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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1f0y NAD Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 1.294
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 1.152
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 1.143
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 1.025
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.850
3f3s NADLambda-crystallin homolog / 0.824
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.819
3adp NAILambda-crystallin 1.1.1.45 0.807
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.798
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.777
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.762
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.758
3hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.758
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.758
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.753
3zw9 NADPeroxisomal bifunctional enzyme 1.1.1.35 0.750
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.745
3ggo NAIPrephenate dehydrogenase / 0.744
3ikt NADRedox-sensing transcriptional repressor Rex / 0.743
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.742
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.742
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.740
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.739
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.737
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.734
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.732
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.732
4dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.732
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.729
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.729
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.728
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.726
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.725
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.724
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.722
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.722
3ggp NADPrephenate dehydrogenase / 0.722
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.722
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.721
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.720
1nqo NADGlyceraldehyde-3-phosphate dehydrogenase / 0.720
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.720
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.718
5a04 NDPGlucose-fructose oxidoreductase / 0.718
1guy NADMalate dehydrogenase / 0.717
2voj NADAlanine dehydrogenase 1.4.1.1 0.717
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.716
3hwr NDP2-dehydropantoate 2-reductase / 0.716
1rm3 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.715
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.714
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.714
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.714
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.712
4xr9 NADCalS8 / 0.712
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.712
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.711
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.711
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.710
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.708
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.708
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.708
3tri NAPPyrroline-5-carboxylate reductase / 0.708
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.708
1uxj NADMalate dehydrogenase / 0.707
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.707
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.707
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.705
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.705
2dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.705
2g5c NADPrephenate dehydrogenase / 0.705
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.705
1zh8 NAPUncharacterized protein / 0.704
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.704
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.704
5a06 NDPGlucose-fructose oxidoreductase / 0.704
3keo NADRedox-sensing transcriptional repressor Rex / 0.702
5a02 NAPGlucose-fructose oxidoreductase / 0.702
3wle NAD(R)-specific carbonyl reductase / 0.701
3wsw NADL-lactate dehydrogenase / 0.701
4kug NAD3-hydroxybutyryl-CoA dehydrogenase / 0.701
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.700
1gad NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.700
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.699
1dbv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.697
3zdf NADGlyceraldehyde-3-phosphate dehydrogenase / 0.697
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.696
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.696
1uxk NADMalate dehydrogenase / 0.695
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.694
5a03 NDPGlucose-fructose oxidoreductase / 0.694
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.693
1f8f NADBenzyl alcohol dehydrogenase / 0.692
4yai NAIC alpha-dehydrogenase / 0.692
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.691
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.691
4k28 NADShikimate dehydrogenase family protein / 0.691
1hku NADC-terminal-binding protein 1 1.1.1 0.689
3oet NADErythronate-4-phosphate dehydrogenase / 0.689
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.688
2ph5 NADHomospermidine synthase / 0.688
3jv7 NADSecondary alcohol dehydrogenase / 0.688
3pqf NADL-lactate dehydrogenase 1.1.1.27 0.687
3q3c NADNAD-dependent L-serine dehydrogenase / 0.687
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.685
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.685
5a05 NDPGlucose-fructose oxidoreductase / 0.685
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.684
3k2b NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.684
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.683
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.683
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.682
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.682
3dbv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.682
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.682
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.681
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.681
3a14 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.680
3ket NADRedox-sensing transcriptional repressor Rex / 0.679
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.678
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.677
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.677
2qg4 NADUDP-glucose 6-dehydrogenase 1.1.1.22 0.677
3v1y NADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic 1.2.1.12 0.677
5bsg NAPPyrroline-5-carboxylate reductase / 0.677
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.677
1a7k NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.676
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.676
2d2i NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.675
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.675
2i3g NAPN-acetyl-gamma-glutamyl-phosphate reductase 1.2.1.38 0.674
1jn0 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.673
4boy NADGlyceraldehyde-3-phosphate dehydrogenase / 0.673
4xq9 NADHomospermidine synthase 2.5.1.44 0.673
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.672
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.672
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.672
1o6z NADMalate dehydrogenase / 0.670
3au8 NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.670
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.670
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.670
1vc2 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.669
2wdz NADGalactitol dehydrogenase / 0.668
2yvf NADFerredoxin reductase / 0.668
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.667
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.666
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.666
2xaa NADSecondary alcohol dehydrogenase / 0.666
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.666
4bmv NAPShort-chain dehydrogenase / 0.666
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.666
4c4o NADSADH / 0.665
4oaq NDPR-specific carbonyl reductase / 0.665
3m2t NADProbable dehydrogenase / 0.664
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.663
2rcy NAPPyrroline-5-carboxylate reductase / 0.663
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.663
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.663
2iyp NAP6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.662
3ing NDPHomoserine dehydrogenase related protein / 0.662
1dc6 NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.661
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.661
2dph NADFormaldehyde dismutase / 0.661
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.661
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.661
1u7h NADPutative ornithine cyclodeaminase / 0.659
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.659
2o4c NADErythronate-4-phosphate dehydrogenase / 0.659
3d64 NADAdenosylhomocysteinase / 0.659
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.658
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.658
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.658
4j43 NADUncharacterized protein / 0.658
4xgi NADGlutamate dehydrogenase / 0.658
4xrg NADHomospermidine synthase 2.5.1.44 0.658
1qxs NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.657
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.657
3gvi ADPMalate dehydrogenase / 0.657
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.656
1nyt NAPShikimate dehydrogenase (NADP(+)) / 0.656
1o0s NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.656
1x7d NADPutative ornithine cyclodeaminase / 0.656
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.656
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.655
2fkn NADUrocanate hydratase 4.2.1.49 0.655
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.655
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.655
4l0q NADAlcohol dehydrogenase class-3 / 0.655
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.654
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.654
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.654
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.654
1i36 NAPConserved protein / 0.653
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.653
3two NDPMannitol dehydrogenase / 0.653
4pzd NAD3-Hydroxyacyl-CoA dehydrogenase / 0.653
4xb1 NDP319aa long hypothetical homoserine dehydrogenase / 0.653
4z0h NADGlyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic 1.2.1.12 0.653
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.652
4dpl NAPMalonyl-CoA reductase 1.2.1.75 0.652
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.651
1rm5 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.651
2pkr NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.651
1orr NADCDP-paratose 2-epimerase / 0.650