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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fkr45KCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fkr45KCyclin-dependent kinase 22.7.11.221.000
3s2pPMUCyclin-dependent kinase 22.7.11.220.604
1w0xOLOCyclin-dependent kinase 22.7.11.220.596
2w06FRVCyclin-dependent kinase 22.7.11.220.591
3qu0X40Cyclin-dependent kinase 22.7.11.220.587
3rmf20ZCyclin-dependent kinase 22.7.11.220.587
3sw418KCyclin-dependent kinase 22.7.11.220.587
3rak03ZCyclin-dependent kinase 22.7.11.220.586
3s1h56ZCyclin-dependent kinase 22.7.11.220.578
4fkv61KCyclin-dependent kinase 22.7.11.220.573
3qtzX42Cyclin-dependent kinase 22.7.11.220.568
4fkq42KCyclin-dependent kinase 22.7.11.220.565
3ti1B49Cyclin-dependent kinase 22.7.11.220.562
4acm7YGCyclin-dependent kinase 22.7.11.220.561
4fkt48KCyclin-dependent kinase 22.7.11.220.558
3qtxX43Cyclin-dependent kinase 22.7.11.220.555
3r9dX6BCyclin-dependent kinase 22.7.11.220.555
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.550
3rpv26ZCyclin-dependent kinase 22.7.11.220.549
3rk708ZCyclin-dependent kinase 22.7.11.220.548
1pxmCK5Cyclin-dependent kinase 22.7.11.220.546
2r64740Cyclin-dependent kinase 22.7.11.220.545
1ke9LS5Cyclin-dependent kinase 22.7.11.220.543
3r71X86Cyclin-dependent kinase 22.7.11.220.543
2c6iDT1Cyclin-dependent kinase 22.7.11.220.542
3r9oZ71Cyclin-dependent kinase 22.7.11.220.541
3ral04ZCyclin-dependent kinase 22.7.11.220.541
3r8lZ30Cyclin-dependent kinase 22.7.11.220.540
3rk507ZCyclin-dependent kinase 22.7.11.220.539
1p2a5BNCyclin-dependent kinase 22.7.11.220.537
4bgh3I6Cyclin-dependent kinase 22.7.11.220.537
3qxoX65Cyclin-dependent kinase 22.7.11.220.536
3rpy27ZCyclin-dependent kinase 22.7.11.220.536
1ke7LS3Cyclin-dependent kinase 22.7.11.220.534
1urwI1PCyclin-dependent kinase 22.7.11.220.534
2uzoC62Cyclin-dependent kinase 22.7.11.220.533
3fz1B98Cyclin-dependent kinase 22.7.11.220.533
3sqq99ZCyclin-dependent kinase 22.7.11.220.533
4fkw62KCyclin-dependent kinase 22.7.11.220.533
2r3iSCFCyclin-dependent kinase 22.7.11.220.532
3qtuX44Cyclin-dependent kinase 22.7.11.220.532
4ek816KCyclin-dependent kinase 22.7.11.220.532
4fkg4CKCyclin-dependent kinase 22.7.11.220.532
3rjc06ZCyclin-dependent kinase 22.7.11.220.531
3rni21ZCyclin-dependent kinase 22.7.11.220.531
2btrU73Cyclin-dependent kinase 22.7.11.220.530
2w1hL0FCyclin-dependent kinase 22.7.11.220.530
3r1yX76Cyclin-dependent kinase 22.7.11.220.529
3qzhX69Cyclin-dependent kinase 22.7.11.220.528
4ez30S0Cyclin-dependent kinase 22.7.11.220.528
1oitHDTCyclin-dependent kinase 22.7.11.220.527
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.527
3qwjX6ACyclin-dependent kinase 22.7.11.220.527
4ek610KCyclin-dependent kinase 22.7.11.220.527
1ke6LS2Cyclin-dependent kinase 22.7.11.220.526
3r73X87Cyclin-dependent kinase 22.7.11.220.526
4fks46KCyclin-dependent kinase 22.7.11.220.526
2j9mPY8Cyclin-dependent kinase 22.7.11.220.525
2r3lSCWCyclin-dependent kinase 22.7.11.220.525
3py0SU9Cyclin-dependent kinase 22.7.11.220.525
1ckpPVBCyclin-dependent kinase 22.7.11.220.524
2r3kSCQCyclin-dependent kinase 22.7.11.220.523
4fkpLS5Cyclin-dependent kinase 22.7.11.220.522
2c6o4SPCyclin-dependent kinase 22.7.11.220.521
1ke5LS1Cyclin-dependent kinase 22.7.11.220.520
3iggEFQCyclin-dependent kinase 22.7.11.220.520
1di8DTQCyclin-dependent kinase 22.7.11.220.519
3r7iX9ICyclin-dependent kinase 22.7.11.220.519
2xmyCDKCyclin-dependent kinase 22.7.11.220.518
3r7uX96Cyclin-dependent kinase 22.7.11.220.518
1gih1PUCyclin-dependent kinase 22.7.11.220.515
1pxoCK7Cyclin-dependent kinase 22.7.11.220.515
3roy22ZCyclin-dependent kinase 22.7.11.220.515
3unk0BYCyclin-dependent kinase 22.7.11.220.515
3lfsA07Cyclin-dependent kinase 22.7.11.220.514
3qqhX0ACyclin-dependent kinase 22.7.11.220.514
3r7yZ04Cyclin-dependent kinase 22.7.11.220.514
3qqkX02Cyclin-dependent kinase 22.7.11.220.513
3qruX19Cyclin-dependent kinase 22.7.11.220.513
1vyzN5BCyclin-dependent kinase 22.7.11.220.512
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.512
3unj0BXCyclin-dependent kinase 22.7.11.220.511
2a0cCK9Cyclin-dependent kinase 22.7.11.220.510
3r1sX73Cyclin-dependent kinase 22.7.11.220.509
4fki09KCyclin-dependent kinase 22.7.11.220.509
3r7vZ02Cyclin-dependent kinase 22.7.11.220.507
1g5sI17Cyclin-dependent kinase 22.7.11.220.506
2btsU32Cyclin-dependent kinase 22.7.11.220.506
2r3o2SCCyclin-dependent kinase 22.7.11.220.506
1fvv107Cyclin-dependent kinase 22.7.11.220.504
3qx2X63Cyclin-dependent kinase 22.7.11.220.504
4fx360KCyclin-dependent kinase 22.7.11.220.504
1oiyN41Cyclin-dependent kinase 22.7.11.220.503
4fko20KCyclin-dependent kinase 22.7.11.220.503
3rk909ZCyclin-dependent kinase 22.7.11.220.502
3rkb12ZCyclin-dependent kinase 22.7.11.220.502
3rm719ZCyclin-dependent kinase 22.7.11.220.502
1v1k3FPCyclin-dependent kinase 22.7.11.220.501
3rpo24ZCyclin-dependent kinase 22.7.11.220.501
3sw719KCyclin-dependent kinase 22.7.11.220.501
2vttLZDCyclin-dependent kinase 22.7.11.220.498
3r6xX84Cyclin-dependent kinase 22.7.11.220.498
3r9hZ67Cyclin-dependent kinase 22.7.11.220.498
3rm618ZCyclin-dependent kinase 22.7.11.220.498
4erwSTUCyclin-dependent kinase 22.7.11.220.497
2r3p3SCCyclin-dependent kinase 22.7.11.220.496
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.495
1dm2HMDCyclin-dependent kinase 22.7.11.220.494
1ke8LS4Cyclin-dependent kinase 22.7.11.220.494
2w17I19Cyclin-dependent kinase 22.7.11.220.494
1h1s4SPCyclin-dependent kinase 22.7.11.220.493
2b52D42Cyclin-dependent kinase 22.7.11.220.493
2vthLZ2Cyclin-dependent kinase 22.7.11.220.493
3qtrX36Cyclin-dependent kinase 22.7.11.220.493
3qzfX66Cyclin-dependent kinase 22.7.11.220.492
3qzgX67Cyclin-dependent kinase 22.7.11.220.492
2uznC96Cyclin-dependent kinase 22.7.11.220.491
3pj8404Cyclin-dependent kinase 22.7.11.220.491
2iw84SPCyclin-dependent kinase 22.7.11.220.490
1h0w207Cyclin-dependent kinase 22.7.11.220.489
3pxyJWSCyclin-dependent kinase 22.7.11.220.489
3qqfX07Cyclin-dependent kinase 22.7.11.220.489
3qwkX62Cyclin-dependent kinase 22.7.11.220.489
1fvt106Cyclin-dependent kinase 22.7.11.220.487
1h1r6CPCyclin-dependent kinase 22.7.11.220.487
3ddpRC8Cyclin-dependent kinase 22.7.11.220.487
4nj32KDCyclin-dependent kinase 22.7.11.220.487
1oiqHDUCyclin-dependent kinase 22.7.11.220.486
1oguST8Cyclin-dependent kinase 22.7.11.220.485
3ezvEZVCyclin-dependent kinase 22.7.11.220.485
3r7eX88Cyclin-dependent kinase 22.7.11.220.485
3raiX85Cyclin-dependent kinase 22.7.11.220.485
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.484
2bheBRYCyclin-dependent kinase 22.7.11.220.483
2bhhRYUCyclin-dependent kinase 22.7.11.220.483
2duv371Cyclin-dependent kinase 22.7.11.220.482
2r3fSC8Cyclin-dependent kinase 22.7.11.220.482
4fkj11KCyclin-dependent kinase 22.7.11.220.482
1h0vUN4Cyclin-dependent kinase 22.7.11.220.481
2r3gSC9Cyclin-dependent kinase 22.7.11.220.481
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.481
2wpa889Cyclin-dependent kinase 22.7.11.220.481
1vyw292Cyclin-dependent kinase 22.7.11.220.480
2wxvWXVCyclin-dependent kinase 22.7.11.220.480
2r3mSCXCyclin-dependent kinase 22.7.11.220.479
3ql8X01Cyclin-dependent kinase 22.7.11.220.479
3s0o50ZCyclin-dependent kinase 22.7.11.220.479
4eor4SPCyclin-dependent kinase 22.7.11.220.479
1ykr628Cyclin-dependent kinase 22.7.11.220.478
2r3jSCJCyclin-dependent kinase 22.7.11.220.478
2wihP48Cyclin-dependent kinase 22.7.11.220.478
3qziX72Cyclin-dependent kinase 22.7.11.220.478
1pxpCK8Cyclin-dependent kinase 22.7.11.220.476
1pyePM1Cyclin-dependent kinase 22.7.11.220.476
2c6lDT4Cyclin-dependent kinase 22.7.11.220.476
2vtsLZCCyclin-dependent kinase 22.7.11.220.476
3lfqA28Cyclin-dependent kinase 22.7.11.220.476
4qmpDKISerine/threonine-protein kinase 242.7.11.10.475
1oirHDYCyclin-dependent kinase 22.7.11.220.474
3ig7EFPCyclin-dependent kinase 22.7.11.220.474
4eos1ROCyclin-dependent kinase 22.7.11.220.474
2fvdLIACyclin-dependent kinase 22.7.11.220.473
3ddqRRCCyclin-dependent kinase 22.7.11.220.473
3r1qX75Cyclin-dependent kinase 22.7.11.220.473
3wblPDYCyclin-dependent kinase 22.7.11.220.472
1pxkCK3Cyclin-dependent kinase 22.7.11.220.471
2b53D23Cyclin-dependent kinase 22.7.11.220.471
1e9hINRCyclin-dependent kinase 22.7.11.220.470
1oi9N20Cyclin-dependent kinase 22.7.11.220.470
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.470
4eok4SPCyclin-dependent kinase 22.7.11.220.470
2x1nX1NCyclin-dependent kinase 22.7.11.220.469
3qqlX03Cyclin-dependent kinase 22.7.11.220.469
3rahO1ZCyclin-dependent kinase 22.7.11.220.469
3tiz3TICyclin-dependent kinase 22.7.11.220.469
1gii1PUCyclin-dependent kinase 22.7.11.220.467
2r3r6SCCyclin-dependent kinase 22.7.11.220.466
3uli1N3Cyclin-dependent kinase 22.7.11.220.466
4bcpT3CCyclin-dependent kinase 22.7.11.220.466
3ezrEZRCyclin-dependent kinase 22.7.11.220.464
3r9nZ68Cyclin-dependent kinase 22.7.11.220.463
4lyn1YGCyclin-dependent kinase 22.7.11.220.463
1w8cN69Cyclin-dependent kinase 22.7.11.220.462
3r8pZ46Cyclin-dependent kinase 22.7.11.220.462
1b38ATPCyclin-dependent kinase 22.7.11.220.461
2a4lRRCCyclin-dependent kinase 22.7.11.220.460
2b55D31Cyclin-dependent kinase 22.7.11.220.460
1aq1STUCyclin-dependent kinase 22.7.11.220.459
2dwbANPAurora kinase A2.7.11.10.459
2vu3LZECyclin-dependent kinase 22.7.11.220.459
4eon1ROCyclin-dependent kinase 22.7.11.220.458
1finATPCyclin-dependent kinase 22.7.11.220.457
2eufLQQCyclin-dependent kinase 62.7.11.220.457
3qtwX3ACyclin-dependent kinase 22.7.11.220.456
3r28XA0Cyclin-dependent kinase 22.7.11.220.456
2c5yMTWCyclin-dependent kinase 22.7.11.220.455
3qtqX35Cyclin-dependent kinase 22.7.11.220.455
2c6tDT5Cyclin-dependent kinase 22.7.11.220.453
3gxlQIGTGF-beta receptor type-12.7.11.300.452
1b39ATPCyclin-dependent kinase 22.7.11.220.451
4kd11QKCyclin-dependent kinase 22.7.11.220.450
5dr6SKEAurora kinase A2.7.11.10.450
3dogNNNCyclin-dependent kinase 22.7.11.220.449
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
1e1xNW1Cyclin-dependent kinase 22.7.11.220.448
3r8zZ63Cyclin-dependent kinase 22.7.11.220.448
3tnwF18Cyclin-dependent kinase 22.7.11.220.448
4au8Z3RCyclin-dependent-like kinase 52.7.11.10.448
3s00Z60Cyclin-dependent kinase 22.7.11.220.446
2uzlC94Cyclin-dependent kinase 22.7.11.220.445
4bcnT9NCyclin-dependent kinase 22.7.11.220.445
3ggfGVDSerine/threonine-protein kinase 26/0.444
4eol1ROCyclin-dependent kinase 22.7.11.220.444
2cchATPCyclin-dependent kinase 22.7.11.220.443
2r3q5SCCyclin-dependent kinase 22.7.11.220.443
4eomATPCyclin-dependent kinase 22.7.11.220.443
1gij2PUCyclin-dependent kinase 22.7.11.220.442
2c6kDT2Cyclin-dependent kinase 22.7.11.220.442
1unlRRCCyclin-dependent-like kinase 52.7.11.10.441
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.441
1oiuN76Cyclin-dependent kinase 22.7.11.220.440
1y91CT9Cyclin-dependent kinase 22.7.11.220.440