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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pvyACPFibroblast growth factor receptor 2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pvyACPFibroblast growth factor receptor 2/1.000
5eg3ACPFibroblast growth factor receptor 2/0.541
4nka2K7Fibroblast growth factor receptor 1/0.537
4j97ACPFibroblast growth factor receptor 2/0.535
4zseANPEpidermal growth factor receptor2.7.10.10.528
2pz5ACPFibroblast growth factor receptor 2/0.527
2pwlACPFibroblast growth factor receptor 2/0.525
2itzIREEpidermal growth factor receptor2.7.10.10.520
3ac1KZITyrosine-protein kinase Lck2.7.10.20.517
2pzpACPFibroblast growth factor receptor 2/0.514
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.513
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.507
4gmy0X5Tyrosine-protein kinase JAK2/0.506
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.500
1jpaANPEphrin type-B receptor 22.7.10.10.497
2hk51BMTyrosine-protein kinase HCK2.7.10.20.497
2py3ACPFibroblast growth factor receptor 2/0.497
4k33ACPFibroblast growth factor receptor 32.7.10.10.494
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.493
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.493
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.493
2qo9ANPEphrin type-A receptor 32.7.10.10.492
2fgiPD1Fibroblast growth factor receptor 1/0.491
4e4m0NHTyrosine-protein kinase JAK2/0.491
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.490
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.490
3js2VM1Fibroblast growth factor receptor 1/0.489
4gk2L66Ephrin type-A receptor 32.7.10.10.489
1oiyN41Cyclin-dependent kinase 22.7.11.220.488
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.488
4nks2M2Fibroblast growth factor receptor 1/0.488
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.487
4jia1K3Tyrosine-protein kinase JAK2/0.487
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.486
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.485
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.485
1i44ACPInsulin receptor2.7.10.10.484
2of4979Tyrosine-protein kinase Lck2.7.10.20.484
3ttjJBIMitogen-activated protein kinase 102.7.11.240.484
4gk3L87Ephrin type-A receptor 32.7.10.10.483
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.482
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.482
3d84NDPDihydrofolate reductase1.5.1.30.479
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.479
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.478
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.476
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.476
1di8DTQCyclin-dependent kinase 22.7.11.220.474
2vx17X8Ephrin type-B receptor 42.7.10.10.474
4f640S8Fibroblast growth factor receptor 1/0.473
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.473
2cchATPCyclin-dependent kinase 22.7.11.220.472
2i0ePDSProtein kinase C beta type2.7.11.130.472
2q0bACPFibroblast growth factor receptor 2/0.472
1finATPCyclin-dependent kinase 22.7.11.220.471
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.471
2xa4AZ5Tyrosine-protein kinase JAK2/0.471
2xyuQ9GEphrin type-A receptor 42.7.10.10.471
2xp2VGHALK tyrosine kinase receptor2.7.10.10.470
1s5kCOAAminoglycoside N(6')-acetyltransferase type 1/0.469
2henADPEphrin type-B receptor 22.7.10.10.469
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.469
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.468
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.468
4gk4L90Ephrin type-A receptor 32.7.10.10.468
2x7gPVBSRSF protein kinase 22.7.11.10.467
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.467
3qw4U5POrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative/0.467
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4f630S7Fibroblast growth factor receptor 1/0.466
1bygSTUTyrosine-protein kinase CSK/0.465
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.465
3a7hATPSerine/threonine-protein kinase 242.7.11.10.465
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.464
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
2c6eHPMAurora kinase A2.7.11.10.464
3vjoANPEpidermal growth factor receptor2.7.10.10.464
2qoqANPEphrin type-A receptor 32.7.10.10.463
2vwy7X5Ephrin type-B receptor 42.7.10.10.463
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.463
3dogNNNCyclin-dependent kinase 22.7.11.220.463
4iarERM5-hydroxytryptamine receptor 1B/0.463
2of2547Tyrosine-protein kinase Lck2.7.10.20.462
3oom507Activin receptor type-12.7.11.300.462
4qmySTUSerine/threonine-protein kinase 242.7.11.10.462
5e8xSTUTGF-beta receptor type-12.7.11.300.462
1fwkADPHomoserine kinase2.7.1.390.461
3t3c017Gag-Pol polyprotein3.4.23.160.461
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.461
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.461
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.460
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.460
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.460
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.460
4iebANPCalmodulin-domain protein kinase 1/0.460
4tuvCPZCytochrome P450 1191.140.460
2eb3ANPEpidermal growth factor receptor2.7.10.10.459
3atyFMNProstaglandin F2a synthase/0.459
4jrvKJVEpidermal growth factor receptor2.7.10.10.459
1rw8580TGF-beta receptor type-12.7.11.300.458
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.458
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.458
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.458
4kxn6K62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.458
2qo7ANPEphrin type-A receptor 32.7.10.10.457
4ic7ANPMitogen-activated protein kinase 72.7.11.240.457
4nk92K5Fibroblast growth factor receptor 1/0.457
2xikJ60Serine/threonine-protein kinase 252.7.11.10.456
2y6o1N1Ephrin type-A receptor 42.7.10.10.456
1hpxKNIGag-Pol polyprotein/0.455
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
3gubGUBDeath-associated protein kinase 12.7.11.10.455
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
3s4qNK0Mitogen-activated protein kinase 14/0.455
4dpwAGSMevalonate diphosphate decarboxylase/0.455
4g2fC07Ephrin type-A receptor 32.7.10.10.455
4lopSB4Mitogen-activated protein kinase 14/0.455
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.454
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.454
2v7a627Tyrosine-protein kinase ABL12.7.10.20.454
2vttLZDCyclin-dependent kinase 22.7.11.220.454
2vwu7X1Ephrin type-B receptor 42.7.10.10.454
3c4xATPRhodopsin kinase/0.454
3l8p0CEAngiopoietin-1 receptor2.7.10.10.454
1oi9N20Cyclin-dependent kinase 22.7.11.220.453
1s60COAAminoglycoside N(6')-acetyltransferase type 1/0.453
4anqVGHALK tyrosine kinase receptor2.7.10.10.453
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4qmpDKISerine/threonine-protein kinase 242.7.11.10.453
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.453
1m17AQ4Epidermal growth factor receptor2.7.10.10.452
1pdhFASp-hydroxybenzoate hydroxylase/0.452
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2hog710Serine/threonine-protein kinase Chk12.7.11.10.452
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.452
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.452
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.452
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.452
3zewSTUEphrin type-B receptor 42.7.10.10.452
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.452
4hgs15GCasein kinase I isoform gamma-32.7.11.10.452
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.452
1e3eNAIAlcohol dehydrogenase 41.1.1.10.451
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.451
2acxANPG protein-coupled receptor kinase 62.7.11.160.451
2c6tDT5Cyclin-dependent kinase 22.7.11.220.451
2ittAEEEpidermal growth factor receptor2.7.10.10.451
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.451
2qocANPEphrin type-A receptor 32.7.10.10.451
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.451
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.451
3v3vMYUMitogen-activated protein kinase 82.7.11.240.451
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.451
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.451
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.450
1mrwK57Gag-Pol polyprotein3.4.23.160.450
2itnANPEpidermal growth factor receptor2.7.10.10.450
2pzrACPFibroblast growth factor receptor 2/0.450
2vbdV10Isopenicillin N synthase1.21.3.10.450
2vx07X7Ephrin type-B receptor 42.7.10.10.450
3ac2KSETyrosine-protein kinase Lck2.7.10.20.450
3b2tM33Fibroblast growth factor receptor 2/0.450
3lqfNADGalactitol dehydrogenase/0.450
4fob0USALK tyrosine kinase receptor2.7.10.10.450
4jr3KJREpidermal growth factor receptor2.7.10.10.450
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.449
3iaeD7KBenzaldehyde lyase/0.449
4e03ADPPlasmid partitioning protein ParF/0.449
4e2dFMNDehydrogenase/0.449
1dyjDDFDihydrofolate reductase1.5.1.30.448
2excJNKMitogen-activated protein kinase 102.7.11.240.448
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.448
2vwz7X6Ephrin type-B receptor 42.7.10.10.448
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.448
4y93746Tyrosine-protein kinase/0.448
5eccNAPDehydrofolate reductase type I/0.448
1n5dNDPCarbonyl reductase [NADPH] 1/0.447
1osvCHCBile acid receptor/0.447
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.447
2vwx7X4Ephrin type-B receptor 42.7.10.10.447
3c4wATPRhodopsin kinase/0.447
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.447
3och2MXDihydrofolate reductase1.5.1.30.447
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.447
4fkv61KCyclin-dependent kinase 22.7.11.220.447
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.447
5auzGENDeath-associated protein kinase 12.7.11.10.447
1c6yMK1Protease/0.446
1cf3FADGlucose oxidase1.1.3.40.446
1hncGDNGlutathione S-transferase Mu 22.5.1.180.446
1uyePU9Heat shock protein HSP 90-alpha/0.446
2drcMTXDihydrofolate reductase1.5.1.30.446
2po7CHDFerrochelatase, mitochondrial4.99.1.10.446
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.446
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.446
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.446
3gwfFADCyclohexanone monooxygenase/0.446
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.446
4hvh19RTyrosine-protein kinase JAK32.7.10.20.446
4lj6ACPChaperone protein ClpB/0.446
1me8RVPInosine-5'-monophosphate dehydrogenase/0.445
1npa3NHGag-Pol polyprotein3.4.23.160.445
1npwLGZGag-Pol polyprotein3.4.23.160.445
1ouy094Mitogen-activated protein kinase 14/0.445
1v0oINRCell division control protein 2 homolog2.7.11.220.445
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.445
2zdt46CMitogen-activated protein kinase 102.7.11.240.445
3gstGPRGlutathione S-transferase Mu 12.5.1.180.445
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.445
3vt5YI2Vitamin D3 receptor/0.445
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.445
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.445
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.445
1gqtACPRibokinase/0.444
1ir3ANPInsulin receptor2.7.10.10.444
2briANPUridylate kinase2.7.4.220.444
2iw84SPCyclin-dependent kinase 22.7.11.220.444
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3rmf20ZCyclin-dependent kinase 22.7.11.220.444
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.444
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
3zsh469Mitogen-activated protein kinase 14/0.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
1rb3MTXDihydrofolate reductase1.5.1.30.443
1s3zCOAAminoglycoside N(6')-acetyltransferase type 1/0.443
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.443
3flsFLSMitogen-activated protein kinase 14/0.443
3nglNAPBifunctional protein FolD/0.443
3nj0PYVAbscisic acid receptor PYL2/0.443
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.443
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.443
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.443
4i231C9Epidermal growth factor receptor2.7.10.10.443
4oaeCLMUncharacterized protein/0.443
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.443
5a3bAPRSIR2 family protein/0.443
5aaaVGHALK tyrosine kinase receptor2.7.10.10.443
1h1r6CPCyclin-dependent kinase 22.7.11.220.442
1likADNAdenosine kinase2.7.1.200.442
2px2SAHGenome polyprotein2.7.7.480.442
3nr4PYVAbscisic acid receptor PYL2/0.442
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.442
4a99FADTetX family tetracycline inactivation enzyme/0.442
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.442
4dfrMTXDihydrofolate reductase1.5.1.30.442
4dieC5PCytidylate kinase/0.442
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.442
1bv9XV6Gag-Pol polyprotein3.4.23.160.441
1kzkJE2Gag-Pol polyprotein3.4.23.160.441
1pmn984Mitogen-activated protein kinase 102.7.11.240.441
1xe55FEPlasmepsin-23.4.23.390.441
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.441
2wihP48Cyclin-dependent kinase 22.7.11.220.441
2z97CAMCamphor 5-monooxygenase1.14.15.10.441
3bi6396Wee1-like protein kinase2.7.10.20.441
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.441
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4f9fGDPPutative glycosyltransferase/0.441
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.441
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.441
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.441
4wkqIREEpidermal growth factor receptor2.7.10.10.441
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.441
5cu6ATPCasein kinase II subunit alpha2.7.11.10.441
5e8wSTUTGF-beta receptor type-12.7.11.300.441
1phhFADp-hydroxybenzoate hydroxylase/0.440
2tpsTPSThiamine-phosphate synthase/0.440
3nbvANPKetohexokinase/0.440
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
3ttiKBIMitogen-activated protein kinase 102.7.11.240.440
4btkDTQTau-tubulin kinase 12.7.11.10.440
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.440
4qmlANPSerine/threonine-protein kinase 242.7.11.10.440
4ruoBIVVitamin D3 receptor A/0.440
4xxvNAD3-isopropylmalate dehydrogenase/0.440