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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h3q ANP Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 1.073
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.946
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.849
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.843
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.805
3nie ANPMitogen-activated protein kinase / 0.796
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.796
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.792
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.788
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.774
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.770
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.770
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.769
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.760
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.757
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.756
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.755
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.755
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.752
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.751
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.751
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.747
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.745
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.742
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.742
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.741
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.741
4qny ANPMitogen activated protein kinase, putative / 0.740
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.738
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.738
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.738
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.736
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.735
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.735
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.734
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.733
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.732
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.731
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.729
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.729
3t8o ATPRhodopsin kinase / 0.729
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.727
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.725
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.724
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
3a8w ATPProtein kinase C iota type 2.7.11.13 0.722
3cly ACPFibroblast growth factor receptor 2 / 0.722
3orp AGSSerine/threonine protein kinase / 0.722
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.722
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.722
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.721
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.721
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.721
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.721
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.720
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.720
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.719
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.718
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.717
3c4z ADPRhodopsin kinase / 0.717
1cm8 ANPMitogen-activated protein kinase 12 / 0.716
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.716
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.716
1u54 ACPActivated CDC42 kinase 1 / 0.715
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.713
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.712
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.711
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.711
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.708
5dr2 ATPAurora kinase A 2.7.11.1 0.708
4dee ADPAurora kinase A 2.7.11.1 0.707
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.705
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.705
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.704
1mq4 ADPAurora kinase A 2.7.11.1 0.703
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.703
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.702
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.701
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.700
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.699
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.698
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.698
2pun ACPMethylthioribose kinase 2.7.1.100 0.696
4ysj ADPCalmodulin-like domain protein kinase / 0.696
3ort AGSSerine/threonine protein kinase / 0.695
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
4o1p ANPRibonuclease L / 0.695
4o4e ATPKinase / 0.695
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.695
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.695
3qc9 ADPRhodopsin kinase / 0.694
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.693
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.693
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.693
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.692
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.691
3c50 ADPRhodopsin kinase / 0.691
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.691
4ffr ATPUncharacterized protein / 0.691
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.691
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.690
2pml ANPUncharacterized protein / 0.690
2py3 ACPFibroblast growth factor receptor 2 / 0.690
2pz5 ACPFibroblast growth factor receptor 2 / 0.690
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.690
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.689
3c4w ATPRhodopsin kinase / 0.689
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.689
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.689
5dos ATPAurora kinase A 2.7.11.1 0.689
2pui ADPMethylthioribose kinase 2.7.1.100 0.688
2pzp ACPFibroblast growth factor receptor 2 / 0.688
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.688
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.687
3llt ANPProtein serine/threonine kinase-1 / 0.687
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.686
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.686
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.686
4bn1 ADPAurora kinase A 2.7.11.1 0.685
4xlv ACPInsulin receptor 2.7.10.1 0.685
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
5eg3 ACPFibroblast growth factor receptor 2 / 0.684
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.683
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.683
1ol5 ADPAurora kinase A 2.7.11.1 0.682
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.682
3oro AGSSerine/threonine protein kinase / 0.682
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.681
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.681
4ffl ADPUncharacterized protein / 0.681
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.680
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.678
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.677
2yaa ATPDeath-associated protein kinase 2 / 0.677
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
1ir3 ANPInsulin receptor 2.7.10.1 0.674
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.673
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.673
2pup ADPMethylthioribose kinase 2.7.1.100 0.672
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.672
3ork AGSSerine/threonine protein kinase / 0.672
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.672
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.672
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.672
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.670
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.670
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.669
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.669
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.669
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.669
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.669
4o0w ADNAurora kinase A 2.7.11.1 0.669
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.668
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.667
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.667
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.667
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.667
5drd ATPAurora kinase A 2.7.11.1 0.667
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.666
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.666
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.666
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.665
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.665
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.665
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.664
2wqe ADPAurora kinase A 2.7.11.1 0.664
4ceg ADPAurora kinase A 2.7.11.1 0.664
4ffm ADPUncharacterized protein / 0.663
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.662
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.662
2e15 SAHDiphthine synthase / 0.661
2e7r SAHDiphthine synthase / 0.661
2ehl SAHDiphthine synthase / 0.661
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.661
4o4f ATPKinase / 0.661
4q5h ANPProtein kinase OspG 2.7 0.661
4utd ACPAurora kinase A 2.7.11.1 0.660
5dt4 ATPAurora kinase A 2.7.11.1 0.660
5e9e ANPMyosin heavy chain kinase A 2.7.11.7 0.660
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.659
3ori AGSSerine/threonine protein kinase / 0.659
5dnr ATPAurora kinase A 2.7.11.1 0.659
2cjm ATPCyclin-dependent kinase 2 2.7.11.22 0.658
3mfu ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.658
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.658
5ce3 ADPProtein kinase YopO / 0.658
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.657
2egl SAHDiphthine synthase / 0.656
3bu5 ATPInsulin receptor 2.7.10.1 0.656
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4o0u ADNAurora kinase A 2.7.11.1 0.656
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.655
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.655
2cch ATPCyclin-dependent kinase 2 2.7.11.22 0.654
4c3r ACPAurora kinase A 2.7.11.1 0.654
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.653
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.653
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.653
2dwb ANPAurora kinase A 2.7.11.1 0.653
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.652
4s1h ADPPyridoxal kinase, putative / 0.652
4wh3 ATPN-acetylhexosamine 1-kinase 2.7.1.162 0.652
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.651
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4lrj ANPUncharacterized protein / 0.651
4mv3 ACPBiotin carboxylase 6.3.4.14 0.651
4ix4 ADPUncharacterized protein / 0.650