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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3uixQ17Serine/threonine-protein kinase pim-12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3uixQ17Serine/threonine-protein kinase pim-12.7.11.11.000
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.637
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.628
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.621
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.619
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.617
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.616
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.613
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.604
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.603
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.601
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.592
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.591
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.590
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.586
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.586
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.586
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.579
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.574
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.573
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.573
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.565
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.562
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.559
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.559
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.556
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.556
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.556
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.553
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.549
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.547
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.546
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.545
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.545
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.543
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.542
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.541
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.539
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.536
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.528
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.528
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.528
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.528
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.520
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.516
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.516
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.515
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.513
3umw596Serine/threonine-protein kinase pim-12.7.11.10.512
4dymIYZActivin receptor type-12.7.11.300.510
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.508
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.505
4bgg844Activin receptor type-12.7.11.300.505
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.498
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.498
3iw4LW4Protein kinase C alpha type2.7.11.130.497
1xjdSTUProtein kinase C theta type2.7.11.130.496
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.494
4c02TAKActivin receptor type-12.7.11.300.493
4gg70J8Hepatocyte growth factor receptor2.7.10.10.493
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.492
3a4pDFQHepatocyte growth factor receptor2.7.10.10.491
4gw83RASerine/threonine-protein kinase pim-12.7.11.10.488
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.486
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.486
3mtfA3FActivin receptor type-12.7.11.300.484
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.483
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.481
4i22IREEpidermal growth factor receptor2.7.10.10.481
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.479
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.479
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.478
4iaq2GM5-hydroxytryptamine receptor 1B/0.477
3gubGUBDeath-associated protein kinase 12.7.11.10.475
4gmy0X5Tyrosine-protein kinase JAK2/0.475
4othDRNSerine/threonine-protein kinase N1/0.475
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.474
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
3vetADPnebramycin 5' synthase6.1.2.20.474
3uzcT4EAdenosine receptor A2a/0.474
1q1rFADPutidaredoxin reductase1.18.1.50.473
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.473
1aq1STUCyclin-dependent kinase 22.7.11.220.471
4g170VNCasein kinase I isoform gamma-32.7.11.10.471
3h4vNAPPteridine reductase 11.5.1.330.470
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.470
1bxoPP7Penicillopepsin-13.4.23.200.469
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.469
1q4u4CA4-hydroxybenzoyl-CoA thioesterase3.1.2.230.468
2wecPP5Penicillopepsin-13.4.23.200.468
3vt7VDXVitamin D3 receptor/0.468
1k7fIAVTryptophan synthase alpha chain/0.467
2ckeIQUDeath-associated protein kinase 2/0.467
2uzlC94Cyclin-dependent kinase 22.7.11.220.467
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.467
1wvxBD4Death-associated protein kinase 12.7.11.10.466
5cvhADPCasein kinase II subunit alpha2.7.11.10.466
1dawANPCasein kinase II subunit alpha2.7.11.10.465
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.464
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.464
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2h96893Mitogen-activated protein kinase 82.7.11.240.463
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.463
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.463
5auwQUEDeath-associated protein kinase 12.7.11.10.463
2jedLG8Protein kinase C theta type2.7.11.130.462
4bchT7ZCyclin-dependent kinase 92.7.11.220.462
1zys199Serine/threonine-protein kinase Chk12.7.11.10.461
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.461
4hvi19STyrosine-protein kinase JAK32.7.10.20.461
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.461
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.461
5auxKMPDeath-associated protein kinase 12.7.11.10.461
3oom507Activin receptor type-12.7.11.300.460
4hni16WCasein kinase I isoform epsilon2.7.11.10.460
4nj32KDCyclin-dependent kinase 22.7.11.220.460
5av2KMPDeath-associated protein kinase 12.7.11.10.460
1q4t4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.459
4iarERM5-hydroxytryptamine receptor 1B/0.459
5auuLU2Death-associated protein kinase 12.7.11.10.459
5fm7ADPRuvB-like helicase/0.459
2wihP48Cyclin-dependent kinase 22.7.11.220.458
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.458
5e8wSTUTGF-beta receptor type-12.7.11.300.458
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.457
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.457
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.457
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.457
3vewADPnebramycin 5' synthase6.1.2.20.457
4jq8KJ8Epidermal growth factor receptor2.7.10.10.457
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.456
1x2hLPALipoate-protein ligase A6.3.1.200.456
3gxlQIGTGF-beta receptor type-12.7.11.300.456
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.455
3bqr4RBDeath-associated protein kinase 3/0.455
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.455
3uyt0CKCasein kinase I isoform delta2.7.11.10.455
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.455
4ib4ERM5-hydroxytryptamine receptor 2B/0.455
4nc3ERM5-hydroxytryptamine receptor 2B/0.455
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.454
3b7dCNIGlutamate receptor 2/0.454
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.454
3qu0X40Cyclin-dependent kinase 22.7.11.220.454
3unj0BXCyclin-dependent kinase 22.7.11.220.454
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.454
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
4dgnLU2Casein kinase II subunit alpha2.7.11.10.454
4jia1K3Tyrosine-protein kinase JAK2/0.454
1oi9N20Cyclin-dependent kinase 22.7.11.220.453
1pkdUCNCyclin-dependent kinase 22.7.11.220.453
2ay84TBAromatic-amino-acid aminotransferase2.6.1.570.453
2c5nCK8Cyclin-dependent kinase 22.7.11.220.453
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.453
4grb0XGCasein kinase II subunit alpha2.7.11.10.453
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.453
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.452
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.452
3du8553Glycogen synthase kinase-3 beta2.7.11.260.452
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.452
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.452
4riyADPEpidermal growth factor receptor2.7.10.10.452
1oiyN41Cyclin-dependent kinase 22.7.11.220.451
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.451
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2hog710Serine/threonine-protein kinase Chk12.7.11.10.451
3blrCPBCyclin-dependent kinase 92.7.11.220.451
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.451
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.451
1h1s4SPCyclin-dependent kinase 22.7.11.220.450
2uzeC95Cyclin-dependent kinase 22.7.11.220.450
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.450
3oroAGSSerine/threonine protein kinase/0.450
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.450
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.450
5av4GENDeath-associated protein kinase 12.7.11.10.450
2bhhRYUCyclin-dependent kinase 22.7.11.220.449
2pvnP63Casein kinase II subunit alpha2.7.11.10.449
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.449
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.449
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.449
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.449
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.449
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1k6tXN1Gag-Pol polyprotein3.4.23.160.448
1kkq471Peroxisome proliferator-activated receptor alpha/0.448
1oiuN76Cyclin-dependent kinase 22.7.11.220.448
3gc9B45Mitogen-activated protein kinase 112.7.11.240.448
4fkg4CKCyclin-dependent kinase 22.7.11.220.448
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.448
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2pvhP19Casein kinase II subunit alpha2.7.11.10.447
3rpv26ZCyclin-dependent kinase 22.7.11.220.447
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.447
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.446
1pagFMPAntiviral protein I3.2.2.220.446
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.446
2xikJ60Serine/threonine-protein kinase 252.7.11.10.446
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.446
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.446
3sheI85MAP kinase-activated protein kinase 32.7.11.10.446
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.446
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.446
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
1vrqFONSubunit alpha of sarocosine oxidase/0.445
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2j0j4STFocal adhesion kinase 12.7.10.20.445
3litE15Protease/0.445
3vryB43Tyrosine-protein kinase HCK2.7.10.20.445
4l4cCAMCamphor 5-monooxygenase1.14.15.10.445
1zhwHC2Oxysterol-binding protein homolog 4/0.444
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.444
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.444
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.444
2ijmADPFocal adhesion kinase 12.7.10.20.444
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.444
3rni21ZCyclin-dependent kinase 22.7.11.220.444
3vt8YI3Vitamin D3 receptor/0.444
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4e4m0NHTyrosine-protein kinase JAK2/0.444
4eok4SPCyclin-dependent kinase 22.7.11.220.444
4fnyI3KALK tyrosine kinase receptor2.7.10.10.444
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.444
4yuqKS1Calmodulin-like domain protein kinase/0.444
5auvAGIDeath-associated protein kinase 12.7.11.10.444
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.443
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4yryFADGlutamate synthase, beta subunit/0.443
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.442
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3ormAGSSerine/threonine protein kinase/0.442
3r9dX6BCyclin-dependent kinase 22.7.11.220.442
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.442
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4eevL1XHepatocyte growth factor receptor2.7.10.10.442
4ewqMWLMitogen-activated protein kinase 14/0.442
4wsqKSAAP2-associated protein kinase 12.7.11.10.442
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.441
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.441
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.441
3hllI45Mitogen-activated protein kinase 14/0.441
3mtlFEFCyclin-dependent kinase 162.7.11.220.441
3pe2E1BCasein kinase II subunit alpha2.7.11.10.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
4hvh19RTyrosine-protein kinase JAK32.7.10.20.441
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.441
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.440
1ppm0P1Penicillopepsin-13.4.23.200.440
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.440
1u54ACPActivated CDC42 kinase 1/0.440
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.440
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.440
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.440
2pvlP55Casein kinase II subunit alpha2.7.11.10.440
2xmyCDKCyclin-dependent kinase 22.7.11.220.440
3a60STURibosomal protein S6 kinase beta-12.7.11.10.440
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.440
3vf2ADPnebramycin 5' synthase6.1.2.20.440
4bbe3O4Tyrosine-protein kinase JAK2/0.440
4dgo0JWCasein kinase II subunit alpha2.7.11.10.440
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.440
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4qmpDKISerine/threonine-protein kinase 242.7.11.10.440