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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ue6FMNAureochrome1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ue6FMNAureochrome1/1.000
4eerFMNPhototropin-22.7.11.10.597
4hhdFMNPhototropin-12.7.11.10.593
2pr5FMNBlue-light photoreceptor/0.577
5djtFMNNPH1-2/0.567
1n9nFMNPutative blue light receptor/0.564
5djuFMNNPH1-2/0.561
3t50FMNBlue-light-activated histidine kinase2.7.13.30.560
4eepFMNPhototropin-22.7.11.10.559
2z6dFMNPhototropin-22.7.11.10.558
4wujFMNGlycoside hydrolase family 15, cellulose signaling associated protein envoy/0.553
5dkkFMNPredicted protein/0.536
4eeuFMNPhototropin-22.7.11.10.526
2pd7FADVivid PAS protein VVD/0.516
4r38RBFBlue-light-activated histidine kinase 22.7.13.30.512
1g28FMNPHY3/0.510
4eetFMNPhototropin-22.7.11.10.509
5efwFMNNPH1-1/0.507
2pdtFADVivid PAS protein VVD/0.506
2v1aFMNNPH1-1/0.506
2mwgFMNBlue-light photoreceptor/0.498
2v0uFMNNPH1-1/0.498
2z6cFMNPhototropin-12.7.11.10.498
3is2FADVivid PAS protein VVD/0.495
1n9lFMNPutative blue light receptor/0.494
5j3wFMNSensory box protein/0.490
3p7nFMNLight-activated DNA-binding protein EL222/0.488
4hiaFMNLOV protein/0.488
5j4eFMNSensory box protein/0.487
4kukRBFPutative blue-light photoreceptor/0.485
4hj6FMNLOV protein/0.480
2pd8FADVivid PAS protein VVD/0.479
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.478
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.476
2p4yC03Peroxisome proliferator-activated receptor gamma/0.473
4bfuZVUPantothenate kinase2.7.1.330.471
5kghACOPredicted acetyltransferase/0.471
1n4uFAECholesterol oxidase1.1.3.60.469
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.469
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.469
4lxhC1EAlpha/beta hydrolase fold/0.469
4yswFADXanthine dehydrogenase/oxidase/0.469
3gfbNADL-threonine 3-dehydrogenase/0.468
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.467
3sw1FMNSensory box protein/0.466
3d8vUD1Bifunctional protein GlmU/0.465
1f20FADNitric oxide synthase, brain1.14.13.390.464
3gobHXXDdmC/0.464
3vt7VDXVitamin D3 receptor/0.464
4u2lSFDCholesterol oxidase1.1.3.60.464
1mxtFAECholesterol oxidase1.1.3.60.462
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.462
4xxgFADCholesterol oxidase1.1.3.60.462
2ebaFADPutative glutaryl-CoA dehydrogenase/0.461
3slkNDPPolyketide synthase extender module 2/0.461
3wv9FEGHmd co-occurring protein HcgE/0.461
2ejzSAHDiphthine synthase/0.460
1ewyFADFerredoxin--NADP reductase1.18.1.20.459
4eesFMNPhototropin-22.7.11.10.459
4r21STRCytochrome P450 family 17 polypeptide 2/0.459
1kkq471Peroxisome proliferator-activated receptor alpha/0.458
1t1sCBQ1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.456
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.456
1vcfFMNIsopentenyl-diphosphate delta-isomerase/0.455
3sf6FDAGlutaryl-CoA dehydrogenase/0.455
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4jqh1MFAlr2278 protein/0.455
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.455
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2gpjFADSiderophore-interacting protein/0.454
3in6FMNUncharacterized protein/0.454
4xwrFADCholesterol oxidase1.1.3.60.454
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.453
1xddAAYIntegrin alpha-L/0.453
1y4lSVRBasic phospholipase A2 homolog 2/0.453
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.453
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3zv64HBCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.453
4l0qNADAlcohol dehydrogenase class-3/0.453
4v12POGMaoC like domain protein/0.453
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2bpoFADNADPH--cytochrome P450 reductase/0.452
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.452
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
4udqFAD5-(hydroxymethyl)furfural oxidase/0.452
2dv4SAHDiphthine synthase/0.451
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.451
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4m10ICDProstaglandin G/H synthase 21.14.99.10.451
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.450
1xkdNAPIsocitrate dehydrogenase [NADP]/0.450
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.450
4a81DXCMajor pollen allergen Bet v 1-A/0.450
4gt8ADPSensor protein VraS2.7.13.30.450
1o5rFR9Adenosine deaminase3.5.4.40.449
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.449
2ejvNADL-threonine 3-dehydrogenase/0.449
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.449
3b9lAZZSerum albumin/0.449
3cntFADPolyamine oxidase FMS1/0.449
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.449
4hj4FMNLOV protein/0.449
4rekFADCholesterol oxidase1.1.3.60.449
1uyhPU0Heat shock protein HSP 90-alpha/0.448
2fgjATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.448
2zbaZBATrichothecene 3-O-acetyltransferase/0.448
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.448
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.448
3vthAP2Carbamoyltransferase/0.448
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4wucANPDNA gyrase subunit B/0.448
4xgxADPFAD:protein FMN transferase/0.448
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.447
2emuSAHDiphthine synthase/0.447
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.447
3gyiFADCholesterol oxidase1.1.3.60.447
3icsADPCoenzyme A disulfide reductase/0.447
4q71FADBifunctional protein PutA/0.447
1jr8FADFAD-linked sulfhydryl oxidase ERV21.8.3.20.446
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2c29NAPDihydroflavonol 4-reductase/0.446
2qa2FADPolyketide oxygenase CabE/0.446
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3pqbVGPPutative oxidoreductase/0.446
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.446
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.445
2gv8NDPThiol-specific monooxygenase1.14.130.445
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.445
4c3yANB3-ketosteroid dehydrogenase/0.445
1cboFADCholesterol oxidase1.1.3.60.444
1j7kATPHolliday junction ATP-dependent DNA helicase RuvB/0.444
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.444
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.444
2q5g1FAPeroxisome proliferator-activated receptor delta/0.444
3kb1ADPIron-sulfur cluster carrier protein/0.444
3mdmFJZCholesterol 24-hydroxylase/0.444
3owaFADAcyl-CoA dehydrogenase/0.444
4a6nFADTetX family tetracycline inactivation enzyme/0.444
4ktoFADPutative isovaleryl-CoA dehydrogenase protein/0.444
4r20AERCytochrome P450 family 17 polypeptide 2/0.444
5kgpACOPredicted acetyltransferase/0.444
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.443
2ifaFMNUncharacterized protein/0.443
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.443
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.443
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.443
3vqrFADPutative oxidoreductase/0.443
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4udrFAD5-(hydroxymethyl)furfural oxidase/0.443
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.443
5hsaFASAlcohol oxidase 11.1.3.130.443
1mf0GDPAdenylosuccinate synthetase isozyme 1/0.442
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.442
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3gyjFADCholesterol oxidase1.1.3.60.442
3hhu819Heat shock protein HSP 90-alpha/0.442
4djaFAD(6-4) photolyase/0.442
4enhFVXCholesterol 24-hydroxylase/0.442
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.442
1hfqMOTDihydrofolate reductase1.5.1.30.441
1me6IVSPlasmepsin-23.4.23.390.441
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.441
2q4bNAPUncharacterized protein At5g02240/0.441
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.441
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.441
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.441
3tfyCOAN-alpha-acetyltransferase 502.3.10.441
4dc0NDPPutative ketoacyl reductase1.3.10.441
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4k28NADShikimate dehydrogenase family protein/0.441
4mlp2CXCryptochrome-2/0.441
4ryvZEAProtein LlR18A/0.441
4xiwAZMCarbonic anhydrase, alpha type/0.441
5kf8ACOPredicted acetyltransferase/0.441
1eioGCHGastrotropin/0.440
1fm4DXCMajor pollen allergen Bet v 1-L/0.440
1zeoC01Peroxisome proliferator-activated receptor gamma/0.440
2p5cSAHDiphthine synthase/0.440
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.440
4zohFADPutative oxidoreductase FAD-binding subunit/0.440