sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 1.000 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.504 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.494 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.490 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.486 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.485 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.483 | |
| 3mje | NDP | AmphB | / | 0.480 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.479 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.477 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.475 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.474 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.474 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.473 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.473 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.473 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.473 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.472 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.472 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.472 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.471 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.471 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.470 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.468 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.467 | |
| 3u9e | COA | Lmo1369 protein | / | 0.467 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.466 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.466 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.465 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.465 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.465 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.464 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.464 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.464 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.463 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.463 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.462 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.462 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.460 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.460 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.459 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.459 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.459 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.459 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.458 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.458 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.457 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 2d2i | NAP | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.457 | |
| 2izu | P01 | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.457 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.457 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.457 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.457 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.456 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.456 | |
| 2y3r | TRK | TamL | / | 0.456 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.456 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.456 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.456 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.456 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.456 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.455 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.455 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.455 | |
| 3s8c | CDP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.455 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.455 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.455 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.454 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.454 | |
| 1dbv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.454 | |
| 2d52 | COA | 5,7-dihydroxy-2-methylchromone synthase | 2.3.1.216 | 0.454 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.454 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.454 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.454 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.453 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.453 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.453 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.453 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.453 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.453 | |
| 4cy8 | FDA | 2-hydroxybiphenyl-3-monooxygenase | / | 0.453 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.453 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.453 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.453 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.452 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 3h18 | PMS | Esterase/lipase | / | 0.452 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
| 4boy | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.452 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.452 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.452 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.452 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2y3s | TIR | TamL | / | 0.451 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.451 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.451 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.451 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.451 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.451 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.451 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.451 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.450 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3b9l | AZZ | Serum albumin | / | 0.450 | |
| 3tdl | 11D | Serum albumin | / | 0.450 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.450 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.450 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.449 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.449 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.448 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.448 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.448 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.448 | |
| 3vy2 | FMN | FMN-binding protein | / | 0.448 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.448 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.448 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.448 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.448 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 2b9f | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.447 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.447 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.447 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.447 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.447 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.447 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.447 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2bxm | IMN | Serum albumin | / | 0.446 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.446 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.446 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.446 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.446 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.446 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.446 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.446 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.445 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2wpx | ACO | Orf14 | / | 0.445 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.445 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.445 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.445 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.445 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.445 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.444 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.444 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 2oz6 | CMP | Cyclic AMP receptor-like protein | / | 0.444 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.444 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.444 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.444 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.443 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.443 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.443 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.443 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.443 | |
| 4akn | S5B | Bromodomain-containing protein 2 | / | 0.443 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.443 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.442 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 2e17 | SAH | Diphthine synthase | / | 0.442 | |
| 2itz | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.442 | |
| 3awh | FMN | FMN-binding protein | / | 0.442 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.442 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.442 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4eh6 | 0ON | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.441 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.441 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.441 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.441 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.441 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.441 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.440 | |
| 1yjq | NAP | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.440 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.440 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.440 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.440 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.440 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3w4y | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.440 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.440 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4yek | THM | Thymidine phosphorylase | / | 0.440 | |
| 5ify | UMP | Glucose-1-phosphate thymidylyltransferase | / | 0.440 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 |