Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
1xyv | FMN | Flavodoxin |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
1xyv | FMN | Flavodoxin | / | 1.000 | |
2fx2 | FMN | Flavodoxin | / | 0.625 | |
1akw | FMN | Flavodoxin | / | 0.587 | |
3kap | FMN | Flavodoxin | / | 0.584 | |
1fx1 | FMN | Flavodoxin | / | 0.575 | |
4fx2 | FMN | Flavodoxin | / | 0.569 | |
1azl | FMN | Flavodoxin | / | 0.568 | |
1j9g | FMN | Flavodoxin | / | 0.563 | |
1bu5 | RBF | Flavodoxin | / | 0.562 | |
3f6r | FMN | Flavodoxin | / | 0.560 | |
5xra | FMN | Cannabinoid receptor 1 | / | 0.560 | |
1wsb | FMN | Flavodoxin | / | 0.558 | |
3f90 | FMN | Flavodoxin | / | 0.554 | |
1j8q | FMN | Flavodoxin | / | 0.551 | |
1xyy | FMN | Flavodoxin | / | 0.545 | |
5tgz | FMN | Cannabinoid receptor 1 | / | 0.545 | |
5fx2 | FMN | Flavodoxin | / | 0.543 | |
2bf4 | FMN | NADPH--cytochrome P450 reductase | / | 0.528 | |
3kaq | FMN | Flavodoxin | / | 0.528 | |
1akr | FMN | Flavodoxin | / | 0.522 | |
3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.520 | |
1c7f | FMN | Flavodoxin | / | 0.510 | |
3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.507 | |
2fcr | FMN | Flavodoxin | / | 0.503 | |
3hr4 | FMN | Nitric oxide synthase, inducible | 1.14.13.39 | 0.497 | |
1ykg | FMN | Sulfite reductase [NADPH] flavoprotein alpha-component | / | 0.495 | |
1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.494 | |
3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.492 | |
4y7c | FMN | NADPH--cytochrome P450 reductase | / | 0.492 | |
5xr8 | FMN | Cannabinoid receptor 1 | / | 0.490 | |
4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.487 | |
1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.486 | |
2bpo | FAD | NADPH--cytochrome P450 reductase | / | 0.486 | |
1j9z | FMN | NADPH--cytochrome P450 reductase | / | 0.484 | |
2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.483 | |
2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.483 | |
1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.481 | |
3fpk | FAD | Ferredoxin-NADP reductase | / | 0.480 | |
5d0r | B1T | Adenylate cyclase type 10 | / | 0.479 | |
1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.478 | |
2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.476 | |
3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.476 | |
3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.476 | |
3jqr | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.475 | |
3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.473 | |
4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.472 | |
4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.472 | |
2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.471 | |
2r8p | T6F | Transketolase 1 | / | 0.471 | |
1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.470 | |
2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.470 | |
3f6s | FMN | Flavodoxin | / | 0.470 | |
1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.469 | |
3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.468 | |
4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
1aku | FMN | Flavodoxin | / | 0.467 | |
2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.467 | |
4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.467 | |
5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.467 | |
2g1n | 1IG | Renin | 3.4.23.15 | 0.466 | |
1fue | FMN | Flavodoxin | / | 0.465 | |
1lnm | DTX | Bilin-binding protein | / | 0.465 | |
1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
2mt9 | FMN | Flavodoxin 2 | / | 0.465 | |
4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.465 | |
4oxx | FMN | Cindoxin | / | 0.465 | |
4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.464 | |
3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
3w5u | FAD | Ferredoxin | / | 0.463 | |
4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.463 | |
4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.463 | |
4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.463 | |
3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.462 | |
1qk3 | 5GP | Hypoxanthine-guanine-xanthine phosphoribosyltransferase | 2.4.2.22 | 0.461 | |
4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
1czn | FMN | Flavodoxin | / | 0.460 | |
1n9m | BTN | Streptavidin | / | 0.460 | |
1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.460 | |
2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.460 | |
4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.460 | |
2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.459 | |
3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
3go4 | SAH | Uncharacterized protein | / | 0.459 | |
3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.459 | |
3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.459 | |
1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.458 | |
2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.458 | |
2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.458 | |
4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.458 | |
4kby | C2E | Stimulator of interferon genes protein | / | 0.458 | |
2b5o | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
2v5u | FMN | Flavodoxin | / | 0.456 | |
2xls | NAP | Putative flavin-containing monooxygenase | / | 0.456 | |
3gwf | FAD | Cyclohexanone monooxygenase | / | 0.456 | |
4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
1gaq | FAD | Ferredoxin | / | 0.455 | |
1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.455 | |
4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
4kfq | KFQ | Glutamate receptor ionotropic, NMDA 1 | / | 0.455 | |
1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.454 | |
2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.454 | |
2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.454 | |
3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
3wtk | TH4 | Acetylcholine-binding protein | / | 0.454 | |
1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.453 | |
2vke | TAC | Tetracycline repressor protein class D | / | 0.453 | |
2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.453 | |
3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.453 | |
4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.453 | |
1odj | GMP | Purine nucleoside phosphorylase | / | 0.452 | |
1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.452 | |
3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.452 | |
4at0 | FAD | Possible succinate dehydrogenase | / | 0.452 | |
1ahn | FMN | Flavodoxin 1 | / | 0.451 | |
1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.451 | |
1ofv | FMN | Flavodoxin | / | 0.451 | |
1oxo | IK2 | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.451 | |
1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.451 | |
3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.451 | |
4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.451 | |
4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.451 | |
2mok | FMN | Flavodoxin 1 | / | 0.450 | |
2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
2zwa | SAH | tRNA wybutosine-synthesizing protein 4 | 2.1.1.290 | 0.450 | |
2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.450 | |
3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
3g5m | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.450 | |
3ho9 | N3A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.450 | |
3v49 | PK0 | Androgen receptor | / | 0.450 | |
3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.450 | |
4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.450 | |
4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.450 | |
1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.449 | |
2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
3c14 | FOK | Adenylate cyclase type 2 | / | 0.449 | |
3c14 | FOK | Adenylate cyclase type 5 | / | 0.449 | |
3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.449 | |
4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.449 | |
4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.449 | |
5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.449 | |
1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.448 | |
1xdd | AAY | Integrin alpha-L | / | 0.448 | |
2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.448 | |
2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.448 | |
2gvd | FKP | Adenylate cyclase type 2 | / | 0.448 | |
2gvd | FKP | Adenylate cyclase type 5 | / | 0.448 | |
3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.448 | |
3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.448 | |
4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.447 | |
3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.447 | |
3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.447 | |
3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.447 | |
4bmp | FMN | Protein NrdI | / | 0.447 | |
4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.447 | |
1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
1qrs | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.446 | |
2c20 | NAD | UDP-glucose 4-epimerase | / | 0.446 | |
2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.446 | |
3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.446 | |
3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
4gi5 | FAD | Putative NAD(P)H dehydrogenase (Quinone) | / | 0.446 | |
4hh4 | SAH | CcbJ | / | 0.446 | |
1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.445 | |
2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.445 | |
3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.445 | |
3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.445 | |
3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
4nv0 | MG7 | 7-methylguanosine phosphate-specific 5'-nucleotidase | / | 0.445 | |
4xj4 | 3AT | Cyclic GMP-AMP synthase | / | 0.445 | |
4xxg | FAD | Cholesterol oxidase | 1.1.3.6 | 0.445 | |
5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.445 | |
1nqw | 5YL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
1xh7 | R96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.444 | |
3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
3ojx | FAD | NADPH--cytochrome P450 reductase | / | 0.444 | |
3wag | TYD | Glycosyltransferase | / | 0.444 | |
4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.444 | |
4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
1lrm | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.443 | |
1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.443 | |
2g24 | 7IG | Renin | 3.4.23.15 | 0.443 | |
2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.443 | |
3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.443 | |
4e32 | DWN | Methyltransferase | / | 0.443 | |
4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.443 | |
1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.442 | |
1c7o | PPG | Hemolysin | / | 0.442 | |
1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.442 | |
1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
1vf3 | GDN | Glutathione S-transferase 3 | 2.5.1.18 | 0.442 | |
2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.442 | |
2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.442 | |
3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
3lm8 | VIB | Thiamine pyrophosphokinase | 2.7.6.2 | 0.442 | |
3rpe | FAD | Putative modulator of drug activity | / | 0.442 | |
3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.442 | |
4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
1cjt | FOK | Adenylate cyclase type 2 | / | 0.441 | |
1cjt | FOK | Adenylate cyclase type 5 | / | 0.441 | |
1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
1z71 | L17 | Prothrombin | 3.4.21.5 | 0.441 | |
2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
2e1z | B4P | Propionate kinase | / | 0.441 | |
2v13 | C40 | Renin | 3.4.23.15 | 0.441 | |
3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.441 | |
4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
1cs4 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
1cs4 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
1jdz | FMB | Purine nucleoside phosphorylase | / | 0.440 | |
1lke | DOG | Bilin-binding protein | / | 0.440 | |
1x8l | OXR | Retinol dehydratase | / | 0.440 | |
2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.440 | |
3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.440 | |
4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.440 | |
4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.440 |