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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ohx NAD Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.407
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.357
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.349
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.349
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.349
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.348
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.348
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.348
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.348
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.347
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.347
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.347
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.347
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.340
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.334
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.330
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.313
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.298
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.297
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.291
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.278
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.275
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.262
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.260
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.244
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.240
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.234
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.196
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.169
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.167
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.166
3cos NADAlcohol dehydrogenase 4 1.1.1.1 1.058
1h2b NAJNAD-dependent alcohol dehydrogenase / 1.029
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.018
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.976
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.976
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.942
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.939
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.917
1yqd NAPSinapyl alcohol dehydrogenase / 0.915
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.913
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.908
3jv7 NADSecondary alcohol dehydrogenase / 0.898
4c4o NADSADH / 0.891
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.885
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.884
4oaq NDPR-specific carbonyl reductase / 0.868
3two NDPMannitol dehydrogenase / 0.860
1yqx NAPSinapyl alcohol dehydrogenase / 0.854
3wle NAD(R)-specific carbonyl reductase / 0.853
4rqu NADAlcohol dehydrogenase class-P / 0.851
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.841
1uxk NADMalate dehydrogenase / 0.838
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.838
1u7h NADPutative ornithine cyclodeaminase / 0.832
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.832
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.828
1x7d NADPutative ornithine cyclodeaminase / 0.827
2dph NADFormaldehyde dismutase / 0.810
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.808
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.803
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.802
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.802
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.798
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.797
1gv0 NADMalate dehydrogenase / 0.796
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.796
4l0q NADAlcohol dehydrogenase class-3 / 0.794
4cpd NADAlcohol dehydrogenase / 0.792
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.780
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.778
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.775
1uxj NADMalate dehydrogenase / 0.775
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.773
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.767
2voj NADAlanine dehydrogenase 1.4.1.1 0.766
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.758
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.755
4jji NADAlcohol dehydrogenase class-3 / 0.753
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.753
2vwh NAPGlucose 1-dehydrogenase / 0.748
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.747
3uko NADAlcohol dehydrogenase class-3 / 0.744
2o4c NADErythronate-4-phosphate dehydrogenase / 0.742
2vhx NADAlanine dehydrogenase 1.4.1.1 0.742
2x0r NADMalate dehydrogenase / 0.742
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.738
1llu NADAlcohol dehydrogenase / 0.737
2x0i NAIMalate dehydrogenase / 0.737
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.737
4jk3 NADUncharacterized protein / 0.736
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.735
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.731
1c1d NAIPhenylalanine dehydrogenase / 0.729
2dfv NADL-threonine 3-dehydrogenase / 0.729
4b7x NAPProbable oxidoreductase / 0.729
4j49 NADUncharacterized protein / 0.729
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.728
2xaa NADSecondary alcohol dehydrogenase / 0.728
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.727
3ikt NADRedox-sensing transcriptional repressor Rex / 0.726
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.722
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.720
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.719
1ur5 NADMalate dehydrogenase / 0.718
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.716
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.713
3adp NAILambda-crystallin 1.1.1.45 0.713
3wsw NADL-lactate dehydrogenase / 0.713
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.711
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.711
1ie3 NADMalate dehydrogenase / 0.709
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.708
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.707
4xq9 NADHomospermidine synthase 2.5.1.44 0.707
1guy NADMalate dehydrogenase / 0.706
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.706
4xqc NADHomospermidine synthase 2.5.1.44 0.705
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.704
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.704
2y05 NAPProstaglandin reductase 1 / 0.703
1ib6 NADMalate dehydrogenase / 0.702
3wfj NAD2-dehydropantoate 2-reductase / 0.702
4k28 NADShikimate dehydrogenase family protein / 0.702
5a1t NAIL-lactate dehydrogenase / 0.702
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.702
1o6z NADMalate dehydrogenase / 0.701
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.701
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.700
2aa3 AP0L-lactate dehydrogenase / 0.699
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.697
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.697
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.697
4j4b NAIUncharacterized protein / 0.696
4tvb NADHomospermidine synthase 2.5.1.44 0.695
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.694
1wze NADMalate dehydrogenase / 0.693
2a92 NAIL-lactate dehydrogenase / 0.693
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.693
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.692
3oet NADErythronate-4-phosphate dehydrogenase / 0.692
1b8v NADMalate dehydrogenase / 0.691
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.691
1pzh NADLactate dehydrogenase / 0.690
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.690
4plp NADHomospermidine synthase 2.5.1.44 0.688
1pjc NADAlanine dehydrogenase / 0.686
4j49 NAIUncharacterized protein / 0.685
4xrg NADHomospermidine synthase 2.5.1.44 0.685
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.685
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.682
3ggo NAIPrephenate dehydrogenase / 0.682
4gl4 NAIAlcohol dehydrogenase class-3 / 0.682
2ejv NADL-threonine 3-dehydrogenase / 0.681
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.681
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.680
2cda NAPGlucose 1-dehydrogenase / 0.680
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.680
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.679
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.678
2fkn NADUrocanate hydratase 4.2.1.49 0.678
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.678
3d64 NADAdenosylhomocysteinase / 0.678
3x2f NAIAdenosylhomocysteinase / 0.677
4j43 NADUncharacterized protein / 0.675
1b8u NADMalate dehydrogenase / 0.674
2v7g NADUrocanate hydratase 4.2.1.49 0.674
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.674
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.673
3kb6 NADD-lactate dehydrogenase / 0.672
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.671
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.671
2ome NADC-terminal-binding protein 2 / 0.669
3ec7 NADInositol 2-dehydrogenase / 0.668
4ros APRMalate dehydrogenase / 0.668
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.667
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.666
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.665
1xcb NADRedox-sensing transcriptional repressor Rex / 0.665
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.665
3tqh NDPQuinone oxidoreductase / 0.665
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.665
2d8a NADL-threonine 3-dehydrogenase / 0.664
2vwq NAPGlucose 1-dehydrogenase / 0.664
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.664
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.663
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.663
2cdc NAPGlucose 1-dehydrogenase / 0.662
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.660
2c29 NAPDihydroflavonol 4-reductase / 0.660
2dbz NAPGlyoxylate reductase 1.1.1.26 0.660
2ydx NAPMethionine adenosyltransferase 2 subunit beta / 0.660
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.659
3x2e NAIAdenosylhomocysteinase / 0.659
4z0p NDPNAD-dependent dehydrogenase / 0.659
5bsg NAPPyrroline-5-carboxylate reductase / 0.659
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.658
2b5v NAPGlucose 1-dehydrogenase / 0.658
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.658
2rgj FADFlavin-containing monooxygenase / 0.658
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.656
4weq NAPNAD-dependent dehydrogenase / 0.656
1bdm NAXMalate dehydrogenase / 0.655
3keo NADRedox-sensing transcriptional repressor Rex / 0.655
4emi NADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.655
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.655
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.654
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.654
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.654
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.654
1bmd NADMalate dehydrogenase / 0.653
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.653
2rir NAPDipicolinate synthase subunit A / 0.653
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.653
3ggp NADPrephenate dehydrogenase / 0.652
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.651
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.651
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.651
1qlh NADAlcohol dehydrogenase E chain 1.1.1.1 0.650