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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ogjFADFerredoxin--NADP reductase1.18.1.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ogjFADFerredoxin--NADP reductase1.18.1.21.000
1ogiFADFerredoxin--NADP reductase1.18.1.20.885
1h42FADFerredoxin--NADP reductase1.18.1.20.803
1e62FADFerredoxin--NADP reductase1.18.1.20.704
1queFADFerredoxin--NADP reductase1.18.1.20.681
4c43FADFerredoxin--NADP reductase1.18.1.20.655
1gr1FADFerredoxin--NADP reductase1.18.1.20.643
1e63FADFerredoxin--NADP reductase1.18.1.20.639
1gawFADFerredoxin/0.635
1e64FADFerredoxin--NADP reductase1.18.1.20.631
1go2FADFerredoxin--NADP reductase1.18.1.20.628
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.625
1bjkFADFerredoxin--NADP reductase1.18.1.20.623
1qgzFADFerredoxin--NADP reductase1.18.1.20.621
1gjrFADFerredoxin--NADP reductase1.18.1.20.620
1qgyFADFerredoxin--NADP reductase1.18.1.20.615
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.613
3zbtFADFerredoxin--NADP reductase1.18.1.20.613
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.611
3zc3FADFerredoxin--NADP reductase1.18.1.20.610
3vo2FADFerredoxin--NADP reductase/0.605
1h85FADFerredoxin--NADP reductase1.18.1.20.604
1qh0FADFerredoxin--NADP reductase1.18.1.20.603
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.602
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.600
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.593
3w5uFADFerredoxin/0.590
1gaqFADFerredoxin/0.580
2b5oFADFerredoxin--NADP reductase1.18.1.20.576
4bprFADFerredoxin--NADP reductase1.18.1.20.575
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.571
1ewyFADFerredoxin--NADP reductase1.18.1.20.564
2rc6FADFerredoxin--NADP reductase/0.564
1sm4FADFerredoxin--NADP reductase/0.563
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.555
3jqrFADFerredoxin--NADP reductase, apicoplast/0.536
1w35FADFerredoxin--NADP reductase1.18.1.20.531
1b2rFADFerredoxin--NADP reductase1.18.1.20.526
3fpkFADFerredoxin-NADP reductase/0.523
1w87FADFerredoxin--NADP reductase1.18.1.20.520
4yaoFADNADPH--cytochrome P450 reductase/0.513
2ok8FADFerredoxin--NADP reductase, apicoplast/0.511
1j9zFADNADPH--cytochrome P450 reductase/0.505
1amoFADNADPH--cytochrome P450 reductase/0.504
3qfsFADNADPH--cytochrome P450 reductase/0.497
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.495
2rc5FADFerredoxin--NADP reductase/0.492
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.485
3ojxFADNADPH--cytochrome P450 reductase/0.485
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.484
5ah5LSSLeucine--tRNA ligase/0.483
3qftFADNADPH--cytochrome P450 reductase/0.481
4y9uFADNADPH--cytochrome P450 reductase/0.479
1gky5GPGuanylate kinase2.7.4.80.478
3i0pNADMalate dehydrogenase, putative/0.477
2hk9NAPShikimate dehydrogenase (NADP(+))/0.476
1ex75GPGuanylate kinase2.7.4.80.475
4b68FADL-ornithine N(5)-monooxygenase/0.475
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.472
4i101BSBeta-secretase 13.4.23.460.472
4wx2F6FTryptophan synthase alpha chain/0.470
4wx2F6FTryptophan synthase beta chain4.2.1.200.470
3fr5I4AFatty acid-binding protein, adipocyte/0.468
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.467
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.467
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.466
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.466
4bfuZVUPantothenate kinase2.7.1.330.465
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.464
4jxxATPGlutamine--tRNA ligase6.1.1.180.464
5a4vQUEGlutathione S-transferase F22.5.1.180.464
3zoiM2WIsopenicillin N synthase1.21.3.10.463
1hb1OCVIsopenicillin N synthase1.21.3.10.462
3vf60H6Glucokinase2.7.1.20.462
4bb3KKAIsopenicillin N synthase1.21.3.10.462
1ja1FADNADPH--cytochrome P450 reductase/0.461
1tllFADNitric oxide synthase, brain1.14.13.390.461
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.461
2jb4A14Isopenicillin N synthase1.21.3.10.461
1qjfACSIsopenicillin N synthase1.21.3.10.460
2gjnFMNNitronate monooxygenase1.13.12.160.460
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.459
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
4b4vL34Bifunctional protein FolD/0.456
4nbh9CATerminal oxygenase component of carbazole/0.456
1qoqIGPTryptophan synthase alpha chain/0.455
1ndzFR5Adenosine deaminase3.5.4.40.454
2iviACWIsopenicillin N synthase1.21.3.10.454
2zevIPEGeranylgeranyl pyrophosphate synthase/0.454
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.454
3sn6P0GBeta-2 adrenergic receptor/0.454
3k8q22APurine nucleoside phosphorylase2.4.2.10.453
3s41S41Glucokinase2.7.1.20.453
3p0gP0GBeta-2 adrenergic receptor/0.453
1a8pFADFerredoxin--NADP reductase/0.452
2rd2QSIGlutamine--tRNA ligase6.1.1.180.452
3hl0NADMaleylacetate reductase/0.452
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
3qfcFADNADPH--cytochrome P450 reductase/0.452
3vkjFNRIsopentenyl-diphosphate delta-isomerase/0.452
5c8a5ADProbable transcriptional regulator/0.452
2bpoFADNADPH--cytochrome P450 reductase/0.451
2wzySQXSoluble acetylcholine receptor/0.451
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.451
3zkyWT4Isopenicillin N synthase1.21.3.10.451
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.451
1x1bSAHC-20 methyltransferase/0.450
1ejeFMNProtein MTH_152/0.449
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.449
3ntrNADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.449
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
3p2oNADBifunctional protein FolD/0.448
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.448
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.447
1ut6A8NAcetylcholinesterase3.1.1.70.447
1xs7MMIBeta-secretase 13.4.23.460.447
2hxzH7JCathepsin S3.4.22.270.447
2re8GSUGlutamine--tRNA ligase6.1.1.180.447
2vnjFADNADPH:ferredoxin reductase/0.447
3bw4FMNPutative 2-nitropropane dioxygenase/0.447
3p0fBAUUridine phosphorylase 22.4.2.30.447
4b4w9L9Bifunctional protein FolD/0.447
4b7754MBeta-secretase 13.4.23.460.447
4k2xFADPolyketide oxygenase/hydroxylase/0.447
1akaPLPAspartate aminotransferase, mitochondrial2.6.1.10.446
1fdrFADFerredoxin--NADP reductase1.18.1.20.446
1swtBTNStreptavidin/0.446
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.446
2wo7ASVIsopenicillin N synthase1.21.3.10.446
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.446
4dz7D02Carbonic anhydrase 24.2.1.10.446
4to2DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.446
4zj8SUVOrexin receptor type 1/0.446
1qrsATPGlutamine--tRNA ligase6.1.1.180.445
1vceSAHDiphthine synthase/0.445
2vr1ATFBiotin carboxylase6.3.4.140.445
3q7fED2Uncharacterized protein/0.445
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.444
2zrvFNRIsopentenyl-diphosphate delta-isomerase/0.444
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.444
3rtnRTNBeta-secretase 13.4.23.460.444
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.444
1hb3SCVIsopenicillin N synthase1.21.3.10.443
1qtqQSIGlutamine--tRNA ligase6.1.1.180.443
2e94364Geranylgeranyl pyrophosphate synthase/0.443
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.443
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3pftFMNFlavin reductase/0.443
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.443
4bfxZVXPantothenate kinase2.7.1.330.443
4n4wSNTSmoothened homolog/0.443
1h60STRPentaerythritol tetranitrate reductase/0.442
2ea2F77Methionine aminopeptidase 2/0.442
2p6dSAHDiphthine synthase/0.442
2zryFNRIsopentenyl-diphosphate delta-isomerase/0.442
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.442
1kceCB3Thymidylate synthase/0.441
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.441
2owfSAHDiphthine synthase/0.441
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.441
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.441
4b2gV1NUncharacterized protein/0.441
2ejkSAHDiphthine synthase/0.440
2vd0D27Hematopoietic prostaglandin D synthase/0.440
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.440
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.440
3h2sNDPPutative NADH-flavin reductase/0.440
3h3r14HCollagen type IV alpha-3-binding protein/0.440
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.440
4j7hTRHPCZA361.3/0.440
4q7f3D1Uncharacterized protein/0.440