sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1nq7 | ARL | Nuclear receptor ROR-beta |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 1.000 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.605 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.550 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.529 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.525 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.522 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.519 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.519 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.509 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.500 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.497 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.493 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.491 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.488 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.488 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.487 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.486 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.485 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.485 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.484 | |
| 1s60 | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.484 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.484 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.484 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.483 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.482 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.481 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.481 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.481 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.480 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.480 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.478 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.477 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.477 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.477 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.477 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.476 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.475 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.475 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.475 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.474 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.474 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.474 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.473 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.473 | |
| 3zux | TCH | Transporter | / | 0.473 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.472 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.472 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.472 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.472 | |
| 1sn5 | T3 | Transthyretin | / | 0.471 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.471 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.471 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.471 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.470 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.470 | |
| 1kgj | FL8 | Transthyretin | / | 0.469 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.469 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.468 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.468 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.468 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.468 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.467 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.467 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.467 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.467 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.467 | |
| 3w0p | ADP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.467 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.466 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.466 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.466 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.466 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.466 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.466 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 4l9q | 9TP | Serum albumin | / | 0.466 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.465 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.465 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.465 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.465 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.465 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.464 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.464 | |
| 3qly | 55V | Uncharacterized protein | / | 0.464 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.464 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.464 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.464 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.463 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.463 | |
| 1zhw | HC2 | Oxysterol-binding protein homolog 4 | / | 0.463 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.463 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.463 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.463 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 3lu8 | IQX | Serum albumin | / | 0.463 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.463 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.463 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.462 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.462 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.462 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.461 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.461 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.461 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.461 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.461 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.461 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.461 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.460 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 2jfz | 003 | Glutamate racemase | / | 0.460 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.460 | |
| 3abi | NAD | Uncharacterized protein | / | 0.460 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.460 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.460 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.460 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.460 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.459 | |
| 1zhz | ERG | Oxysterol-binding protein homolog 4 | / | 0.459 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.459 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.459 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.459 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.459 | |
| 3qlh | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.459 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.459 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.458 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.458 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.458 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.457 | |
| 1ezf | IN0 | Squalene synthase | 2.5.1.21 | 0.457 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.457 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.457 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.457 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.457 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.456 | |
| 1ie4 | T44 | Transthyretin | / | 0.456 | |
| 3aba | FLI | Cytochrome P450 | / | 0.456 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.456 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.456 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.455 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.455 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.455 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.455 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.455 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.455 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.455 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.455 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.455 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.455 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.455 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.455 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.455 | |
| 4xxv | NAD | 3-isopropylmalate dehydrogenase | / | 0.455 | |
| 4ylf | FAD | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog | / | 0.455 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.454 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.454 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
| 4i3w | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.454 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.454 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.454 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.454 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.453 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.453 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.453 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.453 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.453 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.453 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.453 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.452 | |
| 3tdl | 11D | Serum albumin | / | 0.452 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.452 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.452 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.451 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.451 | |
| 2p15 | EZT | Estrogen receptor | / | 0.451 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.451 | |
| 4a0m | NAD | Betaine aldehyde dehydrogenase, chloroplastic | 1.2.1.8 | 0.451 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 4nxw | ADP | Mitochondrial dynamics protein MID51 | / | 0.451 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.451 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.450 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.450 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.450 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.450 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.450 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.450 | |
| 4b1f | KRH | Glutamate racemase | / | 0.450 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.450 | |
| 4o7u | THF | Thymidylate synthase | / | 0.450 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.450 | |
| 1chw | HXC | Chalcone synthase 2 | 2.3.1.74 | 0.449 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1pp9 | SMA | Cytochrome b | / | 0.449 | |
| 1ppj | ANY | Cytochrome b | / | 0.449 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.449 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2cdu | FAD | NADH oxidase | / | 0.449 | |
| 3eek | 53S | Uncharacterized protein | / | 0.449 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.449 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.449 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4ii5 | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.449 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.448 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.448 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.448 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.448 | |
| 4hjf | C2E | GGDEF family protein | / | 0.448 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.448 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.448 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1j4j | ACO | Acetyltransferase | 2.3.1 | 0.447 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.447 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.447 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.447 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.447 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.447 | |
| 4zas | TYD | CalS13 | / | 0.447 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.446 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1soz | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.446 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.446 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.446 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.446 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.446 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.446 | |
| 1bq1 | CB3 | Thymidylate synthase | / | 0.445 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.445 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.445 | |
| 2gnf | Y27 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.445 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.445 | |
| 2r3y | VAL_TYR_TRP_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.445 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.445 | |
| 3b20 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.445 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 3zuy | TCH | Transporter | / | 0.445 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.445 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.445 | |
| 4l9k | EHF | Serum albumin | / | 0.445 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.445 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.445 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.444 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.444 | |
| 1sqv | UHD | Cytochrome b | / | 0.444 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.444 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.444 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3meg | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 3w1f | 1O5 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.444 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.444 | |
| 4irn | FAD | AnaB | / | 0.444 | |
| 1ci7 | CB3 | Thymidylate synthase | 2.1.1.45 | 0.443 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 1ict | T44 | Transthyretin | / | 0.443 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.443 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.443 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.443 | |
| 3u4u | LNH | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.443 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.443 | |
| 4pd6 | URI | Nucleoside permease | / | 0.443 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.443 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1eio | GCH | Gastrotropin | / | 0.442 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.442 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.442 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.442 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.442 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.442 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.442 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.442 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.442 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.442 | |
| 4eil | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.442 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 5g3s | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 0.442 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.442 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.442 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.441 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.441 | |
| 1s9e | ADB | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2ovm | AS0 | Progesterone receptor | / | 0.441 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.441 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.441 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.441 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.441 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.441 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.441 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4b5p | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.441 | |
| 4cnj | FAD | L-amino acid oxidase | / | 0.441 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.441 | |
| 4kfn | 1QR | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.441 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.441 | |
| 4z44 | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.441 | |
| 5cvf | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.440 | |
| 1ysx | 4EB | Serum albumin | / | 0.440 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.440 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3f47 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.440 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.440 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.440 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.440 | |
| 3uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.440 | |
| 4gs4 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.440 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.440 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.440 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.440 |