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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ogjFADFerredoxin--NADP reductase1.18.1.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ogjFADFerredoxin--NADP reductase1.18.1.21.000
1ogiFADFerredoxin--NADP reductase1.18.1.20.887
1h42FADFerredoxin--NADP reductase1.18.1.20.805
1e62FADFerredoxin--NADP reductase1.18.1.20.704
1queFADFerredoxin--NADP reductase1.18.1.20.681
4c43FADFerredoxin--NADP reductase1.18.1.20.655
1gr1FADFerredoxin--NADP reductase1.18.1.20.643
1e63FADFerredoxin--NADP reductase1.18.1.20.639
1gawFADFerredoxin/0.635
1e64FADFerredoxin--NADP reductase1.18.1.20.631
1go2FADFerredoxin--NADP reductase1.18.1.20.628
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.626
1bjkFADFerredoxin--NADP reductase1.18.1.20.623
1qgzFADFerredoxin--NADP reductase1.18.1.20.621
1gjrFADFerredoxin--NADP reductase1.18.1.20.620
1qgyFADFerredoxin--NADP reductase1.18.1.20.615
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.613
3zbtFADFerredoxin--NADP reductase1.18.1.20.613
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.611
3zc3FADFerredoxin--NADP reductase1.18.1.20.610
3vo2FADFerredoxin--NADP reductase/0.605
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.604
1h85FADFerredoxin--NADP reductase1.18.1.20.604
1qh0FADFerredoxin--NADP reductase1.18.1.20.603
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.601
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.593
3w5uFADFerredoxin/0.590
1gaqFADFerredoxin/0.580
2b5oFADFerredoxin--NADP reductase1.18.1.20.576
4bprFADFerredoxin--NADP reductase1.18.1.20.575
1ewyFADFerredoxin--NADP reductase1.18.1.20.573
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.571
2rc6FADFerredoxin--NADP reductase/0.564
1sm4FADFerredoxin--NADP reductase/0.563
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.559
3jqrFADFerredoxin--NADP reductase, apicoplast/0.537
1w35FADFerredoxin--NADP reductase1.18.1.20.531
1b2rFADFerredoxin--NADP reductase1.18.1.20.526
3fpkFADFerredoxin-NADP reductase/0.524
1w87FADFerredoxin--NADP reductase1.18.1.20.520
4yaoFADNADPH--cytochrome P450 reductase/0.513
4y9uFADNADPH--cytochrome P450 reductase/0.512
2ok8FADFerredoxin--NADP reductase, apicoplast/0.511
1j9zFADNADPH--cytochrome P450 reductase/0.505
1amoFADNADPH--cytochrome P450 reductase/0.504
3ojxFADNADPH--cytochrome P450 reductase/0.502
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.498
3qfsFADNADPH--cytochrome P450 reductase/0.497
3qfcFADNADPH--cytochrome P450 reductase/0.496
2bf4FADNADPH--cytochrome P450 reductase/0.494
1hb1OCVIsopenicillin N synthase1.21.3.10.493
2rc5FADFerredoxin--NADP reductase/0.493
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.492
2piaFMNPhthalate dioxygenase reductase/0.492
2jb4A14Isopenicillin N synthase1.21.3.10.490
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.490
3qe2FADNADPH--cytochrome P450 reductase/0.488
1gky5GPGuanylate kinase2.7.4.80.487
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.484
2bpoFADNADPH--cytochrome P450 reductase/0.483
3qftFADNADPH--cytochrome P450 reductase/0.482
4b2gV1NUncharacterized protein/0.482
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.481
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.481
4bb3KKAIsopenicillin N synthase1.21.3.10.481
4yauFADNADPH--cytochrome P450 reductase/0.481
4bfuZVUPantothenate kinase2.7.1.330.480
1tllFADNitric oxide synthase, brain1.14.13.390.478
4y9rFADNADPH--cytochrome P450 reductase/0.478
1ex75GPGuanylate kinase2.7.4.80.477
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.477
4wx2F6FTryptophan synthase alpha chain/0.476
4wx2F6FTryptophan synthase beta chain4.2.1.200.476
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.474
2iviACWIsopenicillin N synthase1.21.3.10.473
3rsv3RSBeta-secretase 13.4.23.460.473
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.472
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.470
1hb3SCVIsopenicillin N synthase1.21.3.10.469
3fr5I4AFatty acid-binding protein, adipocyte/0.469
5a4vQUEGlutathione S-transferase F22.5.1.180.469
4b4vL34Bifunctional protein FolD/0.468
5f54TMPSingle-stranded-DNA-specific exonuclease/0.468
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.467
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.466
1qjfACSIsopenicillin N synthase1.21.3.10.465
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.465
3vf60H6Glucokinase2.7.1.20.464
1ja1FADNADPH--cytochrome P450 reductase/0.463
3zkyWT4Isopenicillin N synthase1.21.3.10.463
4yafFADNADPH--cytochrome P450 reductase/0.463
3p0gP0GBeta-2 adrenergic receptor/0.463
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.462
1qiqACCIsopenicillin N synthase1.21.3.10.462
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.461
2e94364Geranylgeranyl pyrophosphate synthase/0.461
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.460
3zoiM2WIsopenicillin N synthase1.21.3.10.460
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.460
4blcNDPCatalase1.11.1.60.460
1ndzFR5Adenosine deaminase3.5.4.40.459
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.459
4y7cFADNADPH--cytochrome P450 reductase/0.459
2e0nSAHPrecorrin-2 C20-methyltransferase/0.458
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.458
4glx0XSDNA ligase6.5.1.20.458
4h1q0XXMatrix metalloproteinase-93.4.24.350.457
3sn6P0GBeta-2 adrenergic receptor/0.457
1jqdSAHHistamine N-methyltransferase2.1.1.80.456
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.456
4b4w9L9Bifunctional protein FolD/0.456
4b7754MBeta-secretase 13.4.23.460.456
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.455
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.455
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.455
4asuADPATP synthase subunit alpha, mitochondrial/0.455
1s9dAFBCytohesin-2/0.454
1s9dAFBADP-ribosylation factor 1/0.454
1x1cSAHC-20 methyltransferase/0.454
2vn1FK5Peptidylprolyl isomerase/0.454
4boeCLRJapanin/0.454
1akaPLPAspartate aminotransferase, mitochondrial2.6.1.10.453
1x1bSAHC-20 methyltransferase/0.453
2wzySQXSoluble acetylcholine receptor/0.453
3frkTQPQdtB/0.453
3s41S41Glucokinase2.7.1.20.453
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.453
1a8pFADFerredoxin--NADP reductase/0.452
1z71L17Prothrombin3.4.21.50.452
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.452
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.451
1ut6A8NAcetylcholinesterase3.1.1.70.451
2bu9HFVIsopenicillin N synthase1.21.3.10.451
2g8yNADHydroxycarboxylate dehydrogenase B/0.451
2p6dSAHDiphthine synthase/0.451
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.451
2vbdV10Isopenicillin N synthase1.21.3.10.451
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.451
2wo7ASVIsopenicillin N synthase1.21.3.10.451
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.451
5ah5LSSLeucine--tRNA ligase/0.451
5choFADFlavin reductase/0.451
1bk0ACVIsopenicillin N synthase1.21.3.10.450
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.450
2pncCLUPrimary amine oxidase, liver isozyme/0.450
2rd2QSIGlutamine--tRNA ligase6.1.1.180.450
2re8GSUGlutamine--tRNA ligase6.1.1.180.450
2y60M8FIsopenicillin N synthase1.21.3.10.450
4g090VDHistidinol dehydrogenase/0.450
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.450
4to2DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.450
1ejeFMNProtein MTH_152/0.449
1pqc444Oxysterols receptor LXR-beta/0.449
1u1jC2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 12.1.1.140.449
1vbiNADMalate/L-lactate dehydrogenase family protein/0.449
2j83BATUlilysin3.4.240.449
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.449
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.449
3kp4MIITranscriptional regulator TcaR/0.449
1o2g696Prothrombin3.4.21.50.448
1qtqQSIGlutamine--tRNA ligase6.1.1.180.448
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
1x1dSAHC-20 methyltransferase/0.448
1xs7MMIBeta-secretase 13.4.23.460.448
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
3k8q22APurine nucleoside phosphorylase2.4.2.10.448
3p0fBAUUridine phosphorylase 22.4.2.30.448
3pn1IVHDNA ligase/0.448
1h69ARHNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.447
1swtBTNStreptavidin/0.447
2v57PRLTetR family transcriptional regulator/0.447
2vnjFADNADPH:ferredoxin reductase/0.447
2weaPP6Penicillopepsin-13.4.23.200.447
3h2sNDPPutative NADH-flavin reductase/0.447
3hl0NADMaleylacetate reductase/0.447
1fdrFADFerredoxin--NADP reductase1.18.1.20.446
1oc1ASVIsopenicillin N synthase1.21.3.10.446
2ejkSAHDiphthine synthase/0.446
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.446
2zryFNRIsopentenyl-diphosphate delta-isomerase/0.446
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.446
3rtnRTNBeta-secretase 13.4.23.460.446
3uayADNPurine nucleoside phosphorylase DeoD-type/0.446
4bfxZVXPantothenate kinase2.7.1.330.446
4dz7D02Carbonic anhydrase 24.2.1.10.446
1h60STRPentaerythritol tetranitrate reductase/0.445
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.445
2zrvFNRIsopentenyl-diphosphate delta-isomerase/0.445
3zeiAWHO-acetylserine sulfhydrylase/0.445
4a87NARMajor pollen allergen Bet v 1-A/0.445
4n4v2GYTankyrase-12.4.2.300.445
4n4wSNTSmoothened homolog/0.445
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.444
1diaL24C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.444
1jdtMTAPurine nucleoside phosphorylase/0.444
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
1xddAAYIntegrin alpha-L/0.444
2fsvNAPNAD(P) transhydrogenase subunit beta1.6.1.20.444
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.443
1ja1FMNNADPH--cytochrome P450 reductase/0.443
2cleF6FTryptophan synthase alpha chain/0.443
2vkeTACTetracycline repressor protein class D/0.443
2ztsADPUncharacterized protein/0.443
3br3ETHTH-type transcriptional regulator QacR/0.443
3c1oNAPEugenol synthase/0.443
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.443
1d3pBT3Prothrombin3.4.21.50.442
2ea2F77Methionine aminopeptidase 2/0.442
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.442
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.442
3ivcFG4Pantothenate synthetase6.3.2.10.442
4e2zJHZMethyltransferase/0.442
5a4wQCTGlutathione S-transferase F22.5.1.180.442
5dp2NAPCurF/0.442
1kceCB3Thymidylate synthase/0.441
1ppjANYCytochrome b/0.441
1qoqIGPTryptophan synthase alpha chain/0.441
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2bf4FMNNADPH--cytochrome P450 reductase/0.441
2lfoGCHFatty acid-binding protein, liver/0.441
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.441
4c49HCYCorticosteroid-binding globulin/0.441
4df2FMNNADPH dehydrogenase/0.441
4j7hTRHPCZA361.3/0.441
4l7j1W2Beta-secretase 13.4.23.460.441
4q0kGA3Phytohormone-binding protein/0.441
4xbjIN5Alanine racemase, biosynthetic/0.441
4u163C0Muscarinic acetylcholine receptor M3/0.441
1aqv0HGGlutathione S-transferase P2.5.1.180.440
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.440
2ed3SAHDiphthine synthase/0.440
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.440
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.440
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.440
3dwbRDFEndothelin-converting enzyme 13.4.24.710.440
4a6eASEAcetylserotonin O-methyltransferase2.1.1.40.440