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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3mvjXFEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3mvjXFEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.596
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.591
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.583
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.581
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.580
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.574
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.574
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.571
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.570
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.564
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.555
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.553
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.544
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.541
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.541
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.540
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.540
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.537
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.536
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.533
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.532
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.532
3mv5XFERAC-alpha serine/threonine-protein kinase2.7.11.10.532
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.526
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.525
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.515
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.514
3mb714ICasein kinase II subunit alpha2.7.11.10.514
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.514
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.509
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.506
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
2pvmP29Casein kinase II subunit alpha2.7.11.10.502
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
4bcmT7ZCyclin-dependent kinase 22.7.11.220.499
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
2zjwREFCasein kinase II subunit alpha2.7.11.10.498
3at4CCKCasein kinase II subunit alpha2.7.11.10.497
4jia1K3Tyrosine-protein kinase JAK2/0.496
3lltANPProtein serine/threonine kinase-1/0.494
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.494
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.492
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.492
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.491
3bqr4RBDeath-associated protein kinase 3/0.491
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.489
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
5cvfATPCasein kinase II subunit alpha2.7.11.10.485
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.484
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.482
3rak03ZCyclin-dependent kinase 22.7.11.220.481
3pe2E1BCasein kinase II subunit alpha2.7.11.10.480
4grb0XGCasein kinase II subunit alpha2.7.11.10.479
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.477
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.476
4ysjADPCalmodulin-like domain protein kinase/0.476
2etrY27Rho-associated protein kinase 12.7.11.10.475
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.475
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.475
2uzbC75Cyclin-dependent kinase 22.7.11.220.474
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.474
4hvi19STyrosine-protein kinase JAK32.7.10.20.474
5av2KMPDeath-associated protein kinase 12.7.11.10.474
5dpvSKEAurora kinase A2.7.11.10.474
4dgmAGICasein kinase II subunit alpha2.7.11.10.473
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.472
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.472
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.472
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
1yvj4STTyrosine-protein kinase JAK32.7.10.20.470
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.470
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.470
2yaaATPDeath-associated protein kinase 2/0.469
4dt9GMPAPH(2'')-Id/0.469
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4anmWULCasein kinase II subunit alpha2.7.11.10.468
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.466
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.466
3axwTIDCasein kinase II subunit alpha2.7.11.10.466
3juhANPCasein kinase II subunit alpha2.7.11.10.466
3q9xEMOCasein kinase II subunit alpha2.7.11.10.466
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.465
4e6d0NUTyrosine-protein kinase JAK2/0.465
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3be9P04Casein kinase II subunit alpha2.7.11.10.464
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2f2uM77Rho-associated protein kinase 22.7.11.10.463
3i60E86Mitogen-activated protein kinase 12.7.11.240.463
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2pmoHMDProtein kinase 7/0.461
3nux3NVCyclin-dependent kinase 62.7.11.220.461
4l9i8PRRhodopsin kinase/0.461
2pvlP55Casein kinase II subunit alpha2.7.11.10.460
4j98ACPFibroblast growth factor receptor 2/0.460
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.459
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.459
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.459
2vu3LZECyclin-dependent kinase 22.7.11.220.458
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.458
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.457
1jklANPDeath-associated protein kinase 12.7.11.10.455
3ncz3NCRho-associated protein kinase 12.7.11.10.455
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.455
2pvhP19Casein kinase II subunit alpha2.7.11.10.454
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3dneLL1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.454
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.454
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.453
1m2pHNACasein kinase II subunit alpha2.7.11.10.452
3my5RFZCyclin-dependent kinase 22.7.11.220.452
1om1IQACasein kinase II subunit alpha2.7.11.10.451
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.451
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.451
4otiMI1Serine/threonine-protein kinase N1/0.451
2ckeIQUDeath-associated protein kinase 2/0.450
3eb0DRKUncharacterized protein/0.450
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.450
4btjATPTau-tubulin kinase 12.7.11.10.450
4dgnLU2Casein kinase II subunit alpha2.7.11.10.450
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
5av3KMPDeath-associated protein kinase 12.7.11.10.450
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.449
3gu83GUDeath-associated protein kinase 12.7.11.10.449
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3u4uLNHCasein kinase II subunit alpha2.7.11.10.449
1qmzATPCyclin-dependent kinase 22.7.11.220.448
4fv6E57Mitogen-activated protein kinase 12.7.11.240.448
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.448
4ii5ADPCyclin-dependent kinase 22.7.11.220.447
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.447
5e8ySTUTGF-beta receptor type-22.7.11.300.447
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2ijmADPFocal adhesion kinase 12.7.10.20.446
4aguD15Cyclin-dependent kinase-like 1/0.446
4o0wADNAurora kinase A2.7.11.10.446
1w0xOLOCyclin-dependent kinase 22.7.11.220.445
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.445
3qxpX64Cyclin-dependent kinase 22.7.11.220.444
4crsAGSSerine/threonine-protein kinase N22.7.11.130.444
2wouZZFTGF-beta receptor type-12.7.11.300.443
3zewSTUEphrin type-B receptor 42.7.10.10.443
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4dtaADNAPH(2'')-Id/0.443
5aut2ANDeath-associated protein kinase 12.7.11.10.443
2pvjP44Casein kinase II subunit alpha2.7.11.10.442
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
3w2rW2REpidermal growth factor receptor2.7.10.10.442
3w2sW2REpidermal growth factor receptor2.7.10.10.442
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2fvdLIACyclin-dependent kinase 22.7.11.220.441
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.441
3dfcANPDeath-associated protein kinase 12.7.11.10.441
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4xw5ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
5dr9SKEAurora kinase A2.7.11.10.441
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4btmF8ETau-tubulin kinase 12.7.11.10.440
4fv9E71Mitogen-activated protein kinase 12.7.11.240.440
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440