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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1lrmHBIPhenylalanine-4-hydroxylase1.14.16.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1lrmHBIPhenylalanine-4-hydroxylase1.14.16.11.000
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.733
1tg2H2BPhenylalanine-4-hydroxylase1.14.16.10.640
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.633
4pahLNRPhenylalanine-4-hydroxylase1.14.16.10.627
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.623
2tohHBITyrosine 3-monooxygenase1.14.16.20.620
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.591
1ltzHBIPhenylalanine-4-hydroxylase1.14.16.10.525
1mmkH4BPhenylalanine-4-hydroxylase1.14.16.10.520
5stdUNNScytalone dehydratase4.2.1.940.490
3up3XCAaceDAF-12/0.489
3abxRCBGlucanase/0.484
1kw0H4BPhenylalanine-4-hydroxylase1.14.16.10.480
1u71MXADihydrofolate reductase1.5.1.30.480
3up0D7SaceDAF-12/0.480
3gf4UPGUDP-galactopyranose mutase5.4.99.90.479
4glx0XSDNA ligase6.5.1.20.479
1gky5GPGuanylate kinase2.7.4.80.478
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.478
2xf3J01Uncharacterized protein/0.478
3n19FNRXenobiotic reductase/0.476
1nqxRLP6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.472
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.472
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
1yw7A41Methionine aminopeptidase 2/0.470
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.470
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.469
3lfeZ84Mitogen-activated protein kinase 14/0.469
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.469
1r58AO5Methionine aminopeptidase 2/0.468
2vn1FK5Peptidylprolyl isomerase/0.468
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.468
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.467
3mauPLRPutative sphingosine-1-phosphate lyase/0.465
5dp2NAPCurF/0.465
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.464
4uy6SAHHistidine N-alpha-methyltransferase/0.464
5irnADPNucleotide binding oligomerization domain containing 2/0.464
2c92TP66,7-dimethyl-8-ribityllumazine synthase2.5.1.780.463
2cekN8TAcetylcholinesterase3.1.1.70.463
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.462
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
1u1gBBBUridine phosphorylase2.4.2.30.461
2lbaCHOFatty acid binding protein 6/0.460
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.460
3arvSAUChitinase A/0.460
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.460
3zm62GNUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.460
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.460
1jtuLYBThymidylate synthase/0.459
2rteBTNStreptavidin/0.459
1c7oPPGHemolysin/0.458
1qjfACSIsopenicillin N synthase1.21.3.10.458
3fr5I4AFatty acid-binding protein, adipocyte/0.458
1s36CEIObelin/0.457
1hfpMOTDihydrofolate reductase1.5.1.30.456
1pqc444Oxysterols receptor LXR-beta/0.456
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.456
2rtoIMIStreptavidin/0.456
3d5wADPSerine/threonine-protein kinase PLK/0.456
4dlcUMPDeoxyuridine triphosphatase, putative/0.456
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
1swtBTNStreptavidin/0.455
3pn1IVHDNA ligase/0.455
4dbc3QPAspartate aminotransferase2.6.1.10.455
1hvyD16Thymidylate synthase2.1.1.450.454
2r86ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.454
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.454
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
3stdMQ0Scytalone dehydratase4.2.1.940.454
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.453
3arpDEQChitinase A/0.453
3bgxMEFThymidylate synthase/0.453
4jlj1NMDeoxycytidine kinase2.7.1.740.453
1nceCB3Thymidylate synthase/0.452
1p8dCO1Oxysterols receptor LXR-beta/0.452
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.452
3gg2UGASugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family/0.452
3mauEXTPutative sphingosine-1-phosphate lyase/0.452
4bfuZVUPantothenate kinase2.7.1.330.452
4dvq1CACytochrome P450 11B2, mitochondrial1.14.15.40.452
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.452
4kbn25UDihydrofolate reductase1.5.1.30.452
4s1iPLPPyridoxal kinase, putative/0.452
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.451
1qiqACCIsopenicillin N synthase1.21.3.10.451
1zdwFLVPrenyltransferase/0.451
3fhxPXLPyridoxal kinase2.7.1.350.451
3junAKDPhenazine biosynthesis protein A/B/0.451
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.450
1h22E10Acetylcholinesterase3.1.1.70.450
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2rds1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.450
3er93ATPoly(A) polymerase catalytic subunit2.7.7.190.450
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4h6pFMNChromate reductase/0.450
4oztP1AEcdysone receptor, putative/0.450
1touB1VFatty acid-binding protein, adipocyte/0.449
4du82P0Mevalonate diphosphate decarboxylase/0.449
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.449
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.449
4utlFNRXenobiotic reductase/0.449
4xwtU5PRibonuclease J/0.449
1dx6GNTAcetylcholinesterase3.1.1.70.448
1tw4CHDFatty acid-binding protein, liver/0.448
2rqfJH3Hemolymph juvenile hormone binding protein/0.448
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.448
3bsyACOUDP-N-acetylbacillosamine N-acetyltransferase2.3.1.2030.448
4x9dU5PUncharacterized protein MJ1435/0.448
2vutNADNitrogen metabolite repression protein nmrA/0.447
2x06NADL-sulfolactate dehydrogenase/0.447
3b9oFMNAlkane monoxygenase/0.447
3c1oNAPEugenol synthase/0.447
4bj9UHBTankyrase-22.4.2.300.447
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.446
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.446
3c6n2S8Protein TRANSPORT INHIBITOR RESPONSE 1/0.446
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.446
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3g8dADPBiotin carboxylase6.3.4.140.446
3wznBTNStreptavidin/0.446
4nv0MG77-methylguanosine phosphate-specific 5'-nucleotidase/0.446
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.445
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.445
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.445
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.445
4hcy0YNTransketolase/0.445
4qzuRTLRetinol-binding protein 2/0.445
4twnB96Ephrin type-A receptor 32.7.10.10.445
1mrqSTRAldo-keto reductase family 1 member C1/0.444
1srfMTBStreptavidin/0.444
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3ielU5PRibonuclease TTHA02523.10.444
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.444
4bfyZVYPantothenate kinase2.7.1.330.444
4ead0NPThymidine phosphorylase2.4.2.40.444
4xczT3QQdtf/0.444
1stdBFSScytalone dehydratase4.2.1.940.443
1w29TS16,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
1xddAAYIntegrin alpha-L/0.443
3gwfNAPCyclohexanone monooxygenase/0.443
3nxoD2BDihydrofolate reductase1.5.1.30.443
3r8hZOMAldo-keto reductase family 1 member C3/0.443
4a33PS8Glycylpeptide N-tetradecanoyltransferase/0.443
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2ea4F79Methionine aminopeptidase 2/0.442
2gciMRRProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.442
2rtgBTNStreptavidin/0.442
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.442
4bfwZVWPantothenate kinase2.7.1.330.442
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.442
4eqrCOACoenzyme A disulfide reductase/0.442
4n4v2GYTankyrase-12.4.2.300.442
4xo7ASDAldo-keto reductase family 1 member C2/0.442
1qvuPRLHTH-type transcriptional regulator QacR/0.441
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2bf7HBIPteridine reductase 11.5.1.330.441
2c97JCL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2cjeDUNDUTPase/0.441
2p1t3TNRetinoic acid receptor RXR-alpha/0.441
2zevB71Geranylgeranyl pyrophosphate synthase/0.441
3fhxPLPPyridoxal kinase2.7.1.350.441
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4b66NAPL-ornithine N(5)-monooxygenase/0.441
1w4lGL8Acetylcholinesterase3.1.1.70.440
1xmmM7Gm7GpppX diphosphatase3.6.1.590.440
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.440
2e1zB4PPropionate kinase/0.440
2ga2A19Methionine aminopeptidase 2/0.440
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
3c3xNAPEugenol synthase 11.1.1.3180.440
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.440
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.440
3uyk0CXProbable NDP-rhamnosyltransferase/0.440
4arbC57Acetylcholinesterase3.1.1.70.440
4g95OAGDihydrofolate reductase1.5.1.30.440