220.440
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.440
4bbfO19Tyrosine-protein kinase JAK2/0.440
4c62XWWTyrosine-protein kinase JAK2/0.440
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.440
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
5e8ySTUTGF-beta receptor type-22.7.11.300.440