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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ka0MK3MAP kinase-activated protein kinase 22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ka0MK3MAP kinase-activated protein kinase 22.7.11.11.000
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.516
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.503
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.500
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.494
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.493
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.491
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.490
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.489
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.488
3nup3NUCyclin-dependent kinase 62.7.11.220.487
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.486
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.484
4qnaX11Serine/threonine-protein kinase 242.7.11.10.484
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.481
3zh8C58Protein kinase C iota type2.7.11.130.481
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.481
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.480
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.477
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.477
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.477
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.477
2vd5BI8Myotonin-protein kinase2.7.11.10.476
3sheI85MAP kinase-activated protein kinase 32.7.11.10.475
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.474
2c4g514Cyclin-dependent kinase 22.7.11.220.473
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.473
4aguD15Cyclin-dependent kinase-like 1/0.473
4fv8E63Mitogen-activated protein kinase 12.7.11.240.473
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.472
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.472
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.472
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.472
2btsU32Cyclin-dependent kinase 22.7.11.220.471
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.471
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.471
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.469
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.469
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.468
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.468
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.468
1pkdUCNCyclin-dependent kinase 22.7.11.220.467
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.466
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.466
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.466
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.465
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.465
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
1di8DTQCyclin-dependent kinase 22.7.11.220.463
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.463
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.462
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.462
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.462
3a62STURibosomal protein S6 kinase beta-12.7.11.10.462
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.462
2izuP01Casein kinase I isoform gamma-32.7.11.10.461
2j0j4STFocal adhesion kinase 12.7.10.20.461
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.461
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.461
4nmbFADBifunctional protein PutA/0.461
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.461
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.460
2uzbC75Cyclin-dependent kinase 22.7.11.220.460
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.460
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.460
4b99R4LMitogen-activated protein kinase 72.7.11.240.460
4bcmT7ZCyclin-dependent kinase 22.7.11.220.460
4ez50RSCyclin-dependent kinase 62.7.11.220.460
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.460
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.460
1j39UPGDNA beta-glucosyltransferase/0.459
1oiyN41Cyclin-dependent kinase 22.7.11.220.459
3at4CCKCasein kinase II subunit alpha2.7.11.10.459
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.459
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
5cu6ATPCasein kinase II subunit alpha2.7.11.10.459
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.458
3ezrEZRCyclin-dependent kinase 22.7.11.220.458
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.458
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.457
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.457
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.457
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.457
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.456
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.456
4hgs15GCasein kinase I isoform gamma-32.7.11.10.456
4dgo0JWCasein kinase II subunit alpha2.7.11.10.455
1e9hINRCyclin-dependent kinase 22.7.11.220.454
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.454
2hog710Serine/threonine-protein kinase Chk12.7.11.10.454
3axwTIDCasein kinase II subunit alpha2.7.11.10.454
4fki09KCyclin-dependent kinase 22.7.11.220.454
2ojj82AMitogen-activated protein kinase 12.7.11.240.453
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.453
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.452
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.452
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.452
4c62XWWTyrosine-protein kinase JAK2/0.452
5dr2ATPAurora kinase A2.7.11.10.452
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.451
3bqr4RBDeath-associated protein kinase 3/0.451
3q9xEMOCasein kinase II subunit alpha2.7.11.10.451
4ogrADNCyclin-dependent kinase 92.7.11.220.451
1ipeNDPTropinone reductase 21.1.1.2360.450
1zrzBI1Protein kinase C iota type2.7.11.130.450
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.450
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.449
2ckeIQUDeath-associated protein kinase 2/0.449
2iw84SPCyclin-dependent kinase 22.7.11.220.449
3nux3NVCyclin-dependent kinase 62.7.11.220.449
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.449
3u4uLNHCasein kinase II subunit alpha2.7.11.10.449
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.449
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.449
4jqeANPCasein kinase II subunit alpha2.7.11.10.449
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.448
1v1k3FPCyclin-dependent kinase 22.7.11.220.448
2pvnP63Casein kinase II subunit alpha2.7.11.10.448
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.448
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.448
4bcnT9NCyclin-dependent kinase 22.7.11.220.448
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.448
4fv9E71Mitogen-activated protein kinase 12.7.11.240.448
4xhgADPUncharacterized protein/0.448
5auvAGIDeath-associated protein kinase 12.7.11.10.448
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.447
1oi9N20Cyclin-dependent kinase 22.7.11.220.447
2c475IDCasein kinase I isoform gamma-2/0.447
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.447
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.447
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.447
2zjwREFCasein kinase II subunit alpha2.7.11.10.447
3gc9B45Mitogen-activated protein kinase 112.7.11.240.447
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.447
3my5RFZCyclin-dependent kinase 22.7.11.220.447
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.447
4hvi19STyrosine-protein kinase JAK32.7.10.20.447
1wvxBD4Death-associated protein kinase 12.7.11.10.446
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.446
3tnwF18Cyclin-dependent kinase 22.7.11.220.446
4grb0XGCasein kinase II subunit alpha2.7.11.10.446
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.445
2qbnCAMCamphor 5-monooxygenase1.14.15.10.445
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.445
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
5e8xSTUTGF-beta receptor type-12.7.11.300.445
1oguST8Cyclin-dependent kinase 22.7.11.220.444
1phePIYCamphor 5-monooxygenase1.14.15.10.444
1r78FMDCyclin-dependent kinase 22.7.11.220.444
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.444
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.444
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4asdBAXVascular endothelial growth factor receptor 22.7.10.10.444
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.444
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.444
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.443
2pvmP29Casein kinase II subunit alpha2.7.11.10.443
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.443
3i60E86Mitogen-activated protein kinase 12.7.11.240.443
3uvqFS8Mitogen-activated protein kinase 14/0.443
4bcoT6QCyclin-dependent kinase 22.7.11.220.443
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.443
4wkqIREEpidermal growth factor receptor2.7.10.10.443
5auwQUEDeath-associated protein kinase 12.7.11.10.443
1m2rMNYCasein kinase II subunit alpha2.7.11.10.442
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.442
2qboCAMCamphor 5-monooxygenase1.14.15.10.442
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.442
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.442
3gubGUBDeath-associated protein kinase 12.7.11.10.442
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4hgt15GCasein kinase I isoform delta2.7.11.10.442
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1nzdUPGDNA beta-glucosyltransferase/0.441
1wvySTUDeath-associated protein kinase 12.7.11.10.441
1yrcCAMCamphor 5-monooxygenase1.14.15.10.441
2wotZZGTGF-beta receptor type-12.7.11.300.441
3r1sX73Cyclin-dependent kinase 22.7.11.220.441
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.441
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.441
4ienCOAPutative acyl-CoA hydrolase/0.441
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.440
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.440
4fuxE75Mitogen-activated protein kinase 12.7.11.240.440