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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.153

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1531.000
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.645
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.631
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.611
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.609
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.606
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.600
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.596
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.592
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.588
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.587
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.586
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.585
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.581
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.581
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.578
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.572
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.571
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.567
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.564
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.564
3pre3REPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.557
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.555
4j6i1JVPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.554
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.552
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.550
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.549
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.543
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.539
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.538
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.538
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.535
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.530
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.524
3ibeL64Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.523
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.523
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.520
4fa60TAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.518
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.517
3qarQARPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.515
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.514
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.511
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.508
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.507
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.505
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.498
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.488
4bcmT7ZCyclin-dependent kinase 22.7.11.220.479
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.476
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.473
4c35NU3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.470
2pvnP63Casein kinase II subunit alpha2.7.11.10.467
2xikJ60Serine/threonine-protein kinase 252.7.11.10.466
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.465
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.464
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.464
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.463
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.462
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.461
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.461
5av2KMPDeath-associated protein kinase 12.7.11.10.461
3oroAGSSerine/threonine protein kinase/0.460
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.459
4eol1ROCyclin-dependent kinase 22.7.11.220.459
3qu0X40Cyclin-dependent kinase 22.7.11.220.458
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.458
4dgnLU2Casein kinase II subunit alpha2.7.11.10.458
4eoi1ROCyclin-dependent kinase 22.7.11.220.457
2izrBRKCasein kinase I isoform gamma-32.7.11.10.456
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.456
4iarERM5-hydroxytryptamine receptor 1B/0.456
4l2yXXKPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.456
1e9hINRCyclin-dependent kinase 22.7.11.220.455
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.455
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.455
4nc3ERM5-hydroxytryptamine receptor 2B/0.455
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.454
5auuLU2Death-associated protein kinase 12.7.11.10.454
1jklANPDeath-associated protein kinase 12.7.11.10.453
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.453
2ckeIQUDeath-associated protein kinase 2/0.453
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.453
2zdt46CMitogen-activated protein kinase 102.7.11.240.453
3bqr4RBDeath-associated protein kinase 3/0.453
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
3my5RFZCyclin-dependent kinase 22.7.11.220.452
3zh8C58Protein kinase C iota type2.7.11.130.452
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.451
2i0ePDSProtein kinase C beta type2.7.11.130.451
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.451
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.451
4nk92K5Fibroblast growth factor receptor 1/0.451
5e8xSTUTGF-beta receptor type-12.7.11.300.451
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.450
2pywADPMethylthioribose kinase2.7.1.1000.450
3zewSTUEphrin type-B receptor 42.7.10.10.450
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.450
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.450
5cvhADPCasein kinase II subunit alpha2.7.11.10.450
4bfsZVSPantothenate kinase2.7.1.330.449
4dgo0JWCasein kinase II subunit alpha2.7.11.10.449
4ix6ADPUncharacterized protein/0.449
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.448
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.448
3at3ATKCasein kinase II subunit alpha2.7.11.10.448
4iaq2GM5-hydroxytryptamine receptor 1B/0.448
5auwQUEDeath-associated protein kinase 12.7.11.10.448
1oi9N20Cyclin-dependent kinase 22.7.11.220.447
2vn0TDZCytochrome P450 2C8/0.447
2w05FRTCyclin-dependent kinase 22.7.11.220.447
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.447
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.447
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2bfyH1NAurora kinase B-A2.7.11.10.446
2yn8STUEphrin type-B receptor 42.7.10.10.446
3at4CCKCasein kinase II subunit alpha2.7.11.10.446
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.446
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
2hog710Serine/threonine-protein kinase Chk12.7.11.10.445
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.445
3inxJZCHeat shock protein HSP 90-alpha/0.445
4qmpDKISerine/threonine-protein kinase 242.7.11.10.445
1urwI1PCyclin-dependent kinase 22.7.11.220.444
2itnANPEpidermal growth factor receptor2.7.10.10.444
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
3ormAGSSerine/threonine protein kinase/0.444
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1h1r6CPCyclin-dependent kinase 22.7.11.220.443
2iw84SPCyclin-dependent kinase 22.7.11.220.443
2v7a627Tyrosine-protein kinase ABL12.7.10.20.443
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.443
3l8p0CEAngiopoietin-1 receptor2.7.10.10.443
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.443
3u8hBHPPhospholipase A2, membrane associated/0.443
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.443
4hgt15GCasein kinase I isoform delta2.7.11.10.443
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.443
1v7aFRCAdenosine deaminase3.5.4.40.442
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.442
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.442
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.442
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.442
4e4m0NHTyrosine-protein kinase JAK2/0.442
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.442
4yuqKS1Calmodulin-like domain protein kinase/0.442
5cu6ATPCasein kinase II subunit alpha2.7.11.10.442
1gheACOAcetyltransferase2.3.10.441
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.441
4bcpT3CCyclin-dependent kinase 22.7.11.220.441
4g160VMCasein kinase I isoform gamma-32.7.11.10.441
4kb81QNCasein kinase I isoform delta2.7.11.10.441
4nka2K7Fibroblast growth factor receptor 1/0.441
4oavACP2-5A-dependent ribonuclease3.1.260.441
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1xjdSTUProtein kinase C theta type2.7.11.130.440
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.440
2h96893Mitogen-activated protein kinase 82.7.11.240.440
3oqkS52Renin3.4.23.150.440
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.440
4gk4L90Ephrin type-A receptor 32.7.10.10.440
4j97ACPFibroblast growth factor receptor 2/0.440
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4qmzB49Serine/threonine-protein kinase 242.7.11.10.440