sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3uvv | REA | Retinoic acid receptor RXR-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 1.000 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.619 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.613 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.605 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.604 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.603 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.601 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.590 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.582 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.580 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.575 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.575 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.569 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.568 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.568 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.565 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.564 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.563 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.559 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.553 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.553 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.549 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.543 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.492 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.491 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.489 | |
| 3cse | N22 | Uncharacterized protein | / | 0.487 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.487 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.484 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.483 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.482 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.482 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.481 | |
| 3qly | 55V | Uncharacterized protein | / | 0.481 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.481 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.480 | |
| 2p15 | EZT | Estrogen receptor | / | 0.477 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.477 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.476 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.475 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.475 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.474 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.473 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.472 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.471 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.470 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.469 | |
| 2chw | 039 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.469 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.468 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.468 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.467 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.467 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.466 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.465 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.465 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.464 | |
| 3eel | 53T | Uncharacterized protein | / | 0.464 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.464 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.463 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.463 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.463 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.463 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.463 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.463 | |
| 1sr7 | MOF | Progesterone receptor | / | 0.462 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.462 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.462 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.462 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.462 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.461 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.460 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.460 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.460 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.460 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1ysx | 4EB | Serum albumin | / | 0.459 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.459 | |
| 3p9t | TCL | Repressor | / | 0.459 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.459 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.459 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 4iae | 1DX | Alr2278 protein | / | 0.459 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.459 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.458 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.458 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 2jfz | 003 | Glutamate racemase | / | 0.458 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.458 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.458 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.458 | |
| 4l9k | EHF | Serum albumin | / | 0.458 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.458 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.458 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.457 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.456 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.456 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.455 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.455 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.455 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.455 | |
| 1fml | RTL | Retinol dehydratase | / | 0.454 | |
| 1kb9 | SMA | Cytochrome b | / | 0.454 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3bjh | NBB | Odorant binding protein ASP1 | / | 0.454 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3eek | 53S | Uncharacterized protein | / | 0.454 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.454 | |
| 3tgu | WF3 | Cytochrome b | / | 0.454 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.454 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.454 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.454 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.454 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.454 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.454 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.453 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.453 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.453 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.452 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.452 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.452 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.452 | |
| 2hnz | PC0 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.452 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.452 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.452 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.452 | |
| 3vi7 | CBD | Hematopoietic prostaglandin D synthase | / | 0.452 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.452 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.451 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.451 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.451 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.451 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.450 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.450 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.450 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 3h1j | SMA | Cytochrome b | / | 0.450 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.450 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.450 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.450 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.449 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.449 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.449 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.449 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.449 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.449 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.448 | |
| 2xvv | 9DN | Serum albumin | / | 0.448 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.448 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3oq1 | 3OQ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.448 | |
| 4l8u | 9AZ | Serum albumin | / | 0.448 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.448 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1l0l | FMX | Cytochrome b | / | 0.447 | |
| 1vru | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.447 | |
| 2bxq | IMN | Serum albumin | / | 0.447 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.447 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3lu8 | IQX | Serum albumin | / | 0.447 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.447 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.447 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.446 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1w22 | NHB | Histone deacetylase 8 | 3.5.1.98 | 0.446 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.446 | |
| 2jkc | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.446 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 3a0i | AJI | Glucokinase | 2.7.1.2 | 0.446 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.446 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.446 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.446 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.446 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1e7a | PFL | Serum albumin | / | 0.445 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.445 | |
| 1sqv | UHD | Cytochrome b | / | 0.445 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.445 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.445 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.444 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.444 | |
| 3eem | 53V | Uncharacterized protein | / | 0.444 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.444 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.444 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.444 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.444 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 4iah | 1DX | Alr2278 protein | / | 0.444 | |
| 4ivy | 1GT | Estrogen receptor | / | 0.444 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.444 | |
| 1ezv | SMA | Cytochrome b | / | 0.443 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.443 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 2fhj | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.443 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.443 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.443 | |
| 3eej | 53R | Uncharacterized protein | / | 0.443 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3nef | PYV | Abscisic acid receptor PYL1 | / | 0.443 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.443 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.443 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.443 | |
| 4jnc | 1LF | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.443 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1eio | GCH | Gastrotropin | / | 0.442 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.442 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2bxm | IMN | Serum albumin | / | 0.442 | |
| 2cl5 | BIE | Catechol O-methyltransferase | 2.1.1.6 | 0.442 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.442 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.442 | |
| 3l71 | AZO | Cytochrome b | / | 0.442 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 4apu | A2K | Progesterone receptor | / | 0.442 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.442 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.442 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.441 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.441 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.441 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.441 | |
| 2xvw | 9NR | Serum albumin | / | 0.441 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.441 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.441 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.441 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.441 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.441 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.441 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.440 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.440 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.440 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.440 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.440 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.440 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.440 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.440 |