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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2bfyH1NAurora kinase B-A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2bfyH1NAurora kinase B-A2.7.11.11.000
2vgoAD5Aurora kinase B-A2.7.11.10.523
2ijmATPFocal adhesion kinase 12.7.10.20.510
4fob0USALK tyrosine kinase receptor2.7.10.10.509
2w1fL0FAurora kinase A2.7.11.10.497
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.497
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.494
3k5uPFQAurora kinase A2.7.11.10.493
4fod0UVALK tyrosine kinase receptor2.7.10.10.492
3ztxZTXAurora kinase B-A2.7.11.10.490
4foc0UUALK tyrosine kinase receptor2.7.10.10.488
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.488
5aaaVGHALK tyrosine kinase receptor2.7.10.10.487
1bygSTUTyrosine-protein kinase CSK/0.486
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.485
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.484
2j4z626Aurora kinase A2.7.11.10.483
4cd0AWJALK tyrosine kinase receptor2.7.10.10.483
4ix6ADPUncharacterized protein/0.483
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.482
2c6eHPMAurora kinase A2.7.11.10.481
2j0m4STFocal adhesion kinase 12.7.10.20.481
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.481
2vwu7X1Ephrin type-B receptor 42.7.10.10.481
2xvdAS6Ephrin type-B receptor 42.7.10.10.481
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.481
2itqITQEpidermal growth factor receptor2.7.10.10.480
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.479
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.478
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.477
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
2j0lANPFocal adhesion kinase 12.7.10.20.476
2x6dX6DAurora kinase A2.7.11.10.476
4c3pACPAurora kinase A2.7.11.10.476
2xp2VGHALK tyrosine kinase receptor2.7.10.10.475
4ansVGHALK tyrosine kinase receptor2.7.10.10.475
5aacVGHALK tyrosine kinase receptor2.7.10.10.475
5e8wSTUTGF-beta receptor type-12.7.11.300.475
3pxkPXKFocal adhesion kinase 12.7.10.20.474
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
4anqVGHALK tyrosine kinase receptor2.7.10.10.474
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.472
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.472
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
3efwAK8Aurora kinase A2.7.11.10.470
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.470
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.470
5l8lADPAurora kinase A2.7.11.10.470
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.469
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
2qo9ANPEphrin type-A receptor 32.7.10.10.468
2x9fX9FEphrin type-B receptor 42.7.10.10.468
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.468
4gk3L87Ephrin type-A receptor 32.7.10.10.468
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.467
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.467
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.467
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.467
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.467
3zewSTUEphrin type-B receptor 42.7.10.10.467
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
5aabVGHALK tyrosine kinase receptor2.7.10.10.467
4b99R4LMitogen-activated protein kinase 72.7.11.240.466
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.466
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.466
2xb7GUIALK tyrosine kinase receptor2.7.10.10.465
4f650S9Fibroblast growth factor receptor 1/0.465
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.465
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.464
3e5aVX6Aurora kinase A2.7.11.10.464
3t8oATPRhodopsin kinase/0.464
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.463
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.463
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.463
4b8mVX6Aurora kinase B-A2.7.11.10.463
4qmzB49Serine/threonine-protein kinase 242.7.11.10.463
4qo9627Serine/threonine-protein kinase 242.7.11.10.463
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.462
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.462
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.462
4o0uADNAurora kinase A2.7.11.10.462
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.461
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.461
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.461
4y95746Tyrosine-protein kinase/0.461
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.460
3vthAPCCarbamoyltransferase/0.460
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.459
2etm7PYFocal adhesion kinase 12.7.10.20.459
2v7a627Tyrosine-protein kinase ABL12.7.10.20.459
3mtfA3FActivin receptor type-12.7.11.300.459
3ttiKBIMitogen-activated protein kinase 102.7.11.240.459
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.459
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.459
4c4jX21Dual specificity protein kinase TTK2.7.12.10.459
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.458
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.458
2yfxVGHALK tyrosine kinase receptor2.7.10.10.458
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.458
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
4jboWPHAurora kinase A2.7.11.10.458
4jia1K3Tyrosine-protein kinase JAK2/0.458
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.458
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.457
3a62STURibosomal protein S6 kinase beta-12.7.11.10.457
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.457
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.457
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.457
2w1eL0EAurora kinase A2.7.11.10.456
4bb432WEphrin type-B receptor 42.7.10.10.456
1i44ACPInsulin receptor2.7.10.10.455
2ckeIQUDeath-associated protein kinase 2/0.455
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.455
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.455
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.455
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.455
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.454
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.454
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.454
3gubGUBDeath-associated protein kinase 12.7.11.10.454
3qyw6PBMitogen-activated protein kinase 12.7.11.240.454
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4ccbOFGALK tyrosine kinase receptor2.7.10.10.454
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.453
3hllI45Mitogen-activated protein kinase 14/0.453
4brxKGWFocal adhesion kinase 12.7.10.20.453
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.453
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.453
2vx07X7Ephrin type-B receptor 42.7.10.10.452
2xneASHAurora kinase A2.7.11.10.452
3ggfGVDSerine/threonine-protein kinase 26/0.452
4i4e1BQFocal adhesion kinase 12.7.10.20.452
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.451
2vwz7X6Ephrin type-B receptor 42.7.10.10.451
3a7hATPSerine/threonine-protein kinase 242.7.11.10.451
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.451
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.451
4c57FEFCyclin-G-associated kinase2.7.11.10.451
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.451
4gk2L66Ephrin type-A receptor 32.7.10.10.451
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.451
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.450
4bgg844Activin receptor type-12.7.11.300.450
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1u54ACPActivated CDC42 kinase 1/0.449
2itnANPEpidermal growth factor receptor2.7.10.10.449
2qoqANPEphrin type-A receptor 32.7.10.10.449
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3w16P9JAurora kinase A2.7.11.10.449
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.449
4g2fC07Ephrin type-A receptor 32.7.10.10.449
1mqbANPEphrin type-A receptor 22.7.10.10.448
1ol6ATPAurora kinase A2.7.11.10.448
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.448
4dymIYZActivin receptor type-12.7.11.300.448
4ix5ANPUncharacterized protein/0.448
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1zrzBI1Protein kinase C iota type2.7.11.130.447
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.447
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.447
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4c62XWWTyrosine-protein kinase JAK2/0.447
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.447
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.446
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.446
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.446
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.446
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.445
2vrx447Aurora kinase B-A2.7.11.10.445
3a1nNADNDP-sugar epimerase/0.445
3gu83GUDeath-associated protein kinase 12.7.11.10.445
3nxe2NCProtease/0.445
4fv6E57Mitogen-activated protein kinase 12.7.11.240.445
5e8xSTUTGF-beta receptor type-12.7.11.300.445
1pmn984Mitogen-activated protein kinase 102.7.11.240.444
1xjdSTUProtein kinase C theta type2.7.11.130.444
2jkqVG8Focal adhesion kinase 12.7.10.20.444
2qi6MZ8Gag-Pol polyprotein/0.444
2wqeADPAurora kinase A2.7.11.10.444
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.444
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.444
4c4f7CEDual specificity protein kinase TTK2.7.12.10.444
4gmy0X5Tyrosine-protein kinase JAK2/0.444
4qgiROCGag-Pol polyprotein3.4.23.160.444
5dr6SKEAurora kinase A2.7.11.10.444
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.443
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.443
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.443
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.443
2q9fC3SCholesterol 24-hydroxylase/0.443
2qhcAB1Protease/0.443
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.443
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.443
3i60E86Mitogen-activated protein kinase 12.7.11.240.443
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.443
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.443
1c6x3INProtease/0.442
1eh4IC1Casein kinase I homolog 12.7.11.10.442
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.442
2pwlACPFibroblast growth factor receptor 2/0.442
2vwx7X4Ephrin type-B receptor 42.7.10.10.442
2wxvWXVCyclin-dependent kinase 22.7.11.220.442
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.442
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.442
4ez50RSCyclin-dependent kinase 62.7.11.220.442
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.442
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.442
4o4eATPKinase/0.442
5av3KMPDeath-associated protein kinase 12.7.11.10.442
1difA85Gag-Pol polyprotein/0.441
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2xru400Aurora kinase A2.7.11.10.441
2xrwANPMitogen-activated protein kinase 82.7.11.240.441
3c4xATPRhodopsin kinase/0.441
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.441
3ndxRITGag-Pol polyprotein3.4.23.160.441
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.441
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.441
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.441
4id71G0Activated CDC42 kinase 1/0.441
1vjy460TGF-beta receptor type-12.7.11.300.440
2cig1DGDihydrofolate reductase1.5.1.30.440
2itpAEEEpidermal growth factor receptor2.7.10.10.440
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.440
3linE13Protease/0.440
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.440
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3o9cK20Pol polyprotein/0.440
3slkNDPPolyketide synthase extender module 2/0.440
4c02TAKActivin receptor type-12.7.11.300.440
4jbqVX6Aurora kinase A2.7.11.10.440
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.440