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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xyvFMNFlavodoxin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1xyvFMNFlavodoxin/1.000
2fx2FMNFlavodoxin/0.625
1akwFMNFlavodoxin/0.587
3kapFMNFlavodoxin/0.584
1fx1FMNFlavodoxin/0.575
4fx2FMNFlavodoxin/0.569
1azlFMNFlavodoxin/0.568
1j9gFMNFlavodoxin/0.563
1bu5RBFFlavodoxin/0.562
3f6rFMNFlavodoxin/0.560
5xraFMNCannabinoid receptor 1/0.560
1wsbFMNFlavodoxin/0.558
3f90FMNFlavodoxin/0.554
1j8qFMNFlavodoxin/0.551
1xyyFMNFlavodoxin/0.545
5tgzFMNCannabinoid receptor 1/0.545
5fx2FMNFlavodoxin/0.543
2bf4FMNNADPH--cytochrome P450 reductase/0.528
3kaqFMNFlavodoxin/0.528
1akrFMNFlavodoxin/0.522
3ojxFMNNADPH--cytochrome P450 reductase/0.520
1c7fFMNFlavodoxin/0.510
3ojwFMNNADPH--cytochrome P450 reductase/0.507
2fcrFMNFlavodoxin/0.503
3hr4FMNNitric oxide synthase, inducible1.14.13.390.497
1ykgFMNSulfite reductase [NADPH] flavoprotein alpha-component/0.495
1f20FADNitric oxide synthase, brain1.14.13.390.494
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.492
4y7cFMNNADPH--cytochrome P450 reductase/0.492
5xr8FMNCannabinoid receptor 1/0.490
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.487
1ja0FMNNADPH--cytochrome P450 reductase/0.486
2bpoFADNADPH--cytochrome P450 reductase/0.486
1j9zFMNNADPH--cytochrome P450 reductase/0.484
2bn4FMNNADPH--cytochrome P450 reductase/0.483
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.483
1tllFMNNitric oxide synthase, brain1.14.13.390.481
3fpkFADFerredoxin-NADP reductase/0.480
5d0rB1TAdenylate cyclase type 10/0.479
1pqc444Oxysterols receptor LXR-beta/0.478
2qimZEAClass 10 plant pathogenesis-related protein/0.476
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.476
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.476
3jqrFADFerredoxin--NADP reductase, apicoplast/0.475
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.473
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.472
4c43FADFerredoxin--NADP reductase1.18.1.20.472
2pncCLUPrimary amine oxidase, liver isozyme/0.471
2r8pT6FTransketolase 1/0.471
1bjkFADFerredoxin--NADP reductase1.18.1.20.470
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.470
3f6sFMNFlavodoxin/0.470
1v3q2DIPurine nucleoside phosphorylase2.4.2.10.469
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.469
3q9bB3NAcetylpolyamine amidohydrolase/0.468
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.468
1akuFMNFlavodoxin/0.467
2bf4FADNADPH--cytochrome P450 reductase/0.467
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.467
5stdUNNScytalone dehydratase4.2.1.940.467
2g1n1IGRenin3.4.23.150.466
1fueFMNFlavodoxin/0.465
1lnmDTXBilin-binding protein/0.465
1zgbA1EAcetylcholinesterase3.1.1.70.465
2mt9FMNFlavodoxin 2/0.465
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.465
4oxxFMNCindoxin/0.465
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.464
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.464
3fhxPLPPyridoxal kinase2.7.1.350.463
3w5uFADFerredoxin/0.463
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.463
4wx2F6FTryptophan synthase alpha chain/0.463
4wx2F6FTryptophan synthase beta chain4.2.1.200.463
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.462
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.462
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.461
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.461
1cznFMNFlavodoxin/0.460
1n9mBTNStreptavidin/0.460
1sdwIYTPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.460
2xlpNAPPutative flavin-containing monooxygenase/0.460
4b1hAR6Poly(ADP-ribose) glycohydrolase3.2.1.1430.460
2ym1FADPhenylacetone monooxygenase1.14.13.920.459
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3go4SAHUncharacterized protein/0.459
3phiNDPShikimate dehydrogenase (NADP(+))/0.459
3qe2FMNNADPH--cytochrome P450 reductase/0.459
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.458
2b82ADNClass B acid phosphatase3.1.3.20.458
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.458
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.458
4kbyC2EStimulator of interferon genes protein/0.458
2b5oFADFerredoxin--NADP reductase1.18.1.20.457
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
1obnASVIsopenicillin N synthase1.21.3.10.456
2v5uFMNFlavodoxin/0.456
2xlsNAPPutative flavin-containing monooxygenase/0.456
3gwfFADCyclohexanone monooxygenase/0.456
4jtqNAPAldo-keto reductase family 1 member C2/0.456
1gaqFADFerredoxin/0.455
1pq944BOxysterols receptor LXR-beta/0.455
4jtrIZPAldo-keto reductase family 1 member C2/0.455
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.455
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.454
2a9z26AAdenosine kinase2.7.1.200.454
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.454
2x7hPFNProstaglandin reductase 310.454
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3wtkTH4Acetylcholine-binding protein/0.454
1h42FADFerredoxin--NADP reductase1.18.1.20.453
2vkeTACTetracycline repressor protein class D/0.453
2x06NADL-sulfolactate dehydrogenase/0.453
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
4b68FADL-ornithine N(5)-monooxygenase/0.453
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.453
1odjGMPPurine nucleoside phosphorylase/0.452
1rkwPNTHTH-type transcriptional regulator QacR/0.452
3aosJH2Hemolymph juvenile hormone binding protein/0.452
4at0FADPossible succinate dehydrogenase/0.452
1ahnFMNFlavodoxin 1/0.451
1h69ARHNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1jqdSAHHistamine N-methyltransferase2.1.1.80.451
1ofvFMNFlavodoxin/0.451
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.451
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.451
3wqmB29Diterpene synthase3.1.7.80.451
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.451
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.451
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.451
2mokFMNFlavodoxin 1/0.450
2whqHI6Acetylcholinesterase3.1.1.70.450
2xi4AFTAcetylcholinesterase3.1.1.70.450
2zwaSAHtRNA wybutosine-synthesizing protein 42.1.1.2900.450
2zz0FADThioredoxin reductase 1, cytoplasmic1.8.1.90.450
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3g5mFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.450
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.450
3v49PK0Androgen receptor/0.450
3zkyWT4Isopenicillin N synthase1.21.3.10.450
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.450
4dk70KSOxysterols receptor LXR-beta/0.450
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.450
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.450
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.449
2w3mFOLDihydrofolate reductase1.5.1.30.449
3c14FOKAdenylate cyclase type 2/0.449
3c14FOKAdenylate cyclase type 5/0.449
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3f0aACOSpermidine N(1)-acetyltransferase/0.449
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4n3l2FNProthrombin3.4.21.50.449
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.449
5a4vQUEGlutathione S-transferase F22.5.1.180.449
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.448
1xddAAYIntegrin alpha-L/0.448
2b8jADNClass B acid phosphatase3.1.3.20.448
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.448
2gvdFKPAdenylate cyclase type 2/0.448
2gvdFKPAdenylate cyclase type 5/0.448
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.448
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.448
4b7zQ4QAcetylcholinesterase3.1.1.70.448
4twnB96Ephrin type-A receptor 32.7.10.10.448
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.447
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.447
3fr5I4AFatty acid-binding protein, adipocyte/0.447
3fznD7KBenzoylformate decarboxylase4.1.1.70.447
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3pm1ETHTH-type transcriptional regulator QacR/0.447
4bmpFMNProtein NrdI/0.447
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.447
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1qrsATPGlutamine--tRNA ligase6.1.1.180.446
2c20NADUDP-glucose 4-epimerase/0.446
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.446
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.446
3kozZ97D-ornithine 4,5-aminomutase subunit beta/0.446
3qfrFMNNADPH--cytochrome P450 reductase/0.446
4gi5FADPutative NAD(P)H dehydrogenase (Quinone)/0.446
4hh4SAHCcbJ/0.446
1e64FADFerredoxin--NADP reductase1.18.1.20.445
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.445
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.445
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.445
3lkhLT6Genome polyprotein2.7.7.480.445
3mauEXTPutative sphingosine-1-phosphate lyase/0.445
3rsv3RSBeta-secretase 13.4.23.460.445
4nv0MG77-methylguanosine phosphate-specific 5'-nucleotidase/0.445
4xj43ATCyclic GMP-AMP synthase/0.445
4xxgFADCholesterol oxidase1.1.3.60.445
5irnADPNucleotide binding oligomerization domain containing 2/0.445
1nqw5YL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.444
3ojxFADNADPH--cytochrome P450 reductase/0.444
3wagTYDGlycosyltransferase/0.444
4a86H35Major pollen allergen Bet v 1-A/0.444
4ey6GNTAcetylcholinesterase3.1.1.70.444
1hfqMOTDihydrofolate reductase1.5.1.30.443
1lrmHBIPhenylalanine-4-hydroxylase1.14.16.10.443
1ut6A8NAcetylcholinesterase3.1.1.70.443
2aj4ANPGalactokinase2.7.1.60.443
2g247IGRenin3.4.23.150.443
2jh5895Prothrombin3.4.21.50.443
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.443
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.443
4e32DWNMethyltransferase/0.443
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.443
1a9cGTPGTP cyclohydrolase 13.5.4.160.442
1c7oPPGHemolysin/0.442
1gjrFADFerredoxin--NADP reductase1.18.1.20.442
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.442
1pl6572Sorbitol dehydrogenase1.1.1.140.442
1qtiGNTAcetylcholinesterase3.1.1.70.442
1vf3GDNGlutathione S-transferase 32.5.1.180.442
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.442
2jh6894Prothrombin3.4.21.50.442
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3lm8VIBThiamine pyrophosphokinase2.7.6.20.442
3rpeFADPutative modulator of drug activity/0.442
3zj7C1KStrictosidine-O-beta-D-glucosidase3.2.1.1050.442
4h1e10JBeta-secretase 13.4.23.460.442
1cjtFOKAdenylate cyclase type 2/0.441
1cjtFOKAdenylate cyclase type 5/0.441
1ogiFADFerredoxin--NADP reductase1.18.1.20.441
1z71L17Prothrombin3.4.21.50.441
2cmfF11Acetylcholinesterase3.1.1.70.441
2e1zB4PPropionate kinase/0.441
2v13C40Renin3.4.23.150.441
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
4ax9N5NProthrombin3.4.21.50.441
4jq3NAPAldo-keto reductase family 1 member C2/0.441
1cs4FOKAdenylate cyclase type 2/0.440
1cs4FOKAdenylate cyclase type 5/0.440
1jdzFMBPurine nucleoside phosphorylase/0.440
1lkeDOGBilin-binding protein/0.440
1x8lOXRRetinol dehydratase/0.440
2rqfJH3Hemolymph juvenile hormone binding protein/0.440
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3nxvD2FDihydrofolate reductase1.5.1.30.440
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.440
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.440
4n9qFMNFMN-dependent NADH-azoreductase 1/0.440
4u140HKMuscarinic acetylcholine receptor M3/0.440