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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xkkFMMEpidermal growth factor receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1xkkFMMEpidermal growth factor receptor2.7.10.11.000
3w33W19Epidermal growth factor receptor2.7.10.10.663
3w32W32Epidermal growth factor receptor2.7.10.10.618
3poz03PEpidermal growth factor receptor2.7.10.10.617
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.611
3w2sW2REpidermal growth factor receptor2.7.10.10.587
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.580
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.559
3vs3VSETyrosine-protein kinase HCK2.7.10.20.558
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.558
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.551
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.546
3vryB43Tyrosine-protein kinase HCK2.7.10.20.543
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.543
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.542
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.539
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.535
4i22IREEpidermal growth factor receptor2.7.10.10.533
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.529
4hjoAQ4Epidermal growth factor receptor2.7.10.10.527
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.513
3gxlQIGTGF-beta receptor type-12.7.11.300.510
3vt7VDXVitamin D3 receptor/0.508
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.501
4a6cQG9Gag-Pol polyprotein3.4.23.160.501
2itzIREEpidermal growth factor receptor2.7.10.10.499
3hmm855TGF-beta receptor type-12.7.11.300.499
1vjy460TGF-beta receptor type-12.7.11.300.496
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.494
1m17AQ4Epidermal growth factor receptor2.7.10.10.493
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.493
5e8wSTUTGF-beta receptor type-12.7.11.300.493
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.492
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.491
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.491
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.491
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.490
2wotZZGTGF-beta receptor type-12.7.11.300.489
3l8p0CEAngiopoietin-1 receptor2.7.10.10.489
1u4dDBQActivated CDC42 kinase 1/0.488
2wouZZFTGF-beta receptor type-12.7.11.300.487
3vt9YI4Vitamin D3 receptor/0.487
4hvh19RTyrosine-protein kinase JAK32.7.10.20.487
4jq7KJQEpidermal growth factor receptor2.7.10.10.487
4id71G0Activated CDC42 kinase 1/0.486
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.485
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.484
1iyzNDPProbable quinone oxidoreductase/0.483
4a6bQG8Gag-Pol polyprotein3.4.23.160.483
4jq8KJ8Epidermal growth factor receptor2.7.10.10.483
1sh9RITGag-Pol polyprotein3.4.23.160.482
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.482
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.482
4riyADPEpidermal growth factor receptor2.7.10.10.482
2bpw1INGag-Pol polyprotein3.4.23.160.481
3d1xROCGag-Pol polyprotein3.4.23.160.481
3zptM8YGag-Pol polyprotein3.4.23.160.481
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.480
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.480
2fdd385Pol protein/0.479
3ucb017Gag-Pol polyprotein/0.479
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.479
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.478
4jr3KJREpidermal growth factor receptor2.7.10.10.478
1u3dFADCryptochrome-1/0.477
2uxzHI1Gag-Pol polyprotein3.4.23.160.477
3linE13Protease/0.477
3jw2017Gag-Pol polyprotein3.4.23.160.476
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.476
1ida0POGag-Pol polyprotein3.4.23.470.475
4j54G52Gag-Pol polyprotein3.4.23.160.475
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.474
4b7dQLECytochrome P450 monooxygenase PikC/0.474
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.474
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.474
4zseANPEpidermal growth factor receptor2.7.10.10.474
2upjU02Gag-Pol polyprotein3.4.23.160.473
3tl9ROCGag-Pol polyprotein3.4.23.160.473
3tqhNDPQuinone oxidoreductase/0.473
1py5PY1TGF-beta receptor type-12.7.11.300.472
2uy0HV1Gag-Pol polyprotein3.4.23.160.472
3saa77FProtease/0.472
3t3c017Gag-Pol polyprotein3.4.23.160.472
4djqM86Pol polyprotein/0.472
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.472
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.471
3ekp478Gag-Pol polyprotein3.4.23.160.471
2itpAEEEpidermal growth factor receptor2.7.10.10.470
2pmdGNPTranslation initiation factor 2 subunit gamma/0.470
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.470
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.470
9hvp0E9Gag-Pol polyprotein/0.470
1c6yMK1Protease/0.469
1k6pXN3Gag-Pol polyprotein3.4.23.160.469
2xa4AZ5Tyrosine-protein kinase JAK2/0.469
3livE16Protease/0.469
3ogqAB1Pol polyprotein/0.469
3s56ROCProtease/0.469
4fnzNZFALK tyrosine kinase receptor2.7.10.10.469
1g35AHFGag-Pol polyprotein3.4.23.160.468
2avvMK1Gag-Pol polyprotein3.4.23.160.468
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.468
2hk51BMTyrosine-protein kinase HCK2.7.10.20.468
4wkqIREEpidermal growth factor receptor2.7.10.10.468
1aq1STUCyclin-dependent kinase 22.7.11.220.467
1c6zROCProtease/0.467
1hosPHPGag-Pol polyprotein/0.467
1w5vBE3Gag-Pol polyprotein3.4.23.160.467
2bb9AKCGag-Pol polyprotein3.4.23.160.467
2bpv1INGag-Pol polyprotein3.4.23.160.467
2h96893Mitogen-activated protein kinase 82.7.11.240.467
2nnpROCProtease/0.467
2qnqQN3Gag-Pol polyprotein3.4.23.160.467
2xyeCXGGag-Pol polyprotein/0.467
3ufnROCGag-Pol polyprotein/0.467
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.467
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.467
2rkfAB1Pol protein/0.466
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.466
3sacAF8Protease/0.466
3zpuM8BGag-Pol polyprotein3.4.23.160.466
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.466
4fk1FADPutative thioredoxin reductase/0.466
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.466
4nka2K7Fibroblast growth factor receptor 1/0.466
1npa3NHGag-Pol polyprotein3.4.23.160.465
1npwLGZGag-Pol polyprotein3.4.23.160.465
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2cen4AHProtease/0.465
2ieo017Protease/0.465
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.465
3w2rW2REpidermal growth factor receptor2.7.10.10.465
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.465
1bveDMPGag-Pol polyprotein3.4.23.160.464
2aquDR7Gag-Pol polyprotein3.4.23.160.464
2pk6O33V-1 protease/0.464
3cktYDPGag-Pol polyprotein3.4.23.160.464
4aa0AA0Mitogen-activated protein kinase 14/0.464
4gyiADPUncharacterized protein/0.464
4hvg19QTyrosine-protein kinase JAK32.7.10.20.464
4qgiROCGag-Pol polyprotein3.4.23.160.464
1d4kPI8Gag-Pol polyprotein3.4.23.160.463
1idb0DOGag-Pol polyprotein/0.463
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.463
1t7kBH0Gag-Pol polyprotein3.4.23.160.463
2bpy3INGag-Pol polyprotein3.4.23.160.463
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.463
3cyxROCGag-Pol polyprotein3.4.23.160.463
3nduROCGag-Pol polyprotein3.4.23.160.463
3vfa031Gag-Pol polyprotein3.4.23.160.463
3vs1VSATyrosine-protein kinase HCK2.7.10.20.463
1rw8580TGF-beta receptor type-12.7.11.300.462
2f8g017Gag-Pol polyprotein3.4.23.160.462
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.462
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.462
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.462
3el4ROCGag-Pol polyprotein3.4.23.160.462
3lfnA27Cyclin-dependent kinase 22.7.11.220.462
3nxe2NCProtease/0.462
3oom507Activin receptor type-12.7.11.300.462
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.462
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4djoMK5Pol polyprotein/0.462
4hdpG52Gag-Pol polyprotein3.4.23.160.462
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.462
4kiq1RAMitogen-activated protein kinase 14/0.462
4yuqKS1Calmodulin-like domain protein kinase/0.462
1difA85Gag-Pol polyprotein/0.461
1ec0BEDGag-Pol polyprotein3.4.23.160.461
1fm9570Peroxisome proliferator-activated receptor gamma/0.461
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.461
1rl8RITGag-Pol polyprotein3.4.23.160.461
2f3kRO1Protease/0.461
2r5pMK1Gag-Pol polyprotein/0.461
3gubGUBDeath-associated protein kinase 12.7.11.10.461
3i2l2NCProtease/0.461
3pwrROCGag-Pol polyprotein3.4.23.160.461
1b6mPI6Gag-Pol polyprotein3.4.23.160.460
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
2gs7ANPEpidermal growth factor receptor2.7.10.10.460
2om9AJAPeroxisome proliferator-activated receptor gamma/0.460
2p3c3TLProtease/0.460
3a2oKNJGag-Pol polyprotein3.4.23.160.460
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.460
3vf5031Gag-Pol polyprotein3.4.23.160.460
4b7sQLECytochrome P450 monooxygenase PikC/0.460
4nk92K5Fibroblast growth factor receptor 1/0.460
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.460
1bai0Q4Gag-Pro polyprotein/0.459
1ebk0Q4Gag-Pol polyprotein3.4.23.160.459
1jipKTN6-deoxyerythronolide B hydroxylase/0.459
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1sguMK1Gag-Pol polyprotein3.4.23.160.459
2vu3LZECyclin-dependent kinase 22.7.11.220.459
3cyw017Gag-Pol polyprotein3.4.23.160.459
3kfr3TLGag-Pol polyprotein/0.459
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.459
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.459
3upjU03Gag-Pol polyprotein/0.459
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.459
4j5j478Gag-Pol polyprotein3.4.23.160.459
4njsG08Protease/0.459
1hiiC20Gag-Pol polyprotein/0.458
1hxwRITGag-Pol polyprotein/0.458
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.458
1ivq0PXGag-Pol polyprotein/0.458
1jld0PPGag-Pol polyprotein/0.458
1muiAB1Protease/0.458
2csnCKICasein kinase I homolog 12.7.11.10.458
2idw017Protease/0.458
3aidARQGag-Pol polyprotein3.4.23.160.458
3ekwDR7Gag-Pol polyprotein3.4.23.160.458
3ggu017Gag-Pol polyprotein3.4.23.160.458
3kfs3TLGag-Pol polyprotein/0.458
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3orn3ORDual specificity mitogen-activated protein kinase kinase 12.7.12.20.458
3oxcROCProtease/0.458
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.458
3s85LK0Gag-Pol polyprotein/0.458
4jrvKJVEpidermal growth factor receptor2.7.10.10.458
4kbk1QGCasein kinase I isoform delta2.7.11.10.458
1bv7XV6Gag-Pol polyprotein3.4.23.160.457
1mrxK57Gag-Pol polyprotein3.4.23.160.457
1npvL27Gag-Pol polyprotein3.4.23.160.457
1u54ACPActivated CDC42 kinase 1/0.457
2nmyROCProtease/0.457
2p3a3TLPol protein/0.457
2q5g1FAPeroxisome proliferator-activated receptor delta/0.457
2wl05AHGag-Pol polyprotein/0.457
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.457
2xgs44PUncharacterized protein/0.457
3b70NAPEnoyl reductase LovC10.457
3em4DR7Gag-Pol polyprotein3.4.23.160.457
3uhl2NCGag-Pol polyprotein3.4.23.160.457
4djpM73Pol polyprotein/0.457
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1ec2BEJGag-Pol polyprotein3.4.23.160.456
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.456
3dcrKVSProtease/0.456
3el51UNGag-Pol polyprotein/0.456
3jvy017Gag-Pol polyprotein3.4.23.160.456
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.456
3ndtROCGag-Pol polyprotein3.4.23.160.456
3r9dX6BCyclin-dependent kinase 22.7.11.220.456
3t2zFADSulfide-quinone reductase/0.456
3vt8YI3Vitamin D3 receptor/0.456
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4ia7BIVVitamin D3 receptor A/0.456
5br4NADLactaldehyde reductase1.1.1.770.456
1bdrIM1Gag-Pol polyprotein3.4.23.160.455
1ebzBECGag-Pol polyprotein3.4.23.160.455
1hvjA78Gag-Pol polyprotein/0.455
1qrpHH0Pepsin A-43.4.23.10.455
1zyjBI5Mitogen-activated protein kinase 14/0.455
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
2hcdBIVVitamin D3 receptor A/0.455
2wkz5AHGag-Pol polyprotein/0.455
3ggxGGXGag-Pol polyprotein/0.455
3ttiKBIMitogen-activated protein kinase 102.7.11.240.455
4dymIYZActivin receptor type-12.7.11.300.455
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
5aaaVGHALK tyrosine kinase receptor2.7.10.10.455
1bdqIM1Gag-Pol polyprotein3.4.23.160.454
1d4lPI9Gag-Pol polyprotein3.4.23.160.454
1k6tXN1Gag-Pol polyprotein3.4.23.160.454
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1u3cFADCryptochrome-1/0.454
1yt9OISGag-Pol polyprotein/0.454
2qnpQN2Gag-Pol polyprotein3.4.23.160.454
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.454
2z3uCRRCytochrome P450/0.454
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.454
3mvl38PMitogen-activated protein kinase 14/0.454
3tmz06XCytochrome P450 2B41.14.14.10.454
3vt5YI2Vitamin D3 receptor/0.454
3zh8C58Protein kinase C iota type2.7.11.130.454
4djr0KJPol polyprotein/0.454
4r21STRCytochrome P450 family 17 polypeptide 2/0.454
1b16NAQAlcohol dehydrogenase1.1.1.10.453
1bvgDMPGag-Pol polyprotein3.4.23.160.453
1msnJE2Gag-Pol polyprotein3.4.23.160.453
1p0hACOMycothiol acetyltransferase2.3.1.1890.453
1t7i017Gag-Pol polyprotein3.4.23.160.453
1wbk568Pol protein/0.453
2g20L1ARenin3.4.23.150.453
2pwcG3GGag-Pol polyprotein3.4.23.160.453
2qd8065Gag-Pol polyprotein3.4.23.160.453
2qi3MZ5Gag-Pol polyprotein/0.453
3dk1G05Gag-Pol polyprotein3.4.23.160.453
3mtfA3FActivin receptor type-12.7.11.300.453
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.453
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
1d4sTPVGag-Pol polyprotein3.4.23.160.452
1ec1BEEGag-Pol polyprotein3.4.23.160.452
1ec3MS3Gag-Pol polyprotein3.4.23.160.452
1hviA77Protease/0.452
1jioDEB6-deoxyerythronolide B hydroxylase/0.452
1kzkJE2Gag-Pol polyprotein3.4.23.160.452
1xl2189Gag-Pol polyprotein3.4.23.160.452
1yb5NAPQuinone oxidoreductase1.6.5.50.452
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.452
2fxeDR7Gag-Pol polyprotein3.4.23.160.452
2izrBRKCasein kinase I isoform gamma-32.7.11.10.452
3ekx1UNGag-Pol polyprotein3.4.23.160.452
3gi6D78Gag-Pol polyprotein/0.452
4b7xNAPProbable oxidoreductase/0.452
4f650S9Fibroblast growth factor receptor 1/0.452
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.452
4fmqANPMitogen-activated protein kinase 12.7.11.240.452
5e8xSTUTGF-beta receptor type-12.7.11.300.452
1hpoUNIGag-Pol polyprotein3.4.23.160.451
1hvkA79Gag-Pol polyprotein/0.451
1mesDMPGag-Pol polyprotein3.4.23.160.451
1xl5190Gag-Pol polyprotein3.4.23.160.451
1zhwHC2Oxysterol-binding protein homolog 4/0.451
2bqvA1AProtease/0.451
2duv371Cyclin-dependent kinase 22.7.11.220.451
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.451
2nnkROCProtease/0.451
3hllI45Mitogen-activated protein kinase 14/0.451
3qlrNDPDihydrofolate reductase1.5.1.30.451
3rj9NADAlcohol dehydrogenase1.1.1.10.451
3sa9A68Protease/0.451
4bfxZVXPantothenate kinase2.7.1.330.451
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.451
4btkDTQTau-tubulin kinase 12.7.11.10.451
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.451
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4ih8B43Calmodulin-domain protein kinase 1/0.451
4k4p3TLGag-Pol polyprotein/0.451
4x5jFOLDihydrofolate reductase1.5.1.30.451
7upjINUGag-Pol polyprotein3.4.23.160.451
1hvsA77Gag-Pol polyprotein/0.450
1k2b0Q4Gag-Pol polyprotein3.4.23.160.450
1z1hHBBGag-Pol polyprotein3.4.23.160.450
2pobGW4Peroxisome proliferator-activated receptor gamma/0.450
2pyn1UNGag-Pol polyprotein3.4.23.160.450
2qci065Gag-Pol polyprotein3.4.23.160.450
2qi5MZ7Gag-Pol polyprotein/0.450
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3v9y24LPeroxisome proliferator-activated receptor gamma/0.450
3w0aDS5Vitamin D3 receptor/0.450
3wmxNADNAD dependent epimerase/dehydratase/0.450
3zpsEQMGag-Pol polyprotein3.4.23.160.450
4e4m0NHTyrosine-protein kinase JAK2/0.450
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.450
4ruoBIVVitamin D3 receptor A/0.450
5upjUINGag-Pol polyprotein/0.450
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1iziQ50Gag-Pol polyprotein3.4.23.160.449
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1tcxIM1Gag-Pol polyprotein3.4.23.160.449
2a4fAAUV-1 protease/0.449
2aoe0Q4Gag-Pol polyprotein3.4.23.160.449
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.449
2b7zMK1Gag-Pol polyprotein/0.449
2cciATPCyclin-dependent kinase 22.7.11.220.449
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.449
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
3litE15Protease/0.449
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
3o9aK14Pol polyprotein/0.449
3oxv478Gag-Pol polyprotein3.4.23.160.449
3w0c6DSVitamin D3 receptor/0.449
3zk5Z18Cytochrome P450 monooxygenase PikC/0.449
4dce0JFALK tyrosine kinase receptor2.7.10.10.449
4hdfG52Gag-Pol polyprotein3.4.23.160.449
4ix5ANPUncharacterized protein/0.449
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.449
4jx1CAHCamphor 5-monooxygenase1.14.15.10.449
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.449
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.449
4ye3G04Gag-Pol polyprotein3.4.23.160.449
5av2KMPDeath-associated protein kinase 12.7.11.10.449
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.449
1b6pPI7Gag-Pol polyprotein3.4.23.160.448
1d4hBEHGag-Pol polyprotein3.4.23.160.448
1k2c0Q4Gag-Pol polyprotein3.4.23.160.448
1k6vXN2Gag-Pol polyprotein3.4.23.160.448
1odw0E8Gag-Pol polyprotein3.4.23.160.448
2b60RITPol polyprotein/0.448
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.448
2fleAIProtease/0.448
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.448
3ec0GRLGag-Pol polyprotein3.4.23.470.448
3ndxRITGag-Pol polyprotein3.4.23.160.448
3nu5478Gag-Pol polyprotein3.4.23.160.448
3qroNK9Gag-Pol polyprotein3.4.23.160.448
3r9oZ71Cyclin-dependent kinase 22.7.11.220.448
3uvp048Mitogen-activated protein kinase 14/0.448
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4ic7ANPMitogen-activated protein kinase 72.7.11.240.448
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.448
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.448
4rvj478Protease/0.448
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.447
1bygSTUTyrosine-protein kinase CSK/0.447
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.447
2i4xKGQProtease/0.447
2q5kAB1Protease/0.447
2y05NAPProstaglandin reductase 1/0.447
2y6o1N1Ephrin type-A receptor 42.7.10.10.447
2znoS44Peroxisome proliferator-activated receptor gamma/0.447
3b20NADGlyceraldehyde-3-phosphate dehydrogenase/0.447
3cukFADD-amino-acid oxidase1.4.3.30.447
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.447
3le62BZCyclin-dependent kinase 22.7.11.220.447
3rm618ZCyclin-dependent kinase 22.7.11.220.447
3sa8K83Protease/0.447
4i231C9Epidermal growth factor receptor2.7.10.10.447
1b6kPI5Gag-Pol polyprotein3.4.23.160.446
1hvlA76Gag-Pol polyprotein/0.446
1k6cMK1Gag-Pol polyprotein3.4.23.160.446
1ohr1UNV-1 PROTEASE protein/0.446
2hs1017Protease/0.446
2i0dMUTProtease/0.446
2itnANPEpidermal growth factor receptor2.7.10.10.446
2izsBRQCasein kinase I isoform gamma-32.7.11.10.446
2r43G3GGag-Pol polyprotein3.4.23.160.446
2rewREWPeroxisome proliferator-activated receptor alpha/0.446
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.446
3clyACPFibroblast growth factor receptor 2/0.446
3ekqROCGag-Pol polyprotein3.4.23.160.446
3gi5K62Gag-Pol polyprotein/0.446
3nyg2NCGag-Pol polyprotein3.4.23.160.446
3qn8NI7Gag-Pol polyprotein3.4.23.160.446
3uyt0CKCasein kinase I isoform delta2.7.11.10.446
3vrwYS5Vitamin D3 receptor/0.446
4dqc017Gag-Pol polyprotein/0.446
4gmy0X5Tyrosine-protein kinase JAK2/0.446
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
1d4jMSCGag-Pol polyprotein3.4.23.160.445
1ebyBEBGag-Pol polyprotein3.4.23.160.445
1sbgIM1Gag-Pol polyprotein/0.445
1y0s331Peroxisome proliferator-activated receptor delta/0.445
1z1rHBHGag-Pol polyprotein3.4.23.160.445
2a4lRRCCyclin-dependent kinase 22.7.11.220.445
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.445
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.445
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.445
2pwlACPFibroblast growth factor receptor 2/0.445
2x1nX1NCyclin-dependent kinase 22.7.11.220.445
2xyfG40Gag-Pol polyprotein/0.445
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.445
3ac1KZITyrosine-protein kinase Lck2.7.10.20.445
3frqERYErythromycin resistance repressor protein/0.445
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3lzv017Gag-Pol polyprotein3.4.23.160.445
3nynSGVG protein-coupled receptor kinase 62.7.11.160.445
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.445
3uvqFS8Mitogen-activated protein kinase 14/0.445
4hgs15GCasein kinase I isoform gamma-32.7.11.10.445
4njuTPVProtease/0.445
4ysjADPCalmodulin-like domain protein kinase/0.445
5itzLOCTubulin beta-2B chain/0.445
6gswGPSGlutathione S-transferase Mu 12.5.1.180.445
1c70L75Protease/0.444
1hxbROCGag-Pol polyprotein3.4.23.160.444
1iiq0ZRGag-Pol polyprotein3.4.23.160.444
1zz2B11Mitogen-activated protein kinase 14/0.444
2ca0PXICytochrome P450 monooxygenase PikC/0.444
2harOCCVitamin D3 receptor/0.444
2hs2017Protease/0.444
2o0uC0MMitogen-activated protein kinase 102.7.11.240.444
2p4yC03Peroxisome proliferator-activated receptor gamma/0.444
2p5uNADUDP-glucose 4-epimerase/0.444
2rghFADAlpha-Glycerophosphate Oxidase/0.444
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.444
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.444
3hzc2NCProtease/0.444
3kpkFADSulfide-quinone reductase/0.444
3l0lHC3Nuclear receptor ROR-gamma/0.444
3oxxDR7Gag-Pol polyprotein3.4.23.160.444
3qrsNK8Gag-Pol polyprotein3.4.23.160.444
3qyw6PBMitogen-activated protein kinase 12.7.11.240.444
3sa755AProtease/0.444
3tdaPN0Cytochrome P450 2D6/0.444
4g3jVNTLanosterol 14-alpha-demethylase/0.444
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
4hdbG52Gag-Pol polyprotein3.4.23.160.444
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.444
4njvRITProtease/0.444
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.444
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.444
5jlaNADPutative short-chain dehydrogenase/reductase/0.444
1h0w207Cyclin-dependent kinase 22.7.11.220.443
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.443
1jklANPDeath-associated protein kinase 12.7.11.10.443
1k1u0Q4Gag-Pol polyprotein3.4.23.160.443
1mtrPI6Gag-Pol polyprotein3.4.23.160.443
1qbsDMPGag-Pol polyprotein3.4.23.160.443
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
1sduMK1Gag-Pol polyprotein3.4.23.160.443
1w5xBE5Gag-Pol polyprotein3.4.23.160.443
1xddAAYIntegrin alpha-L/0.443
1ykr628Cyclin-dependent kinase 22.7.11.220.443
2p33J07Mitogen-activated protein kinase 102.7.11.240.443
2p3d3TLProtease/0.443
2pvlP55Casein kinase II subunit alpha2.7.11.10.443
2qd7065Gag-Pol polyprotein3.4.23.160.443
2qhyMZ1Gag-Pol polyprotein/0.443
3bheBZNGag-Pol polyprotein3.4.23.160.443
3ig7EFPCyclin-dependent kinase 22.7.11.220.443
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.443
3liqE14Protease/0.443
3lzu017Gag-Pol polyprotein3.4.23.160.443
3nwxKVSGag-Pol polyprotein3.4.23.160.443
3rkb12ZCyclin-dependent kinase 22.7.11.220.443
3ttp017Gag-Pol polyprotein3.4.23.160.443
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.443
3w5rLOAVitamin D3 receptor/0.443
3zep1NXTyrosine-protein kinase JAK32.7.10.20.443
4c58824Cyclin-G-associated kinase2.7.11.10.443
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.443
4fkv61KCyclin-dependent kinase 22.7.11.220.443
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.443
1bwaXV6Gag-Pol polyprotein3.4.23.160.442
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.442
1mrwK57Gag-Pol polyprotein3.4.23.160.442
1qbu846Gag-Pol polyprotein3.4.23.160.442
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.442
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.442
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.442
2avsMK1Gag-Pol polyprotein3.4.23.160.442
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.442
2getCOKPantothenate kinase2.7.1.330.442
2hamC33Vitamin D3 receptor/0.442
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2qi6MZ8Gag-Pol polyprotein/0.442
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
2wleCOAPolysialic acid O-acetyltransferase/0.442
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
3drcMTXDihydrofolate reductase1.5.1.30.442
3flwFLWMitogen-activated protein kinase 14/0.442
3mws017Pol protein/0.442
3nwq2NCGag-Pol polyprotein3.4.23.160.442
3qp0NI8Gag-Pol polyprotein3.4.23.160.442
3r7iX9ICyclin-dependent kinase 22.7.11.220.442
4ewhT77Activated CDC42 kinase 1/0.442
4fhi0S4Vitamin D3 receptor A/0.442
4ly91YYGlucokinase regulatory protein/0.442
4o2bLOCTubulin beta-2B chain/0.442
4y93746Tyrosine-protein kinase/0.442
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
1bdlIM1Gag-Pol polyprotein3.4.23.160.441
1cc2FADCholesterol oxidase1.1.3.60.441
1daz0Q4Gag-Pol polyprotein3.4.23.160.441
1fg62NCGag-Pol polyprotein3.4.23.160.441
1hvrXK2Gag-Pol polyprotein/0.441
1ir3ANPInsulin receptor2.7.10.10.441
1mg5NAIAlcohol dehydrogenase1.1.1.10.441
1nqaNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
1wbmBLLPol protein/0.441
2aidTHKGag-Pol polyprotein3.4.23.160.441
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
2pqzG0GGag-Pol polyprotein3.4.23.160.441
2qi4MZ6Gag-Pol polyprotein/0.441
2vbdV10Isopenicillin N synthase1.21.3.10.441
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.441
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.441
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.441
3ekv478Gag-Pol polyprotein3.4.23.160.441
3el9DR7Gag-Pol polyprotein3.4.23.160.441
3gi4K60Gag-Pol polyprotein/0.441
3gstGPRGlutathione S-transferase Mu 12.5.1.180.441
3gw9VNILanosterol 14-alpha-demethylase/0.441
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
3hwrNDP2-dehydropantoate 2-reductase/0.441
3i7eDJRGag-Pol polyprotein/0.441
3k4vROCGag-Pol polyprotein3.4.23.160.441
3kq7KQ7Mitogen-activated protein kinase 14/0.441
3o9dK19Pol polyprotein/0.441
3o9gF53Gag-Pol polyprotein/0.441
3oy4017Gag-Pol polyprotein3.4.23.160.441
3qpjN4IGag-Pol polyprotein3.4.23.160.441
3rpv26ZCyclin-dependent kinase 22.7.11.220.441
3rvg17PTyrosine-protein kinase JAK2/0.441
3s43478Protease/0.441
3s4qNK0Mitogen-activated protein kinase 14/0.441
3sa5A69Protease/0.441
3t2kFADSulfide-quinone reductase/0.441
3ttjJBIMitogen-activated protein kinase 102.7.11.240.441
3zuyTCHTransporter/0.441
4dqe017Gag-Pol polyprotein/0.441
4erwSTUCyclin-dependent kinase 22.7.11.220.441
4hegG52Gag-Pol polyprotein3.4.23.160.441
4ia3BIVVitamin D3 receptor A/0.441
4iteTEYVitamin D3 receptor/0.441
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.441
1hpv478Gag-Pol polyprotein/0.440
1lf3EH5Plasmepsin-23.4.23.390.440
1msmJE2Gag-Pol polyprotein3.4.23.160.440
1rdtL79Retinoic acid receptor RXR-alpha/0.440
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.440
2hasC3OVitamin D3 receptor/0.440
2hw2RFPRifampin ADP-ribosyl transferase/0.440
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.440
2p55MRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
2x7hPFNProstaglandin reductase 310.440
3djkG55Gag-Pol polyprotein3.4.23.160.440
3gobHXXDdmC/0.440
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.440
3ndwRITGag-Pol polyprotein3.4.23.160.440
3owaFADAcyl-CoA dehydrogenase/0.440
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.440
4a4qUX9Pol protein/0.440
4fob0USALK tyrosine kinase receptor2.7.10.10.440
4gu610NFocal adhesion kinase 12.7.10.20.440
4ix6ADPUncharacterized protein/0.440
4j97ACPFibroblast growth factor receptor 2/0.440
4kb81QNCasein kinase I isoform delta2.7.11.10.440
4lopSB4Mitogen-activated protein kinase 14/0.440
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.440
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
5bsgNAPPyrroline-5-carboxylate reductase/0.440
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440