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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bdcODHSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bdcODHSerine/threonine-protein kinase Chk22.7.11.11.000
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.716
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.674
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.657
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.618
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.607
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.606
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.603
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.595
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.584
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.579
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.579
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.578
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.577
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.573
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.562
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.539
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.519
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.519
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.517
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.515
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.514
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.514
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.512
2c475IDCasein kinase I isoform gamma-2/0.509
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.509
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.508
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.506
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.503
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.503
4b99R4LMitogen-activated protein kinase 72.7.11.240.502
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.502
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.501
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.499
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.499
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.499
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.498
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.498
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.497
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.496
2hog710Serine/threonine-protein kinase Chk12.7.11.10.495
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.495
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.495
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.495
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.495
3bqr4RBDeath-associated protein kinase 3/0.494
4iebANPCalmodulin-domain protein kinase 1/0.492
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.491
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.490
2j0m4STFocal adhesion kinase 12.7.10.20.489
3c4xATPRhodopsin kinase/0.489
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.489
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.489
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.488
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.488
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.485
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.485
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.484
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.484
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.484
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.483
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.483
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.482
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.481
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.481
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.480
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.480
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.479
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.479
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.478
3gubGUBDeath-associated protein kinase 12.7.11.10.478
3t8oATPRhodopsin kinase/0.478
4fyn0VETyrosine-protein kinase SYK2.7.10.20.478
5av2KMPDeath-associated protein kinase 12.7.11.10.478
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.477
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.477
4gt3ATPMitogen-activated protein kinase 12.7.11.240.477
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.475
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.475
4fv9E71Mitogen-activated protein kinase 12.7.11.240.475
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.475
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.474
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.474
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.474
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
4bdeCWSSerine/threonine-protein kinase Chk22.7.11.10.474
4gmy0X5Tyrosine-protein kinase JAK2/0.474
5auwQUEDeath-associated protein kinase 12.7.11.10.474
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.473
2yfxVGHALK tyrosine kinase receptor2.7.10.10.473
3a62STURibosomal protein S6 kinase beta-12.7.11.10.473
3bu5ATPInsulin receptor2.7.10.10.473
4riyADPEpidermal growth factor receptor2.7.10.10.473
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.472
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.472
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.472
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.471
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.471
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.471
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.470
2vrx447Aurora kinase B-A2.7.11.10.470
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.470
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.469
3zewSTUEphrin type-B receptor 42.7.10.10.468
4ansVGHALK tyrosine kinase receptor2.7.10.10.468
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.468
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.468
2ckeIQUDeath-associated protein kinase 2/0.467
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.467
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.467
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.467
4fob0USALK tyrosine kinase receptor2.7.10.10.467
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.466
2yaaATPDeath-associated protein kinase 2/0.466
3i60E86Mitogen-activated protein kinase 12.7.11.240.466
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.466
4jia1K3Tyrosine-protein kinase JAK2/0.466
4l9i8PRRhodopsin kinase/0.466
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.465
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.465
4i22IREEpidermal growth factor receptor2.7.10.10.465
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.464
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.464
1bygSTUTyrosine-protein kinase CSK/0.463
4anqVGHALK tyrosine kinase receptor2.7.10.10.463
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
1mqbANPEphrin type-A receptor 22.7.10.10.462
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.462
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.462
3il1B5DGlutamate receptor 2/0.462
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.462
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.461
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.461
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.461
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.461
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.460
1wvxBD4Death-associated protein kinase 12.7.11.10.459
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.459
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.459
4a9rRU5Serine/threonine-protein kinase Chk22.7.11.10.459
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.459
4k8aK8AFocal adhesion kinase 12.7.10.20.459
4o0uADNAurora kinase A2.7.11.10.459
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.458
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.458
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.457
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.457
2xp2VGHALK tyrosine kinase receptor2.7.10.10.457
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.457
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.457
4jq8KJ8Epidermal growth factor receptor2.7.10.10.457
5aacVGHALK tyrosine kinase receptor2.7.10.10.457
5e8wSTUTGF-beta receptor type-12.7.11.300.457
2j7t274Serine/threonine-protein kinase 102.7.11.10.456
4e4m0NHTyrosine-protein kinase JAK2/0.456
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.456
4yuqKS1Calmodulin-like domain protein kinase/0.456
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.455
4fv8E63Mitogen-activated protein kinase 12.7.11.240.455
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.455
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.454
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.454
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.454
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.454
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.454
3w2o03PEpidermal growth factor receptor2.7.10.10.454
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.454
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.454
2xvdAS6Ephrin type-B receptor 42.7.10.10.453
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.453
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.453
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.453
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.453
5auvAGIDeath-associated protein kinase 12.7.11.10.453
1zys199Serine/threonine-protein kinase Chk12.7.11.10.452
2acxANPG protein-coupled receptor kinase 62.7.11.160.452
2j0lANPFocal adhesion kinase 12.7.10.20.452
2qo9ANPEphrin type-A receptor 32.7.10.10.452
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.452
4fv6E57Mitogen-activated protein kinase 12.7.11.240.452
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.452
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.452
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.451
2ijmADPFocal adhesion kinase 12.7.10.20.451
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.451
3ztxZTXAurora kinase B-A2.7.11.10.451
4wkqIREEpidermal growth factor receptor2.7.10.10.451
5av4GENDeath-associated protein kinase 12.7.11.10.451
1jklANPDeath-associated protein kinase 12.7.11.10.450
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.450
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.450
3d7tSTUTyrosine-protein kinase CSK/0.450
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.450
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.449
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.449
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1k6vXN2Gag-Pol polyprotein3.4.23.160.448
2x9fX9FEphrin type-B receptor 42.7.10.10.448
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.448
4qo9627Serine/threonine-protein kinase 242.7.11.10.448
5kjcPFBAlcohol dehydrogenase E chain1.1.1.10.448
4a9sRU9Serine/threonine-protein kinase Chk22.7.11.10.447
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.447
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.447
4fuxE75Mitogen-activated protein kinase 12.7.11.240.447
4hgt15GCasein kinase I isoform delta2.7.11.10.447
5av3KMPDeath-associated protein kinase 12.7.11.10.447
1k6cMK1Gag-Pol polyprotein3.4.23.160.446
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.446
2c6eHPMAurora kinase A2.7.11.10.446
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.446
2znq401Peroxisome proliferator-activated receptor delta/0.446
3hx4ANPCalmodulin-domain protein kinase 1/0.446
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.446
3lltANPProtein serine/threonine kinase-1/0.446
3zh8C58Protein kinase C iota type2.7.11.130.446
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.446
4fnyI3KALK tyrosine kinase receptor2.7.10.10.446
4xlvACPInsulin receptor2.7.10.10.446
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.445
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.445
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.445
4jqeANPCasein kinase II subunit alpha2.7.11.10.445
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3begANPSRSF protein kinase 12.7.11.10.444
3lctADPALK tyrosine kinase receptor2.7.10.10.444
3op5REBSerine/threonine-protein kinase VRK12.7.11.10.444
3w2sW2REpidermal growth factor receptor2.7.10.10.444
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.444
4fod0UVALK tyrosine kinase receptor2.7.10.10.444
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.444
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
2henADPEphrin type-B receptor 22.7.10.10.443
2j0j4STFocal adhesion kinase 12.7.10.20.443
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.443
3gu6ADPDeath-associated protein kinase 12.7.11.10.443
4hgs15GCasein kinase I isoform gamma-32.7.11.10.443
1yvj4STTyrosine-protein kinase JAK32.7.10.20.442
2ijmATPFocal adhesion kinase 12.7.10.20.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.442
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.442
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.442
4aguD15Cyclin-dependent kinase-like 1/0.442
4kba1QMCasein kinase I isoform delta2.7.11.10.442
4q73FADBifunctional protein PutA/0.442
4wsqKSAAP2-associated protein kinase 12.7.11.10.442
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.441
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.441
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.441
4bdaVFBSerine/threonine-protein kinase Chk22.7.11.10.441
4jboWPHAurora kinase A2.7.11.10.441
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.441
4pd6URINucleoside permease/0.441
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.440
4grb0XGCasein kinase II subunit alpha2.7.11.10.440