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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2yi7BZ8Heat shock protein HSP 90-alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2yi7BZ8Heat shock protein HSP 90-alpha/1.000
2uwd2GGHeat shock protein HSP 90-alpha/0.733
2cct2E1Heat shock protein HSP 90-alpha/0.689
2bsmBSMHeat shock protein HSP 90-alpha/0.675
2wi1ZZ2Heat shock protein HSP 90-alpha/0.658
2wi5ZZ5Heat shock protein HSP 90-alpha/0.643
2vci2GJHeat shock protein HSP 90-alpha/0.642
2yi66QMHeat shock protein HSP 90-alpha/0.640
4fcq2N6Heat shock protein HSP 90-alpha/0.615
2vcj2EQHeat shock protein HSP 90-alpha/0.614
3ft5MO8Heat shock protein HSP 90-alpha/0.606
2wi2ZZ3Heat shock protein HSP 90-alpha/0.590
2yjwYJWHeat shock protein HSP 90-alpha/0.581
2ye92D4Heat shock protein HSP 90-alpha/0.579
4egh0OYHeat shock protein HSP 90-alpha/0.571
3d0bSNXHeat shock protein HSP 90-alpha/0.561
2xjxXJXHeat shock protein HSP 90-alpha/0.559
4egkRDCHeat shock protein HSP 90-alpha/0.553
4xclAGSHeat shock cognate 90 kDa protein/0.551
1uy7PU4Heat shock protein HSP 90-alpha/0.549
3o0iP54Heat shock protein HSP 90-alpha/0.543
2yeiXQIHeat shock protein HSP 90-alpha/0.536
1yc443PHeat shock protein HSP 90-alpha/0.528
4ipeANPTNF receptor-associated protein 1/0.528
2ccu2D9Heat shock protein HSP 90-alpha/0.526
2wi6ZZ6Heat shock protein HSP 90-alpha/0.526
3k981RCHeat shock protein HSP 90-alpha/0.526
2qg0A94Heat shock protein HSP 90-alpha/0.525
1osfKOSHeat shock protein HSP 90-alpha/0.523
3hyz42CHeat shock protein HSP 90-alpha/0.522
1uy8PU5Heat shock protein HSP 90-alpha/0.518
1yetGDMHeat shock protein HSP 90-alpha/0.518
2xjjL81Heat shock protein HSP 90-alpha/0.517
4xcjADPHeat shock cognate 90 kDa protein/0.513
2xhtC0YHeat shock protein HSP 90-alpha/0.510
3omuIBDHeat shock protein 83/0.510
2werRDCATP-dependent molecular chaperone HSP82/0.507
4jqlVJ6Heat shock protein HSP 90-alpha/0.507
1uykPUXHeat shock protein HSP 90-alpha/0.505
2xabVHDHeat shock protein HSP 90-alpha/0.505
1yc14BCHeat shock protein HSP 90-alpha/0.503
3k974CDHeat shock protein HSP 90-alpha/0.503
3r4pFU7Heat shock protein HSP 90-alpha/0.503
3vhaVHAHeat shock protein HSP 90-alpha/0.503
1uyiPUZHeat shock protein HSP 90-alpha/0.501
3opdHIEHeat shock protein 83/0.501
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.501
2yegXQGHeat shock protein HSP 90-alpha/0.500
3ekrPY9Heat shock protein HSP 90-alpha/0.499
2xd6XD6ATP-dependent molecular chaperone HSP82/0.498
3whaWHAHeat shock protein HSP 90-alpha/0.497
3k99PFTHeat shock protein HSP 90-alpha/0.495
2iorADPChaperone protein HtpG/0.493
4awo99BHeat shock protein HSP 90-alpha/0.493
2yejZZ3Heat shock protein HSP 90-alpha/0.492
3inxJZCHeat shock protein HSP 90-alpha/0.492
4xdmGDMHeat shock cognate 90 kDa protein/0.492
3t2sAGSHeat shock protein HSP 90-alpha/0.488
4nh82LCHeat shock protein HSP 90-alpha/0.487
4ivgANPTNF receptor-associated protein 1/0.485
1byqADPHeat shock protein HSP 90-alpha/0.484
1qy8RDIEndoplasmin/0.484
4ce3L4VATP-dependent molecular chaperone HSP82/0.484
2iwsNP4ATP-dependent molecular chaperone HSP82/0.483
2uzlC94Cyclin-dependent kinase 22.7.11.220.482
3qtqX35Cyclin-dependent kinase 22.7.11.220.482
2xk2ADPHeat shock protein HSP 90-alpha/0.481
2yecXQ0Heat shock protein HSP 90-alpha/0.481
3ekoPYUHeat shock protein HSP 90-alpha/0.481
3r4oFU3Heat shock protein HSP 90-alpha/0.481
2bt0CT5Heat shock protein HSP 90-alpha/0.480
2gqpPA7Endoplasmin/0.480
4asg814ATP-dependent molecular chaperone HSP82/0.480
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.479
4fcr0TMHeat shock protein HSP 90-alpha/0.479
2ye42FYHeat shock protein HSP 90-alpha/0.478
3hx4ANPCalmodulin-domain protein kinase 1/0.478
3rlq3RQHeat shock protein HSP 90-alpha/0.478
4ce17FKATP-dependent molecular chaperone HSP82/0.478
3h6vNS6Glutamate receptor 2/0.477
4bqjXKLHeat shock protein HSP 90-alpha/0.477
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.477
2bz5AB4Heat shock protein HSP 90-alpha/0.476
2breKJ2ATP-dependent molecular chaperone HSP82/0.472
4loqSB4Mitogen-activated protein kinase 14/0.472
1dz8CAMCamphor 5-monooxygenase1.14.15.10.471
1h1s4SPCyclin-dependent kinase 22.7.11.220.471
2byh2D7Heat shock protein HSP 90-alpha/0.471
2xjgXJGHeat shock protein HSP 90-alpha/0.471
4egiB2JHeat shock protein HSP 90-alpha/0.470
3s1dZIRCytokinin dehydrogenase 11.5.99.120.469
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.467
2qhyMZ1Gag-Pol polyprotein/0.466
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.466
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.466
3mpt1GKMitogen-activated protein kinase 14/0.466
4nmbFADBifunctional protein PutA/0.466
2fznFADBifunctional protein PutA1.5.5.20.465
2wxvWXVCyclin-dependent kinase 22.7.11.220.465
3rlp3RPHeat shock protein HSP 90-alpha/0.464
4as94QSATP-dependent molecular chaperone HSP82/0.464
4qmzB49Serine/threonine-protein kinase 242.7.11.10.464
2byi2DDHeat shock protein HSP 90-alpha/0.462
3fskRO6Mitogen-activated protein kinase 14/0.462
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
4u03GTPCyclic GMP-AMP synthase/0.461
1p31EPUUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.460
4ekeD1IGlycogen phosphorylase, muscle form2.4.1.10.460
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.460
5auuLU2Death-associated protein kinase 12.7.11.10.460
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.459
3flyFLYMitogen-activated protein kinase 14/0.459
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.459
3r9uFADThioredoxin reductase/0.458
2c5nCK8Cyclin-dependent kinase 22.7.11.220.457
3ixp834Ecdysone receptor/0.457
3p8zSAHGenome polyprotein2.1.1.560.457
3qu0X40Cyclin-dependent kinase 22.7.11.220.457
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.456
3o9cK20Pol polyprotein/0.456
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.456
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.456
4qmpDKISerine/threonine-protein kinase 242.7.11.10.456
4xj3GTPCyclic GMP-AMP synthase/0.456
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.455
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.455
1zz2B11Mitogen-activated protein kinase 14/0.455
2iwuNP5ATP-dependent molecular chaperone HSP82/0.455
2izsBRQCasein kinase I isoform gamma-32.7.11.10.455
2xcmADPCytosolic heat shock protein 90/0.455
2xnbY8LCyclin-dependent kinase 22.7.11.220.455
3d84NDPDihydrofolate reductase1.5.1.30.455
3jvhHHV2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.455
3oqfS51Renin3.4.23.150.455
4nbwNADShort-chain dehydrogenase/reductase SDR/0.455
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.455
1l4mNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.454
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.454
3bv3P39Mitogen-activated protein kinase 14/0.454
3saa77FProtease/0.454
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.454
4nm9FADBifunctional protein PutA/0.454
5a9sNAPPutative dehydrogenase/0.454
5e8wSTUTGF-beta receptor type-12.7.11.300.454
4djpM73Pol polyprotein/0.453
4r20AERCytochrome P450 family 17 polypeptide 2/0.453
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.452
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.452
2zdxP4A[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.452
3iphG11Mitogen-activated protein kinase 14/0.452
3raiX85Cyclin-dependent kinase 22.7.11.220.452
3uqdADPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.452
4bb3KKAIsopenicillin N synthase1.21.3.10.452
5cp4CAMCamphor 5-monooxygenase1.14.15.10.452
5dr6SKEAurora kinase A2.7.11.10.452
5f8fSFGPossible transcriptional regulatory protein/0.452
1gqtACPRibokinase/0.451
1me7MOAInosine-5'-monophosphate dehydrogenase/0.451
2emuSAHDiphthine synthase/0.451
2p5fSAHDiphthine synthase/0.451
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.451
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.451
3dt1P40Mitogen-activated protein kinase 14/0.451
3hvcGG5Mitogen-activated protein kinase 14/0.451
3il1B5DGlutamate receptor 2/0.451
3r7iX9ICyclin-dependent kinase 22.7.11.220.451
4fod0UVALK tyrosine kinase receptor2.7.10.10.451
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.451
4q73FADBifunctional protein PutA/0.451
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.450
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.450
4aa4QC0Mitogen-activated protein kinase 14/0.450
4kugNAD3-hydroxybutyryl-CoA dehydrogenase/0.450
4qi7FADCellobiose dehydrogenase/0.450
4tuvCPZCytochrome P450 1191.140.450
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.450
5f8eSAHPossible transcriptional regulatory protein/0.450
1l4lNCNNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase2.4.2.210.449
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.449
2eufLQQCyclin-dependent kinase 62.7.11.220.449
2uxuNARHTH-type transcriptional regulator TtgR/0.449
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.449
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4efuEFUHeat shock protein HSP 90-alpha/0.449
1pvgANPDNA topoisomerase 25.99.1.30.448
1u54ACPActivated CDC42 kinase 1/0.448
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.448
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.448
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.448
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2r6gATPMaltose/maltodextrin import ATP-binding protein MalK/0.448
2uzeC95Cyclin-dependent kinase 22.7.11.220.448
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.448
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.448
3zewSTUEphrin type-B receptor 42.7.10.10.448
4c62XWWTyrosine-protein kinase JAK2/0.448
4ke11R6Beta-secretase 13.4.23.460.448
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.448
5dr9SKEAurora kinase A2.7.11.10.448
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.447
1oguST8Cyclin-dependent kinase 22.7.11.220.447
2q7vFADThioredoxin reductase/0.447
2qfoA13Heat shock protein HSP 90-alpha/0.447
3b895GP16S rRNA methylase/0.447
3bhtMFRCyclin-dependent kinase 22.7.11.220.447
3nww3NWMitogen-activated protein kinase 14/0.447
3qlrNDPDihydrofolate reductase1.5.1.30.447
4xc0ACPHeat shock cognate 90 kDa protein/0.447
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1zrzBI1Protein kinase C iota type2.7.11.130.446
2owkSAHDiphthine synthase/0.446
4eh70OOMitogen-activated protein kinase 14/0.446
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.446
4l4dCAMCamphor 5-monooxygenase1.14.15.10.446
5br4NADLactaldehyde reductase1.1.1.770.446
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.445
1llwFMNFerredoxin-dependent glutamate synthase 21.4.7.10.445
1oirHDYCyclin-dependent kinase 22.7.11.220.445
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.445
2xa4AZ5Tyrosine-protein kinase JAK2/0.445
3e2sFADBifunctional protein PutA1.5.5.20.445
3fln3FNMitogen-activated protein kinase 14/0.445
3ms421NGlycogen phosphorylase, muscle form2.4.1.10.445
3sa8K83Protease/0.445
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.445
4aa5NQBMitogen-activated protein kinase 14/0.445
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4i231C9Epidermal growth factor receptor2.7.10.10.445
4mcc21XtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.445
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.445
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.445
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
1krv147Galactoside O-acetyltransferase2.3.1.180.444
1phePIYCamphor 5-monooxygenase1.14.15.10.444
1svmATPLarge T antigen3.6.40.444
1t2cNAIL-lactate dehydrogenase1.1.1.270.444
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.444
2csnCKICasein kinase I homolog 12.7.11.10.444
2r3o2SCCyclin-dependent kinase 22.7.11.220.444
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.444
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.444
3imgBZ2Pantothenate synthetase6.3.2.10.444
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.444
4erwSTUCyclin-dependent kinase 22.7.11.220.444
4gk4L90Ephrin type-A receptor 32.7.10.10.444
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.444
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.444
4jajXU1Aurora kinase A2.7.11.10.444
4lopSB4Mitogen-activated protein kinase 14/0.444
4opuFDAConserved Archaeal protein/0.444
4v2gITCTetracycline repressor protein class D/0.444
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.444
1g5sI17Cyclin-dependent kinase 22.7.11.220.443
1ofeFMNFerredoxin-dependent glutamate synthase 21.4.7.10.443
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.443
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.443
2esaGDMEndoplasmin/0.443
2he5NDPAldo-keto reductase family 1 member C211.1.10.443
2i51FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding/0.443
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.443
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.443
2xyuQ9GEphrin type-A receptor 42.7.10.10.443
3flwFLWMitogen-activated protein kinase 14/0.443
3hl7I47Mitogen-activated protein kinase 14/0.443
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.443
4a9hTVPBromodomain-containing protein 2/0.443
4ck2NVUIntegrase/0.443
4e4m0NHTyrosine-protein kinase JAK2/0.443
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.443
4hvi19STyrosine-protein kinase JAK32.7.10.20.443
4nakPBQ2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic2.7.7.600.443
4xivACPChemotaxis protein CheA2.7.13.30.443
1gij2PUCyclin-dependent kinase 22.7.11.220.442
1nm5NAPNAD(P) transhydrogenase subunit beta1.6.1.20.442
1xe55FEPlasmepsin-23.4.23.390.442
1z5aADPType 2 DNA topoisomerase 6 subunit B/0.442
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.442
2oegUPGUDP-glucose pyrophosphorylase/0.442
2wgjVGHHepatocyte growth factor receptor2.7.10.10.442
2xhd7T9Glutamate receptor 2/0.442
2zjaACPATP-dependent DNA helicase Hel308/0.442
3a8wATPProtein kinase C iota type2.7.11.130.442
3dogNNNCyclin-dependent kinase 22.7.11.220.442
3gi4K60Gag-Pol polyprotein/0.442
3jvwDMPGag-Pol polyprotein3.4.23.160.442
3lzu017Gag-Pol polyprotein3.4.23.160.442
3o99K13Pol polyprotein/0.442
3ral04ZCyclin-dependent kinase 22.7.11.220.442
4a87NARMajor pollen allergen Bet v 1-A/0.442
4du82P0Mevalonate diphosphate decarboxylase/0.442
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.442
4jx1CAHCamphor 5-monooxygenase1.14.15.10.442
4mwhATPCasein kinase II subunit alpha2.7.11.10.442
5dt3ATPAurora kinase A2.7.11.10.442
1bdrIM1Gag-Pol polyprotein3.4.23.160.441
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.441
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.441
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2ojj82AMitogen-activated protein kinase 12.7.11.240.441
2z97CAMCamphor 5-monooxygenase1.14.15.10.441
3litE15Protease/0.441
3rjc06ZCyclin-dependent kinase 22.7.11.220.441
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.441
3uylTYDProbable NDP-rhamnosyltransferase/0.441
4a862ANMajor pollen allergen Bet v 1-A/0.441
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.441
4g95OAGDihydrofolate reductase1.5.1.30.441
4ib4ERM5-hydroxytryptamine receptor 2B/0.441
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1dz4CAMCamphor 5-monooxygenase1.14.15.10.440
1h0w207Cyclin-dependent kinase 22.7.11.220.440
1nooCAHCamphor 5-monooxygenase1.14.15.10.440
1obnASVIsopenicillin N synthase1.21.3.10.440
1suoCPZCytochrome P450 2B41.14.14.10.440
1t85CAMCamphor 5-monooxygenase1.14.15.10.440
1w2xRCPAcetyl-CoA carboxylase/0.440
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
1yonA2R2-dehydropantoate 2-reductase1.1.1.1690.440
2o1uANPEndoplasmin/0.440
2qn7HBZGlycogen phosphorylase, muscle form2.4.1.10.440
2y6o1N1Ephrin type-A receptor 42.7.10.10.440
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.440
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.440
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.440
3dk1G05Gag-Pol polyprotein3.4.23.160.440
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.440
3mxdK53Gag-Pol polyprotein3.4.23.160.440
3sa9A68Protease/0.440
3uleC69Actin-related protein 3/0.440
4c3rACPAurora kinase A2.7.11.10.440
4gk3L87Ephrin type-A receptor 32.7.10.10.440
4pd6URINucleoside permease/0.440
4xgiNADGlutamate dehydrogenase/0.440
4xj43ATCyclic GMP-AMP synthase/0.440
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4zlaBESCytosol aminopeptidase3.4.11.10.440
5dn3ATPAurora kinase A2.7.11.10.440
5drdATPAurora kinase A2.7.11.10.440