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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ccx SAH tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 1.147
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 1.135
1i9g SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.907
2yvl SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.867
2pwy SAHtRNA (adenine(58)-N(1))-methyltransferase TrmI 2.1.1.220 0.861
3lga SAHtRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI 2.1.1.219 0.851
3orh SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.836
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.828
3emd SFGMethyltransferase / 0.773
2g1p SAHDNA adenine methylase 2.1.1.72 0.771
4azw SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.767
2bzg SAHThiopurine S-methyltransferase 2.1.1.67 0.758
3lcc SAHThiocyanate methyltransferase 1 / 0.758
3duw SAHO-methyltransferase, putative / 0.757
4o29 SAHProtein-L-isoaspartate O-methyltransferase / 0.756
5k7w SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.753
4ctj SAMGenome polyprotein / 0.749
1yf3 SAHDNA adenine methylase / 0.747
2px2 SAHGenome polyprotein 2.7.7.48 0.746
3grr SAHProbable ribosomal RNA small subunit methyltransferase A / 0.745
3ssm SAHMycinamicin VI 2''-O-methyltransferase / 0.744
3evb SAHGenome polyprotein 2.1.1.56 0.742
1wy7 SAHUncharacterized protein / 0.739
3uj8 SFGPhosphoethanolamine N-methyltransferase / 0.736
4kwc SAHMethyltransferase domain family / 0.736
1p1b SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.734
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.734
3gry SAMProbable ribosomal RNA small subunit methyltransferase A / 0.733
4gbe SAHDNA adenine methylase 2.1.1.72 0.733
2hnk SAHSAM-dependent O-methyltransferase / 0.732
2ji7 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.732
4nec SAHPutative SAM-dependent methyltransferase / 0.732
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.731
1l3i SAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) / 0.730
3uj7 SAMPhosphoethanolamine N-methyltransferase / 0.730
3c3y SAHO-methyltransferase / 0.728
3ou2 SAHSAM-dependent methyltransferase / 0.728
5je2 SAHMethyl transferase / 0.727
4oa5 SAHO-methyltransferase family protein / 0.725
5il2 SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.725
2px5 SAHGenome polyprotein 2.7.7.48 0.724
3g07 SAM7SK snRNA methylphosphate capping enzyme 2.1.1 0.724
4e2x SAHMethyltransferase / 0.724
4k6m SAHGenome polyprotein / 0.724
4qdk SAHMagnesium-protoporphyrin O-methyltransferase 2.1.1.11 0.724
3v8v SAMRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.723
4iv0 SAMPhosphoethanolamine N-methyltransferase, putative / 0.723
2i9k SAHModification methylase HhaI 2.1.1.37 0.722
2yqz SAMUncharacterized protein / 0.722
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.722
4ax8 SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.722
4mwz SAMPhosphoethanolamine N-methyltransferase, putative / 0.722
2bm9 SAMCephalosporin hydroxylase CmcI / 0.721
1p1c SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.720
4rtk SAHDNA adenine methylase 2.1.1.72 0.720
5f2k SAHUncharacterized protein / 0.720
1nbh SAMGlycine N-methyltransferase 2.1.1.20 0.719
4hc4 SAHProtein arginine N-methyltransferase 6 / 0.719
4yac NAIC alpha-dehydrogenase / 0.719
3v97 SAHRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.717
2uyh SAHModification methylase HhaI 2.1.1.37 0.716
3lkz SFGGenome polyprotein / 0.716
3rw9 DSHSpermidine synthase 2.5.1.16 0.716
1khh SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.715
3sr4 TT8Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.715
5jjr SAHGenome polyprotein / 0.714
3tr6 SAHO-methyltransferase / 0.713
1wg8 SAMRibosomal RNA small subunit methyltransferase H / 0.711
3fri SAH16S rRNA methylase / 0.711
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.711
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.710
2nyu SAMrRNA methyltransferase 2, mitochondrial / 0.709
3pt9 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.709
4ctk SAMGenome polyprotein / 0.709
4kdr SAHUbiquinone biosynthesis O-methyltransferase / 0.709
1boo SAHModification methylase PvuII 2.1.1.113 0.708
3ou6 SAMSAM-dependent methyltransferase / 0.708
1nbi SAMGlycine N-methyltransferase 2.1.1.20 0.707
4lwp SAHArginine N-methyltransferase, putative / 0.707
3cbg SAHO-methyltransferase / 0.706
4xvy SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.706
7mht SAHModification methylase HhaI 2.1.1.37 0.706
3evc SAHGenome polyprotein 2.1.1.56 0.705
4hh4 SAHCcbJ / 0.705
4krh SAMPhosphoethanolamine N-methyltransferase 2 / 0.705
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.704
2eju SAHtRNA (guanine(26)-N(2))-dimethyltransferase / 0.704
3e23 SAMUncharacterized protein / 0.704
3mte SAM16S rRNA (adenine(1408)-N(1))-methyltransferase 2.1.1.180 0.704
4gf5 SAHCalS11 / 0.704
4j2w FADKynurenine 3-monooxygenase / 0.704
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.704
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.703
3q87 SAMN6 ADENINE SPECIFIC DNA METHYLASE (METHYLTRANSFERASE SUPERFAMILY) / 0.703
3vyw SAMUncharacterized protein / 0.703
1ve3 SAMUncharacterized protein / 0.702
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.702
4uy6 SAHHistidine N-alpha-methyltransferase / 0.702
5fa5 MTAProtein arginine N-methyltransferase 5 / 0.702
1eg2 MTAModification methylase RsrI 2.1.1.72 0.701
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.701
3dmg SAHProbable ribosomal RNA small subunit methyltransferase / 0.701
1bc5 SAHChemotaxis protein methyltransferase 2.1.1.80 0.700
3kpj SAHPhenylethanolamine N-methyltransferase 2.1.1.28 0.700
5jr3 SAHCarminomycin 4-O-methyltransferase DnrK 2.1.1.292 0.700
1g60 SAMModification methylase MboII 2.1.1.72 0.699
3iv6 SAMUncharacterized protein / 0.699
5bp9 SAHPutative methyltransferase protein / 0.699
2vdv SAMtRNA (guanine-N(7)-)-methyltransferase / 0.698
2zzm SAMtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.698
4rvd SAMD-mycarose 3-C-methyltransferase / 0.698
2nxe SAMRibosomal protein L11 methyltransferase 2.1.1 0.697
5k7u SAMN6-adenosine-methyltransferase 70 kDa subunit / 0.697
3ely SAHMethyltransferase / 0.696
4fp9 SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.696
4j33 FADKynurenine 3-monooxygenase / 0.696
4fgz SAHPhosphoethanolamine N-methyltransferase / 0.695
4y9d NAIC alpha-dehydrogenase / 0.695
2qa2 FADPolyketide oxygenase CabE / 0.694
3egv SAHRibosomal protein L11 methyltransferase 2.1.1 0.694
4g56 SAHProtein arginine N-methyltransferase 5 / 0.694
4gdp FADPolyamine oxidase FMS1 / 0.694
1f3l SAHProtein arginine N-methyltransferase 3 / 0.693
3swr SFGDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.693
4gqb 0XUProtein arginine N-methyltransferase 5 / 0.693
1g1a NADdTDP-glucose 4,6-dehydratase / 0.692
1i3l NADUDP-glucose 4-epimerase / 0.692
1rje SAHLeucine carboxyl methyltransferase 1 2.1.1.233 0.692
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.692
2pkk 2FAAdenosine kinase 2.7.1.20 0.692
3reo SAH(Iso)eugenol O-methyltransferase 2.1.1.146 0.692
3wst SAHProtein arginine N-methyltransferase 7 2.1.1 0.692
1skm SAHModification methylase HhaI 2.1.1.37 0.691
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.691
3go4 SAHUncharacterized protein / 0.691
2okc SAMProbable type I restriction enzyme BthVORF4518P M protein 2.1.1.72 0.690
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.690
2gs9 SAHUncharacterized protein / 0.689
2o06 MTASpermidine synthase 2.5.1.16 0.689
4c03 SFGProtein arginine N-methyltransferase 6 / 0.689
2p35 SAHTrans-aconitate 2-methyltransferase / 0.688
4qpp SAHProtein arginine N-methyltransferase 6 / 0.688
2a14 SAHIndolethylamine N-methyltransferase 2.1.1.49 0.687
2pxa SAHGenome polyprotein 2.7.7.48 0.687
4blw SAHRibosomal RNA large subunit methyltransferase J / 0.687
3elu SAMMethyltransferase / 0.685
3kkz SAMUncharacterized protein / 0.685
3mht SAHModification methylase HhaI 2.1.1.37 0.685
2c7q SAHModification methylase HhaI 2.1.1.37 0.684
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.684
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.684
3p8z SAHGenome polyprotein 2.1.1.56 0.684
4tlz FADKtzI / 0.683
5bxy SAHPutative RNA methylase family UPF0020 / 0.683
5jdz SAHMethyl transferase / 0.683
3axs SFGtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase / 0.682
3eld SFGMethyltransferase / 0.682
3eva SAHGenome polyprotein 2.1.1.56 0.682
3sgl SAMtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.682
4c04 SFGProtein arginine N-methyltransferase 6 / 0.682
4u7t SAHDNA (cytosine-5)-methyltransferase 3A 2.1.1.37 0.682
4x3q SAHSibL / 0.682
1kr5 SAHProtein-L-isoaspartate(D-aspartate) O-methyltransferase 2.1.1.77 0.681
2hms NAIKtr system potassium uptake protein A / 0.681
2plw SAMRibosomal RNA methyltransferase, putative / 0.681
4rtj SFGDNA adenine methylase 2.1.1.72 0.680
5cku FADL-ornithine N(5)-monooxygenase / 0.680
1ptj SNDNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.679
2o07 MTASpermidine synthase 2.5.1.16 0.679
2p5u NADUDP-glucose 4-epimerase / 0.679
3cjt SAHRibosomal protein L11 methyltransferase 2.1.1 0.679
3lcu SAH16S rRNA (guanine(1405)-N(7))-methyltransferase 2.1.1.179 0.679
3p97 SAMGenome polyprotein 2.1.1.56 0.679
2ytz SAHtRNA (guanine(26)-N(2))-dimethyltransferase / 0.678
4m37 SAHProtein arginine N-methyltransferase 7 2.1.1 0.678
4ube 2FAAdenosine kinase 2.7.1.20 0.678
2pzj NADPutative nucleotide sugar epimerase/ dehydratase / 0.677
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.677
4guv FADTetX family tetracycline inactivation enzyme / 0.677
4l7v SAHProtein-L-isoaspartate O-methyltransferase / 0.677
4r6x SAHPhosphoethanolamine N-methyltransferase / 0.677
5dto SAHGenome polyprotein / 0.677
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.676
3dh0 SAMUncharacterized protein / 0.676
3gsi FADDimethylglycine oxidase 1.5.3.10 0.676
2c20 NADUDP-glucose 4-epimerase / 0.675
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.675
5je3 SAHMethyl transferase / 0.675
2ih2 NEAModification methylase TaqI 2.1.1.72 0.674
2qe6 SAMUncharacterized protein / 0.674
3ldg SAHUncharacterized protein / 0.674
5dwq SFGHistone-arginine methyltransferase CARM1 / 0.674
3tsc NADUncharacterized protein / 0.673
4wxx SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.673
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.672
1pdh FASp-hydroxybenzoate hydroxylase / 0.672
1u2d NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.672
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.672
3gwz SAHMitomycin biosynthesis 6-O-methyltransferase / 0.672
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.672
10mh SAHModification methylase HhaI 2.1.1.37 0.671
3dlc SAMSAM (And some other nucleotide) binding motif:Generic methyltransferase / 0.671
3tm4 SAMUncharacterized protein / 0.671
2yx1 SFGtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.670
3sso SAHMycinamicin VI 2''-O-methyltransferase / 0.670
1jr4 CL4Catechol O-methyltransferase 2.1.1.6 0.669
3eey SAMrRNA methylase / 0.669
4kvz SAHPtnL protein / 0.669
5epe SAHUncharacterized protein / 0.669
1l9k SAHGenome polyprotein 2.7.7.48 0.668
2i62 SAHNicotinamide N-methyltransferase 2.1.1.1 0.668
2ih5 NEAModification methylase TaqI 2.1.1.72 0.668
2oy0 SAHGenome polyprotein / 0.668
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.668
4obw SAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial / 0.668
2zfu SAHRibosomal RNA-processing protein 8 / 0.667
3lfz ADPUncharacterized protein MJ1225 / 0.667
3ua3 SAHProtein arginine N-methyltransferase 5 / 0.667
4ckc SAHmRNA-capping enzyme catalytic subunit 2.1.1.56 0.667
4gc9 SAMDimethyladenosine transferase 1, mitochondrial 2.1.1 0.667
1sqf SAMRibosomal RNA small subunit methyltransferase B 2.1.1.176 0.666
3a25 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.666
1r6a SAHGenome polyprotein 2.7.7.48 0.664
1z3c SA8mRNA cap guanine-N7 methyltransferase 2.1.1.56 0.664
2ibt NEAModification methylase TaqI 2.1.1.72 0.664
3pt6 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.664
5je4 SAHMethyl transferase / 0.664
1x15 NADNAD(P) transhydrogenase subunit alpha 1.6.1.2 0.663
2zwv SAHProbable ribosomal RNA small subunit methyltransferase / 0.663
4n48 SAMCap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 2.1.1.57 0.663
5f8e SAHPossible transcriptional regulatory protein / 0.663
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.662
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.662
5icf SAH(S)-norcoclaurine 6-O-methyltransferase / 0.662
1kia SAMGlycine N-methyltransferase 2.1.1.20 0.661
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.661
3lby SAHUncharacterized protein / 0.661
4qtu SAM18S rRNA (guanine(1575)-N(7))-methyltransferase / 0.661
5d4u SAMUncharacterized protein MJ0489 / 0.661
1qaq SFGrRNA adenine N-6-methyltransferase 2.1.1.184 0.660
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.660
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.660
3icp NADNAD-dependent epimerase/dehydratase / 0.659
4x7y SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.659
1fjx SAHModification methylase HhaI 2.1.1.37 0.658
4ce0 SAHProbable O-methyltransferase / 0.658
5ahk FADAcetolactate synthase II, large subunit / 0.658
2yy7 NADL-threonine dehydrogenase / 0.657
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.656
2dpm SAMModification methylase DpnIIA 2.1.1.72 0.656
2h39 ADQADP-glucose phosphorylase / 0.656
3p9k SAHCaffeic acid O-methyltransferase / 0.656
4eaj ATP5'-AMP-activated protein kinase subunit gamma-1 / 0.655
4rtm SAMDNA adenine methylase 2.1.1.72 0.655
5d4v SAHUncharacterized protein MJ0489 / 0.655
1nw3 SAMHistone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.654
2v7g NADUrocanate hydratase 4.2.1.49 0.654
3h5n ATPMccB protein / 0.654
3o7w SAMLeucine carboxyl methyltransferase 1 2.1.1.233 0.654
4dcm SAMRibosomal RNA large subunit methyltransferase G 2.1.1.174 0.654
4k5r FADOxygenase / 0.654
5jjs SAHGenome polyprotein / 0.654
1zq9 SAMProbable dimethyladenosine transferase / 0.653
2zcj SAHModification methylase HhaI 2.1.1.37 0.653
3ou7 SAMSAM-dependent methyltransferase / 0.653
3r6t LU1Catechol O-methyltransferase 2.1.1.6 0.653
3wdm ADN4-phosphopantoate--beta-alanine ligase 6.3.2.36 0.653
4eak ATP5'-AMP-activated protein kinase subunit gamma-1 / 0.653
1f8g NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.652
1r00 SAHAclacinomycin 10-hydroxylase RdmB 4.1.1 0.652
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.652
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.652
3wv8 ATPHmd co-occurring protein HcgE / 0.652
4dmg SAMUncharacterized protein / 0.652
4rtl SFGDNA adenine methylase 2.1.1.72 0.652
2j9l ATPH(+)/Cl(-) exchange transporter 5 / 0.651
3nwe 662Catechol O-methyltransferase 2.1.1.6 0.651
4b63 FADL-ornithine N(5)-monooxygenase / 0.651
1k0l FADp-hydroxybenzoate hydroxylase / 0.650
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.650
3fpf MTAUncharacterized protein / 0.650
4rtp SAMDNA adenine methylase 2.1.1.72 0.650