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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dit0KDGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dit0KDGlycogen synthase kinase-3 beta2.7.11.261.000
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.586
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.572
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.553
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.544
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.540
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.539
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.526
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.524
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.523
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.519
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.516
3eb0DRKUncharacterized protein/0.510
4aguD15Cyclin-dependent kinase-like 1/0.507
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.506
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.506
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.504
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.502
4j95ACPFibroblast growth factor receptor 2/0.500
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.499
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.498
3i60E86Mitogen-activated protein kinase 12.7.11.240.496
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.495
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.490
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.489
4fv6E57Mitogen-activated protein kinase 12.7.11.240.486
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.483
2vu3LZECyclin-dependent kinase 22.7.11.220.482
3zh8C58Protein kinase C iota type2.7.11.130.482
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.481
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.479
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.478
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.478
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.478
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.476
3du8553Glycogen synthase kinase-3 beta2.7.11.260.476
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.476
5e8ySTUTGF-beta receptor type-22.7.11.300.476
4qnyANPMitogen activated protein kinase, putative/0.475
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
4hvi19STyrosine-protein kinase JAK32.7.10.20.474
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.474
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.473
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.473
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.473
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.473
4jia1K3Tyrosine-protein kinase JAK2/0.473
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.472
3be9P04Casein kinase II subunit alpha2.7.11.10.472
4wsqKSAAP2-associated protein kinase 12.7.11.10.472
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.471
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.471
2hog710Serine/threonine-protein kinase Chk12.7.11.10.470
4fv9E71Mitogen-activated protein kinase 12.7.11.240.470
3rak03ZCyclin-dependent kinase 22.7.11.220.469
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.469
2pvnP63Casein kinase II subunit alpha2.7.11.10.468
2w05FRTCyclin-dependent kinase 22.7.11.220.467
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
4j99ACPFibroblast growth factor receptor 2/0.466
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.464
2h96893Mitogen-activated protein kinase 82.7.11.240.464
4btjATPTau-tubulin kinase 12.7.11.10.464
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.464
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.463
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.462
2fvdLIACyclin-dependent kinase 22.7.11.220.461
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.461
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.460
1wvxBD4Death-associated protein kinase 12.7.11.10.460
2pvhP19Casein kinase II subunit alpha2.7.11.10.460
3bqr4RBDeath-associated protein kinase 3/0.460
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.460
4o0wADNAurora kinase A2.7.11.10.460
5dr9SKEAurora kinase A2.7.11.10.460
1jklANPDeath-associated protein kinase 12.7.11.10.459
4ez50RSCyclin-dependent kinase 62.7.11.220.459
4hge15VTyrosine-protein kinase JAK2/0.459
5cvfATPCasein kinase II subunit alpha2.7.11.10.459
5dnrATPAurora kinase A2.7.11.10.459
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.458
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
2vv9IM9Cyclin-dependent kinase 22.7.11.220.458
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.458
4deeADPAurora kinase A2.7.11.10.458
4gmy0X5Tyrosine-protein kinase JAK2/0.458
2ckeIQUDeath-associated protein kinase 2/0.457
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.457
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.457
2pvmP29Casein kinase II subunit alpha2.7.11.10.457
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
4bcmT7ZCyclin-dependent kinase 22.7.11.220.457
2xngA0HAurora kinase A2.7.11.10.456
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.456
4ix6ADPUncharacterized protein/0.456
5dosATPAurora kinase A2.7.11.10.456
3q9xEMOCasein kinase II subunit alpha2.7.11.10.455
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.455
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.455
1fvv107Cyclin-dependent kinase 22.7.11.220.454
2x6dX6DAurora kinase A2.7.11.10.454
3sheI85MAP kinase-activated protein kinase 32.7.11.10.454
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.454
2uzbC75Cyclin-dependent kinase 22.7.11.220.453
3a62STURibosomal protein S6 kinase beta-12.7.11.10.453
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3nux3NVCyclin-dependent kinase 62.7.11.220.453
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.453
4jbpYPHAurora kinase A2.7.11.10.453
1m2pHNACasein kinase II subunit alpha2.7.11.10.452
1w8cN69Cyclin-dependent kinase 22.7.11.220.452
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
2j0m4STFocal adhesion kinase 12.7.10.20.451
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.451
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3gubGUBDeath-associated protein kinase 12.7.11.10.451
4ic7ANPMitogen-activated protein kinase 72.7.11.240.451
1h1r6CPCyclin-dependent kinase 22.7.11.220.450
4anmWULCasein kinase II subunit alpha2.7.11.10.450
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4k33ACPFibroblast growth factor receptor 32.7.10.10.450
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3at4CCKCasein kinase II subunit alpha2.7.11.10.449
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.449
4o0sADNAurora kinase A2.7.11.10.449
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.448
1yvj4STTyrosine-protein kinase JAK32.7.10.20.447
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.447
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.447
3s1h56ZCyclin-dependent kinase 22.7.11.220.447
4c3pACPAurora kinase A2.7.11.10.447
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.447
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.446
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.446
2w1fL0FAurora kinase A2.7.11.10.445
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.445
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.444
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.444
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.444
4fob0USALK tyrosine kinase receptor2.7.10.10.444
5auwQUEDeath-associated protein kinase 12.7.11.10.444
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.443
3nieANPMitogen-activated protein kinase/0.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4erwSTUCyclin-dependent kinase 22.7.11.220.443
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.443
5dpvSKEAurora kinase A2.7.11.10.443
5drdATPAurora kinase A2.7.11.10.443
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.442
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.442
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.442
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.442
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.442
4hvh19RTyrosine-protein kinase JAK32.7.10.20.442
5av2KMPDeath-associated protein kinase 12.7.11.10.442
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.441
2dwbANPAurora kinase A2.7.11.10.441
3lltANPProtein serine/threonine kinase-1/0.441
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.441
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4fkv61KCyclin-dependent kinase 22.7.11.220.441
1dawANPCasein kinase II subunit alpha2.7.11.10.440
1pmn984Mitogen-activated protein kinase 102.7.11.240.440
1pyePM1Cyclin-dependent kinase 22.7.11.220.440
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.440
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
1tvoFRZMitogen-activated protein kinase 12.7.11.240.440
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2ijmADPFocal adhesion kinase 12.7.10.20.440
2vtqLZACyclin-dependent kinase 22.7.11.220.440
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.440
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.440
4eooATPCyclin-dependent kinase 22.7.11.220.440
4hgs15GCasein kinase I isoform gamma-32.7.11.10.440
4q5hANPProtein kinase OspG2.70.440
5dr6SKEAurora kinase A2.7.11.10.440