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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1d7oTCLEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1d7oTCLEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.91.000
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.583
4igfCHVEnoyl-acyl carrier reductase/0.562
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.528
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.527
1uh5TCLEnoyl-ACP reductase/0.504
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.495
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.495
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.490
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.489
1hfqMOTDihydrofolate reductase1.5.1.30.486
2o2yTCLEnoyl-ACP reductase/0.486
2op07PCEnoyl-ACP reductase/0.486
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.485
2nnqT4BFatty acid-binding protein, adipocyte/0.484
3lsyFT0Enoyl-ACP reductase/0.483
4e37NDPCatalase1.11.1.60.482
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.482
1x8lOXRRetinol dehydratase/0.481
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.481
3nj8NJ8Enoyl-acyl carrier reductase/0.478
3h3qH13Collagen type IV alpha-3-binding protein/0.477
3lt1FT2Enoyl-ACP reductase/0.477
2foiJPAEnoyl-acyl carrier reductase/0.476
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.474
1fmjRTLRetinol dehydratase/0.473
1zw1TN5Enoyl-ACP reductase/0.473
3f4bTCLEnoyl-acyl carrier protein reductase/0.472
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.471
2o2sTCLEnoyl-acyl carrier reductase/0.471
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.469
1zsnTN2Enoyl-ACP reductase/0.469
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.468
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.467
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2uxoTACHTH-type transcriptional regulator TtgR/0.465
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.465
1pqc444Oxysterols receptor LXR-beta/0.464
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.464
2zda32UProthrombin3.4.21.50.464
3am5TCLEnoyl-ACP reductase/0.464
3h3t16HCollagen type IV alpha-3-binding protein/0.464
1nhwTCCEnoyl-ACP reductase/0.463
2ejzSAHDiphthine synthase/0.463
2qboCAMCamphor 5-monooxygenase1.14.15.10.463
2x23TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
3h4vDVPPteridine reductase 11.5.1.330.463
3vjcZGASqualene synthase2.5.1.210.462
4igeCHJEnoyl-acyl carrier reductase/0.462
3eq02TSProthrombin3.4.21.50.461
1nhgTCLEnoyl-ACP reductase/0.460
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.460
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.460
4lb2DM5Serum albumin/0.460
2oz57XYUncharacterized protein/0.459
4o8aFADBifunctional protein PutA1.2.1.880.459
2zhf49UProthrombin3.4.21.50.458
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
2ol4JPNEnoyl-ACP reductase/0.457
2v8pCDP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.457
3dhk23UProthrombin3.4.21.50.456
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.456
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.456
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.455
3gwfFADCyclohexanone monooxygenase/0.455
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.455
3zoiM2WIsopenicillin N synthase1.21.3.10.455
4mv1ADPBiotin carboxylase6.3.4.140.455
5kf1ACOPredicted acetyltransferase/0.455
1cqp803Integrin alpha-L/0.454
1n83CLRNuclear receptor ROR-alpha/0.454
2zff53UProthrombin3.4.21.50.454
3biu10UProthrombin3.4.21.50.454
3hl0NADMaleylacetate reductase/0.454
3ielU5PRibonuclease TTHA02523.10.454
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.454
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.454
3lt2FT3Enoyl-ACP reductase/0.454
1fmlRTLRetinol dehydratase/0.453
3qly55VUncharacterized protein/0.453
3uayADNPurine nucleoside phosphorylase DeoD-type/0.453
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.452
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3fr4F8AFatty acid-binding protein, adipocyte/0.452
3v0o4GWHisto-blood group ABO system transferase/0.452
4krs1SXTankyrase-12.4.2.300.452
4p9dTMPDeoxycytidylate deaminase/0.452
1pkfEPDEpothilone C/D epoxidase1.140.451
3zkyWT4Isopenicillin N synthase1.21.3.10.451
4c9wVGH7,8-dihydro-8-oxoguanine triphosphatase3.6.1.550.451
4dxlC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.451
1ae8AZLProthrombin3.4.21.50.450
1dr3HBIDihydrofolate reductase1.5.1.30.450
1euyQSIGlutamine--tRNA ligase6.1.1.180.450
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.450
2aouCQAHistamine N-methyltransferase2.1.1.80.450
3c1kT15Prothrombin3.4.21.50.450
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4j3mAJ8Tankyrase-22.4.2.300.450
1rf9DBRCamphor 5-monooxygenase1.14.15.10.449
2zbaZBATrichothecene 3-O-acetyltransferase/0.449
2zg050UProthrombin3.4.21.50.449
3h1vTK1Glucokinase2.7.1.20.449
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2bfmTOPPteridine reductase 11.5.1.330.448
2w6oOA3Biotin carboxylase6.3.4.140.448
3am4FT1Enoyl-ACP reductase/0.448
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.448
4b722FBBeta-secretase 13.4.23.460.448
4q71FADBifunctional protein PutA/0.448
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1rd4L08Integrin alpha-L/0.447
2nr4FMNConserved protein/0.447
2p7zOHTEstrogen-related receptor gamma/0.447
3e2sFADBifunctional protein PutA1.5.5.20.447
3ov4EQUSteroid Delta-isomerase5.3.3.10.447
3p6oETGCamphor 5-monooxygenase1.14.15.10.447
4jq8KJ8Epidermal growth factor receptor2.7.10.10.447
4x5jFOLDihydrofolate reductase1.5.1.30.447
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1zg32HIIsoflavone 4'-O-methyltransferase/0.446
2bvs2CEProthrombin3.4.21.50.446
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.446
2y60M8FIsopenicillin N synthase1.21.3.10.446
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.446
3p3zP3ZPutative cytochrome P450/0.446
3pqbVGPPutative oxidoreductase/0.446
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.446
1culFOKAdenylate cyclase type 2/0.445
1culFOKAdenylate cyclase type 5/0.445
1mczRMNBenzoylformate decarboxylase4.1.1.70.445
1tj2FADBifunctional protein PutA1.5.5.20.445
1xm1GAHProthrombin3.4.21.50.445
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.445
2ea4F79Methionine aminopeptidase 2/0.445
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.445
3k1wBFXRenin3.4.23.150.445
3x2fNAIAdenosylhomocysteinase/0.445
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4jx1CAMCamphor 5-monooxygenase1.14.15.10.445
4xwtU5PRibonuclease J/0.445
1afeALZProthrombin3.4.21.50.444
1dhfFOLDihydrofolate reductase1.5.1.30.444
1g63FMNEpidermin decarboxylase4.1.10.444
1synF89Thymidylate synthase/0.444
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.444
2zc922UProthrombin3.4.21.50.444
3ddw055Glycogen phosphorylase, liver form2.4.1.10.444
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.444
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4ayv9MQProthrombin3.4.21.50.444
4bb3KKAIsopenicillin N synthase1.21.3.10.444
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4egnTWOCytochrome P450/0.444
4ips1G4Mycocyclosin synthase1.14.21.90.444
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1k7fIAVTryptophan synthase alpha chain/0.443
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3p6nDSOCamphor 5-monooxygenase1.14.15.10.443
4jpe1M7Beta-secretase 13.4.23.460.443
4la0198Serum albumin/0.443
4uyf73BBromodomain-containing protein 2/0.443
1blzACVIsopenicillin N synthase1.21.3.10.442
1obnASVIsopenicillin N synthase1.21.3.10.442
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1yc2NADNAD-dependent protein deacylase 2/0.442
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2ft9CHDFatty acid-binding protein 2, liver/0.442
2oazI96Methionine aminopeptidase 2/0.442
2q4wFADCytokinin dehydrogenase 71.5.99.120.442
3hu1AGSTransitional endoplasmic reticulum ATPase3.6.4.60.442
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
1re9DSOCamphor 5-monooxygenase1.14.15.10.441
1toiHCIAspartate aminotransferase2.6.1.10.441
2jh0701Prothrombin3.4.21.50.441
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.441
2w6pOA4Biotin carboxylase6.3.4.140.441
2zgx29UProthrombin3.4.21.50.441
2ziq26UProthrombin3.4.21.50.441
3am3TCLEnoyl-ACP reductase/0.441
3nfrEWQRibosyldihydronicotinamide dehydrogenase [quinone]/0.441
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3vv8B02Beta-secretase 13.4.23.460.441
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.441
4ax9N5NProthrombin3.4.21.50.441
4hyf1AKTankyrase-22.4.2.300.441
5cc9DDFDihydrofolate reductase1.5.1.30.441
1ia4TQ6Dihydrofolate reductase1.5.1.30.440
1x2hLPALipoate-protein ligase A6.3.1.200.440
1ypjUIBProthrombin3.4.21.50.440
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.440
2cf9348Prothrombin3.4.21.50.440
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2pbzATPUncharacterized protein/0.440
2r2mI50Prothrombin3.4.21.50.440
2vbpVB1Isopenicillin N synthase1.21.3.10.440
2zdv37UProthrombin3.4.21.50.440
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3h3r14HCollagen type IV alpha-3-binding protein/0.440
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.440
4djw0KPBeta-secretase 13.4.23.460.440
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.440
4kbyC2EStimulator of interferon genes protein/0.440
4ypuSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.440