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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z8962PAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1z8962PAldose reductase1.1.1.211.000
2iki388Aldose reductase1.1.1.210.788
2ikj393Aldose reductase1.1.1.210.749
1t40ID5Aldose reductase1.1.1.210.741
2fz9ZSTAldose reductase1.1.1.210.715
2dv0ZSTAldose reductase1.1.1.210.705
2fz8ZSTAldose reductase1.1.1.210.701
3lboLDTAldose reductase1.1.1.210.672
2qxwLDTAldose reductase1.1.1.210.664
2hv5ZSTAldose reductase1.1.1.210.661
1t41ID5Aldose reductase1.1.1.210.658
3lqlLDTAldose reductase1.1.1.210.658
4gca2X9Aldose reductase1.1.1.210.658
3m4h388Aldose reductase1.1.1.210.656
2pdxZSTAldose reductase1.1.1.210.653
2ikhLITAldose reductase1.1.1.210.652
1z3n3NAAldose reductase1.1.1.210.645
3m64393Aldose reductase1.1.1.210.634
2i16LDTAldose reductase1.1.1.210.628
3ghrLDTAldose reductase1.1.1.210.627
2pdg47DAldose reductase1.1.1.210.617
3mb9ZSTAldose reductase1.1.1.210.612
2pdp393Aldose reductase1.1.1.210.609
4yu153NAldose reductase1.1.1.210.609
1pwlBFIAldose reductase1.1.1.210.605
2pd5ZSTAldose reductase1.1.1.210.602
3lz5LDTAldose reductase1.1.1.210.599
3ld5LDTAldose reductase1.1.1.210.598
2duzZSTAldose reductase1.1.1.210.596
2pdh47DAldose reductase1.1.1.210.590
3lenZSTAldose reductase1.1.1.210.589
3t423T4Aldose reductase1.1.1.210.589
2pdbZSTAldose reductase1.1.1.210.584
2pdu393Aldose reductase1.1.1.210.582
2i17LDTAldose reductase1.1.1.210.579
3ghsLDTAldose reductase1.1.1.210.579
2pdfZSTAldose reductase1.1.1.210.577
2pdn47DAldose reductase1.1.1.210.577
2pdc393Aldose reductase1.1.1.210.576
2duxZSTAldose reductase1.1.1.210.571
2pdlTOLAldose reductase1.1.1.210.571
3g5eQ74Aldose reductase1.1.1.210.571
2pzn393Aldose reductase1.1.1.210.569
3ghtLDTAldose reductase1.1.1.210.568
1ieiZESAldose reductase1.1.1.210.567
2agtFIDAldose reductase1.1.1.210.564
3mc5393Aldose reductase1.1.1.210.564
3m0iZSTAldose reductase1.1.1.210.561
2fzdTOLAldose reductase1.1.1.210.553
3ghuLDTAldose reductase1.1.1.210.552
1frbZSTAldose reductase-related protein 2/0.546
2pdj393Aldose reductase1.1.1.210.541
1us0LDTAldose reductase1.1.1.210.536
1ah3TOLAldose reductase1.1.1.210.516
2pdwFIDAldose reductase1.1.1.210.516
2hvoZSTAldose reductase1.1.1.210.515
2pdq47DAldose reductase1.1.1.210.506
2bfmTOPPteridine reductase 11.5.1.330.497
4pnmNU1Tankyrase-22.4.2.300.494
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.485
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.482
3mjrAC2Deoxycytidine kinase2.7.1.740.481
3f3y4OABile salt sulfotransferase2.8.2.140.479
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.474
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.472
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.472
2f2kTGGAldose reductase1.1.1.210.471
2oazI96Methionine aminopeptidase 2/0.469
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
2f3815MAldo-keto reductase family 1 member C3/0.468
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
1xf0ASDAldo-keto reductase family 1 member C3/0.467
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.467
4phlPILPhosphodiesterase/0.467
4u163C0Muscarinic acetylcholine receptor M3/0.466
4dbuBT9Aldo-keto reductase family 1 member C3/0.465
2iqdLPAAldose reductase1.1.1.210.464
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.462
2xuhTZ4Acetylcholinesterase3.1.1.70.462
3af1GDPPantothenate kinase2.7.1.330.462
5liu388Aldo-keto reductase family 1 member B101.1.10.462
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.461
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.460
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2cbqTH2Neocarzinostatin/0.459
2zsbADPPantothenate kinase2.7.1.330.459
4dbs0HVAldo-keto reductase family 1 member C3/0.459
1lnmDTXBilin-binding protein/0.458
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.458
1yw7A41Methionine aminopeptidase 2/0.458
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.458
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.457
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.457
2c6c24IGlutamate carboxypeptidase 23.4.17.210.456
4d2dALA_ALA_ALADi-or tripeptide:H+ symporter/0.456
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
1ry0PG2Aldo-keto reductase family 1 member C3/0.455
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.455
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.455
1x8lOXRRetinol dehydratase/0.455
2vrjNCWBeta-glucosidase A3.2.1.210.455
2pdyFIDAldose reductase1.1.1.210.454
2qimZEAClass 10 plant pathogenesis-related protein/0.454
3af0GDPPantothenate kinase2.7.1.330.454
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3af4GCPPantothenate kinase2.7.1.330.453
1rxjBNIStreptavidin/0.452
3aezGDPPantothenate kinase2.7.1.330.452
4ey7E20Acetylcholinesterase3.1.1.70.452
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.452
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.451
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
3q9bB3NAcetylpolyamine amidohydrolase/0.451
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.451
2vq7FADPutative flavin-containing monooxygenase/0.450
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.450
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.449
1p8dCO1Oxysterols receptor LXR-beta/0.449
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.449
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.449
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.449
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.449
2ea4F79Methionine aminopeptidase 2/0.448
2fzbTOLAldose reductase1.1.1.210.448
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.448
1dx6GNTAcetylcholinesterase3.1.1.70.447
4fam0SZAldo-keto reductase family 1 member C3/0.447
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.446
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2gbyBRNHTH-type transcriptional regulator QacR/0.446
3vf60H6Glucokinase2.7.1.20.446
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.446
4b7zQ4QAcetylcholinesterase3.1.1.70.446
4dvi2IWTankyrase-12.4.2.300.446
1fmlRTLRetinol dehydratase/0.445
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.445
2w6cBM4Acetylcholinesterase3.1.1.70.445
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.445
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4k4eK4ETankyrase-12.4.2.300.445
4li61XOTankyrase-12.4.2.300.445
5fd8A5APutative carboxypeptidase yocD/0.445
1ihiIU5Aldo-keto reductase family 1 member C2/0.444
1u08PLPMethionine aminotransferase/0.444
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2ga2A19Methionine aminopeptidase 2/0.444
2zs9ADPPantothenate kinase2.7.1.330.444
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
3v35NTIAldose reductase1.1.1.210.444
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4araC56Acetylcholinesterase3.1.1.70.444
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.444
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.444
1odnAPVIsopenicillin N synthase1.21.3.10.443
1ut6A8NAcetylcholinesterase3.1.1.70.443
2d06ESTSulfotransferase 1A12.8.2.10.443
2xupTZ5Acetylcholinesterase3.1.1.70.443
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
3r8hZOMAldo-keto reductase family 1 member C3/0.443
3zkuHCVIsopenicillin N synthase1.21.3.10.443
4psbGA3Cytokinin-specific binding protein/0.443
1h22E10Acetylcholinesterase3.1.1.70.442
1s07PLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.442
1zuaTOLAldo-keto reductase family 1 member B101.1.10.442
2xi4AFTAcetylcholinesterase3.1.1.70.442
2xujTZ5Acetylcholinesterase3.1.1.70.442
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.442
4dbw511Aldo-keto reductase family 1 member C3/0.442
4e0u0MVCyclic dipeptide N-prenyltransferase/0.442
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.441
1votHUPAcetylcholinesterase3.1.1.70.441
2xuqTZ4Acetylcholinesterase3.1.1.70.441
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.441
4ey6GNTAcetylcholinesterase3.1.1.70.441
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4jq3ZOMAldo-keto reductase family 1 member C2/0.441
1e2lTMCThymidine kinase/0.440
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2aotSAHHistamine N-methyltransferase2.1.1.80.440
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.440
2tplHPPTyrosine phenol-lyase4.1.99.20.440
2zsaADPPantothenate kinase2.7.1.330.440
3x025GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.440
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.440
4bftZVTPantothenate kinase2.7.1.330.440