sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 1.274 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 1.086 | |
| 2p5y | NAD | UDP-glucose 4-epimerase | / | 0.975 | |
| 3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.965 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.949 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.948 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.939 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.935 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.926 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.920 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.909 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.898 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.882 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.882 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.881 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.880 | |
| 3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.874 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.874 | |
| 4u7w | NDP | MxaA | / | 0.871 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.868 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.861 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.860 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.859 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.857 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.846 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.845 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.845 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.842 | |
| 3mje | NDP | AmphB | / | 0.838 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.829 | |
| 4hxy | NDP | Plm1 | / | 0.827 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.824 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.819 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.817 | |
| 3uce | NDP | Dehydrogenase | / | 0.814 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.814 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.813 | |
| 3bmo | NAP | Pteridine reductase | / | 0.812 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.809 | |
| 4lk3 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.809 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.808 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.806 | |
| 4id9 | NAD | Putative UDP-glucose 4-epimerase | / | 0.803 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.802 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.798 | |
| 2b69 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.795 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.795 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.794 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.794 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.793 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.793 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.793 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.791 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.790 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.789 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.788 | |
| 1sny | NAP | LD36273p | / | 0.788 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.786 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.785 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.784 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.784 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.781 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.781 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.779 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.778 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.777 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.777 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.777 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.776 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.776 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.776 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.775 | |
| 5d2e | NAP | MlnE | / | 0.775 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.772 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.772 | |
| 1w8d | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.771 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.770 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.769 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.766 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.763 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.762 | |
| 2x86 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.761 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.760 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.757 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.756 | |
| 4qec | NAP | ElxO | / | 0.756 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.755 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.755 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.755 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.755 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.755 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.755 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.754 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.753 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.753 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.753 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.753 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.752 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.752 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.751 | |
| 4qed | NAP | ElxO | / | 0.751 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.749 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.749 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.748 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.748 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.748 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.747 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.747 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.747 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.747 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.746 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.746 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.746 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.745 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.743 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.743 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.743 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.741 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.741 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.740 | |
| 1rpn | NDP | GDP-mannose 4,6-dehydratase | / | 0.739 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.739 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.737 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.737 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.737 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.736 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.735 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.735 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.735 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.735 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.735 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.735 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.735 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.734 | |
| 3pvz | NAD | UDP-N-acetylglucosamine 4,6-dehydratase | / | 0.734 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.733 | |
| 4kwh | NAP | Reductase homolog | / | 0.733 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.732 | |
| 1w73 | NAP | 2,4-dienoyl-CoA reductase, mitochondrial | 1.3.1.34 | 0.731 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.731 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.731 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.731 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.731 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.731 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.731 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.729 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.729 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.729 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.728 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.728 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.725 | |
| 4m55 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.725 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.723 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.723 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.723 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.723 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.722 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.721 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.721 | |
| 1nai | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.720 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.720 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.719 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.718 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.717 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.717 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.716 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.716 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.716 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.716 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.716 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.715 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.715 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.715 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.714 | |
| 3sju | NDP | Keto reductase | / | 0.712 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.711 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.710 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.710 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.710 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.710 | |
| 1iy8 | NAD | Levodione reductase | / | 0.709 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.709 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.709 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.709 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.705 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.705 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.704 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.702 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.701 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.700 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.698 | |
| 2bfo | NDP | Pteridine reductase 1 | 1.5.1.33 | 0.698 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.698 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.698 | |
| 2gn8 | NAP | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.697 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.697 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.697 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.697 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.696 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.696 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.694 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.693 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.693 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.692 | |
| 3qvx | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.692 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.691 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.691 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.691 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.691 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.691 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.690 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.690 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.690 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.689 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.689 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.689 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.688 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.688 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.688 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.687 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.686 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.684 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.684 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.684 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.684 | |
| 5a1t | NAI | L-lactate dehydrogenase | / | 0.684 | |
| 2nyu | SAM | rRNA methyltransferase 2, mitochondrial | / | 0.683 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.683 | |
| 1enp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.681 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.680 | |
| 3mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.680 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.679 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.679 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.678 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.678 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.678 | |
| 4clo | NAP | Pteridine reductase | / | 0.678 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.678 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.677 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.676 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.675 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.675 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.674 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.673 | |
| 1qyx | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.673 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.673 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.673 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.673 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.672 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.672 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.671 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.671 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.670 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.669 | |
| 4bgi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.669 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.668 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.667 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.667 | |
| 2hmv | ADP | Ktr system potassium uptake protein A | / | 0.666 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.665 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.664 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.663 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.663 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.662 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.660 | |
| 2p35 | SAH | Trans-aconitate 2-methyltransferase | / | 0.658 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.658 | |
| 3qvt | NAI | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.657 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.657 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.656 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.653 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.650 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.650 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.650 | |
| 4l4x | NDP | AmphI | / | 0.650 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.650 |