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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1w35FADFerredoxin--NADP reductase1.18.1.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1w35FADFerredoxin--NADP reductase1.18.1.21.000
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.637
1gjrFADFerredoxin--NADP reductase1.18.1.20.630
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.623
3vo2FADFerredoxin--NADP reductase/0.623
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.620
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.617
3zbtFADFerredoxin--NADP reductase1.18.1.20.615
1gr1FADFerredoxin--NADP reductase1.18.1.20.608
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.604
1gawFADFerredoxin/0.602
3zc3FADFerredoxin--NADP reductase1.18.1.20.602
1h42FADFerredoxin--NADP reductase1.18.1.20.600
1sm4FADFerredoxin--NADP reductase/0.598
1w87FADFerredoxin--NADP reductase1.18.1.20.591
1e62FADFerredoxin--NADP reductase1.18.1.20.590
3qfcFADNADPH--cytochrome P450 reductase/0.590
4c43FADFerredoxin--NADP reductase1.18.1.20.585
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.580
1gaqFADFerredoxin/0.580
2b5oFADFerredoxin--NADP reductase1.18.1.20.578
3w5uFADFerredoxin/0.578
2rc6FADFerredoxin--NADP reductase/0.574
3qe2FADNADPH--cytochrome P450 reductase/0.571
1e64FADFerredoxin--NADP reductase1.18.1.20.569
1e63FADFerredoxin--NADP reductase1.18.1.20.568
1queFADFerredoxin--NADP reductase1.18.1.20.568
1ja1FADNADPH--cytochrome P450 reductase/0.567
3fpkFADFerredoxin-NADP reductase/0.567
1qgyFADFerredoxin--NADP reductase1.18.1.20.565
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.564
2ok8FADFerredoxin--NADP reductase, apicoplast/0.564
3qfsFADNADPH--cytochrome P450 reductase/0.564
4bprFADFerredoxin--NADP reductase1.18.1.20.562
4y9uFADNADPH--cytochrome P450 reductase/0.559
4yaoFADNADPH--cytochrome P450 reductase/0.559
1bjkFADFerredoxin--NADP reductase1.18.1.20.552
4yafFADNADPH--cytochrome P450 reductase/0.550
1go2FADFerredoxin--NADP reductase1.18.1.20.546
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.544
1h85FADFerredoxin--NADP reductase1.18.1.20.544
3jqrFADFerredoxin--NADP reductase, apicoplast/0.535
1qgzFADFerredoxin--NADP reductase1.18.1.20.530
1qh0FADFerredoxin--NADP reductase1.18.1.20.526
3qftFADNADPH--cytochrome P450 reductase/0.526
1amoFADNADPH--cytochrome P450 reductase/0.520
1ewyFADFerredoxin--NADP reductase1.18.1.20.520
4yauFADNADPH--cytochrome P450 reductase/0.503
4y9rFADNADPH--cytochrome P450 reductase/0.502
1ogjFADFerredoxin--NADP reductase1.18.1.20.500
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.498
2rc5FADFerredoxin--NADP reductase/0.497
1ja0FADNADPH--cytochrome P450 reductase/0.495
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.492
2ok7FADFerredoxin--NADP reductase, apicoplast/0.491
1b2rFADFerredoxin--NADP reductase1.18.1.20.485
1tllFADNitric oxide synthase, brain1.14.13.390.485
3ojxFADNADPH--cytochrome P450 reductase/0.484
1ogiFADFerredoxin--NADP reductase1.18.1.20.483
1fdrFADFerredoxin--NADP reductase1.18.1.20.481
4fk8FADFerredoxin--NADP reductase/0.480
1a8pFADFerredoxin--NADP reductase/0.479
2vnkFADNADPH:ferredoxin reductase/0.479
1j9zFADNADPH--cytochrome P450 reductase/0.478
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.477
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.477
3qfrFMNNADPH--cytochrome P450 reductase/0.476
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.474
2bf4FADNADPH--cytochrome P450 reductase/0.471
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.470
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.469
2cndFADNitrate reductase [NADH]1.7.1.10.468
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.468
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.466
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.465
2piaFMNPhthalate dioxygenase reductase/0.464
2vyqFADFerredoxin--NADP reductase1.18.1.20.464
3rsv3RSBeta-secretase 13.4.23.460.464
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.463
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.463
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.462
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.462
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.462
2g247IGRenin3.4.23.150.461
3qe2FMNNADPH--cytochrome P450 reductase/0.461
4b4w9L9Bifunctional protein FolD/0.461
1ja1FMNNADPH--cytochrome P450 reductase/0.460
4k1xFADNADPH:ferredoxin reductase/0.460
4r81FMNPredicted NADH dehydrogenase/0.460
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.459
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.459
2uxoTACHTH-type transcriptional regulator TtgR/0.459
3ojxFMNNADPH--cytochrome P450 reductase/0.459
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.459
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.457
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.457
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.457
1knpFADL-aspartate oxidase1.4.3.160.456
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.456
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.455
2wu4HBPAcetylcholinesterase3.1.1.70.455
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.455
3ojwFMNNADPH--cytochrome P450 reductase/0.454
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.454
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.454
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.453
1z71L17Prothrombin3.4.21.50.453
3w6hAZMCarbonic anhydrase 14.2.1.10.453
4bftZVTPantothenate kinase2.7.1.330.453
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.453
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.453
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.452
2pidYSATyrosine--tRNA ligase, mitochondrial6.1.1.10.452
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.452
4b2gV1NUncharacterized protein/0.452
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.451
3nz2ACOHexapeptide-repeat containing-acetyltransferase/0.451
3wqmB29Diterpene synthase3.1.7.80.451
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.451
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.451
4v2gITCTetracycline repressor protein class D/0.451
1krrACOGalactoside O-acetyltransferase2.3.1.180.450
2bgjFADNADPH:ferredoxin reductase/0.450
2j83BATUlilysin3.4.240.450
2zevB71Geranylgeranyl pyrophosphate synthase/0.450
3bgxMEFThymidylate synthase/0.450
2c12FADNitroalkane oxidase1.7.3.10.449
2g8yNADHydroxycarboxylate dehydrogenase B/0.449
4q0kGA3Phytohormone-binding protein/0.449
1hb1OCVIsopenicillin N synthase1.21.3.10.448
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.448
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.448
2ejzSAHDiphthine synthase/0.448
2rqfJH3Hemolymph juvenile hormone binding protein/0.448
1eioGCHGastrotropin/0.447
1xs7MMIBeta-secretase 13.4.23.460.447
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.447
2vnjFADNADPH:ferredoxin reductase/0.447
3fcjFADNitroalkane oxidase1.7.3.10.447
4jtqNAPAldo-keto reductase family 1 member C2/0.447
1xddAAYIntegrin alpha-L/0.446
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.446
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.446
2z1qFADAcyl-CoA dehydrogenase/0.446
3s5wFADL-ornithine N(5)-monooxygenase/0.446
4ryvZEAProtein LlR18A/0.446
2ikuLIYRenin3.4.23.150.445
2iviACWIsopenicillin N synthase1.21.3.10.445
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.445
4n3l2FNProthrombin3.4.21.50.445
1ja0FMNNADPH--cytochrome P450 reductase/0.444
2vn1FK5Peptidylprolyl isomerase/0.444
2xytTC9Soluble acetylcholine receptor/0.444
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
3p0fBAUUridine phosphorylase 22.4.2.30.444
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.444
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.444
4wx2F6FTryptophan synthase alpha chain/0.444
4wx2F6FTryptophan synthase beta chain4.2.1.200.444
5dp2NAPCurF/0.444
2oz57XYUncharacterized protein/0.443
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
4b68FADL-ornithine N(5)-monooxygenase/0.443
4e2yJHZMethyltransferase/0.443
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.442
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.442
3gnvXNZGenome polyprotein2.7.7.480.442
4a802ANMajor pollen allergen Bet v 1-A/0.442
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.442
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2bgiFADNADPH:ferredoxin reductase/0.441
2eeqSAHDiphthine synthase/0.441
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.441
2vcmM11Isopenicillin N synthase1.21.3.10.441
2x9dITCTetracycline repressor protein class D/0.441
3abxRCBGlucanase/0.441
3c1oNAPEugenol synthase/0.441
3crzFADFerredoxin--NADP+ reductase/0.441
3rtnRTNBeta-secretase 13.4.23.460.441
4frkDWDBeta-secretase 13.4.23.460.441
4q36CO8Uncharacterized protein/0.441
2bf4FMNNADPH--cytochrome P450 reductase/0.440
3csoXNIGenome polyprotein2.7.7.480.440