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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5la6GTPTubulin alpha-1B chain

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5la6GTPTubulin alpha-1B chain/1.000
4wbnGTPTubulin alpha-1B chain/0.792
4tuyGTPTubulin alpha-1B chain/0.783
4tv9GTPTubulin alpha-1B chain/0.782
4ihjGTPTubulin alpha-1B chain/0.772
4o4iGTPTubulin alpha-1B chain/0.733
4zolGTPTubulin alpha-1B chain/0.654
3ryhGTPTubulin alpha chain/0.630
4ffbGTPTubulin alpha-1 chain/0.613
5jqgGTPTubulin alpha-1B chain/0.594
4iijGTPTubulin alpha-1B chain/0.571
4o4lGTPTubulin alpha-1B chain/0.563
2z4sADPChromosomal replication initiator protein DnaA/0.498
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.496
3u9eCOALmo1369 protein/0.490
5la6GDPTubulin beta-2B chain/0.488
1i59ANPChemotaxis protein CheA2.7.13.30.486
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.479
4yj2GTPTubulin alpha-1B chain/0.479
3zidGDPTubulin-like protein CetZ/0.478
4u3jGTPTubulin beta chain/0.475
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.473
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.471
2o12FMNChorismate synthase/0.468
1xdpATPPolyphosphate kinase/0.467
1xddAAYIntegrin alpha-L/0.466
2fxfACODiamine acetyltransferase 1/0.466
3giyFMN(S)-mandelate dehydrogenase1.1.99.310.465
5itzGTPTubulin alpha-1B chain/0.464
1yb5NAPQuinone oxidoreductase1.6.5.50.463
3lqfNADGalactitol dehydrogenase/0.462
1in5ADPHolliday junction ATP-dependent DNA helicase RuvB/0.461
1vrqFMNSubunit alpha of sarocosine oxidase/0.461
1vrqFMNSubunit beta of sarcosine oxidase/0.461
2gesCOKPantothenate kinase2.7.1.330.461
2qenADPWalker-Type ATPase/0.461
2r8pT6FTransketolase 1/0.461
4ambDUDPutative glycosyl transferase/0.461
4dptAGSMevalonate diphosphate decarboxylase/0.460
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.460
1i5bANPChemotaxis protein CheA2.7.13.30.459
2rlcCHDCholoylglycine hydrolase3.5.1.240.459
3c35KAIGlutamate receptor ionotropic, kainate 1/0.459
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.459
1bpjUMPThymidylate synthase/0.458
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.458
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.457
1njfADPDNA polymerase III subunit tau2.7.7.70.456
2a94AP0L-lactate dehydrogenase1.1.1.270.456
3c36KAIGlutamate receptor ionotropic, kainate 1/0.456
1b8uNADMalate dehydrogenase/0.455
1hb3SCVIsopenicillin N synthase1.21.3.10.455
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.455
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.455
3a0tADPSensor histidine kinase/0.453
1ypeUIPProthrombin3.4.21.50.452
2r0cFADPutative FAD-monooxygenase/0.452
3af4GCPPantothenate kinase2.7.1.330.452
4f6rGDPTubulin beta chain/0.452
1x2hLPALipoate-protein ligase A6.3.1.200.451
2v5aLZLBiotin carboxylase6.3.4.140.451
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.451
4k6fNAPPutative Acetoacetyl-CoA reductase/0.451
2b9yFADPutative aminooxidase/0.450
2d3aADPGlutamine synthetase root isozyme 36.3.1.20.450
2dvoITTdITP/XTP pyrophosphatase3.6.1.190.450
4dpy2P0Mevalonate diphosphate decarboxylase/0.450
4du82P0Mevalonate diphosphate decarboxylase/0.450
4kgkGTPUncharacterized protein/0.450
5c1mCLRMu-type opioid receptor/0.450
1qrpHH0Pepsin A-43.4.23.10.449
4k9oTPPBenzoylformate decarboxylase4.1.1.70.449
1obnASVIsopenicillin N synthase1.21.3.10.448
2bf4FMNNADPH--cytochrome P450 reductase/0.448
2vkeTACTetracycline repressor protein class D/0.448
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.448
3mjeNDPAmphB/0.448
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.447
2a4xBLMMitomycin-binding protein/0.447
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.447
4yaw2AMNADPH--cytochrome P450 reductase/0.447
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.447
2ex1C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.446
2fxuBIDActin, alpha skeletal muscle/0.446
2vwqNAPGlucose 1-dehydrogenase/0.446
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.446
3hyoADPPyridoxal kinase/0.446
3tr05GPGuanylate kinase/0.446
4dldTZGGlutamate receptor ionotropic, kainate 1/0.446
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.446
4p9dTMPDeoxycytidylate deaminase/0.446
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2yj5ATPCopper-transporting ATPase/0.445
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.445
1thyUMPThymidylate synthase/0.444
2a87FADThioredoxin reductase1.8.1.90.444
3f63GTXGlutathione transferase GST1-4/0.444
3wqmB29Diterpene synthase3.1.7.80.444
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.444
4qmySTUSerine/threonine-protein kinase 242.7.11.10.444
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.443
1t2cNAIL-lactate dehydrogenase1.1.1.270.443
2anb5GPGuanylate kinase2.7.4.80.443
2bi4NADLactaldehyde reductase1.1.1.770.443
2hckQUETyrosine-protein kinase HCK2.7.10.20.443
2ydbNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
2ylrNAPPhenylacetone monooxygenase1.14.13.920.443
3tjzGNPADP-ribosylation factor 1/0.443
3tlc7MDMicrocin C7 self-immunity protein MccF/0.443
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.443
1wuaAP8Actin, alpha skeletal muscle/0.442
2zsdCOAPantothenate kinase2.7.1.330.442
4hxyNDPPlm1/0.442
4q72FADBifunctional protein PutA/0.442
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.441
1qx4FADNADH-cytochrome b5 reductase 31.6.2.20.441
1w5sADPORC1-type DNA replication protein 2/0.441
1zdwFLVPrenyltransferase/0.441
2jb4A14Isopenicillin N synthase1.21.3.10.441
3qlrNDPDihydrofolate reductase1.5.1.30.441
4bftZVTPantothenate kinase2.7.1.330.441
4j16NADNAD/NADP transhydrogenase alpha subunit 1/0.441
1ae1NAPTropinone reductase 1/0.440
1bcpATPPertussis toxin subunit 4/0.440
1bcpATPPertussis toxin subunit 5/0.440
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1l8qADPChromosomal replication initiator protein DnaA/0.440
1qm5PLPMaltodextrin phosphorylase2.4.1.10.440
2getCOKPantothenate kinase2.7.1.330.440
2i7pACOPantothenate kinase 32.7.1.330.440
2iyfERYOleandomycin glycosyltransferase2.4.10.440
3af3GCPPantothenate kinase2.7.1.330.440
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.440
4fryNADPutative signal-transduction protein with CBS domains/0.440