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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xk9P34Exotoxin A2.4.2.36

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1xk9P34Exotoxin A2.4.2.361.000
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.623
4pnmNU1Tankyrase-22.4.2.300.621
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.606
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.601
3b82NADExotoxin A2.4.2.360.600
4tjy3GNTankyrase-22.4.2.300.596
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.589
4bjbP34Tankyrase-22.4.2.300.586
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.584
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.577
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.577
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.576
4bj9UHBTankyrase-22.4.2.300.575
3b8hNADExotoxin A2.4.2.360.574
2zitNADExotoxin A2.4.2.360.569
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.569
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.568
4bjcRPBTankyrase-22.4.2.300.568
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.567
3u9y09LTankyrase-22.4.2.300.562
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.559
1zm4TADExotoxin A2.4.2.360.555
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.555
3b78NADExotoxin A2.4.2.360.554
4pnrG18Tankyrase-22.4.2.300.554
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.554
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.552
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.551
3geyP34Poly [ADP-ribose] polymerase 152.4.2.300.550
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.545
4tkg09LTankyrase-22.4.2.300.541
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.539
4krs1SXTankyrase-12.4.2.300.538
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.535
4hkkAGITankyrase-22.4.2.300.534
4j21AJ6Tankyrase-22.4.2.300.532
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.531
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.527
4hlm16STankyrase-22.4.2.300.525
4msk2C8Tankyrase-12.4.2.300.522
4avwG18Tankyrase-22.4.2.300.520
3q9oNADCholix toxin2.4.2.360.513
4iueAJ4Tankyrase-22.4.2.300.512
4j3mAJ8Tankyrase-22.4.2.300.511
4l091URTankyrase-22.4.2.300.511
4l321VFTankyrase-22.4.2.300.505
4hlf15ZTankyrase-22.4.2.300.502
4l0i1UWTankyrase-22.4.2.300.501
1ddtAPUDiphtheria toxin/0.499
1f0lAPUDiphtheria toxin/0.499
4li81XQTankyrase-12.4.2.300.498
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.497
3kr8XAVTankyrase-22.4.2.300.494
4l33F70Tankyrase-22.4.2.300.494
4l0t1V0Tankyrase-22.4.2.300.491
4kzl20DTankyrase-22.4.2.300.490
4buxF35Tankyrase-22.4.2.300.489
1icqOPD12-oxophytodienoate reductase 11.3.1.420.485
4kzuA73Tankyrase-22.4.2.300.483
4bufF36Tankyrase-22.4.2.300.482
4l0v1V1Tankyrase-22.4.2.300.482
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.481
4l341VGTankyrase-22.4.2.300.480
4buwF33Tankyrase-22.4.2.300.479
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.476
4j22AJ7Tankyrase-22.4.2.300.476
4bu908CTankyrase-22.4.2.300.475
1x1bSAHC-20 methyltransferase/0.474
4l31F08Tankyrase-22.4.2.300.474
2xysSY9Soluble acetylcholine receptor/0.473
3p0pNNFTankyrase-22.4.2.300.473
4l2f1V3Tankyrase-22.4.2.300.472
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.468
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.468
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.468
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.468
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.467
1rszDIHPurine nucleoside phosphorylase2.4.2.10.466
1ry8RUTAldo-keto reductase family 1 member C3/0.466
1x8lOXRRetinol dehydratase/0.466
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.466
2g1a5HGClass B acid phosphatase3.1.3.20.463
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
4bueJQFTankyrase-22.4.2.300.462
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
3g70A5TRenin3.4.23.150.460
2b8jADNClass B acid phosphatase3.1.3.20.459
3k1wBFXRenin3.4.23.150.459
4l2g1V4Tankyrase-22.4.2.300.459
3c35KAIGlutamate receptor ionotropic, kainate 1/0.458
4hlg20BTankyrase-22.4.2.300.458
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.457
3b9oFMNAlkane monoxygenase/0.457
4l10A63Tankyrase-22.4.2.300.457
5aku29FTankyrase-22.4.2.300.457
2xnvVU3Soluble acetylcholine receptor/0.456
3s5wFADL-ornithine N(5)-monooxygenase/0.456
3zkyWT4Isopenicillin N synthase1.21.3.10.456
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.456
4l2k1V8Tankyrase-22.4.2.300.456
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.455
4bud29FTankyrase-22.4.2.300.455
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.455
1mczRMNBenzoylformate decarboxylase4.1.1.70.454
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.454
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.454
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4hknLU2Tankyrase-22.4.2.300.454
1mrqSTRAldo-keto reductase family 1 member C1/0.453
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.453
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.453
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.453
4xzjNADPutative NAD(+)--arginine ADP-ribosyltransferase Vis2.4.2.310.453
2wo7ASVIsopenicillin N synthase1.21.3.10.452
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.452
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.452
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.451
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.451
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
4hkiFLNTankyrase-22.4.2.300.450
1hb3SCVIsopenicillin N synthase1.21.3.10.449
1zdwFLVPrenyltransferase/0.449
1zuaTOLAldo-keto reductase family 1 member B101.1.10.449
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.449
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4bb3KKAIsopenicillin N synthase1.21.3.10.449
4bus32FTankyrase-22.4.2.300.449
4hlh20DTankyrase-22.4.2.300.449
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.448
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.448
2xveFADPutative flavin-containing monooxygenase/0.448
3gsiTHGDimethylglycine oxidase1.5.3.100.448
3arvSAUChitinase A/0.447
4buuF38Tankyrase-22.4.2.300.447
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4phlPILPhosphodiesterase/0.447
1e66HUXAcetylcholinesterase3.1.1.70.446
1q84TZ4Acetylcholinesterase3.1.1.70.446
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.446
3g6zA7TRenin3.4.23.150.446
3ndjJHZMethyltransferase/0.446
4b65NDPL-ornithine N(5)-monooxygenase/0.446
4dbuBT9Aldo-keto reductase family 1 member C3/0.446
2v57PRLTetR family transcriptional regulator/0.445
2vcmM11Isopenicillin N synthase1.21.3.10.445
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.445
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.445
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.445
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.444
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.444
4h6rFDAProline dehydrogenase/0.444
5c1gGDUHisto-blood group ABO system transferase/0.444
1qiqACCIsopenicillin N synthase1.21.3.10.443
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.443
2jb4A14Isopenicillin N synthase1.21.3.10.443
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.443
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.443
2g6pHM2Methionine aminopeptidase 1/0.442
1uzwCDHIsopenicillin N synthase1.21.3.10.441
1yhjR6CPyridoxal kinase2.7.1.350.441
2b82ADNClass B acid phosphatase3.1.3.20.441
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.441
2qg2A91Heat shock protein HSP 90-alpha/0.441
2xytTC9Soluble acetylcholine receptor/0.441
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.441
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.441
1bk0ACVIsopenicillin N synthase1.21.3.10.440
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.440
2ed3SAHDiphthine synthase/0.440
2futH1SHeparin and heparin-sulfate lyase/0.440
2g8yNADHydroxycarboxylate dehydrogenase B/0.440
2vbpVB1Isopenicillin N synthase1.21.3.10.440
2y60M8FIsopenicillin N synthase1.21.3.10.440
4h7c10HAldo-keto reductase family 1 member C3/0.440
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
4l0s1UZTankyrase-22.4.2.300.440
4mt92D6Tankyrase-12.4.2.300.440