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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3gfeP37Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3gfeP37Mitogen-activated protein kinase 14/1.000
3s4qNK0Mitogen-activated protein kinase 14/0.620
3fskRO6Mitogen-activated protein kinase 14/0.604
3itzP66Mitogen-activated protein kinase 14/0.604
3iphG11Mitogen-activated protein kinase 14/0.598
2zb0GK3Mitogen-activated protein kinase 14/0.584
3l8xN4DMitogen-activated protein kinase 14/0.579
3uvqFS8Mitogen-activated protein kinase 14/0.573
3fklFKLMitogen-activated protein kinase 14/0.569
3fmn530Mitogen-activated protein kinase 14/0.565
4aa4QC0Mitogen-activated protein kinase 14/0.563
3flyFLYMitogen-activated protein kinase 14/0.558
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.556
3fi4FI4Mitogen-activated protein kinase 14/0.554
1ouy094Mitogen-activated protein kinase 14/0.553
3dt1P40Mitogen-activated protein kinase 14/0.553
3u8w09JMitogen-activated protein kinase 14/0.553
1di9MSQMitogen-activated protein kinase 14/0.551
2balPQAMitogen-activated protein kinase 14/0.551
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.549
3nww3NWMitogen-activated protein kinase 14/0.545
1zyjBI5Mitogen-activated protein kinase 14/0.543
2rg6287Mitogen-activated protein kinase 14/0.543
3uvp048Mitogen-activated protein kinase 14/0.542
4nka2K7Fibroblast growth factor receptor 1/0.542
4aacAAVMitogen-activated protein kinase 14/0.541
4kin1M8Mitogen-activated protein kinase 14/0.540
4nks2M2Fibroblast growth factor receptor 1/0.539
2zazGK1Mitogen-activated protein kinase 14/0.538
3flzFLZMitogen-activated protein kinase 14/0.537
3ha85JZMitogen-activated protein kinase 14/0.535
3mvl38PMitogen-activated protein kinase 14/0.531
3mpt1GKMitogen-activated protein kinase 14/0.529
4kip1R9Mitogen-activated protein kinase 14/0.527
2itqITQEpidermal growth factor receptor2.7.10.10.525
3hp552PMitogen-activated protein kinase 14/0.525
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.524
2gfsPQBMitogen-activated protein kinase 14/0.523
3fln3FNMitogen-activated protein kinase 14/0.523
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.522
4aa5NQBMitogen-activated protein kinase 14/0.522
3flwFLWMitogen-activated protein kinase 14/0.519
3fsfFSSMitogen-activated protein kinase 14/0.519
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.519
3roc29AMitogen-activated protein kinase 14/0.518
4eh60ONMitogen-activated protein kinase 14/0.518
3fl4FL4Mitogen-activated protein kinase 14/0.517
4f640S8Fibroblast growth factor receptor 1/0.514
2of2547Tyrosine-protein kinase Lck2.7.10.20.513
3gc9B45Mitogen-activated protein kinase 112.7.11.240.513
1ouk084Mitogen-activated protein kinase 14/0.510
2rg5279Mitogen-activated protein kinase 14/0.510
3fmh533Mitogen-activated protein kinase 14/0.510
3fmlFMLMitogen-activated protein kinase 14/0.510
3uibSB2Putative mitogen-activated protein kinase/0.510
3ds6A17Mitogen-activated protein kinase 14/0.509
3fkoFKOMitogen-activated protein kinase 14/0.509
4kiq1RAMitogen-activated protein kinase 14/0.509
1m7qDQOMitogen-activated protein kinase 14/0.508
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.507
2fgiPD1Fibroblast growth factor receptor 1/0.507
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.506
1w7h3IPMitogen-activated protein kinase 14/0.505
3bv2P38Mitogen-activated protein kinase 14/0.505
3hl7I47Mitogen-activated protein kinase 14/0.505
3hllI45Mitogen-activated protein kinase 14/0.505
4lopSB4Mitogen-activated protein kinase 14/0.505
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.504
3rinI2OMitogen-activated protein kinase 14/0.504
2hk51BMTyrosine-protein kinase HCK2.7.10.20.503
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.503
3flsFLSMitogen-activated protein kinase 14/0.503
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.503
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.501
4eym0RXMitogen-activated protein kinase 132.7.11.240.501
3ocgOCGMitogen-activated protein kinase 14/0.500
4f630S7Fibroblast growth factor receptor 1/0.499
3mpaSB2Mitogen-activated protein kinase 14/0.498
1ywrLI9Mitogen-activated protein kinase 14/0.497
3gc7B45Mitogen-activated protein kinase 14/0.497
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.496
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.495
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.494
3bv3P39Mitogen-activated protein kinase 14/0.494
3fmkFMKMitogen-activated protein kinase 14/0.494
4nk92K5Fibroblast growth factor receptor 1/0.494
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.493
3js2VM1Fibroblast growth factor receptor 1/0.493
3mvm39PMitogen-activated protein kinase 14/0.493
2zb1GK4Mitogen-activated protein kinase 14/0.492
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.492
1ove358Mitogen-activated protein kinase 14/0.491
2i0ePDSProtein kinase C beta type2.7.11.130.490
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.489
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.489
3fknFKNMitogen-activated protein kinase 14/0.489
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.488
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.488
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.487
2itwITQEpidermal growth factor receptor2.7.10.10.486
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.486
4jr3KJREpidermal growth factor receptor2.7.10.10.485
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.485
3ac2KSETyrosine-protein kinase Lck2.7.10.20.483
3bx5304Mitogen-activated protein kinase 14/0.483
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.482
2qd9LGFMitogen-activated protein kinase 14/0.480
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
1m17AQ4Epidermal growth factor receptor2.7.10.10.479
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.479
3t2kFADSulfide-quinone reductase/0.478
4fnzNZFALK tyrosine kinase receptor2.7.10.10.478
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.478
3vs3VSETyrosine-protein kinase HCK2.7.10.20.477
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.477
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.476
2of4979Tyrosine-protein kinase Lck2.7.10.20.476
3fc152PMitogen-activated protein kinase 14/0.476
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.475
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.474
3fmmXI2Mitogen-activated protein kinase 14/0.474
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.474
2y6o1N1Ephrin type-A receptor 42.7.10.10.473
2vwx7X4Ephrin type-B receptor 42.7.10.10.472
5f0a1FBcGMP-dependent protein kinase, putative/0.472
1agwSU2Fibroblast growth factor receptor 1/0.471
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.471
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.471
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.471
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.470
2zybKSLTyrosine-protein kinase Lck2.7.10.20.470
3vjoANPEpidermal growth factor receptor2.7.10.10.470
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.469
1w84L12Mitogen-activated protein kinase 14/0.468
4dfrMTXDihydrofolate reductase1.5.1.30.468
1k6cMK1Gag-Pol polyprotein3.4.23.160.467
3drcMTXDihydrofolate reductase1.5.1.30.467
1rf9DBRCamphor 5-monooxygenase1.14.15.10.466
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
4eh50OMMitogen-activated protein kinase 14/0.466
4gk2L66Ephrin type-A receptor 32.7.10.10.466
4looSB4Mitogen-activated protein kinase 14/0.466
4i231C9Epidermal growth factor receptor2.7.10.10.464
4eh70OOMitogen-activated protein kinase 14/0.463
1bl6SB6Mitogen-activated protein kinase 14/0.462
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.462
2cmvNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.462
2vx07X7Ephrin type-B receptor 42.7.10.10.462
3e92G6AMitogen-activated protein kinase 14/0.462
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.462
3zsh469Mitogen-activated protein kinase 14/0.462
4l06NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.462
4nc3ERM5-hydroxytryptamine receptor 2B/0.462
1rbmKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.461
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.461
3lfa1N1Mitogen-activated protein kinase 14/0.461
3opdHIEHeat shock protein 83/0.461
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.461
1j39UPGDNA beta-glucosyltransferase/0.460
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.460
3fmjFMJMitogen-activated protein kinase 14/0.460
4gk3L87Ephrin type-A receptor 32.7.10.10.460
3hvcGG5Mitogen-activated protein kinase 14/0.459
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.459
4dlj6RGMitogen-activated protein kinase 14/0.459
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.458
3eigMTXDihydrofolate reductase1.5.1.30.458
3obgSB2Mitogen-activated protein kinase 14/0.458
4ic7ANPMitogen-activated protein kinase 72.7.11.240.458
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.457
4jq7KJQEpidermal growth factor receptor2.7.10.10.457
1yqj6NPMitogen-activated protein kinase 14/0.456
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.456
2gstGPSGlutathione S-transferase Mu 12.5.1.180.456
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.456
2vwz7X6Ephrin type-B receptor 42.7.10.10.456
4e5yNDPGDP-L-fucose synthase1.1.1.2710.456
4j97ACPFibroblast growth factor receptor 2/0.456
1u3dFADCryptochrome-1/0.455
2eb3ANPEpidermal growth factor receptor2.7.10.10.455
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.455
2oz6CMPCyclic AMP receptor-like protein/0.455
2vzmNRBCytochrome P450 monooxygenase PikC/0.455
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.454
3vrwYS5Vitamin D3 receptor/0.454
4hys1BJMitogen-activated protein kinase 82.7.11.240.454
4l04NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.454
4z34ON7Lysophosphatidic acid receptor 1/0.454
2izrBRKCasein kinase I isoform gamma-32.7.11.10.453
2vd5BI8Myotonin-protein kinase2.7.11.10.453
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3fpjSAMUncharacterized protein/0.453
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.453
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.453
1w2xRCPAcetyl-CoA carboxylase/0.452
2vx17X8Ephrin type-B receptor 42.7.10.10.452
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.452
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.452
4gk4L90Ephrin type-A receptor 32.7.10.10.452
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.452
1ie8KH1Vitamin D3 receptor/0.451
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.451
4cd2FOLDihydrofolate reductase1.5.1.30.451
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.451
1bsvNDPGDP-L-fucose synthase/0.450
1bveDMPGag-Pol polyprotein3.4.23.160.450
2itzIREEpidermal growth factor receptor2.7.10.10.450
2pvyACPFibroblast growth factor receptor 2/0.450
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.450
4ewqMWLMitogen-activated protein kinase 14/0.450
4qnaX11Serine/threonine-protein kinase 242.7.11.10.450
3gstGPRGlutathione S-transferase Mu 12.5.1.180.449
3qlrNDPDihydrofolate reductase1.5.1.30.449
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.449
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.449
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.449
1k6vXN2Gag-Pol polyprotein3.4.23.160.448
1oecAA2Fibroblast growth factor receptor 2/0.448
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2baqPQBMitogen-activated protein kinase 14/0.448
2c7xNRBCytochrome P450 monooxygenase PikC/0.448
2cppCAMCamphor 5-monooxygenase1.14.15.10.448
3a62STURibosomal protein S6 kinase beta-12.7.11.10.448
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.448
4c9oCAMCytochrome P450/0.448
4fuxE75Mitogen-activated protein kinase 12.7.11.240.448
4iteTEYVitamin D3 receptor/0.448
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.448
1k6pXN3Gag-Pol polyprotein3.4.23.160.447
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.447
3ac1KZITyrosine-protein kinase Lck2.7.10.20.447
3hx4ANPCalmodulin-domain protein kinase 1/0.447
3l8sBFFMitogen-activated protein kinase 14/0.447
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.447
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.447
3sz0FADSulfide-quinone reductase/0.447
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
4y8wSTRSteroid 21-hydroxylase/0.447
1e7qNAPGDP-L-fucose synthase/0.446
1jpaANPEphrin type-B receptor 22.7.10.10.446
2vwu7X1Ephrin type-B receptor 42.7.10.10.446
3gcq1BUMitogen-activated protein kinase 14/0.446
3hv3R49Mitogen-activated protein kinase 14/0.446
3iodA6DPantothenate synthetase6.3.2.10.446
3iqeF42F420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.446
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.446
5f8eSAHPossible transcriptional regulatory protein/0.446
5k2cZMAAdenosine receptor A2a/0.446
2g5cNADPrephenate dehydrogenase/0.445
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.445
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.445
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.445
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.445
5c8yACPTubulin tyrosine ligase/0.445
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.444
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.444
3och2MXDihydrofolate reductase1.5.1.30.444
3p2oNADBifunctional protein FolD/0.444
3t2zFADSulfide-quinone reductase/0.444
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.444
4nfn2KCTau-tubulin kinase 12.7.11.10.444
6gsxGPSGlutathione S-transferase Mu 12.5.1.180.444
1ie3NADMalate dehydrogenase/0.443
1nzdUPGDNA beta-glucosyltransferase/0.443
2gekGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.443
2vwy7X5Ephrin type-B receptor 42.7.10.10.443
3vryB43Tyrosine-protein kinase HCK2.7.10.20.443
3zh8C58Protein kinase C iota type2.7.11.130.443
4eh3NARMitogen-activated protein kinase 14/0.443
4gt3ATPMitogen-activated protein kinase 12.7.11.240.443
1u3cFADCryptochrome-1/0.442
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3gggNADPrephenate dehydrogenase/0.442
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.442
3zk5Z18Cytochrome P450 monooxygenase PikC/0.442
4dce0JFALK tyrosine kinase receptor2.7.10.10.442
4l03NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.442
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.442
4qa0SHHHistone deacetylase 83.5.1.980.442
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.441
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.441
3b2tM33Fibroblast growth factor receptor 2/0.441
3da1FADGlycerol-3-phosphate dehydrogenase/0.441
3dafFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.441
3hazFADBifunctional protein PutA/0.441
4qmuSKESerine/threonine-protein kinase 242.7.11.10.441
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1bwsNDPGDP-L-fucose synthase/0.440
1lhvNOGSex hormone-binding globulin/0.440
2c6hPXICytochrome P450 monooxygenase PikC/0.440
2ghmLICMitogen-activated protein kinase 14/0.440
2ittAEEEpidermal growth factor receptor2.7.10.10.440
2woeAR6ADP-ribosyl-[dinitrogen reductase] glycohydrolase3.2.2.240.440
2x7gPVBSRSF protein kinase 22.7.11.10.440
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3hjaNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.440
3tnlNADShikimate dehydrogenase (NADP(+))/0.440
4bcmT7ZCyclin-dependent kinase 22.7.11.220.440
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4ndnSAMS-adenosylmethionine synthase isoform type-22.5.1.60.440