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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.141.000
1ep3FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.654
3oixFMNDihydroorotate dehydrogenase/0.529
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.504
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.500
1xe55FEPlasmepsin-23.4.23.390.498
2djxFMNDihydroorotate dehydrogenase (fumarate)1.3.98.10.496
4wzhFMNDihydroorotate dehydrogenase (fumarate)/0.490
1xe65FPPlasmepsin-23.4.23.390.485
3gyeFMNDihydroorotate dehydrogenase (fumarate)/0.480
3u9eCOALmo1369 protein/0.479
1t2cNAIL-lactate dehydrogenase1.1.1.270.478
2vwqNAPGlucose 1-dehydrogenase/0.477
1w6hTITPlasmepsin-23.4.23.390.474
3gqvNAPEnoyl reductase LovC10.473
4g7gVFVLanosterol 14-alpha-demethylase/0.472
1udaUFGUDP-glucose 4-epimerase5.1.3.20.471
2iyfERYOleandomycin glycosyltransferase2.4.10.470
2oapANPType II secretion system protein (GspE-2)/0.470
3imgBZ2Pantothenate synthetase6.3.2.10.470
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.469
5hs1VORLanosterol 14-alpha demethylase/0.468
3vqsJT1Genome polyprotein/0.467
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.466
2q85973UDP-N-acetylenolpyruvoylglucosamine reductase1.3.1.980.465
3tjzGNPADP-ribosylation factor 1/0.465
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.465
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.465
2dxwSAHDiphthine synthase/0.464
3omuIBDHeat shock protein 83/0.464
1bim0QBRenin3.4.23.150.462
4qxq1YEStimulator of interferon genes protein/0.461
1v35NAIEnoyl-ACP reductase/0.460
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.459
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.459
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.459
2vkmBSDBeta-secretase 13.4.23.460.458
4djaFAD(6-4) photolyase/0.458
2dxvSAHDiphthine synthase/0.457
2el0SAHDiphthine synthase/0.457
4qxr1YEStimulator of interferon genes protein/0.457
1g6kNADGlucose 1-dehydrogenase1.1.1.470.456
1tehNADAlcohol dehydrogenase class-31.1.1.10.456
2e07SAHDiphthine synthase/0.456
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.456
3enkUPGUDP-glucose 4-epimerase/0.456
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.455
4bftZVTPantothenate kinase2.7.1.330.455
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.455
4m83ERYOleandomycin glycosyltransferase2.4.10.455
2ehlSAHDiphthine synthase/0.454
2emrSAHDiphthine synthase/0.454
2owkSAHDiphthine synthase/0.454
3in6FMNUncharacterized protein/0.454
3kb1ADPIron-sulfur cluster carrier protein/0.454
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.453
4g6gFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.453
1kp3ATPArgininosuccinate synthase6.3.4.50.452
1me6IVSPlasmepsin-23.4.23.390.452
1rfuADPPyridoxal kinase2.7.1.350.452
2znpK55Peroxisome proliferator-activated receptor delta/0.452
3hl0NADMaleylacetate reductase/0.452
3pm1ETHTH-type transcriptional regulator QacR/0.452
3bk2U5PRibonuclease J/0.451
3c1y2BADNA integrity scanning protein DisA/0.451
4bfvZVVPantothenate kinase2.7.1.330.451
2z1mNDPGDP-mannose 4,6-dehydratase/0.450
3gw9VNILanosterol 14-alpha-demethylase/0.450
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
5eioNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.450
1xddAAYIntegrin alpha-L/0.449
2dsiSAHDiphthine synthase/0.449
2gv8NDPThiol-specific monooxygenase1.14.130.449
3bc3OPTCathepsin L13.4.22.150.449
3ijoB4DGlutamate receptor 2/0.449
3t2kFADSulfide-quinone reductase/0.449
4ambDUDPutative glycosyl transferase/0.449
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
4q73FADBifunctional protein PutA/0.449
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1u2yGOXPancreatic alpha-amylase/0.448
2a5kAZPReplicase polyprotein 1ab3.4.220.448
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.448
2gjlFMNNitronate monooxygenase1.13.12.160.448
3p82FMNPentaerythritol tetranitrate reductase/0.448
3r95ACOMccE protein/0.448
1lbcCYZGlutamate receptor 2/0.447
1vceSAHDiphthine synthase/0.447
2owuSAHDiphthine synthase/0.447
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.447
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.447
3qlsNDPDihydrofolate reductase1.5.1.30.447
4bfzZVZPantothenate kinase2.7.1.330.447
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.447
4q72FADBifunctional protein PutA/0.447
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.447
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.446
2cv2GSUGlutamate--tRNA ligase6.1.1.170.446
2eh5SAHDiphthine synthase/0.446
2ek2SAHDiphthine synthase/0.446
2ek7SAHDiphthine synthase/0.446
3a6rFMNFMN-binding protein/0.446
3b70NAPEnoyl reductase LovC10.446
4bfxZVXPantothenate kinase2.7.1.330.446
4q71FADBifunctional protein PutA/0.446
1h2bNAJNAD-dependent alcohol dehydrogenase/0.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
2x8hFADThioredoxin glutathione reductase/0.445
3lqfNADGalactitol dehydrogenase/0.445
4ddhMS0Pantothenate synthetase6.3.2.10.445
4xq6FMNDihydroorotate dehydrogenase (quinone)/0.445
1bil0IURenin3.4.23.150.444
1orrNADCDP-paratose 2-epimerase/0.444
1sq5ADPPantothenate kinase2.7.1.330.444
1vyrFMNPentaerythritol tetranitrate reductase/0.444
2e8sSAHDiphthine synthase/0.444
2ed5SAHDiphthine synthase/0.444
2emuSAHDiphthine synthase/0.444
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2he5NDPAldo-keto reductase family 1 member C211.1.10.444
2iko7IGRenin3.4.23.150.444
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.444
3qe2FMNNADPH--cytochrome P450 reductase/0.444
4b4w9L9Bifunctional protein FolD/0.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4lcjNADC-terminal-binding protein 2/0.444
1eq2ADQADP-L-glycero-D-manno-heptose-6-epimerase/0.443
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1tj0FADBifunctional protein PutA1.5.5.20.443
2a1oCAMCamphor 5-monooxygenase1.14.15.10.443
2dsgSAHDiphthine synthase/0.443
2eh2SAHDiphthine synthase/0.443
2g1n1IGRenin3.4.23.150.443
2p5fSAHDiphthine synthase/0.443
2z3lPHE_ARG_TYR_LEU_GLYLeucyl/phenylalanyl-tRNA--protein transferase2.3.2.60.443
3ig6438Urokinase-type plasminogen activator3.4.21.730.443
4ipw1G7Mycocyclosin synthase1.14.21.90.443
4o1mNADEnoyl-acyl carrier reductase/0.443
2e16SAHDiphthine synthase/0.442
2f3rG5PGuanylate kinase2.7.4.80.442
2watCOAFatty acid synthase subunit alpha2.3.1.860.442
3g70A5TRenin3.4.23.150.442
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.442
4xr9NADCalS8/0.442
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2e8rSAHDiphthine synthase/0.441
2p6dSAHDiphthine synthase/0.441
3a1nNADNDP-sugar epimerase/0.441
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4a862ANMajor pollen allergen Bet v 1-A/0.441
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1rneC60Renin3.4.23.150.440
2c20NADUDP-glucose 4-epimerase/0.440
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.440
2ejkSAHDiphthine synthase/0.440
2g247IGRenin3.4.23.150.440
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.440
2p6iSAHDiphthine synthase/0.440
2pb4SAHDiphthine synthase/0.440
2yj4ATPCopper-transporting ATPase/0.440
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4g3jVNTLanosterol 14-alpha-demethylase/0.440
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.440
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440