Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mwhATPCasein kinase II subunit alpha2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4mwhATPCasein kinase II subunit alpha2.7.11.11.000
4fi1ATPCasein kinase II subunit alpha2.7.11.10.924
5cvhADPCasein kinase II subunit alpha2.7.11.10.588
4jr7GNPCasein kinase II subunit alpha2.7.11.10.569
1lp4ANPCasein kinase II subunit alpha2.7.11.10.548
4anmWULCasein kinase II subunit alpha2.7.11.10.545
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.543
1dawANPCasein kinase II subunit alpha2.7.11.10.534
2pvnP63Casein kinase II subunit alpha2.7.11.10.533
3be9P04Casein kinase II subunit alpha2.7.11.10.531
4dgnLU2Casein kinase II subunit alpha2.7.11.10.530
1dayGNPCasein kinase II subunit alpha2.7.11.10.525
1m2qMNXCasein kinase II subunit alpha2.7.11.10.522
4jqeANPCasein kinase II subunit alpha2.7.11.10.522
3nszANPCasein kinase II subunit alpha2.7.11.10.519
1m2rMNYCasein kinase II subunit alpha2.7.11.10.518
4dgo0JWCasein kinase II subunit alpha2.7.11.10.514
3q9zTXQCasein kinase II subunit alpha2.7.11.10.513
2c6tDT5Cyclin-dependent kinase 22.7.11.220.496
1m2pHNACasein kinase II subunit alpha2.7.11.10.494
1om1IQACasein kinase II subunit alpha2.7.11.10.494
2uzlC94Cyclin-dependent kinase 22.7.11.220.493
1u4dDBQActivated CDC42 kinase 1/0.490
2x1nX1NCyclin-dependent kinase 22.7.11.220.490
5drdATPAurora kinase A2.7.11.10.490
3c50ADPRhodopsin kinase/0.488
4dgmAGICasein kinase II subunit alpha2.7.11.10.486
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.485
2wihP48Cyclin-dependent kinase 22.7.11.220.484
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.482
3at3ATKCasein kinase II subunit alpha2.7.11.10.482
3oriAGSSerine/threonine protein kinase/0.482
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.476
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.475
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.473
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.472
4grb0XGCasein kinase II subunit alpha2.7.11.10.472
5dt3ATPAurora kinase A2.7.11.10.472
2xikJ60Serine/threonine-protein kinase 252.7.11.10.471
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.471
1ol7ADPAurora kinase A2.7.11.10.470
2b53D23Cyclin-dependent kinase 22.7.11.220.470
2zdt46CMitogen-activated protein kinase 102.7.11.240.470
3hmm855TGF-beta receptor type-12.7.11.300.470
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
1e9hINRCyclin-dependent kinase 22.7.11.220.468
3qu0X40Cyclin-dependent kinase 22.7.11.220.468
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.468
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.468
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.468
4c02TAKActivin receptor type-12.7.11.300.468
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.468
1ol5ADPAurora kinase A2.7.11.10.467
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.467
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.467
1rfuADPPyridoxal kinase2.7.1.350.466
3rps4B0Casein kinase II subunit alpha2.7.11.10.466
1g5sI17Cyclin-dependent kinase 22.7.11.220.465
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.465
1di8DTQCyclin-dependent kinase 22.7.11.220.464
2pvkP45Casein kinase II subunit alpha2.7.11.10.463
4e4m0NHTyrosine-protein kinase JAK2/0.463
1y91CT9Cyclin-dependent kinase 22.7.11.220.462
2dwbANPAurora kinase A2.7.11.10.462
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.462
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.462
2xnbY8LCyclin-dependent kinase 22.7.11.220.462
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.462
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
2p33J07Mitogen-activated protein kinase 102.7.11.240.461
3eljGS7Mitogen-activated protein kinase 82.7.11.240.461
4f650S9Fibroblast growth factor receptor 1/0.461
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.461
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
2gjnFMNNitronate monooxygenase1.13.12.160.459
2uzeC95Cyclin-dependent kinase 22.7.11.220.459
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.459
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.459
2j9mPY8Cyclin-dependent kinase 22.7.11.220.458
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.458
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.458
4eji0QACytochrome P450 2A131.14.14.10.458
5auuLU2Death-associated protein kinase 12.7.11.10.458
1eh4IC1Casein kinase I homolog 12.7.11.10.457
1h1s4SPCyclin-dependent kinase 22.7.11.220.457
3begANPSRSF protein kinase 12.7.11.10.457
3fz1B98Cyclin-dependent kinase 22.7.11.220.457
3i81EBIInsulin-like growth factor 1 receptor2.7.10.10.457
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.457
4wh3ATPN-acetylhexosamine 1-kinase2.7.1.1620.457
5dn3ATPAurora kinase A2.7.11.10.457
1fvv107Cyclin-dependent kinase 22.7.11.220.456
1t88CAMCamphor 5-monooxygenase1.14.15.10.456
2iw84SPCyclin-dependent kinase 22.7.11.220.456
2iw94SPCyclin-dependent kinase 22.7.11.220.456
3rk507ZCyclin-dependent kinase 22.7.11.220.456
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4f7l0SOCyclin-dependent kinase 82.7.11.220.456
4iwd1JCHepatocyte growth factor receptor2.7.10.10.456
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.456
5dt4ATPAurora kinase A2.7.11.10.456
1gij2PUCyclin-dependent kinase 22.7.11.220.455
2a1oCAMCamphor 5-monooxygenase1.14.15.10.455
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
2eufLQQCyclin-dependent kinase 62.7.11.220.455
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.455
3owk18ECasein kinase II subunit alpha2.7.11.10.455
3q43D66M1 family aminopeptidase3.4.110.455
3uyt0CKCasein kinase I isoform delta2.7.11.10.455
4gub0Y4Casein kinase II subunit alpha2.7.11.10.455
1oi9N20Cyclin-dependent kinase 22.7.11.220.454
3c4zADPRhodopsin kinase/0.454
1csnATPCasein kinase I homolog 12.7.11.10.453
1xjdSTUProtein kinase C theta type2.7.11.130.453
2excJNKMitogen-activated protein kinase 102.7.11.240.453
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.453
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.453
3ddpRC8Cyclin-dependent kinase 22.7.11.220.453
3ttjJBIMitogen-activated protein kinase 102.7.11.240.453
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.453
4bgg844Activin receptor type-12.7.11.300.453
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1bwsNDPGDP-L-fucose synthase/0.452
1gih1PUCyclin-dependent kinase 22.7.11.220.452
1xddAAYIntegrin alpha-L/0.452
4deeADPAurora kinase A2.7.11.10.452
4g160VMCasein kinase I isoform gamma-32.7.11.10.452
5dosATPAurora kinase A2.7.11.10.452
2r64740Cyclin-dependent kinase 22.7.11.220.451
3gxlQIGTGF-beta receptor type-12.7.11.300.451
3hyoADPPyridoxal kinase/0.451
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.451
3rmf20ZCyclin-dependent kinase 22.7.11.220.451
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
5e92ANPTGF-beta receptor type-22.7.11.300.451
2btsU32Cyclin-dependent kinase 22.7.11.220.450
2izrBRKCasein kinase I isoform gamma-32.7.11.10.450
2znpK55Peroxisome proliferator-activated receptor delta/0.450
3uli1N3Cyclin-dependent kinase 22.7.11.220.450
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.449
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.449
2wxvWXVCyclin-dependent kinase 22.7.11.220.449
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.449
3rk708ZCyclin-dependent kinase 22.7.11.220.449
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.449
4fks46KCyclin-dependent kinase 22.7.11.220.449
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.449
4hvh19RTyrosine-protein kinase JAK32.7.10.20.449
1ir3ANPInsulin receptor2.7.10.10.448
1mq4ADPAurora kinase A2.7.11.10.448
1o76CAMCamphor 5-monooxygenase1.14.15.10.448
1t85CAMCamphor 5-monooxygenase1.14.15.10.448
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2qo9ANPEphrin type-A receptor 32.7.10.10.448
2x7gPVBSRSF protein kinase 22.7.11.10.448
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.448
3ql8X01Cyclin-dependent kinase 22.7.11.220.448
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.448
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4ek816KCyclin-dependent kinase 22.7.11.220.448
5itzLOCTubulin beta-2B chain/0.448
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.447
1ke6LS2Cyclin-dependent kinase 22.7.11.220.447
1v0oINRCell division control protein 2 homolog2.7.11.220.447
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.447
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.447
2v7a627Tyrosine-protein kinase ABL12.7.10.20.447
2vagV25Dual specificity protein kinase CLK12.7.12.10.447
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.447
3a7jADPSerine/threonine-protein kinase 242.7.11.10.447
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3d8vUD1Bifunctional protein GlmU/0.447
3rni21ZCyclin-dependent kinase 22.7.11.220.447
3t2yFADSulfide-quinone reductase/0.447
4btjADPTau-tubulin kinase 12.7.11.10.447
4g170VNCasein kinase I isoform gamma-32.7.11.10.447
4hge15VTyrosine-protein kinase JAK2/0.447
5dnrATPAurora kinase A2.7.11.10.447
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.446
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.446
2xrwANPMitogen-activated protein kinase 82.7.11.240.446
3bhtMFRCyclin-dependent kinase 22.7.11.220.446
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3ziuLSSLeucyl-tRNA synthetase/0.446
4eomATPCyclin-dependent kinase 22.7.11.220.446
4hvg19QTyrosine-protein kinase JAK32.7.10.20.446
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.446
4jboWPHAurora kinase A2.7.11.10.446
4k28NADShikimate dehydrogenase family protein/0.446
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.446
4ocvANPAminoglycoside phosphotransferase/0.446
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
1fvt106Cyclin-dependent kinase 22.7.11.220.445
1oiyN41Cyclin-dependent kinase 22.7.11.220.445
1x2hLPALipoate-protein ligase A6.3.1.200.445
2xgoZKDUncharacterized protein/0.445
2zjwREFCasein kinase II subunit alpha2.7.11.10.445
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.445
4eor4SPCyclin-dependent kinase 22.7.11.220.445
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.444
2xs0ANPMitogen-activated protein kinase 82.7.11.240.444
3at4CCKCasein kinase II subunit alpha2.7.11.10.444
3h6vNS6Glutamate receptor 2/0.444
3ormAGSSerine/threonine protein kinase/0.444
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.444
4ix6ADPUncharacterized protein/0.444
5e8wSTUTGF-beta receptor type-12.7.11.300.444
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.443
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
2qboCAMCamphor 5-monooxygenase1.14.15.10.443
3b70NAPEnoyl reductase LovC10.443
3ortAGSSerine/threonine protein kinase/0.443
3ral04ZCyclin-dependent kinase 22.7.11.220.443
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.443
3wb2YGPUncharacterized protein MJ0488/0.443
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.443
4fkw62KCyclin-dependent kinase 22.7.11.220.443
4l9i8PRRhodopsin kinase/0.443
5fwnNAPPutative dehydrogenase/0.443
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.442
3il1B5DGlutamate receptor 2/0.442
3lqfNADGalactitol dehydrogenase/0.442
3nizADPCdc2-like CDK2/CDC28 like protein kinase/0.442
3qtzX42Cyclin-dependent kinase 22.7.11.220.442
4eu8COASuccinyl-CoA:acetate CoA-transferase/0.442
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.442
4kb81QOCasein kinase I isoform delta2.7.11.10.442
1aj8COACitrate synthase/0.441
1p4fDRGDeath-associated protein kinase 12.7.11.10.441
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.441
2cchATPCyclin-dependent kinase 22.7.11.220.441
2np8CC3Aurora kinase A2.7.11.10.441
3i60E86Mitogen-activated protein kinase 12.7.11.240.441
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3s1dZIRCytokinin dehydrogenase 11.5.99.120.441
4ix4ADPUncharacterized protein/0.441
4l4cCAMCamphor 5-monooxygenase1.14.15.10.441
5e8ySTUTGF-beta receptor type-22.7.11.300.441
1cbsREACellular retinoic acid-binding protein 2/0.440
1dz4CAMCamphor 5-monooxygenase1.14.15.10.440
1oguST8Cyclin-dependent kinase 22.7.11.220.440
1rw8580TGF-beta receptor type-12.7.11.300.440
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
2wotZZGTGF-beta receptor type-12.7.11.300.440
3f03FMNPentaerythritol tetranitrate reductase/0.440
3oqfS51Renin3.4.23.150.440
3tnwF18Cyclin-dependent kinase 22.7.11.220.440
3wrjCAMCamphor 5-monooxygenase1.14.15.10.440
4fkr45KCyclin-dependent kinase 22.7.11.220.440
4i22IREEpidermal growth factor receptor2.7.10.10.440