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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2wihP48Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2wihP48Cyclin-dependent kinase 22.7.11.221.000
2wxvWXVCyclin-dependent kinase 22.7.11.220.688
2wpa889Cyclin-dependent kinase 22.7.11.220.572
1vyw292Cyclin-dependent kinase 22.7.11.220.562
1fvv107Cyclin-dependent kinase 22.7.11.220.547
4fx360KCyclin-dependent kinase 22.7.11.220.540
2cchATPCyclin-dependent kinase 22.7.11.220.532
1oiyN41Cyclin-dependent kinase 22.7.11.220.527
2iw84SPCyclin-dependent kinase 22.7.11.220.527
2uzdC85Cyclin-dependent kinase 22.7.11.220.526
2x1nX1NCyclin-dependent kinase 22.7.11.220.523
3r9hZ67Cyclin-dependent kinase 22.7.11.220.523
4eok4SPCyclin-dependent kinase 22.7.11.220.519
4fkv61KCyclin-dependent kinase 22.7.11.220.519
2c6iDT1Cyclin-dependent kinase 22.7.11.220.518
3rni21ZCyclin-dependent kinase 22.7.11.220.517
2bkzSBCCyclin-dependent kinase 22.7.11.220.516
3rak03ZCyclin-dependent kinase 22.7.11.220.516
4qmpDKISerine/threonine-protein kinase 242.7.11.10.513
1gih1PUCyclin-dependent kinase 22.7.11.220.512
2i40BLZCyclin-dependent kinase 22.7.11.220.512
3qxpX64Cyclin-dependent kinase 22.7.11.220.512
1pkdUCNCyclin-dependent kinase 22.7.11.220.509
3rmf20ZCyclin-dependent kinase 22.7.11.220.508
2iw94SPCyclin-dependent kinase 22.7.11.220.507
2w17I19Cyclin-dependent kinase 22.7.11.220.507
4fkw62KCyclin-dependent kinase 22.7.11.220.507
3ral04ZCyclin-dependent kinase 22.7.11.220.504
1e9hINRCyclin-dependent kinase 22.7.11.220.502
3r73X87Cyclin-dependent kinase 22.7.11.220.502
1h1s4SPCyclin-dependent kinase 22.7.11.220.501
3rk708ZCyclin-dependent kinase 22.7.11.220.501
3rpv26ZCyclin-dependent kinase 22.7.11.220.501
3s1h56ZCyclin-dependent kinase 22.7.11.220.501
4eor4SPCyclin-dependent kinase 22.7.11.220.501
1p2a5BNCyclin-dependent kinase 22.7.11.220.500
3qu0X40Cyclin-dependent kinase 22.7.11.220.500
2c5nCK8Cyclin-dependent kinase 22.7.11.220.498
4fkr45KCyclin-dependent kinase 22.7.11.220.498
2wipP49Cyclin-dependent kinase 22.7.11.220.497
3rk507ZCyclin-dependent kinase 22.7.11.220.497
2c6tDT5Cyclin-dependent kinase 22.7.11.220.496
1oi9N20Cyclin-dependent kinase 22.7.11.220.495
2uzbC75Cyclin-dependent kinase 22.7.11.220.495
4fkt48KCyclin-dependent kinase 22.7.11.220.495
1aq1STUCyclin-dependent kinase 22.7.11.220.493
3qqkX02Cyclin-dependent kinase 22.7.11.220.493
4ek816KCyclin-dependent kinase 22.7.11.220.493
3bhtMFRCyclin-dependent kinase 22.7.11.220.492
3qtxX43Cyclin-dependent kinase 22.7.11.220.492
4fks46KCyclin-dependent kinase 22.7.11.220.492
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.491
1oguST8Cyclin-dependent kinase 22.7.11.220.490
2w05FRTCyclin-dependent kinase 22.7.11.220.490
3lfnA27Cyclin-dependent kinase 22.7.11.220.490
3qzhX69Cyclin-dependent kinase 22.7.11.220.490
1v0oINRCell division control protein 2 homolog2.7.11.220.489
1ke6LS2Cyclin-dependent kinase 22.7.11.220.488
2eufLQQCyclin-dependent kinase 62.7.11.220.488
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.488
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.486
1y91CT9Cyclin-dependent kinase 22.7.11.220.486
3s2pPMUCyclin-dependent kinase 22.7.11.220.486
3r9dX6BCyclin-dependent kinase 22.7.11.220.484
2vv9IM9Cyclin-dependent kinase 22.7.11.220.483
3rk909ZCyclin-dependent kinase 22.7.11.220.483
4bgh3I6Cyclin-dependent kinase 22.7.11.220.483
1unlRRCCyclin-dependent-like kinase 52.7.11.10.482
2uzeC95Cyclin-dependent kinase 22.7.11.220.482
4qmySTUSerine/threonine-protein kinase 242.7.11.10.482
2bhhRYUCyclin-dependent kinase 22.7.11.220.481
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.481
1g5sI17Cyclin-dependent kinase 22.7.11.220.480
3qtzX42Cyclin-dependent kinase 22.7.11.220.480
1di8DTQCyclin-dependent kinase 22.7.11.220.479
1oitHDTCyclin-dependent kinase 22.7.11.220.479
2uzlC94Cyclin-dependent kinase 22.7.11.220.479
2r3r6SCCyclin-dependent kinase 22.7.11.220.478
2vttLZDCyclin-dependent kinase 22.7.11.220.478
2w06FRVCyclin-dependent kinase 22.7.11.220.478
4erwSTUCyclin-dependent kinase 22.7.11.220.478
2xmyCDKCyclin-dependent kinase 22.7.11.220.477
3qtqX35Cyclin-dependent kinase 22.7.11.220.477
3r7yZ04Cyclin-dependent kinase 22.7.11.220.477
4bcmT7ZCyclin-dependent kinase 22.7.11.220.477
2r3p3SCCyclin-dependent kinase 22.7.11.220.476
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.476
2bheBRYCyclin-dependent kinase 22.7.11.220.475
3rkb12ZCyclin-dependent kinase 22.7.11.220.475
1pxlCK4Cyclin-dependent kinase 22.7.11.220.474
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.474
2vu3LZECyclin-dependent kinase 22.7.11.220.474
3qtuX44Cyclin-dependent kinase 22.7.11.220.474
3uli1N3Cyclin-dependent kinase 22.7.11.220.474
3rm719ZCyclin-dependent kinase 22.7.11.220.473
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
1ykr628Cyclin-dependent kinase 22.7.11.220.472
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.472
3ddqRRCCyclin-dependent kinase 22.7.11.220.472
3dogNNNCyclin-dependent kinase 22.7.11.220.472
3ezrEZRCyclin-dependent kinase 22.7.11.220.472
3r7iX9ICyclin-dependent kinase 22.7.11.220.472
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
2c6o4SPCyclin-dependent kinase 22.7.11.220.471
2xnbY8LCyclin-dependent kinase 22.7.11.220.471
4bcnT9NCyclin-dependent kinase 22.7.11.220.471
3qxoX65Cyclin-dependent kinase 22.7.11.220.470
3roy22ZCyclin-dependent kinase 22.7.11.220.470
3t8oATPRhodopsin kinase/0.470
4acm7YGCyclin-dependent kinase 22.7.11.220.470
3le62BZCyclin-dependent kinase 22.7.11.220.468
3r7vZ02Cyclin-dependent kinase 22.7.11.220.468
3tnwF18Cyclin-dependent kinase 22.7.11.220.468
1h1r6CPCyclin-dependent kinase 22.7.11.220.467
3pj8404Cyclin-dependent kinase 22.7.11.220.467
3r1yX76Cyclin-dependent kinase 22.7.11.220.467
4bgg844Activin receptor type-12.7.11.300.467
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.467
2uzoC62Cyclin-dependent kinase 22.7.11.220.466
3my5RFZCyclin-dependent kinase 22.7.11.220.466
3sw719KCyclin-dependent kinase 22.7.11.220.465
1oirHDYCyclin-dependent kinase 22.7.11.220.464
2b52D42Cyclin-dependent kinase 22.7.11.220.464
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.464
2r3iSCFCyclin-dependent kinase 22.7.11.220.464
3lfqA28Cyclin-dependent kinase 22.7.11.220.463
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.463
3r8zZ63Cyclin-dependent kinase 22.7.11.220.463
3ddpRC8Cyclin-dependent kinase 22.7.11.220.462
4eol1ROCyclin-dependent kinase 22.7.11.220.462
1pyePM1Cyclin-dependent kinase 22.7.11.220.461
2b53D23Cyclin-dependent kinase 22.7.11.220.461
3sqq99ZCyclin-dependent kinase 22.7.11.220.461
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.461
4dgnLU2Casein kinase II subunit alpha2.7.11.10.461
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.461
4gmy0X5Tyrosine-protein kinase JAK2/0.461
4j95ACPFibroblast growth factor receptor 2/0.461
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.461
1v1k3FPCyclin-dependent kinase 22.7.11.220.460
4fkq42KCyclin-dependent kinase 22.7.11.220.460
1ke7LS3Cyclin-dependent kinase 22.7.11.220.459
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.459
2btsU32Cyclin-dependent kinase 22.7.11.220.458
2fvdLIACyclin-dependent kinase 22.7.11.220.458
3s0o50ZCyclin-dependent kinase 22.7.11.220.458
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.458
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.457
2r3lSCWCyclin-dependent kinase 22.7.11.220.457
3c4xATPRhodopsin kinase/0.457
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.457
4bcpT3CCyclin-dependent kinase 22.7.11.220.457
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.457
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.457
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.456
1pxkCK3Cyclin-dependent kinase 22.7.11.220.456
2uznC96Cyclin-dependent kinase 22.7.11.220.456
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.456
3i60E86Mitogen-activated protein kinase 12.7.11.240.456
3lfsA07Cyclin-dependent kinase 22.7.11.220.456
3qzgX67Cyclin-dependent kinase 22.7.11.220.456
3r71X86Cyclin-dependent kinase 22.7.11.220.456
1finATPCyclin-dependent kinase 22.7.11.220.455
1h1pCMGCyclin-dependent kinase 22.7.11.220.455
1pxmCK5Cyclin-dependent kinase 22.7.11.220.455
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.455
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.455
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.455
3qwjX6ACyclin-dependent kinase 22.7.11.220.455
3qzfX66Cyclin-dependent kinase 22.7.11.220.455
3r7uX96Cyclin-dependent kinase 22.7.11.220.455
3sw418KCyclin-dependent kinase 22.7.11.220.455
3ezvEZVCyclin-dependent kinase 22.7.11.220.454
3qziX72Cyclin-dependent kinase 22.7.11.220.454
3rpy27ZCyclin-dependent kinase 22.7.11.220.454
4eomATPCyclin-dependent kinase 22.7.11.220.453
1ke5LS1Cyclin-dependent kinase 22.7.11.220.452
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.452
3qqfX07Cyclin-dependent kinase 22.7.11.220.452
3r1sX73Cyclin-dependent kinase 22.7.11.220.452
1w0xOLOCyclin-dependent kinase 22.7.11.220.451
1xjdSTUProtein kinase C theta type2.7.11.130.450
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.450
3mtfA3FActivin receptor type-12.7.11.300.450
4qmzB49Serine/threonine-protein kinase 242.7.11.10.450
1ke9LS5Cyclin-dependent kinase 22.7.11.220.449
2btrU73Cyclin-dependent kinase 22.7.11.220.449
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.449
4ek610KCyclin-dependent kinase 22.7.11.220.449
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.449
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.448
3ql8X01Cyclin-dependent kinase 22.7.11.220.448
3r83Z14Cyclin-dependent kinase 22.7.11.220.448
3r9oZ71Cyclin-dependent kinase 22.7.11.220.448
3raiX85Cyclin-dependent kinase 22.7.11.220.448
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.448
3rjc06ZCyclin-dependent kinase 22.7.11.220.447
3wblPDYCyclin-dependent kinase 22.7.11.220.447
1dm2HMDCyclin-dependent kinase 22.7.11.220.446
1r78FMDCyclin-dependent kinase 22.7.11.220.446
1urwI1PCyclin-dependent kinase 22.7.11.220.446
3a7jADPSerine/threonine-protein kinase 242.7.11.10.446
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.446
3qwkX62Cyclin-dependent kinase 22.7.11.220.446
4fko20KCyclin-dependent kinase 22.7.11.220.446
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.446
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.446
1gii1PUCyclin-dependent kinase 22.7.11.220.445
1ke8LS4Cyclin-dependent kinase 22.7.11.220.445
2r3mSCXCyclin-dependent kinase 22.7.11.220.445
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.445
3rm618ZCyclin-dependent kinase 22.7.11.220.445
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.445
1oiqHDUCyclin-dependent kinase 22.7.11.220.444
1vyzN5BCyclin-dependent kinase 22.7.11.220.444
2pvhP19Casein kinase II subunit alpha2.7.11.10.444
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
4ii5ADPCyclin-dependent kinase 22.7.11.220.444
1oiuN76Cyclin-dependent kinase 22.7.11.220.443
3ig7EFPCyclin-dependent kinase 22.7.11.220.443
3lltANPProtein serine/threonine kinase-1/0.443
3qqlX03Cyclin-dependent kinase 22.7.11.220.443
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.443
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.443
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.443
1fvt106Cyclin-dependent kinase 22.7.11.220.442
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.442
2vthLZ2Cyclin-dependent kinase 22.7.11.220.442
3gxlQIGTGF-beta receptor type-12.7.11.300.442
2f2cAP9Cyclin-dependent kinase 62.7.11.220.441
4bcqTJFCyclin-dependent kinase 22.7.11.220.441
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.441
4jqeANPCasein kinase II subunit alpha2.7.11.10.441
1pxpCK8Cyclin-dependent kinase 22.7.11.220.440
2pvnP63Casein kinase II subunit alpha2.7.11.10.440
2r3kSCQCyclin-dependent kinase 22.7.11.220.440
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.440
3zep1NXTyrosine-protein kinase JAK32.7.10.20.440
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.440