Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ru7 NAD UDP-N-acetylglucosamine 4-epimerase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 1.206
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 1.099
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 1.092
3rud NADUDP-N-acetylglucosamine 4-epimerase / 1.086
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 1.079
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 1.077
3rua NADUDP-N-acetylglucosamine 4-epimerase / 1.064
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 1.059
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.988
2p5y NADUDP-glucose 4-epimerase / 0.937
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.904
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.887
1i3l NADUDP-glucose 4-epimerase / 0.886
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.883
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.881
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.877
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.876
3icp NADNAD-dependent epimerase/dehydratase / 0.871
3ko8 NADNAD-dependent epimerase/dehydratase / 0.870
1orr NADCDP-paratose 2-epimerase / 0.868
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.862
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.854
2pzj NADPutative nucleotide sugar epimerase/ dehydratase / 0.853
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.846
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.844
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.835
3sx2 NADUncharacterized protein / 0.829
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.828
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.825
3aw9 NADNAD-dependent epimerase/dehydratase / 0.822
4twr NADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase / 0.818
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.817
4lk3 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.815
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.805
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.804
2p5u NADUDP-glucose 4-epimerase / 0.803
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.799
4qec NAPElxO / 0.789
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.787
3wds NADNADH-dependent quinuclidinone reductase / 0.787
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.786
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.785
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.784
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.783
4m55 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.782
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.782
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.781
3tsc NADUncharacterized protein / 0.781
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.777
4u7w NDPMxaA / 0.776
1u7t NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.772
4egb NADdTDP-glucose 4,6-dehydratase / 0.772
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.770
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.767
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.766
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.766
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.765
3ak4 NADNADH-dependent quinuclidinone reductase / 0.764
3s55 NADPutative short-chain dehydrogenase/reductase / 0.764
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.764
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.763
2wsb NADGalactitol dehydrogenase / 0.762
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.760
4qed NAPElxO / 0.758
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.757
3orf NADDihydropteridine reductase 1.5.1.34 0.755
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.754
1eq2 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.753
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.753
3qrw NDPPutative ketoacyl reductase 1.3.1 0.753
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.751
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.749
3geg NADShort-chain dehydrogenase/reductase SDR / 0.748
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.748
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.747
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.743
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.743
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.743
1x7g NAPPutative ketoacyl reductase 1.3.1 0.742
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.742
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.742
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.740
3o26 NDPSalutaridine reductase / 0.740
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.740
1zem NADXylitol dehydrogenase / 0.737
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.737
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.736
2c20 NADUDP-glucose 4-epimerase / 0.734
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.732
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.729
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.729
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.729
5lc1 NADL-threonine 3-dehydrogenase / 0.729
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.728
3ai2 NDPNADPH-sorbose reductase / 0.728
1oaa NAPSepiapterin reductase 1.1.1.153 0.726
2wdz NADGalactitol dehydrogenase / 0.726
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.726
2bfo NDPPteridine reductase 1 1.5.1.33 0.725
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.725
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.724
1pr9 NAPL-xylulose reductase 1.1.1.10 0.724
1x7h NDPPutative ketoacyl reductase 1.3.1 0.724
3ai3 NDPNADPH-sorbose reductase / 0.723
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.723
4fn4 NADShort chain dehydrogenase / 0.722
4idg NADPutative UDP-glucose 4-epimerase / 0.721
3wmx NADNAD dependent epimerase/dehydratase / 0.720
4wec NADShort chain dehydrogenase / 0.720
5jla NADPutative short-chain dehydrogenase/reductase / 0.720
2gn8 NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.719
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.719
4b79 NADProbable short-chain dehydrogenase / 0.719
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.718
3a9w NADNDP-sugar epimerase / 0.718
3p19 NDPPutative blue fluorescent protein / 0.717
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.717
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.716
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.716
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.715
2z1m NDPGDP-mannose 4,6-dehydratase / 0.715
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.714
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.714
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.714
1iy8 NADLevodione reductase / 0.712
1n7h NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.711
3a4v NADNDP-sugar epimerase / 0.711
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.708
1rpn NDPGDP-mannose 4,6-dehydratase / 0.707
1t2a NDPGDP-mannose 4,6 dehydratase 4.2.1.47 0.706
4dbz NDPPutative ketoacyl reductase 1.3.1 0.706
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.702
2c29 NAPDihydroflavonol 4-reductase / 0.701
2yut NAPPutative short-chain oxidoreductase / 0.701
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.701
4j7x NAPSepiapterin reductase 1.1.1.153 0.700
1ek5 NADUDP-glucose 4-epimerase / 0.699
2yy7 NADL-threonine dehydrogenase / 0.699
3h4v NAPPteridine reductase 1 1.5.1.33 0.699
3l77 NJPShort-chain alcohol dehydrogenase / 0.699
4hwk NAPSepiapterin reductase 1.1.1.153 0.697
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.696
3o4r NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.696
1g1a NADdTDP-glucose 4,6-dehydratase / 0.695
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.695
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.694
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.694
3ajr NADNDP-sugar epimerase / 0.694
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.693
3sju NDPKeto reductase / 0.693
4yag NAIC alpha-dehydrogenase / 0.693
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.692
4b4o NDPEpimerase family protein SDR39U1 / 0.692
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.691
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.691
1sby NADAlcohol dehydrogenase 1.1.1.1 0.689
1w4z NAPPutative ketoacyl reductase 1.3.1 0.689
2z95 NDPGDP-mannose 4,6-dehydratase / 0.688
4nbw NADShort-chain dehydrogenase/reductase SDR / 0.688
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.687
3uce NDPDehydrogenase / 0.687
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.687
4kwh NAPReductase homolog / 0.687
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.684
2hrb NAPCarbonyl reductase [NADPH] 3 1.1.1.184 0.684
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.684
4j7u NAPSepiapterin reductase 1.1.1.153 0.684
2jah NDPClavaldehyde dehydrogenase / 0.682
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.682
2dte NAIGlucose 1-dehydrogenase related protein / 0.681
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.681
5jyd NADShort chain dehydrogenase / 0.680
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.679
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.679
4id9 NADPutative UDP-glucose 4-epimerase / 0.679
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.679
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.678
4kwc SAHMethyltransferase domain family / 0.678
4bmv NAPShort-chain dehydrogenase / 0.677
1sny NAPLD36273p / 0.676
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.675
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.675
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.674
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.674
4imp NDPPolyketide synthase extender modules 3-4 / 0.674
4i5e NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.673
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.672
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.671
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.671
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.671
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.670
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.670
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.669
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.669
3d3w NAPL-xylulose reductase 1.1.1.10 0.669
3g49 NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.669
3qvt NAIMyo-inositol-1-phosphate synthase (Ino1) / 0.669
4yai NAIC alpha-dehydrogenase / 0.669
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.668
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.668
3u4c NDPNADPH-dependent reductase BacG / 0.668
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.667
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.667
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.667
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.667
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.667
1kc1 NDPdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.666
3lqf NADGalactitol dehydrogenase / 0.666
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.666
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.666
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.665
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.665
4e5y NDPGDP-L-fucose synthase 1.1.1.271 0.665
2bgl NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.663
3ec7 NADInositol 2-dehydrogenase / 0.663
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.663
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.662
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.662
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.661
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.661
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.661
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.660
4yac NAIC alpha-dehydrogenase / 0.660
1p1i NADInositol-3-phosphate synthase 5.5.1.4 0.659
2yw9 NAPEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.659
3mht SAHModification methylase HhaI 2.1.1.37 0.659
4xgi NADGlutamate dehydrogenase / 0.659
1qyv NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.658
1xq6 NAPUncharacterized protein At5g02240 / 0.658
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.658
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.658
4b7x NAPProbable oxidoreductase / 0.657
4i1i NADMalate dehydrogenase / 0.655
4yr9 NADL-threonine 3-dehydrogenase, mitochondrial 1.1.1.103 0.655
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.654
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.653
4fw8 NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.653
1enz NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.652
1hdr NADDihydropteridine reductase 1.5.1.34 0.652
1ipe NDPTropinone reductase 2 1.1.1.236 0.652
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.652
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.652
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.652
5jy1 NADPutative short-chain dehydrogenase/reductase / 0.652
1dhr NADDihydropteridine reductase 1.5.1.34 0.651
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.651
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.650